公开(公告)号：US20160332003A1

公开(公告)日：2016-11-17

申请号：US15218327

申请日：2016-07-25

申请人： The Regents of the University of California ,  Sonogenix, Inc.

发明人： Michael Dae ,  Claire Andrews

IPC分类号： A61N7/00 ,  A61B8/00 ,  A61M1/14 ,  A61B8/08

CPC分类号： A61N7/00 ,  A61B6/507 ,  A61B8/08 ,  A61B8/4477 ,  A61B8/481 ,  A61M1/14 ,  A61N2007/0004 ,  A61N2007/0078 ,  A61N2007/0082

摘要： Improved devices, systems, and methods treatment of patients can be used to help mitigate injury to the kidneys by applying cyclical mechanical pressure energy at low intensities. The energy often be selectively directed from non-invasive transducers disposed outside the patients. The energy will typically comprise low frequency ultrasound energy, shock wave energy, or the like, and may induce the generation and/or release of nitric oxide, thereby enhancing perfusion and ameliorating tissue damage. Superimposed micro and macro duty cycles may help avoid thermal and other injury to tissues of the patient during treatment. Bilateral treatments are facilitated by a support structure that orients at least one transducer toward each kidney.

摘要翻译： 改进的设备，系统和方法治疗患者可用于通过在低强度下施加周期性机械压力能量来帮助减轻对肾脏的损伤。 能量通常从布置在患者外部的非侵入性换能器选择性导向。 能量通常包括低频超声能量，冲击波能量等，并且可以诱导一氧化氮的产生和/或释放，从而增强灌注并改善组织损伤。 叠加的微观和微观占空比可能有助于避免治疗期间患者组织的热和其他损伤。 通过支撑结构来促进双侧治疗，所述支撑结构为每个肾定向至少一个换能器。

公开(公告)号：US20160317840A1

公开(公告)日：2016-11-03

申请号：US15009817

申请日：2016-01-28

申请人： Medtronic, Inc.

发明人： Robert W. Stadler ,  Subham Ghosh

IPC分类号： A61N7/00 ,  A61N1/362 ,  A61B5/0408

CPC分类号： A61N7/00 ,  A61B5/0053 ,  A61B5/04085 ,  A61B5/04286 ,  A61B5/0472 ,  A61B5/1107 ,  A61B5/4848 ,  A61B5/743 ,  A61B2505/05 ,  A61N1/362 ,  A61N1/3627 ,  A61N7/02 ,  A61N2007/0004 ,  A61N2007/0026 ,  A61N2007/0056

摘要： Systems, methods, and interfaces are described herein for noninvasively determining whether a patient can benefit from cardiac resynchronization therapy. One exemplary method involves delivering ultrasonic energy to cardiac tissue. In response to delivering ultrasonic energy to the cardiac tissue, receiving, with a processing unit, a torso-surface potential signal from each of a plurality of electrodes distributed on a torso of a patient. For at least a subset of the plurality of electrodes, calculating, with the processing unit, a torso-surface activation time based on the signal sensed from the electrode. Presenting, by the processing unit, to a user, an indication of a degree of dyssynchrony of the torso-surface activation times via a display.

摘要翻译： 本文描述了系统，方法和界面，用于非侵入性地确定患者是否可以从心脏再同步治疗中受益。 一种示例性方法涉及将超声能量递送到心脏组织。 响应于向心脏组织递送超声能量，用处理单元接收分布在患者躯干上的多个电极中的每一个的躯干表面电位信号。 对于多个电极的至少一个子集，基于从电极感测的信号，利用处理单元计算躯干表面激活时间。 由处理单元向用户呈现经由显示器的躯干表面激活时间的不同步程度的指示。

公开(公告)号：US09427602B2

公开(公告)日：2016-08-30

申请号：US14922885

申请日：2015-10-26

申请人： Ojai Retinal Technology, LLC

发明人： Jeffrey K. Luttrull ,  David B. Chang ,  Benjamin W. L. Margolis

IPC分类号： A61F2/00 ,  A61N7/02 ,  A61N5/06 ,  A61N5/067 ,  A61N7/00 ,  A61N5/10 ,  A61F9/008

CPC分类号： A61N7/022 ,  A61F9/008 ,  A61F9/00817 ,  A61F9/00821 ,  A61F2009/00863 ,  A61N5/06 ,  A61N5/0603 ,  A61N5/0625 ,  A61N5/1017 ,  A61N2005/0604 ,  A61N2005/0609 ,  A61N2005/063 ,  A61N2005/0648 ,  A61N2005/0658 ,  A61N2005/0659 ,  A61N2005/0662 ,  A61N2005/067 ,  A61N2007/0004

摘要： A system and method are disclosed for stimulating activation of heat shock proteins and facilitating protein repair in cells and tissues in order to take advantage of the remediative and restorative nature of the increased heat shock protein activation or production and the facilitation of protein repair, while not damaging the cells and tissues. This is accomplished by treating a specified target area with an ultrasound or electromagnetic radiation source which is pulsed and applied or focused to one or more small areas in order to achieve the necessary temperature rise or sufficiently stress the cells and tissue to stimulate heat shock protein production or activation and facilitate protein repair, while allowing the temperature to decay sufficiently quickly so as not to damage or destroy the treated tissue.

