公开(公告)号：US11994533B2

公开(公告)日：2024-05-28

申请号：US17105475

申请日：2020-11-25

Applicant: The Regents of the University of Colorado, a body corporate

Inventor： Rafael Piestun ,  Simon Labouesse ,  Markus B. Raschke ,  Eric Muller ,  Samuel Johnson

IPC: G01J3/02 ,  G01J3/10 ,  G01J3/28 ,  G01J3/44 ,  G01J3/45 ,  G01Q10/06 ,  G01Q30/04 ,  G01Q60/06 ,  G01Q60/22

CPC classification number: G01Q60/22 ,  G01J3/0208 ,  G01J3/10 ,  G01J3/2846 ,  G01J3/4412 ,  G01J3/45 ,  G01Q10/06 ,  G01Q30/04 ,  G01Q60/06

Abstract: Infrared (IR) vibrational scattering scanning near-field optical microscopy (s-SNOM) has advanced to become a powerful nanoimaging and spectroscopy technique with applications ranging from biological to quantum materials. However, full spatiospectral s-SNOM continues to be challenged by long measurement times and drift during the acquisition of large associated datasets. Various embodiments provide for a novel approach of computational spatiospectral s-SNOM by transforming the basis from the stationary frame into the rotating frame of the IR carrier frequency. Some embodiments see acceleration of IR s-SNOM data collection by a factor of 10 or more in combination with prior knowledge of the electronic or vibrational resonances to be probed, the IR source excitation spectrum, and other general sample characteristics.

公开(公告)号：US11740126B2

公开(公告)日：2023-08-29

申请号：US17351067

申请日：2021-06-17

Applicant: Apple Inc.

Inventor： Trent D. Ridder ,  Mark Alan Arbore ,  Gary Shambat ,  Robert Chen ,  David I. Simon ,  Miikka M. Kangas

IPC: G01J3/427 ,  G01J3/10 ,  G01J3/28 ,  G01J3/42 ,  G01J3/06 ,  G01N21/25 ,  G01N21/35

CPC classification number: G01J3/427 ,  G01J3/06 ,  G01J3/10 ,  G01J3/108 ,  G01J3/2803 ,  G01J3/2846 ,  G01J3/42 ,  G01N21/25 ,  G01N21/35

Abstract: Methods and systems for measuring one or more properties of a sample are disclosed. The methods and systems can include multiplexing measurements of signals associated with a plurality of wavelengths without adding any signal independent noise and without increasing the total measurement time. One or more levels of encoding, where, in some examples, a level of encoding can be nested within one or more other levels of encoding. Multiplexing can include wavelength, position, and detector state multiplexing. In some examples, SNR can be enhanced by grouping together one or more signals based on one or more properties including, but not limited to, signal intensity, drift properties, optical power detected, wavelength, location within one or more components, material properties of the light sources, and electrical power. In some examples, the system can be configured for optimizing the conditions of each group individually based on the properties of a given group.

公开(公告)号：US20180045568A1

公开(公告)日：2018-02-15

申请号：US15637884

申请日：2017-06-29

Applicant: Korea Advanced Institute of Science and Technology

Inventor： Min Hyuk KIM ,  Daniel JEON

IPC: G01J3/28 ,  H01L27/146 ,  G01J1/04 ,  G01J3/02 ,  G01J3/18

CPC classification number: G01J3/2823 ,  G01J1/0411 ,  G01J1/0474 ,  G01J3/0205 ,  G01J3/0208 ,  G01J3/021 ,  G01J3/0229 ,  G01J3/0291 ,  G01J3/14 ,  G01J3/18 ,  G01J3/2846 ,  G01J2003/2826 ,  H01L27/14625

Abstract: A method and a system for acquiring a hyperspectral image by using a kaleidoscope are provided. The method includes copying an input image to generate a specific number of images, generating coded-aperture passed images corresponding to the images by using at least one coded aperture, and acquiring a hyperspectral image for the input image based on the coded-aperture passed images.

