公开(公告)号：US07223341B2

公开(公告)日：2007-05-29

申请号：US11480977

申请日：2006-07-06

Applicant: Xiaosong Wu ,  Chung-Jen Hou ,  Jayesh Dharia ,  Peter Konstantin ,  Yujing Yang

Inventor： Xiaosong Wu ,  Chung-Jen Hou ,  Jayesh Dharia ,  Peter Konstantin ,  Yujing Yang

IPC: B01D39/14 ,  B01D63/00

CPC classification number: B01D67/0088 ,  B01D15/361 ,  B01D15/363 ,  B01D61/00 ,  B01D61/14 ,  B01D69/02 ,  B01D69/10 ,  B01D69/125 ,  B01D71/40 ,  B01D71/44 ,  B01D71/60 ,  B01D71/82 ,  B01D2325/16 ,  B01D2325/30 ,  B01D2325/36 ,  B01J20/28033 ,  B01J20/28035 ,  B01J20/3272 ,  B01J20/3282 ,  B01J41/12 ,  B01J41/13 ,  B01J41/20 ,  B01J47/12 ,  C12N15/1017 ,  G01N33/54393

Abstract: The present invention provides a positively charged microporous membrane having a protein binding capacity of about 25 mg/ml or greater comprising a hydrophilic porous substrate and a crosslinked coating that provides a fixed positive charge to the membrane. The present invention further provides a positively charged microporous membrane comprising a porous substrate and a crosslinked coating comprising pendant cationic groups. The membranes of the present invention find use in a variety of applications including ion-exchange chromatography, macromolecular transfer, as well as detection, filtration and purification of biomolecules such as proteins, nucleic acids, endotoxins, and the like.

Abstract translation: 本发明提供了具有约25mg / ml或更大的蛋白结合能力的带正电荷的微多孔膜，其包含亲水性多孔基底和向膜提供固定的正电荷的交联涂层。 本发明还提供一种带正电的微多孔膜，其包括多孔基材和包含阳离子阳离子基团的交联涂层。 本发明的膜可用于各种应用，包括离子交换层析，大分子转移，以及生物分子如蛋白质，核酸，内毒素等的检测，过滤和纯化。

公开(公告)号：US07157529B2

公开(公告)日：2007-01-02

申请号：US10862724

申请日：2004-06-07

Applicant: William H. Campbell ,  Yung K. Kim ,  Charles E. Skinner

Inventor： William H. Campbell ,  Yung K. Kim ,  Charles E. Skinner

IPC: C08F283/12

CPC classification number: C08G83/003 ,  B01J20/3204 ,  B01J20/3219 ,  B01J20/3257 ,  B01J20/3272 ,  B01J20/328 ,  B01J20/3289 ,  C07K1/22 ,  C08L101/005 ,  Y10T428/2991 ,  Y10T428/2995 ,  Y10T428/2998

Abstract: Multi-layered macromolecules wherein the layers are covalently bonded together and wherein the macromolecules are covalently bonded to solid particulate substrates, methods for the preparation of such compositions, and methods for their uses in a multitude of end use applications ranging from the purification of waste chemical and metal process streams to the separation and identification of proteins, peptides, and oligionucleotides.

公开(公告)号：US20060093836A1

公开(公告)日：2006-05-04

申请号：US11304316

申请日：2005-12-14

Applicant: Jiang Huang ,  Shoujun Xiao ,  Marc Unger

Inventor： Jiang Huang ,  Shoujun Xiao ,  Marc Unger

IPC: B32B9/04 ,  B32B25/20

CPC classification number: B32B3/26 ,  B01J20/285 ,  B01J20/286 ,  B01J20/327 ,  B01J20/3272 ,  B01J2220/54 ,  B01L3/502707 ,  B01L2200/12 ,  B01L2300/16 ,  B01L2300/163 ,  C08F257/02 ,  C08F263/04 ,  C08F265/04 ,  C08F279/02 ,  C08F287/00 ,  C08F291/00 ,  C08J5/12 ,  C08J7/12 ,  F04B43/043 ,  Y10T428/139 ,  Y10T428/1393 ,  Y10T428/24661 ,  Y10T428/24744 ,  Y10T428/249953 ,  Y10T428/249958 ,  Y10T428/249978 ,  Y10T428/31663 ,  Y10T428/31667

