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公开(公告)号：US07842281B2
公开(公告)日：2010-11-30
申请号：US11125488
申请日：2005-05-10
申请人： Yousef Haik , Ching-Jen Chen
发明人： Yousef Haik , Ching-Jen Chen
摘要： Magnetic nanoparticle compositions are provided which provide an inherent temperature regulator for use in magnetic heating, particularly for use in magnetic hyperthermia medical treatments. The composition includes magnetic nanoparticles having a Curie temperature of between 40 and 46° C., preferably about 42° C., and may further include a polymeric material and optionally a drug or radiosensitizing agent. Methods of hyperthermia treatment of a patient in need thereof are provided which include the steps of administering to the patient a composition comprising magnetic nanoparticles having a Curie temperature of between 40 and 46° C.; and exposing the magnetic nanoparticles in the patient to an alternating magnetic field effective to generate hysteresis heat in the nanoparticles.
摘要翻译： 提供磁性纳米颗粒组合物，其提供用于磁加热的固有温度调节剂，特别用于磁疗热疗医疗。 组合物包括居里温度为40至46℃，优选约42℃的磁性纳米颗粒，并且还可包括聚合物材料和任选的药物或放射增敏剂。 提供了对有需要的患者进行热疗治疗的方法，其包括向患者施用包含居里温度为40至46℃的磁性纳米颗粒的组合物的步骤; 并将患者中的磁性纳米颗粒暴露于有效地在纳米颗粒中产生滞后热的交变磁场。
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92.发明授权Systems and methods for combined RF-induced hyperthermia and radioimmunotherapy 有权用于组合RF诱导的高热和放射免疫治疗的系统和方法公开(公告)号：US07627381B2
公开(公告)日：2009-12-01
申请号：US11050478
申请日：2005-02-03
IPC分类号： A61F2/00
CPC分类号： A61K41/0052 , A61N1/403 , A61N1/406 , A61N5/1001 , B82Y5/00
摘要： A combined radiotherapy and hyperthermia therapy is provided, including inducing hyperthermia in at least a portion of a target area—e.g., a tumor or a portion of a tumor or targeted cancerous cells—is provided. Biomolecules labeled with at least one radionuclide suitable for radiotherapy are provided and introduced into a patient; targeted RF absorption enhancers are provided and introduced into a patient; and a hyperthermia generating RF signal is directed via toward the target cells, thereby warming the radionuclide-labeled biomolecules and targeted RF absorption enhancers bound to target cells. The targeted RF absorption enhancers may, in a manner of speaking, add one or more RF absorption frequencies to cells in the target area, which will permit a hyperthermia generating RF signal at that frequency or frequencies to heat the targeted cells. Biomolecules labeled with at least one radionuclide suitable for radiotherapy may be used for both radiotherapy and as RF absorption enhancers for the hyperthermia generating RF signal.
摘要翻译： 提供了联合放疗和高热疗法，包括在目标区域的至少一部分（例如肿瘤或部分肿瘤或靶向癌细胞）中诱导高热。 提供用至少一种适用于放射治疗的放射性核素标记的生物分子并将其引入患者体内; 提供靶向RF吸收增强剂并将其引入患者体内; 并且通过朝向靶细胞引导产生高热的RF信号，从而加热与靶细胞结合的放射性核素标记的生物分子和靶向RF吸收增强剂。 靶向RF吸收增强剂可以以说话的方式将一个或多个RF吸收频率添加到目标区域中的细胞，这将允许产生以该频率或频率的RF信号以加热靶细胞的热疗。 用适合于放射治疗的至少一种放射性核素标记的生物分子可以用于放射治疗，也可以用作RF热吸收增强剂，用于产生高热的RF信号。
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公开(公告)号：US20090157069A1
公开(公告)日：2009-06-18
申请号：US12315360
申请日：2008-12-02
申请人： Curtis Tom , Raj Subramaniam , Mathieu Herbette , Chrysbe Madayag
发明人： Curtis Tom , Raj Subramaniam , Mathieu Herbette , Chrysbe Madayag
CPC分类号： A61B18/18 , A61B18/1815 , A61B2017/00084 , A61B2017/4216 , A61B2018/1861 , A61B2090/3925 , A61K41/0052 , A61K49/1818 , A61N1/406 , B82Y5/00
摘要： Apparatus and methods for treating body tissue by use of thermal treatment material. The thermal treatment material to be injected into target tissue of a body includes: a carrier substrate; a plurality of first particles operative to generate thermal energy in response to an alternating electromagnetic field applied external to the body; and a plurality of second particles, each of the second particles having a core and a coating surrounding the core. The coating is dissolved at a preset temperature by the thermal energy so that the visibility of the core in an external imaging system is affected as the coating is dissolved to expose the core. The variation of the visibility can be used as an indicator to determine if the material has reached the preset temperature.
