公开(公告)号：US20150308960A1

公开(公告)日：2015-10-29

申请号：US14699025

申请日：2015-04-29

Applicant: UNIVERSITY OF HOUSTON SYSTEM

Inventor： Wei-Chuan Shih

IPC: G01N21/65

CPC classification number: G01N21/658 ,  B82Y30/00 ,  G01J3/02 ,  G01J3/44

Abstract: The present disclosure relates the use of a stamping surface enhanced Raman scattering (S-SERS) technique with nanoporous gold disk (NPGD) plasmonic substrates to produce a label-free, multiplexed molecular sensing and imaging technique. A NPGD SERS substrate is stamped onto a surface containing one or more target molecules, followed by SERS measurement of the target molecules located between the surface and SERS substrate. The target molecules may be deposited on the surface, which may be a carrier substrate such as polydimethylsiloxane (PDMS).

Abstract translation: 本公开内容涉及冲压表面增强拉曼散射（S-SERS）技术与纳米多孔金盘（NPGD）等离子体激元基板的使用以产生无标记的复合分子感测和成像技术。 将NPGD SERS底物冲压到含有一种或多种靶分子的表面上，随后对位于表面和SERS底物之间的靶分子进行SERS测量。 靶分子可以沉积在表面上，其可以是载体基底如聚二甲基硅氧烷（PDMS）。

公开(公告)号：US20150276481A1

公开(公告)日：2015-10-01

申请号：US14431080

申请日：2013-09-25

Applicant: THE PENN STATE RESEARCH FOUNDATION ,  WASHINGTON UNIVERSITY

Inventor： Zhiwen Liu ,  Lan Yang ,  Perry Edwards ,  Corey Janisch ,  Bo Peng ,  Sahin Ozdemir

IPC: G01J3/44 ,  G01J3/10 ,  G01J3/02

CPC classification number: G01J3/44 ,  G01J3/0208 ,  G01J3/0224 ,  G01J3/10 ,  G01J3/26 ,  G01J3/2823 ,  G01N21/65

Abstract: Embodiments of the invention provide Raman spectroscopy methods and devices that exploit high quality factor (Q) resonators to enhance Raman signal by several orders of magnitude over the signal typically expected for Raman methods. Embodiments typically include one or more resonators, typically microtoroid microresonators. Embodiments also take advantage of Rayleigh scattering using these microresonators. Embodiments may be particularly useful for non-labeled nanoparticle sensing.

Abstract translation: 本发明的实施方案提供拉曼光谱学方法和器件，其利用高品质因子（Q）谐振器来增强拉曼信号比通常对拉曼方法预期的信号几个数量级。 实施例通常包括一个或多个谐振器，通常是微小体微谐振器。 实施例还利用这些微谐振器的瑞利散射。 实施例对于非标记的纳米颗粒感测可能是特别有用的。

公开(公告)号：US20150260576A1

公开(公告)日：2015-09-17

申请号：US14666249

申请日：2015-03-23

Applicant: MKS Technology (d/b/a Snowy Range Instruments)

Inventor： Mark Watson ,  Shane Buller ,  Keith Carron

IPC: G01J3/44 ,  G01N21/65 ,  G01J3/06

CPC classification number: G01J3/4406 ,  G01J3/06 ,  G01J3/44 ,  G01J2003/062 ,  G01J2003/064 ,  G01N21/65 ,  G01N21/658 ,  G01N33/54313 ,  G01N33/54373 ,  G01N2201/0612

Abstract: A spectrometer is provided. In one implementation, for example, a spectrometer comprises an excitation source, a focusing lens, a movable mirror, and an actuator assembly. The focusing lens is adapted to focus an incident beam from the excitation source. The actuator assembly is adapted to control the movable mirror to move a focused incident beam across a surface of the sample.

Abstract translation: 提供光谱仪。 在一个实施方案中，例如，光谱仪包括激发源，聚焦透镜，可移动反射镜和致动器组件。 聚焦透镜适于聚焦来自激发源的入射光束。 致动器组件适于控制可移动镜以将聚焦的入射光束移动穿过样品的表面。

公开(公告)号：US09134246B2

公开(公告)日：2015-09-15

申请号：US14290833

申请日：2014-05-29

Applicant: CANON KABUSHIKI KAISHA

Inventor： Jumpei Naito ,  Kota Iwasaki ,  Masafumi Kyogaku ,  Yoichi Otsuka

IPC: G01J5/02 ,  G01N21/65 ,  G01J3/44

CPC classification number: G01N21/65 ,  G01J3/0264 ,  G01J3/027 ,  G01J3/10 ,  G01J3/44 ,  G02B21/16 ,  G02B21/365 ,  H01S3/10

Abstract: An optical measurement device includes a light source unit including a first laser light source configured to emit a laser beam having a first wavelength and a second laser light source configured to emit a laser beam having a second wavelength, a measurement wave number setting unit, and a light source adjustment unit configured to adjust at least one of the first wavelength and the second wavelength such that a difference between or a sum of a first wave number corresponding to the first wavelength and a second wave number corresponding to the second wavelength matches a measurement wave number set through the measurement wave number setting unit.