摘要翻译： 公开了一种用于刺激热休克蛋白激活并促进细胞和组织中的蛋白质修复的系统和方法，以利用增加的热休克蛋白激活或产生的补救和恢复性质以及促进蛋白质修复，而不是 破坏细胞和组织。 这是通过用脉冲和施加或聚焦到一个或多个小区域的超声波或电磁辐射源处理指定的目标区域来实现的，以便实现必要的温度升高或充分压力细胞和组织以刺激热休克蛋白产生 或激活并促进蛋白质修复，同时允许温度足够快地衰减，以免损坏或破坏经处理的组织。

公开(公告)号：US20160235976A1

公开(公告)日：2016-08-18

申请号：US15138582

申请日：2016-04-26

申请人： EBR Systems, Inc.

发明人： Debra S. Echt ,  Richard E. Riley ,  Mark W. Cowan ,  Axel F. Brisken

IPC分类号： A61N1/362 ,  A61N7/00 ,  A61N1/378

CPC分类号： A61N1/362 ,  A61N1/3627 ,  A61N1/37205 ,  A61N1/3787 ,  A61N7/00 ,  A61N2007/0004

摘要： The present invention relies on a controller-transmitter device to deliver ultrasound energy into cardiac tissue in order to directly improve cardiac function and/or to energize one or more implanted receiver-stimulator devices that transduce the ultrasound energy to electrical energy to perform excitatory and/or non-excitatory treatments for heart failure. The acoustic energy can be applied as a single burst or as multiple bursts.

摘要翻译： 本发明依赖于控制器 - 发射器装置将超声能量输送到心脏组织中，以便直接改善心脏功能和/或激发一个或多个植入的接收器 - 刺激器装置，其将超声能量转换成电能以进行兴奋和/ 或心脏衰竭的非兴奋性治疗。 声能可以作为单个突发或多个突发应用。

公开(公告)号：US20160144147A1

公开(公告)日：2016-05-26

申请号：US14904906

申请日：2014-07-09

申请人： SRH WALD-KLINIKUM GERA GGMBH

发明人： Frank WOLFRAM ,  Thomas LESSER

IPC分类号： A61M16/14 ,  A61N7/02 ,  A01N1/02

CPC分类号： A61M16/147 ,  A01N1/0236 ,  A61B2018/00541 ,  A61B2018/00577 ,  A61B2018/00791 ,  A61B2090/374 ,  A61B2090/376 ,  A61B2090/378 ,  A61B2217/007 ,  A61M16/0404 ,  A61M16/109 ,  A61M2202/0208 ,  A61M2202/0468 ,  A61M2205/058 ,  A61M2205/33 ,  A61M2205/3368 ,  A61N7/02 ,  A61N2007/0004 ,  A61N2007/0082 ,  A61N2007/0086 ,  A61N2007/027

摘要： The invention relates to an arrangement and method for the in-vitro and in-vivo treatment of bronchial tumors.The aim of the invention to provide an arrangement and a method for operating said arrangement for the in-vitro and in-vivo treatment of bronchial tumors, with said arrangement making the lungs receptive to ultrasound in order to allow the mechanical ultrasound waves to be guided through the healthy lung tissue to the tumor tissue in an optimized manner for the use of FUS therapy, is achieved in that the arrangement comprises a ventilation and respirator system (1) for a lung part to be provided with a gas for respiratory purposes (33), a device for the controlled ventilation and flooding (2) of a lung part to be flooded (34) with a liquid, a therapy system (4), and a central control unit (5), wherein the therapy system (4) consists of at least one therapeutic ultrasonic transducer (40), an imaging-monitoring system (42), and a temperature-monitoring system (41), and the central control unit (5) is connected to the therapeutic ultrasonic transducer (40), the respirator system (1), the device for the controlled ventilation and flooding processes (2), the imaging-monitoring system (42), and the temperature-monitoring system (41) for data-transmission purposes, the respirator system (1) and the device for the controlled ventilation and flooding (2) processes have a gas- and liquid-conducting connection to a lung tube (3), the lung tube (3) can be inserted into a lung containing a tumor (35) in an intratracheal manner, and therapeutic ultrasound doses can be administered by the ultrasonic transducer (40).