摘要翻译： 使用热处理材料处理身体组织的装置和方法。 要注射到身体的靶组织中的热处理材料包括：载体基底; 多个第一粒子，用于响应于施加在身体外部的交变电磁场而产生热能; 和多个第二颗粒，所述第二颗粒中的每一个具有芯和围绕所述芯的涂层。 涂层通过热能在预设温度下溶解，使得当涂层溶解以暴露核心时，外部成像系统中的芯的可视性受到影响。 可见度的变化可以用作指示物，以确定材料是否达到预设温度。
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公开(公告)号：US07530940B2
公开(公告)日：2009-05-12
申请号：US10705614
申请日：2003-11-10
IPC分类号： A61N5/00
CPC分类号： A61N5/00 , A61K41/0038 , A61K41/0052 , A61K47/6849 , A61K47/6923 , A61K47/6929 , A61K49/222 , A61K49/226 , A61N1/406 , A61N5/062 , A61N5/10 , A61N2005/1098 , B82Y5/00 , Y10S977/728 , Y10S977/777 , Y10S977/91 , Y10S977/911 , Y10S977/923 , Y10S977/927 , Y10S977/928 , Y10S977/929 , Y10S977/93
摘要： The present invention provides methods of using metal nanoparticles 0.5 to 400 nm in diameter to enhance the dose and effectiveness of x-rays or of other kinds of radiation in therapeutic regimes of ablating a target tissue, such as tumor. The metal nanoparticles can be administered intravenously, intra-arterially, or locally to achieve specific loading in and around the target tissue. The metal nanoparticles can also be linked to chemical and/or biochemical moieties which bind specifically to the target tissue. The enhanced radiation methods can also be applied to ablate unwanted tissues or cells ex vivo.
摘要翻译： 本发明提供使用直径为0.5-400nm的金属纳米粒子的方法，以增强X射线或其它类型辐射在消融诸如肿瘤的靶组织的治疗方案中的剂量和效力。 金属纳米颗粒可以静脉内，动脉内或局部施用，以实现靶组织内和周围的特异性负载。 金属纳米颗粒也可以连接到特异性结合靶组织的化学和/或生物化学部分。 增强的辐射方法也可用于离体消融不需要的组织或细胞。
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公开(公告)号：US20080125770A1
公开(公告)日：2008-05-29
申请号：US11944974
申请日：2007-11-26
申请人： Gennady Kleyman
发明人： Gennady Kleyman
IPC分类号： A61B18/18
CPC分类号： A61B18/18 , A61B18/1815 , A61B18/20 , A61B18/28 , A61B2017/22051 , A61B2018/1807 , A61N1/406
摘要： Disclosed is an apparatus for ablating biological tissues, the apparatus is configured with a cannula, a balloon inflatable with a gaseous medium and coupled to the cannula, and an electromagnetic antenna coupled to the balloon operative to emit electromagnetic waves which heat the wall of the balloon. The wall is made from wave penetrating material impregnated with a plurality of wave absorbing particles which are heated to the desired ablation temperature by the absorbed electromagnetic waves.