公开(公告)号：US20160309068A1

公开(公告)日：2016-10-20

申请号：US15108271

申请日：2015-01-05

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： Kyle Nadeau ,  Tyler B. Rice ,  Soren Konecky ,  Anthony J. Durkin ,  Bruce J. Tromberg

IPC: H04N5/225 ,  A61B1/06 ,  A61B1/00 ,  G01N21/64 ,  A61B5/026 ,  A61B1/04 ,  A61B5/00 ,  G01J3/28 ,  G01B11/25 ,  A61B5/1455

CPC classification number: H04N5/2256 ,  A61B1/00009 ,  A61B1/043 ,  A61B1/0669 ,  A61B1/0684 ,  A61B5/0073 ,  A61B5/0075 ,  A61B5/0261 ,  A61B5/1455 ,  A61B5/6826 ,  G01B11/2513 ,  G01J3/2846 ,  G01N21/4795 ,  G01N21/6456 ,  G01N21/6486

Abstract: The present invention relates to optical devices and methods of extracting optical properties, and depth and fluorescence information for visualizing samples. In one embodiment, the present invention provides a multi-frequency synthesis and extraction (MSE) method for quantitative tissue imaging. In another embodiment, the present invention provides a method of obtaining optical properties and depth information by illuminating a sample with binary square wave patterns of light, wherein a series of spatial frequency components are simultaneously attenuated and can be extracted. In another embodiment, the present invention provides an optical imaging apparatus comprising a Spatial Frequency Domain Imaging (SFDI) device modified to condense frequency information content into a single charged coupled device (CCD) frame, multi-pixel and/or single-pixel sensor using frequency-synthesized patterns.

Abstract translation: 本发明涉及提取光学特性的光学器件和方法，以及可视化样品的深度和荧光信息。 在一个实施方案中，本发明提供了用于定量组织成像的多频合成和提取（MSE）方法。 在另一个实施例中，本发明提供一种通过用二进制方波模式照亮样本来获得光学特性和深度信息的方法，其中一系列空间频率分量同时被衰减并且可被提取。 在另一个实施例中，本发明提供了一种光学成像设备，其包括被修改以将频率信息内容压缩到单个电荷耦合器件（CCD）帧中的空间频域成像（SFDI）器件，多像素和/或单像素传感器，其使用 频率合成模式。

公开(公告)号：US09253420B2

公开(公告)日：2016-02-02

申请号：US14178904

申请日：2014-02-12

Applicant: Xerox Corporation

Inventor： Peter J. Nystrom ,  Lalit K. Mestha ,  Edgar A. Bernal ,  Xuejin Wen ,  Peter Gulvin

IPC: H04N5/33 ,  G02B5/20 ,  H04N5/335

CPC classification number: H04N5/332 ,  G01J3/021 ,  G01J3/0229 ,  G01J3/0264 ,  G01J3/26 ,  G01J3/2823 ,  G01J3/2846 ,  G02B5/204 ,  H04N5/335

Abstract: A method is provided for using a single-pixel imager in order to spatially reconstruct an image of a scene. The method can comprise the following: configuring a light filtering device including an array of imaging elements to a spatially varying optical filtering process of incoming light according to a series of spatial patterns corresponding to sampling functions. The light filtering device can be a transmissive filter including a first membrane, a second membrane, and a variable gap therebetween. The method further comprises tuning a controller for manipulating a variable dimension of the gap; and, measuring, using a photodetector of the single-pixel imager, a magnitude of an intensity of the filtered light across pixel locations in the series of spatial patterns. The magnitude of the intensity can be equivalent to an integral value of the scene across the pixel locations.