Abstract: The present invention is directed to a surface modified polymer comprising a surface which is covalently bonded to a surface modifying compound. Formation of the covalent bond between the polymer and the surface modifying compound is achieved by a reaction between an intrinsic functional group that is present in the polymer and the functional group of the surface modifying compound. By using a polymer having an intrinsic functional group, a separate surface activation step is avoided.

公开(公告)号：US07037431B2

公开(公告)日：2006-05-02

申请号：US10791272

申请日：2004-03-03

Applicant: Olaf Boese ,  Katja Peterkord

Inventor： Olaf Boese ,  Katja Peterkord

IPC: C02F1/42 ,  B01D15/00

CPC classification number: B01D15/00 ,  B01J20/3272 ,  H01G11/06 ,  H01G11/62 ,  H01M6/164 ,  H01M10/0525 ,  H01M10/0569 ,  H01M2300/0034 ,  Y02E60/13

Abstract: Acids can be removed from aprotic organic liquids by bringing the liquids into contact with polyalkyleneimines that have been applied to a support. Polyethyleneimine that has been applied to amorphous silicon dioxide is particularly suitable for this method. The method can be used, for example, to eliminate acidic components from fluorinated esters.

Abstract translation: 通过使液体与施加到载体上的聚亚烷基亚胺接触，可以将酸从非质子有机液体中除去。 已经应用于无定形二氧化硅的聚乙烯亚胺特别适用于该方法。 该方法可用于例如从氟化酯中除去酸性组分。

公开(公告)号：US07018538B2

公开(公告)日：2006-03-28

申请号：US10936723

申请日：2004-09-09

Applicant: Robert-Matthias Leiser ,  Lutz Plobner ,  Elena Markovna Yaroshevskaya ,  Vitali Pavlovich Zubov ,  Dmitry Valerievich Kapustin ,  Elena Jurievna Yagudaeva

Inventor： Robert-Matthias Leiser ,  Lutz Plobner ,  Elena Markovna Yaroshevskaya ,  Vitali Pavlovich Zubov ,  Dmitry Valerievich Kapustin ,  Elena Jurievna Yagudaeva

IPC: B01D15/08

CPC classification number: B01J20/3272 ,  B01D15/08 ,  B01J20/3204 ,  B01J20/321 ,  B01J20/3212 ,  B01J2220/58 ,  B01J2220/62 ,  B01J2220/84 ,  C07K1/16

Abstract: Use of a composite sorbent having an at least partial coating on a support, which coating comprises essentially polyanilines or derivatives of polyanilines for the separation, isolation, identification, purification and/or detection of biomolecules in particular nucleic acids, proteins, polysaccharides in analytical or preparative scale.

Abstract translation: 在载体上具有至少部分涂层的复合吸附剂的使用，该涂层基本上包含聚苯胺或聚苯胺衍生物，用于分离，分离，鉴定，纯化和/或检测生物分子，特别是分析中的核酸，蛋白质，多糖，或 制备规模。

公开(公告)号：US20060060533A1

公开(公告)日：2006-03-23

申请号：US10536066

申请日：2003-11-20

Applicant: Kazuyuki Miyazawa ,  Taketoshi Kanda ,  Yousuke Toujo ,  Aya Ohkubo ,  Osamu Shirota ,  Kenichi Sukuma ,  Masayoshi Wada

Inventor： Kazuyuki Miyazawa ,  Taketoshi Kanda ,  Yousuke Toujo ,  Aya Ohkubo ,  Osamu Shirota ,  Kenichi Sukuma ,  Masayoshi Wada