摘要翻译： 公开了一种用于烧蚀生物组织的装置，该装置配置有插管，可用气体介质充气并且耦合到插管的气球，以及耦合到气囊的电磁天线，其操作以发射加热气球壁的电磁波 。 该壁由浸渍有多个吸波颗粒的波浪渗透材料制成，其通过吸收的电磁波被加热到期望的消融温度。
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公开(公告)号：US07300452B2
公开(公告)日：2007-11-27
申请号：US10525170
申请日：2003-08-15
申请人： Bernhard Gleich
发明人： Bernhard Gleich
IPC分类号： A61F7/00
CPC分类号： A61B5/0515 , A61B5/05 , A61N1/406
摘要： The invention relates to a method as well as to a system for the local heating of a target region of an object by varying the magnetization of magnetic or magnetizable substances. A magnetic field is then generated whose magnetic field strength varies in space in such a manner that a first sub-region (301) of low magnetic field strength and a second sub-region (302) which encloses the first sub-region and has a higher magnetic field strength are formed in the target region. Subsequently, the position in space of the two sub-regions in the target region is varied with a given frequency for so long that the particles are heated to a desired temperature due to frequent variation of the magnetization.
摘要翻译： 本发明涉及一种方法以及通过改变磁性或可磁化物质的磁化来局部加热物体的目标区域的系统。 然后产生其磁场强度在空间中变化的磁场，使得包围低磁场强度的第一子区域（301）和包围第一子区域的第二子区域（302）具有 在目标区域中形成较高的磁场强度。 随后，以给定频率改变目标区域中的两个子区域的空间中的位置，使得由于磁化强度的频繁变化将颗粒加热到期望的温度。
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97.发明申请Method and device of metamorphosing cells, and treatment apparatus using the same 审中-公开变形细胞的方法和装置，以及使用其的处理装置公开(公告)号：US20070196920A1
公开(公告)日：2007-08-23
申请号：US11507674
申请日：2006-08-22
CPC分类号： A61N5/00 , A61N1/406 , A61N5/0601
摘要： A cell metamorphosing device includes micro dishes which serves as diaphragms and hold a mixed medium containing harmful cells and nano-scale particles, an AC voltage supply, a heater and an inductor. The AC voltage supply faces with the micro dishes 2 with a space, and applies a bias to the micro dishes 2, so that the nano-scale particles are bombarded onto the harmful cells and destroy them.
摘要翻译： 细胞变形装置包括用作隔膜并保持含有有害细胞和纳米级粒子的混合介质，AC电压源，加热器和电感器的微型盘。 交流电压供给面与微型菜肴2具有空间，并向微型菜肴2施加偏压，使得纳米级颗粒被轰击到有害细胞上并将其破坏。
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公开(公告)号：US20070168001A1
公开(公告)日：2007-07-19
申请号：US11601083
申请日：2006-11-16
申请人： Xiao-Dong Xiang , Gang Wang , Haitao Yang , Jonathan Melman , Gerald Dionne
发明人： Xiao-Dong Xiang , Gang Wang , Haitao Yang , Jonathan Melman , Gerald Dionne
IPC分类号： A61F2/00
CPC分类号： A61N1/406 , A61K41/0052 , A61K49/1818
摘要： Embodiments of the present invention are generally related to apparatus and methodology of thermal applicators in cancer therapy. In particular, the present embodiments are directed to a technique called “nanoparticle ferromagnetic resonance heating,” where ferromagnetic resonance heating in addition to an RF hyperthermia treatment is used to cause cell apoptosis and necrosis. An apparatus for carrying out a ferromagnetic resonance heating treatment of a tumor, comprises a volume concentration of super paramagnetic particles contained within the interior of the tumor, the concentration ranging from about 0.1 to about 1 percent; a magnetic field source configured to deliver a gradient DC magnetic field to the region of the tumor; and an energy source configured to deliver to the tumor an RF field at a frequency ranging from about 100 to 200 MHz. The apparatus of claim 1, wherein the super paramagnetic particles are selected from the group consisting of maghemite (γ-Fe2O3) based compounds, and yttrium iron garnet (Y3Fe5O12) based compounds.