Abstract translation: 提供了一种用于使用单像素成像器以便空间重建场景的图像的方法。 该方法可以包括以下：根据与采样功能相对应的一系列空间模式，将包括成像元件阵列的光滤波装置配置到入射光的空间变化的光学滤波处理。 光过滤装置可以是包括第一膜，第二膜和它们之间的可变间隙的透射过滤器。 该方法还包括调整控制器以操纵间隙的可变尺寸; 以及使用所述单像素成像器的光电检测器测量所述一系列空间图案中的像素位置之间的经过滤光的强度的大小。 强度的大小可以等于像素位置上的场景的积分值。

公开(公告)号：US08717560B2

公开(公告)日：2014-05-06

申请号：US13100495

申请日：2011-05-04

Applicant: David Roger Labrecque

Inventor： David Roger Labrecque

IPC: G01J3/40 ,  G01J3/18 ,  G01J3/28 ,  G01J3/02

CPC classification number: G01J3/18 ,  G01J3/02 ,  G01J3/0229 ,  G01J3/0243 ,  G01J3/20 ,  G01J3/28 ,  G01J3/2823 ,  G01J3/2846 ,  G01J3/4406 ,  Y10T29/49826

Abstract: The present invention provides apparatuses including a point light source, a diffraction grating oriented in a light path generated from the point light source wherein the diffraction grating diffracts and concentrates light from the point light source into one or more rings of light, a detector positioned to detect one or more of the rings of light or light transmitted from a sample exposed to said rings of light, and a computer operably connected to the detector to analyze the intensity of one or more of the rings of light or said light transmitted from said sample. Variations including samples and additional components and methods of making the apparatuses of the present invention are also disclosed.

Abstract translation: 本发明提供了一种装置，包括点光源，衍射光栅，其定向在从点光源产生的光路中，其中衍射光栅将来自点光源的光衍射并集中到一个或多个光环中，检测器定位成 检测从暴露于所述光环的样品透射的光或光的一个或多个环，以及可操作地连接到所述检测器的计算机，以分析从所述样品透射的一个或多个所述光或所述光的强度 。 还公开了包括样品和附加组分的变化以及制备本发明的装置的方法。

公开(公告)号：US08305575B1

公开(公告)日：2012-11-06

申请号：US12489906

申请日：2009-06-23

Applicant: Neil Goldstein ,  Jason A. Cline ,  Pajo Vujkovic-Cvijin ,  Steven M. Adler-Golden ,  Marsha J. Fox ,  Brian Gregor ,  Jamine Lee

Inventor： Neil Goldstein ,  Jason A. Cline ,  Pajo Vujkovic-Cvijin ,  Steven M. Adler-Golden ,  Marsha J. Fox ,  Brian Gregor ,  Jamine Lee

IPC: G01J3/28

CPC classification number: G01J3/2846 ,  G01J3/021 ,  G01J3/0229 ,  G01J3/027 ,  G01J3/2889 ,  G01N21/31 ,  G01N2021/1793

Abstract: An adaptive spectral sensor, and methods of using the sensor. The sensor uses a programmable band pass transmission filter to produce both contrast signals, which discriminate specific target materials from background materials by comparing spectral signatures in hardware, and scene radiance spectra. The adaptive spectral sensor may measure one or more scene spectra and may form a spectral image. The sensor may automatically adjust to changing spectral, spatial and temporal conditions in the environment being monitored, by changing sensor resolution in those dimensions and by changing the detection band pass. The programmable band pass can be changed on-the-fly in real time to implement a variety of detection techniques in hardware or measure the spatial or spectral signatures of specific materials and scenes.

Abstract translation: 自适应光谱传感器，以及使用传感器的方法。 传感器使用可编程带通传输滤波器来产生两个对比度信号，通过比较硬件中的光谱特征和场景辐射光谱，将特定的目标材料与背景材料区分开。 自适应光谱传感器可以测量一个或多个场景光谱并且可以形成光谱图像。 传感器可以通过改变这些维度中的传感器分辨率，并通过改变检测带通，自动调整到被监测环境中不断变化的光谱，空间和时间条件。 可实时改变可编程带通，实现硬件中的各种检测技术，或测量特定材料和场景的空间或光谱特征。

公开(公告)号：US20110273707A1

公开(公告)日：2011-11-10

申请号：US13100495

申请日：2011-05-04

Applicant: David Roger LABRECQUE

Inventor： David Roger LABRECQUE

IPC: G01J3/40 ,  B23P11/00 ,  G01J3/28

CPC classification number: G01J3/18 ,  G01J3/02 ,  G01J3/0229 ,  G01J3/0243 ,  G01J3/20 ,  G01J3/28 ,  G01J3/2823 ,  G01J3/2846 ,  G01J3/4406 ,  Y10T29/49826

Abstract: The present invention provides apparatuses including a point light source, a diffraction grating oriented in a light path generated from the point light source wherein the diffraction grating diffracts and concentrates light from the point light source into one or more rings of light, a detector positioned to detect one or more of the rings of light or light transmitted from a sample exposed to said rings of light, and a computer operably connected to the detector to analyze the intensity of one or more of the rings of light or said light transmitted from said sample. Variations including samples and additional components and methods of making the apparatuses of the present invention are also disclosed.