IPC: C02F1/28 ,  B01J20/22 ,  G01N1/28

CPC classification number: B01J20/28019 ,  B01J20/103 ,  B01J20/28057 ,  B01J20/28078 ,  B01J20/286 ,  B01J20/3204 ,  B01J20/3219 ,  B01J20/3242 ,  B01J20/3259 ,  B01J20/3272 ,  B01J20/3276 ,  B01J2220/54 ,  B01J2220/58 ,  C08J7/12 ,  Y10T428/139 ,  Y10T428/2991

Abstract: A method for surface modification of a material by means of introducing the phosphorylcholine group represented by the following formula (1-1) onto the surface of the material by treating a material having amino groups with a chemical compound containing an aldehyde derivative obtained by the oxidative ring-opening reaction of glycerophosphorylcholine. The method of the present invention provides various materials such as medical materials having superior biocompatibility and hydrophilicity.

Abstract translation: 通过将具有氨基的材料与含有通过氧化性的醛衍生物获得的醛衍生物的化合物进行处理，通过将下式（1-1）表示的磷酸胆碱基团引入到材料的表面上来对材料进行表面改性的方法 甘油磷酰胆碱的开环反应。

公开(公告)号：US20060057209A1

公开(公告)日：2006-03-16

申请号：US10942612

申请日：2004-09-16

Applicant: Robert Chapman ,  Mingqi Zhao ,  Jing Ni ,  Luc Bousse ,  John Stults ,  Say Yang

Inventor： Robert Chapman ,  Mingqi Zhao ,  Jing Ni ,  Luc Bousse ,  John Stults ,  Say Yang

IPC: A61K9/14

CPC classification number: B01J20/3289 ,  B01J20/28035 ,  B01J20/321 ,  B01J20/3212 ,  B01J20/3219 ,  B01J20/327 ,  B01J20/3272 ,  B01J20/328 ,  B01J20/3282 ,  B01J20/3285 ,  B01L3/502707 ,  B01L3/502746 ,  B01L2200/12 ,  B01L2300/165 ,  B01L2400/027 ,  B01L2400/0406 ,  B01L2400/0415 ,  B01L2400/0688 ,  B05D1/185 ,  B05D5/04 ,  B05D7/52 ,  H01J49/167

Abstract: Methods are disclosed for coating at least a portion of a hydrophobic surface, including the surfaces of plastics or other polymers. Such methods include the use of a first coating layer and/or region that interacts with the hydrophobic surface, although the formation of a chemical bond between the first coating layer and the hydrophobic surface is not required. Subsequent layers may then interact chemically or non-chemically with at least a portion of the first coating layer and/or region. Such coated surfaces may be part of a device or apparatus, including microfluidic devices.

Abstract translation: 公开了用于涂覆至少一部分疏水表面的方法，包括塑料或其它聚合物的表面。 这种方法包括使用与疏水表面相互作用的第一涂层和/或区域，尽管不需要在第一涂层和疏水表面之间形成化学键。 然后随后的层可以与第一涂层和/或区域的至少一部分化学或非化学相互作用。 这种涂覆的表面可以是包括微流体装置的装置或装置的一部分。

公开(公告)号：US06991852B2

公开(公告)日：2006-01-31

申请号：US10385904

申请日：2003-03-11

Applicant: Peter W. Carr ,  Marc A. Hillmyer ,  Huqun Liu ,  Hao Luo ,  Lianjia Ma ,  Brian C. Trammell

Inventor： Peter W. Carr ,  Marc A. Hillmyer ,  Huqun Liu ,  Hao Luo ,  Lianjia Ma ,  Brian C. Trammell