摘要翻译： 本发明涉及支气管肿瘤的体外和体内治疗的布置和方法。 本发明的目的是提供一种用于操作用于支气管肿瘤的体外和体内治疗的所述装置的装置和方法，其中所述布置使肺接受超声以允许机械超声波被引导 通过健康的肺组织以优化的方式使用FUS治疗，实现了该装置包括通气和呼吸器系统（1），用于肺部被提供用于呼吸目的的气体（33 ），用于用液体淹没（34）的肺部分受控通气和淹没（2）的装置，治疗系统（4）和中央控制单元（5），其中所述治疗系统（4） 由至少一个治疗性超声波换能器（40），成像监视系统（42）和温度监视系统（41）组成，并且中央控制单元（5）连接到治疗性超声波换能器（40） 呼吸器系统（1）， 用于受控通风和淹水过程的设备（2），成像监测系统（42）和用于数据传输目的的温度监测系统（41），呼吸器系统（1）和用于受控通风和 淹没（2）过程具有与肺管（3）的气液导液连接，肺管（3）可以以气管内方式插入含有肿瘤（35）的肺中，并且治疗性超声剂量可以 由超声波换能器（40）施用。

公开(公告)号：US20160082291A1

公开(公告)日：2016-03-24

申请号：US14941276

申请日：2015-11-13

申请人： University of Washington through its Center for Commercialization

发明人： Michael Bailey ,  John Kucewicz ,  Barbrina Dunmire ,  Neil Owen ,  Bryan Cunitz

IPC分类号： A61N7/00

CPC分类号： A61B17/225 ,  A61B5/055 ,  A61B5/7232 ,  A61B6/03 ,  A61B6/485 ,  A61B8/085 ,  A61B8/488 ,  A61B17/2256 ,  A61B2017/22005 ,  A61B2090/378 ,  A61N7/00 ,  A61N2007/0004 ,  A61N2007/0052 ,  A61N2007/0082 ,  G01S7/52071 ,  G01S15/899

摘要： Described herein are methods and apparatus for detecting stones by ultrasound, in which the ultrasound reflections from a stone are preferentially selected and accentuated relative to the ultrasound reflections from blood or tissue. Also described herein are methods and apparatus for applying pushing ultrasound to in vivo stones or other objects, to facilitate the removal of such in vivo objects.

摘要翻译： 这里描述了用于通过超声检测石块的方法和装置，其中相对于来自血液或组织的超声波反射优先选择和加强来自石头的超声反射。 本文还描述了将推进超声应用于体内石块或其它物体的方法和装置，以便于去除这样的体内物体。

公开(公告)号：US09186526B2

公开(公告)日：2015-11-17

申请号：US14132316

申请日：2013-12-18

申请人： OLYMPUS CORPORATION

发明人： Tsunetaka Akagane

IPC分类号： A61N7/00 ,  A61B17/32

CPC分类号： A61N7/00 ,  A61B17/320068 ,  A61B2017/00473 ,  A61B2017/320072 ,  A61B2017/320084 ,  A61B2017/320096 ,  A61B2017/320098 ,  A61B2217/005 ,  A61B17/2258 ,  A61N2007/0004

摘要： An ultrasonic probe includes a first coupled vibration member and a second coupled vibration member each of which extends along a longitudinal axis between a first anti-node position of an ultrasonic vibration and a second anti-node position of the ultrasonic vibration located to a distal direction side of the first anti-node position. The second coupled vibration member vibrates in the same mode as the first coupled vibration member. A first groove of the first coupled vibration member and a second groove of the second coupled vibration member cooperate with each other and thereby form at least a part of a passage inside a multiple-members vibrating portion formed by the first coupled vibration member and the second coupled vibration member.

摘要翻译： 超声波探头包括第一耦合振动部件和第二耦合振动部件，每个振动部件沿着纵向轴线延伸超声波振动的第一反节点位置和位于远端方向的超声波振动的第二反节点位置之间 侧的第一个反节点位置。 第二耦合振动构件以与第一耦合振动构件相同的模式振动。 第一联接振动部件的第一槽和第二联接振动部件的第二槽彼此配合，从而形成由第一联接振动部件形成的多部件振动部分内的通路的至少一部分， 耦合振动件。

公开(公告)号：US20150231416A1

公开(公告)日：2015-08-20

申请号：US14701863

申请日：2015-05-01

申请人： Cedars-Sinai Medical Center ,  Board of Regents of the University of Texas System

发明人： Robert J. Siegel ,  Yochai Birnbaum ,  Huai Luo

IPC分类号： A61N7/00

CPC分类号： A61N7/00 ,  A61H33/00 ,  A61H35/00 ,  A61N2007/0004

摘要： The present invention describes a method of using an ultrasonic bath to enhance tissue perfusion, enhance the development of collateral blood vessels and/or enhance collateral circulation in an extremity in need thereof. Also described is an ultrasonic bath for the inventive method.

