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    Affinity Adsorbents for Fibrinogen
    94.
    发明申请
    Affinity Adsorbents for Fibrinogen 有权
    纤维蛋白原亲和吸附剂

    公开(公告)号：US20090326201A1

    公开(公告)日：2009-12-31

    申请号：US11913528

    申请日：2006-05-09

    Applicant: Jason Richard Betley ,  James Christopher Pearson ,  Ben Martin Beacom ,  Tadeusz Antoni Podgorski ,  Robert William Pannell

    Inventor： Jason Richard Betley ,  James Christopher Pearson ,  Ben Martin Beacom ,  Tadeusz Antoni Podgorski ,  Robert William Pannell

    IPC: C07K14/75 ,  C07D413/10

    CPC classification number: C07D251/48 ,  B01J20/286 ,  B01J20/289 ,  B01J20/3212 ,  B01J20/3219 ,  B01J20/3248 ,  B01J20/3251 ,  B01J20/3253 ,  B01J20/3255 ,  B01J2220/54 ,  B01J2220/58 ,  C07K14/75 ,  G01N33/86

    Abstract: For the separation, removal, isolation, purification, characterisation, identification or quantification of fibrinogen or a protein that is a fibrinogen analogue, an affinity adsorbent is used that is a compound of formula II wherein one X is N and the other is N, C—Cl or C—CN; Y is O, S or NR2; 0 Z is O, S or NR3; R2 and R3 are each H, alkyl, hydroxyalkyl, benzyl or &bgr;-phenylethyl; n is 0 to 6; A is a support matrix, optionally linked to the triazine ring by a spacer; R7 is a group bearing a positive charge at neutral pH; W is an optional linker; V is an aromatic group; and R8 and R9 are each H, OH, alkyl, alkoxy, amino, NH2, acyloxy, acylamino, CO2H, sulphonic acid, carbamoyl, sulphamoyl, alkylsulphonyl or halogen or a cyclic structure such as a morpholino group, or R8 and R9 are linked to form such a cyclic structure.

    Abstract translation: 为了纤维蛋白原或纤维蛋白原类似物的蛋白质的分离，去除，分离，纯化，表征，鉴定或定量，使用亲和吸附剂，其为一种式II化合物，其中一个X为N，另一个为N，C -Cl或C-CN; Y是O，S或NR2; 0 Z是O，S或NR 3; R2和R3各自为H，烷基，羟基烷基，苄基或β-苯乙基; n为0〜6; A是支持基质，任选地通过间隔基与三嗪环连接; R7是在中性pH下带正电荷的基团; W是可选的接头; V是芳族基团; 并且R 8和R 9各自为H，OH，烷基，烷氧基，氨基，NH 2，酰氧基，酰基氨基，CO 2 H，磺酸，氨基甲酰基，氨磺酰基，烷基磺酰基或卤素或环状结构如吗啉代基或R8和R9 形成这样的循环结构。

    Isolation of proteins
    95.
    发明授权
    Isolation of proteins 有权
    蛋白质的分离

    公开(公告)号：US07442779B2

    公开(公告)日：2008-10-28

    申请号：US11098391

    申请日：2005-04-05

    Applicant: Allan Otto Fog Lihme ,  Marie Bendix Hansen

    Inventor： Allan Otto Fog Lihme ,  Marie Bendix Hansen

    IPC: B01D15/00 ,  B01J20/289 ,  C07K1/22

    CPC classification number: C07K16/00 ,  B01D15/1807 ,  B01D15/3804 ,  B01J20/3219 ,  B01J20/3242 ,  B01J20/3253 ,  B01J20/3255 ,  C07K1/22

    Abstract: The present invention relates to a novel method for the isolation or purification of immunoglobulins (a special class of proteins) from a solution containing immunoglobulins, e.g. hybridoma cell culture supernatants, animal plasma or sera, or colostrum. The method includes the use of a minimum of salts, such as lyotropic salts, in the binding process and preferably also the use of small amounts of organic solvents in the elution process. The solid phase matrices, preferably epichlorohydrin activated agarose matricees, are functionalised with mono- or bicyclic aromatic or heteroaromatic ligands (molecular weight: at the most 500 Dalton) which, preferably, comprises an acidic substituent, e.g. a carboxylic acid. The matrices utilised show excellent properties in a “Standard Immunoglobulin Binding Test” and in a “Monoclonal Antibody Array Binding Test” with respect to binding efficiency and purity, and are stable in 1M NaOH.