Abstract translation: 本发明提供了一种装置，包括点光源，衍射光栅，其定向在从点光源产生的光路中，其中衍射光栅将来自点光源的光衍射并集中到一个或多个光环中，检测器定位成 检测从暴露于所述光环的样品透射的光或光的一个或多个环，以及可操作地连接到所述检测器的计算机，以分析从所述样品透射的一个或多个所述光或所述光的强度 。 还公开了包括样品和附加组分的变化以及制备本发明的装置的方法。

公开(公告)号：US20090122299A1

公开(公告)日：2009-05-14

申请号：US12267799

申请日：2008-11-10

Applicant: Zeev ZALEVSKY

Inventor： Zeev ZALEVSKY

IPC: G01N33/48 ,  G01B11/30 ,  G02B6/06

CPC classification number: G01J3/2823 ,  G01J3/02 ,  G01J3/0218 ,  G01J3/2846 ,  G02B27/58

Abstract: An imaging method and system are presented for use in sub-wavelength super resolution imaging of a subject. The imaging system comprises a spatial coding unit configured for collecting light coming from the scanned subject and being spaced from the subject a distance smaller than a wavelength range of said light; a light detection unit located upstream of the spatial coding unit with respect to light propagation from the object, and configured to define a pixel array and a spatial decoding unit, which is associated with said pixel array and is configured for applying spatial decoding to a magnified image of the scanned subject, thereby producing nanometric spatial resolution of the image.

Abstract translation: 本发明提供一种用于受试者的亚波长超分辨率成像的成像方法和系统。 该成像系统包括：空间编码单元，被配置为收集来自被扫描的对象的光，并且与被摄体间隔距离小于所述光的波长范围; 相对于来自物体的光传播而位于空间编码单元的上游的光检测单元，并且被配置为定义与所述像素阵列相关联的像素阵列和空间解码单元，并且被配置为将空间解码应用于放大 扫描对象的图像，从而产生图像的纳米空间分辨率。

公开(公告)号：US07379181B2

公开(公告)日：2008-05-27

申请号：US11421903

申请日：2006-06-02

Applicant: David J. Brady ,  Prasant Potuluri ,  Michael E. Sullivan

Inventor： David J. Brady ,  Prasant Potuluri ,  Michael E. Sullivan

IPC: G01J3/04 ,  G01J3/12

CPC classification number: G01J3/02 ,  G01J3/0216 ,  G01J3/0218 ,  G01J3/0221 ,  G01J3/0229 ,  G01J3/2803 ,  G01J3/2846 ,  G02B2207/129

Abstract: A spatial filter for an optical system, such as an optical spectrometer, collects and spatially filters light using a fiber bundle having a plurality of fibers disposed therein. At an input end of the fiber bundle, the fibers are typically packed tightly together to optimize the collection efficiency. At an output end, the fibers are spread out from the fiber bundle and arranged within a two-dimensional output area according to a two-dimensional pattern corresponding to a coded aperture function. As a result, the two-dimensional pattern of the output end spatially filters the light collected by the input end. Corresponding methods are also described.

Abstract translation: 用于诸如光谱仪的光学系统的空间滤光器使用其中布置有多个光纤的纤维束聚集并空间地过滤光。 在纤维束的输入端，通常将纤维紧密地包装在一起以优化收集效率。 在输出端，根据与编码孔径函数对应的二维图案，纤维从纤维束展开并布置在二维输出区域内。 结果，输出端的二维图案对输入端收集的光进行空间滤波。 还描述了相应的方法。