摘要翻译： 本发明的实施例通常涉及癌症治疗中的热敷装置的装置和方法。 特别地，本实施例涉及一种称为“纳米颗粒铁磁共振加热”的技术，其中使用除RF热疗处理之外的铁磁共振加热以引起细胞凋亡和坏死。 用于进行肿瘤的铁磁共振加热处理的装置包括包含在肿瘤内部的超顺磁性颗粒的体积浓度，其浓度范围为约0.1％至约1％; 磁场源，被配置为向所述肿瘤的区域递送梯度DC磁场; 以及能量源，其被配置为以大约100至200MHz的频率向所述肿瘤递送RF场。 2.根据权利要求1所述的设备，其中所述超顺磁性颗粒选自由以下物质组成的组：基于磁赤铁矿（γ-Fe 2 O 3 O 3）的化合物和钇铁石榴石（Y 3 5 12 12）基的化合物。
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公开(公告)号：US07041047B2
公开(公告)日：2006-05-09
申请号：US10264637
申请日：2002-10-04
IPC分类号： A61N5/00
CPC分类号： A61N1/406 , A61N5/1027 , A61N2005/1009 , A61N2005/1011 , A61N2005/1024 , A61N2005/1025
摘要： A brachytherapy device includes a radiation source and a multi-cannula delivery system for implantation of the radiation source into a body tissue site. The radiation source may be, for example, a substantially straight round wire, a substantially straight flat wire, a detented wire, an embossed wire, a bristled wire, a shaped resilient wire, a twisted round wire, a twisted flat wire, or a coil with or without an inner core, and is adapted for implantation into a body tissue site and for delivery of radiation to the body tissue site. The multi-cannula delivery system includes an outer cannula, an outer stylet, an inner cannula, and an inner stylet. Different configurations of the radiation source according to embodiments of the invention improve distribution of the radiation field in the longitudinal direction and resistance to migration of the radiation source inside a patient's body. The multi-cannula delivery system provides for faster and more accurate placement of the radiation source.
摘要翻译： 近距离放射治疗装置包括辐射源和用于将辐射源植入身体组织部位的多插管递送系统。 辐射源可以是例如基本上直的圆形线，基本上直的扁平线，歪斜线，压纹线，刷毛线，成形弹性线，扭曲圆线，扭绞扁线或 具有或不具有内芯的线圈，并且适于植入体内组织部位并将辐射传送到身体组织部位。 多套管递送系统包括外套管，外管心针，内插管和内探针。 根据本发明的实施例的辐射源的不同配置改善了辐射场在纵向方向上的分布和抵抗辐射源在患者体内的迁移。 多插管递送系统提供了更快更准确地放置辐射源。
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公开(公告)号：US06997863B2
公开(公告)日：2006-02-14
申请号：US10200082
申请日：2002-07-19
申请人： Erik S. Handy , Robert Ivkov , Diane Ellis-Busby , Allan Foreman , Susan J. Braunhut , Douglas U. Gwost , Blair Ardman
发明人： Erik S. Handy , Robert Ivkov , Diane Ellis-Busby , Allan Foreman , Susan J. Braunhut , Douglas U. Gwost , Blair Ardman
IPC分类号： A61N2/00
CPC分类号： A61N1/406 , A61N2/02 , Y10S977/904
摘要： Disclosed are therapeutic methods for the treatment of disease material involving administration of a thermotherapeutic magnetic composition, which contains single-domain magnetic particles attached to a target-specific ligand, to a patient and application of an alternating magnetic field to inductively heat the thermotherapeutic magnetic composition. Also disclosed are methods of administering the thermotherapeutic magnetic material composition. The thermotherapeutic methods may be used where the predetermined target is associated with diseases, such as cancer, diseases of the immune system, and pathogen-borne diseases, and undesirable targets, such as toxins, reactions associated with organ transplants, hormone-related diseases, and non-cancerous diseased cells or tissue.
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