    Abstract translation: 本发明涉及从含有免疫球蛋白的溶液中分离或纯化免疫球蛋白（一类特殊蛋白质）的新方法。 杂交瘤细胞培养上清液，动物血浆或血清或初乳。 该方法包括在结合过程中使用最少量的盐，例如溶性盐，并且还优选在洗脱过程中使用少量的有机溶剂。 固相基质，优选表氯醇活化的琼脂糖基质，用单环或双环芳族或杂芳族配体（分子量：最多500道尔顿）官能化，其优选包含酸性取代基，例如， 羧酸。 所使用的基质在结合效率和纯度方面在“标准免疫球蛋白结合试验”和“单克隆抗体阵列结合试验”中显示出优异的性质，并且在1M NaOH中稳定。

    Method of Chemical Substance Separation
    99.
    发明申请
    Method of Chemical Substance Separation 审中-公开
    化学物质分离方法

    公开(公告)号：US20080017585A1

    公开(公告)日：2008-01-24

    申请号：US10589423

    申请日：2005-02-10

    Applicant: Kazuhiro Chiba

    Inventor： Kazuhiro Chiba

    IPC: C02F1/52

    CPC classification number: B01J20/289 ,  B01J20/3204 ,  B01J20/3206 ,  B01J20/3219 ,  B01J20/3242 ,  B01J20/3251 ,  B01J20/3253 ,  B01J20/3255 ,  B01J20/3287 ,  B01J20/3289 ,  B01J20/3425 ,  B01J20/3483 ,  C07K1/32 ,  G01N30/54 ,  G01N2030/8831

    Abstract: The present invention provides a method of separating substances utilizing a solid phase wherein a substance fixed to a solid phase can be easily separated without the application of a chemical process, biochemical process, exposure to light, electrical excitation, or the like. Disclosed is a method of separating a reaction product generated by the reaction of a first substance and a second substance comprising the steps of: (a) mixing the first substance with a temperature-sensitive carrier residing in a liquid-phase state; (b) fixing an anchor region of the first substance to the temperature-sensitive carrier by converting the temperature-sensitive carrier to a solid-phase state by changing the temperature of the reaction system; (c) generating a reaction product by reacting the second substance with a reaction region of the first substance that is fixed to the temperature-sensitive carrier; (d) removing impurities from the reaction system; and (e) releasing the anchor region of the reaction product from the temperature-sensitive carrier by converting the temperature-sensitive carrier to a liquid-phase state by changing the temperature of the reaction system.

    Abstract translation: 本发明提供一种使用固相分离物质的方法，其中固定在固相上的物质可以容易地分离，而不需要施加化学过程，生化过程，曝光，电激发等。 公开了分离由第一物质和第二物质的反应产生的反应产物的方法，包括以下步骤：（a）将第一物质与位于液相状态的温度敏感载体混合; （b）通过改变反应体系的温度，将温度敏感载体转变成固相状态，将第一物质的锚定区域固定在温度敏感载体上; （c）通过使所述第二物质与固定在所述感温载体上的所述第一物质的反应区域反应而产生反应产物; （d）从反应体系中除去杂质; 和（e）通过改变反应体系的温度，将温度敏感载体转变成液相状态，释放反应产物的锚定区域与温度敏感载体。

    Processes for Production of Silica Gels Carrying Derivatization Agents for Carbonyl Compounds
    100.
    发明申请
    Processes for Production of Silica Gels Carrying Derivatization Agents for Carbonyl Compounds 有权
    生产用于羰基化合物的衍生化剂的硅胶的制备方法

    公开(公告)号：US20080015106A1

    公开(公告)日：2008-01-17

    申请号：US11718960

    申请日：2005-11-10

    Applicant: Mamoru Kubota ,  Hitoshi Uemori

    Inventor： Mamoru Kubota ,  Hitoshi Uemori

    IPC: B01J20/22

    CPC classification number: B01J20/103 ,  B01J20/283 ,  B01J20/286 ,  B01J20/3204 ,  B01J20/3221 ,  B01J20/3251 ,  B01J20/3253 ,  B01J2220/52 ,  B01J2220/54 ,  B01J2220/62 ,  G01N30/6091 ,  Y10T436/200833

    Abstract: The subject of the present invention is to provide a method for producing a silica gel supporting a derivatizing agent for a carbonyl compound that hardly collects carbonyl compounds during production thereof, and a silica gel supporting a derivatizing agent for a carbonyl compound produced by said production method, in order to lower a blank value in measurement of carbonyl compounds. The present invention also relates to a method for producing a silica gel supporting a derivatizing agent for a carbonyl compound characterized by bringing an acid-supported silica gel into contact with an organic solvent containing the derivatizing agent for a carbonyl compound, a silica gel filler supporting a derivatizing agent for a carbonyl compound comprising the silica gel supporting the derivatizing agent for a carbonyl compound produced by the above production method, a method for producing a silica gel supporting a derivatizing agent for a carbonyl compound characterized by treating in advance a silica gel having a cation-exchange group with the derivatizing agent for a carbonyl compound and then bringing it into contact with an organic solvent containing the derivatizing agent for a carbonyl compound, and the like.

    Abstract translation: 本发明的主题是提供一种在制造中难以收集羰基化合物的支持羰基化合物的衍生化剂的硅胶的制造方法，以及通过所述制造方法制造的支持羰基化合物的衍生剂的硅胶 ，以降低测量羰基化合物的空白值。 本发明还涉及一种支持羰基化合物的衍生化剂的硅胶的制造方法，其特征在于使酸性负载型硅胶与含有羰基化合物的衍生化剂的有机溶剂接触， 一种羰基化合物的衍生化剂，其包含支持通过上述制备方法制备的羰基化合物的衍生化剂的硅胶，一种支持羰基化合物的衍生化剂的硅胶的制备方法，其特征在于，预先处理具有 与羰基化合物的衍生物进行阳离子交换基团，然后使其与含有羰基化合物的衍生化剂的有机溶剂接触等。

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