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    Materials and methods for nerve grafting, selection of nerve grafts, and in vitro nerve tissue culture
    91.
    发明申请
    Materials and methods for nerve grafting, selection of nerve grafts, and in vitro nerve tissue culture 有权
    神经移植的材料和方法，神经移植物的选择和体外神经组织培养

    公开(公告)号：US20040180434A1

    公开(公告)日：2004-09-16

    申请号：US10812776

    申请日：2004-03-29

    发明人： David F. Muir

    IPC分类号： C12N005/08 ,  A61F002/02

    CPC分类号： A61L27/3687 ,  A61K35/30 ,  A61K38/51 ,  A61L27/227 ,  A61L27/3604 ,  A61L27/3675 ,  A61L27/3683 ,  A61L27/383 ,  A61L27/3878 ,  A61L31/047 ,  A61L2430/32 ,  A61K2300/00

    摘要： The subject invention pertains to compositions and methods for culturing nerve tissue in vitro and nerve grafts produced using such methods. The compositions and methods of the subject invention can be employed to restore the continuity of nerve interrupted by disease, traumatic events or surgical procedures. The invention also concerns methods for promoting repair of damaged nerve tissue using the present compositions and nerve tissue treated according to such methods.

    摘要翻译： 本发明涉及用于在体外培养神经组织的组合物和方法以及使用这些方法产生的神经移植物。 本发明的组合物和方法可以用于恢复由疾病，外伤事件或外科手术中断的神经的连续性。 本发明还涉及使用本发明组合物和根据这些方法治疗的神经组织促进受损神经组织修复的方法。

    Implant material
    93.
    发明申请
    Implant material 审中-公开
    植入材料

    公开(公告)号：US20040126404A1

    公开(公告)日：2004-07-01

    申请号：US10628308

    申请日：2003-07-29

    申请人： University of Queensland of St. Lucia

    发明人： Julie Hazel Campbell ,  Gordon Ronald Campbell

    IPC分类号： C12N005/00

    CPC分类号： A61L27/3886 ,  A61L27/3604 ,  A61L27/3804 ,  A61L27/3826 ,  A61L27/383 ,  A61L27/507

    摘要： The present invention relates generally to tissue implant material for use in grafting procedures. More particularly, the present invention provides non-vascular tissue for use as vascular graft material. The present invention further contemplates a method of vascular grafting using non-vascular tissue. The tissue of the present invention is preferably autologous relative to the recipient of the graft and is conveniently prepared around or on a molding support or other foreign body inserted into a body cavity of the intended recipient of the graft. The tissues and methods of the present invention are particularly useful in the treatment or prophylaxis of diseased or damaged blood vessels such as in atherosclerosis.

    摘要翻译： 本发明一般涉及用于接枝过程的组织植入材料。 更具体地，本发明提供用作血管移植材料的非血管组织。 本发明还考虑使用非血管组织进行血管移植的方法。 本发明的组织优选相对于移植物的接受者是自体的，并且方便地在插入移植物的预期受体的体腔中的成型支撑体或其它异物周围或周围制备。 本发明的组织和方法特别可用于治疗或预防动脉粥样硬化中患病或受损的血管。

    Vascularization enhanced graft constructs
    94.
    发明申请
    Vascularization enhanced graft constructs 有权
    血管化增强移植物构建体

    公开(公告)号：US20040006395A1

    公开(公告)日：2004-01-08

    申请号：US10428358

    申请日：2003-05-02

    发明人： Stephen F. Badylak

    IPC分类号： A61F002/02

    CPC分类号： A61L27/3886 ,  A61K35/12 ,  A61L27/3604 ,  A61L27/3804 ,  A61L27/3808 ,  A61L27/3813 ,  A61L27/3826 ,  A61L27/383 ,  C12N5/0685 ,  C12N5/069 ,  C12N5/0697 ,  C12N2501/135 ,  C12N2501/15 ,  C12N2501/165 ,  C12N2502/1347 ,  C12N2502/253 ,  C12N2502/28 ,  C12N2509/00

    摘要： A tissue graft construct for use in repairing diseased or damaged tissues is provided. The tissue graft construct comprises a matrix composition selected from the group consisting of urinary bladder submucosa and stomach submucosa, and extracts and hydrolysates thereof, added endothelial cells, and at least one additional preselected, exogenous population of cells which enhance initiation of the formation vessel-like structures in the graft construct. The preselected population of cells can be a population of non-keratinized or keratinized epithelial cells or a population of mesodermally-derived cells selected from the group consisting of fibroblasts, smooth muscle cells, skeletal muscle cells, cardiac muscle cells, multi-potential progenitor cells, pericytes, osteogenic cells, and any other suitable cell type, preferably selected based on the tissue to be repaired. Methods for enhancing the vascularization in vivo of these tissue graft constructs and for preparing these graft constructs are also provided.