摘要翻译： 本发明描述了使用超声波浴以增强组织灌注，增强侧支血管的发育和/或增强有需要的肢体中的侧支循环的方法。 还描述了用于本发明方法的超声波浴。

公开(公告)号：US20150230985A1

公开(公告)日：2015-08-20

申请号：US14674992

申请日：2015-03-31

申请人： Olivia Serdarevic ,  Michael Berry ,  Donald F. Heller

发明人： Olivia Serdarevic ,  Michael Berry ,  Donald F. Heller

IPC分类号： A61F9/008 ,  A61F9/007

CPC分类号： A61F9/008 ,  A61F2/142 ,  A61F9/0079 ,  A61F9/00814 ,  A61F2009/00872 ,  A61N7/00 ,  A61N2007/0004

摘要： The invention includes: a new composition of matter (a composite comprising a naturally occurring in vivo cornea in an in situ eye together with at least one volume of vitrified non-naturally occurring corneal stromal tissue formed within the naturally occurring corneal stromal tissue) wherein the vitrified tissue is modified in structure and properties from its naturally occurring condition into a non-naturally occurring glass-like condition with modifications including but not limited to increased elastic modulus; methods for producing and using the new composition of matter for modifying corneal structure and properties, including but not limited to corneal optical aberrations; wound closure adhesion and transplant adhesion; and a photo vitrification system for producing the new composition of matter comprising at least one photon source with controllable treatment parameters. A reverse template can be added to corneal vitrification systems to increase vitrification and modifications of structure and properties.

摘要翻译： 本发明包括：一种新的物质组合物（包括在原位眼中的天然存在的体内角膜以及在天然存在的角膜基质组织内形成的至少一个玻璃化非天然存在的角膜基质组织体积的复合物），其中 玻璃化组织的结构和性质从其天然存在的状态改变成非天然存在的玻璃状状态，其中包括但不限于增加的弹性模量; 用于生产和使用用于修饰角膜结构和性质的新组合物的方法，包括但不限于角膜光学像差; 伤口闭合粘连和移植附着力; 以及用于产生包含至少一个具有可控处理参数的光子源的新组合物的照相玻璃化系统。 可以向角膜玻璃化系统添加反向模板，以增加玻璃化和结构和性质的修改。

公开(公告)号：US20150230979A1

公开(公告)日：2015-08-20

申请号：US14674890

申请日：2015-03-31

申请人： Olivia Serdarevic ,  Michael Berry ,  Donald F. Heller

发明人： Olivia Serdarevic ,  Michael Berry ,  Donald F. Heller

IPC分类号： A61F9/008 ,  A61N7/00 ,  A61F9/007

CPC分类号： A61F9/008 ,  A61F2/142 ,  A61F9/0079 ,  A61F9/00814 ,  A61F2009/00872 ,  A61N7/00 ,  A61N2007/0004

摘要： The invention includes: a new composition of matter (a composite comprising a naturally occurring in vivo cornea in an in situ eye together with at least one volume of vitrified non-naturally occurring corneal stromal tissue formed within the naturally occurring corneal stromal tissue) wherein the vitrified tissue is modified in structure and properties from its naturally occurring condition into a non-naturally occurring glass-like condition with modifications including but not limited to increased elastic modulus; methods for producing and using the new composition of matter for modifying corneal structure and properties, including but not limited to corneal optical aberrations; wound closure adhesion and transplant adhesion; and a photovitrification system for producing the new composition of matter comprising at least one photon source with controllable treatment parameters. A reverse template can be added to corneal vitrification systems to increase vitrification and modifications of structure and properties.

摘要翻译： 本发明包括：一种新的物质组合物（包括在原位眼中的天然存在的体内角膜以及在天然存在的角膜基质组织内形成的至少一个玻璃化非天然存在的角膜基质组织体积的复合物），其中 玻璃化组织的结构和性质从其天然存在的状态改变成非天然存在的玻璃状状态，其中包括但不限于增加的弹性模量; 用于生产和使用用于修饰角膜结构和性质的新组合物的方法，包括但不限于角膜光学像差; 伤口闭合粘连和移植附着力; 以及用于产生包含至少一个具有可控处理参数的光子源的新组合物的光生产系统。 可以向角膜玻璃化系统添加反向模板，以增加玻璃化和结构和性质的修改。