IPC: B32B9/04

CPC classification number: B82Y30/00 ,  B01D15/322 ,  B01D15/325 ,  B01D15/361 ,  B01D15/3833 ,  B01J20/28097 ,  B01J20/286 ,  B01J20/287 ,  B01J20/3204 ,  B01J20/3219 ,  B01J20/3227 ,  B01J20/327 ,  B01J20/3272 ,  B01J20/3282 ,  B32B9/04 ,  B82Y40/00 ,  C01P2006/10 ,  C09C1/3081 ,  Y10T428/2962 ,  Y10T428/2995 ,  Y10T428/2998 ,  Y10T428/31612 ,  Y10T428/31663

Abstract: A silica-based material that includes a silica-based substrate and a polymerized organic material disposed thereon. The polymerized organic material is made from reactive organic moieties bonded to the silica-based substrate.

公开(公告)号：US20060011533A1

公开(公告)日：2006-01-19

申请号：US10533217

申请日：2003-11-13

Applicant: Shinsuke Suzuki ,  Atsushi Onishi ,  Kazumi Suzuki

Inventor： Shinsuke Suzuki ,  Atsushi Onishi ,  Kazumi Suzuki

IPC: B01D35/30

CPC classification number: B01J20/3272 ,  B01D15/3833 ,  B01J20/103 ,  B01J20/28004 ,  B01J20/28078 ,  B01J20/286 ,  B01J20/29 ,  B01J20/3204 ,  B01J20/3259 ,  B01J20/3274 ,  B01J20/328 ,  B01J2220/54 ,  B01J2220/58

Abstract: The present invention is to provide a method of producing a separating agent for an enantiomeric isomer having high optical resolution power together with sufficient solvent resistance. That is, a method of producing a separating agent for an enantiomeric isomer comprising the steps of allowing the porous carrier to carry the optically active polymer compound by bringing the porous carrier into contact with a dope of the optically active polymer compound; and exposing a product to radiation.

Abstract translation: 本发明提供一种具有高分辨能力的对映异构体分离剂以及足够的耐溶剂性的方法。 也就是说，制备对映体异构体分离剂的方法包括以下步骤：使多孔载体通过使多孔载体与光学活性聚合物化合物的掺杂物相接触来携带光学活性聚合物化合物; 并将产品暴露于辐射。

公开(公告)号：US06946557B2

公开(公告)日：2005-09-20

申请号：US10398915

申请日：2001-10-12

Applicant: Atsushi Onishi ,  Koichi Murazumi ,  Kozo Tachibana

Inventor： Atsushi Onishi ,  Koichi Murazumi ,  Kozo Tachibana

IPC: A61K31/47 ,  B01D15/08 ,  B01D15/18 ,  B01D15/38 ,  B01J20/26 ,  B01J20/281 ,  B01J20/29 ,  B01J20/32 ,  C07B57/00 ,  C07D215/04 ,  C07D215/14

CPC classification number: B01J20/328 ,  B01D15/185 ,  B01D15/3833 ,  B01J20/262 ,  B01J20/265 ,  B01J20/286 ,  B01J20/29 ,  B01J20/3204 ,  B01J20/3272 ,  B01J2220/54 ,  C07B2200/07 ,  C07D215/14

Abstract: The objective of this invention is to provide a process for producing an optically active isomer of ethyl 7-[2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl]-3,5-dihydroxy-6-heptenoate by optically resolving an optical isomer mixture of the compound at a high productivity. The process is characterized by employing a filler comprising a carrier and a specific amount of cellulose tris (4-chlorophenyl carbamate) supported the carrier and carrying out chromatographic separation under the condition that the capacity factors have specific values.

Abstract translation: 本发明的目的是提供通过光学制备7- [2-环丙基-4-（4-氟苯基）喹啉-3-基] -3,5-二羟基-6-庚烯酸乙酯的旋光异构体的方法 以高生产率分解化合物的旋光异构体混合物。 该方法的特征在于使用包含载体和特定量的纤维素三（4-氯苯基氨基甲酸酯）的填料负载载体并在容量因子具有特定值的条件下进行色谱分离。