    摘要翻译： 提供了用于修复患病或受损组织的组织移植物构建体。 组织移植物构建体包含选自膀胱粘膜下层和胃粘膜下层的基质组合物，其提取物和水解物，加入的内皮细胞和至少一种额外的预选的外源细胞群，其增强了形成血管 - 类似结构在移植物构造。 预选的细胞群可以是非角化角化角化细胞或角化细胞上皮细胞群或选自成纤维细胞，平滑肌细胞，骨骼肌细胞，心肌细胞，多潜能祖细胞 ，周细胞，成骨细胞和任何其它合适的细胞类型，优选基于待修复的组织选择。 还提供了用于增强这些组织移植物构建体体内血管形成和制备这些移植物构建体的方法。

    Cultured skin and method of manufacturing the same
    95.
    发明申请
    Cultured skin and method of manufacturing the same 失效
    培养皮肤及其制造方法

    公开(公告)号：US20030096409A1

    公开(公告)日：2003-05-22

    申请号：US10300906

    申请日：2002-11-21

    发明人： Shigeru Yasumoto ,  Masakatsu Takeuchi

    IPC分类号： C12N005/08

    CPC分类号： A61L27/3891 ,  A61L27/3804 ,  A61L27/3813 ,  A61L27/3826 ,  A61L27/383 ,  A61L27/60 ,  C12N5/0698 ,  C12N2502/094 ,  C12N2502/1323 ,  C12N2506/02

    摘要： A cultured skin and a grafting cultured skin sheet are provided, each of which is a cultured reconstructive skin with a high take rate using cells collectable from cells originated from tissue included in an umbilical cord such as tissue included in an umbilical cord originated from a human fetus. The grafting cultured skin stratified sheet is prepared by placing an epithelium sheet on the top surface of a cultured dermis. The cultured dermis includes as components a cultured skin containing cells originated from a tissue included in an umbilical cord, such as umbilical cells, more concretely, umbilical fibroblast cells, being separated and cultured, preferably in a collagen nonwoven fabric. On the other hand, the epithelium sheet is prepared by culturing and stratifying the umbilical cord epithelium cells.

    摘要翻译： 提供培养的皮肤和接枝培养的皮肤片，其中每个皮肤均为使用从包含在脐带中的组织的细胞收集的细胞的高摄取率的细胞，例如包含在源自人的脐带中的组织 胎儿。 通过将上皮片放置在培养的真皮的顶表面上来制备移植培养的皮肤分层片。 培养的真皮包括作为组分的培养皮肤，其含有源自包含在脐带中的组织的细胞，例如脐带细胞，更具体地，分离培养的脐带成纤维细胞，优选在胶原无纺织物中。 另一方面，通过培养和分层脐带上皮细胞来制备上皮片。

    Mx-1 conditionally immortalized cells
    98.
    发明授权
    Mx-1 conditionally immortalized cells 失效
    Mx-1条件永生化细胞

    公开(公告)号：US06392118B1

    公开(公告)日：2002-05-21

    申请号：US08447997

    申请日：1995-05-23

    申请人： Joseph P. Hammang ,  Albee Messing

    发明人： Joseph P. Hammang ,  Albee Messing

    IPC分类号： A01K67027

    CPC分类号： C12N5/0068 ,  A61K48/00 ,  A61L27/18 ,  A61L27/227 ,  A61L27/383 ,  A61L27/3834 ,  A61L27/3839 ,  A61L27/3895 ,  C07K14/82 ,  C12N2510/00 ,  C12N2510/04 ,  C12N2533/30 ,  C12N2533/54 ,  C12N2533/74 ,  C08L83/12

    摘要： This invention relates to methods and compositions of controlling cell distribution within a bioartificial organ by exposing the cells to a treatment that inhibits cell proliferation, promotes cell differentiation, or affects cell attachment to a growth surface within the bioartificial organ. Such treatments include (1) genetically manipulating cells, (2) exposing the cells to a proliferation-inhibiting compound or a differentiation-inducing compound or removing the cells from exposure to a proliferation-stimulating compound or a differentiation-inhibiting compound; exposing the cells to irradiation, and (3) modifying a growth surface of the BAO with ECM molecules, molecules affecting cell proliferation or adhesion, or an inert scaffold, or a combination thereof. These treatments may be used in combination.

    摘要翻译： 本发明涉及通过将细胞暴露于抑制细胞增殖，促进细胞分化或影响细胞附着于生物人造器官内的生长表面的处理来控制生物人造器官内的细胞分布的方法和组合物。 这样的处理包括（1）遗传操纵细胞，（2）将细胞暴露于增殖抑制化合物或分化诱导化合物，或除去细胞暴露于增殖刺激化合物或分化抑制化合物; 使细胞暴露于照射，和（3）用ECM分子修饰BAO的生长表面，影响细胞增殖或粘附的分子，或惰性支架或其组合。 这些处理可以组合使用。

    Method for transplanting cells into the brain and therapeutic uses therefor
    99.
    发明申请
    Method for transplanting cells into the brain and therapeutic uses therefor 审中-公开
    将细胞移植到脑中的方法及其治疗用途

    公开(公告)号：US20020009431A1

    公开(公告)日：2002-01-24

    申请号：US09884431

    申请日：2001-06-18

    发明人： Bruce D. Cherksey

    IPC分类号： A61K045/00 ,  C12N005/08

    CPC分类号： A61L27/3804 ,  A61F2/00 ,  A61K9/0085 ,  A61K9/1676 ,  A61K35/30 ,  A61K47/6923 ,  A61K48/00 ,  A61L27/3813 ,  A61L27/3821 ,  A61L27/383 ,  A61L27/3878 ,  C12N5/0614 ,  C12N5/0618 ,  C12N5/0619 ,  C12N5/0621 ,  C12N2502/08 ,  C12N2531/00 ,  C12N2533/12

    摘要： A method for grafting a cell in the brain of a mammalian subject is accomplished by attaching the cell to a support matrix so that the cell attaches to the matrix surface, and implanting the support matrix with the attached cell into the brain. Preferred support matrices are glass or plastic microbeads, either solid or porous, having a diameter from about 90 to about 125 nullm. The method employs cells of different types, preferably cells of neural or paraneural origin, such as adrenal chromaffin cells. Also useful are cell lines grown in vitro. Cells not of neural or paraneural origin, such as fibroblasts, may also be used following genetic alteration to express a desired neural product such as a neurotransmitter or a neuronal growth factor. The method is used to treat neurological diseases such as Parkinson's disease, Alzheimer's disease, Huntington's disease, epilepsy, and traumatic brain injury.

    摘要翻译： 通过将细胞附着到支持体基质上使得细胞附着于基质表面，并将支持基质与附着的细胞植入大脑中来实现哺乳动物受试者的脑中移植细胞的方法。 优选的支撑基质是直径为约90至约125μm的玻璃或塑料微珠，其为固体或多孔的。 该方法使用不同类型的细胞，优选神经或副神经起源的细胞，例如肾上腺嗜铬细胞。 也有用的是体外生长的细胞系。 不是神经或副神经来源的细胞，如成纤维细胞，也可以在遗传改变后使用以表达期望的神经产物如神经递质或神经元生长因子。 该方法用于治疗神经系统疾病，如帕金森病，阿尔茨海默病，亨廷顿氏病，癫痫和创伤性脑损伤。

    Method for transplanting cells into the brain and therapeutic uses therefor
    100.
    发明授权
    Method for transplanting cells into the brain and therapeutic uses therefor 失效
    将细胞移植到脑中的方法及其治疗用途

    公开(公告)号：US06264943B1

    公开(公告)日：2001-07-24

    申请号：US09467549

    申请日：1999-12-10

    申请人： Bruce D. Cherksey

    发明人： Bruce D. Cherksey

    IPC分类号： A01N6300

    CPC分类号： A61L27/3804 ,  A61F2/00 ,  A61K9/0085 ,  A61K9/1676 ,  A61K35/30 ,  A61K47/6923 ,  A61K48/00 ,  A61L27/3813 ,  A61L27/3821 ,  A61L27/383 ,  A61L27/3878 ,  C12N5/0614 ,  C12N5/0618 ,  C12N5/0619 ,  C12N5/0621 ,  C12N2502/08 ,  C12N2531/00 ,  C12N2533/12

    摘要： A method for grafting a cell in the brain of a mammalian subject is accomplished by attaching the cell to a support matrix so that the cell attaches to the matrix surface, and implanting the support matrix with the attached cell into the brain. Preferred support matrices are glass or plastic microbeads, either solid or porous, having a diameter from about 90 to about 125 &mgr;m. The method employs cells of different types, preferably cells of neural or paraneural origin, such as adrenal chromaffin cells. Also useful are cell lines grown in vitro. Cells not of neural or paraneural origin, such as fibroblasts, may also be used following genetic alteration to express a desired neural product such as a neurotransmitter or a neuronal growth factor. The method is used to treat neurological diseases such as Parkinson's disease, Alzheimer's disease, Huntington's disease, epilepsy, and traumatic brain injury.

    摘要翻译： 将哺乳动物受试者的脑中的细胞移植的方法是通过将细胞附着到支持体基质上来实现的，以使细胞附着于基质表面，并将支持体与附着细胞一起植入脑中。 优选的支撑基质是直径为约90至约125μm的玻璃或塑料微珠，其为固体或多孔的。 该方法使用不同类型的细胞，优选神经或副神经起源的细胞，例如肾上腺嗜铬细胞。 也有用的是体外生长的细胞系。 不是神经或副神经来源的细胞，如成纤维细胞，也可以在遗传改变后使用以表达期望的神经产物如神经递质或神经元生长因子。 该方法用于治疗神经系统疾病，如帕金森病，阿尔茨海默病，亨廷顿氏病，癫痫和创伤性脑损伤。