Abstract translation: 光学测量装置包括：光源单元，包括被配置为发射具有第一波长的激光的第一激光光源和被配置为发射具有第二波长的激光束的第二激光源，测量波数设定单元，以及 光源调节单元，被配置为调节所述第一波长和所述第二波长中的至少一个，使得对应于所述第一波长的第一波数与对应于所述第二波长的第二波数之和或之和与测量值相匹配 通过测量波数设定单位设定波数。

公开(公告)号：US20150253261A1

公开(公告)日：2015-09-10

申请号：US14718624

申请日：2015-05-21

Applicant: Brooks Hart Pate ,  Kevin K. Lehmann

Inventor： Brooks Hart Pate ,  Kevin K. Lehmann

IPC: G01N22/00

CPC classification number: G01N21/3586 ,  G01J3/10 ,  G01J3/4338 ,  G01J3/44 ,  G01N21/31 ,  G01N21/62 ,  G01N21/67 ,  G01N21/69 ,  G01N22/00 ,  H01S3/0057

Abstract: A pulse train comprising chirped pulses can be used to excite a sample, such as for spectroscopic analysis. The respective chirped pulses can include a frequency sweep to establish a first frequency-domain comb. A width of frequency-domain comb peaks can be established at least in part by a total duration of the pulse train, and a bandwidth of the first frequency-domain comb can be determined at least in part by a bandwidth of the frequency sweep of the respective chirped pulses. A free-space or enclosed sample interaction region can be used.

Abstract translation: 包括啁啾脉冲的脉冲串可用于激发样品，例如用于光谱分析。 相应的啁啾脉冲可以包括频率扫描以建立第一频域梳。 频域梳状峰值的宽度可以至少部分地由脉冲序列的总持续时间建立，并且第一频域梳状的带宽可以至少部分地由第一频域梳状物的频率扫描的带宽确定 各自的啁啾脉冲。 可以使用自由空间或封闭的样品相互作用区域。

公开(公告)号：US09128059B2

公开(公告)日：2015-09-08

申请号：US13257194

申请日：2010-03-19

Applicant: Wolfgang Langbein ,  Paola Borri

Inventor： Wolfgang Langbein ,  Paola Borri

IPC: G01J3/44 ,  G01J3/30 ,  G01N21/25 ,  G01J1/58 ,  G01N21/64 ,  G01N21/65 ,  G01J3/02

CPC classification number: G01N21/65 ,  G01J3/02 ,  G01J3/0224 ,  G01J3/44 ,  G01N2021/653

Abstract: A coherent anti-Stokes Raman spectroscopy (CARS) system comprises a laser light source for emitting pulsed light, a dichroic beam splitter for splitting a light pulse from the light source into a pump pulse and a Stokes pulse and directing these pulses along respective distinct paths, chirping means, e.g. dispersive glass blocks for chirping the pump and Stokes pulses, directing means for directing the chirped pump and Stokes samples to a sample in time overlap, and detecting means for detecting light stimulated from the sample by the interaction of the pump and Stokes pulses. The system may comprise a reflector connected to a linear motor, for adjusting the period between the arrival at the sample of the starts of the chirped pump and Stokes pulses. The system may further comprise a pulse replicating unit for converting a pulse from the light source into a plurality of pulses distributed in time.

Abstract translation: 相干的反斯托克斯拉曼光谱（CARS）系统包括用于发射脉冲光的激光光源，用于将来自光源的光脉冲分解为泵脉冲和斯托克斯脉冲的二向色分束器，并将这些脉冲引导到相应的不同路径 啁啾手段，例如 用于啁啾泵和斯托克斯脉冲的分散玻璃块，用于将啁啾的泵和斯托克斯样品以时间重叠的方式引导到样品的引导装置，以及用于通过泵和斯托克斯脉冲的相互作用检测从样品刺激的光的检测装置。 系统可以包括连接到线性电动机的反射器，用于调节到达啁啾泵的起始点与斯托克斯脉冲之间的时间段。 该系统还可以包括用于将来自光源的脉冲转换成在时间上分布的多个脉冲的脉冲复制单元。

公开(公告)号：US09103726B2

公开(公告)日：2015-08-11

申请号：US14002143

申请日：2012-03-02

Applicant: Yasuyuki Ozeki ,  Kazuyoshi Itoh ,  Keisuke Nose

Inventor： Yasuyuki Ozeki ,  Kazuyoshi Itoh ,  Keisuke Nose

IPC: G01J3/44 ,  G01N21/65 ,  G01J3/433 ,  H01S3/00 ,  H01S3/23

CPC classification number: G01J3/4412 ,  G01J3/433 ,  G01J3/44 ,  G01N21/65 ,  G01N2021/655 ,  H01S3/005 ,  H01S3/2391

Abstract: The stimulated Raman scattering detection apparatus includes first and second light pulse generators (1, 2) respectively generating first and second light pulses with first and second pulse periods, an optical system combining the first and second light pulses and focusing the combined light pulses onto a sample, and a detector (10) detecting the second light pulses intensity-modulated by stimulated Raman scattering generated by focusing of the combined light pulses onto the sample. The second light pulse generator divides each raw light pulse emitted with the second pulse period into two light pulses, delays one of the two light pulse with respect to the other thereof and combines the one light pulse divided from one raw light pulse and delayed, with the other light pulse divided from another raw light pulse emitted after the one raw light pulse, to generate the second light pulse.

Abstract translation: 被激发的拉曼散射检测装置包括分别产生具有第一和第二脉冲周期的第一和第二光脉冲的第一和第二光脉冲发生器（1,2），组合第一和第二光脉冲并将组合的光脉冲聚焦到 样品和检测器（10），检测通过将组合的光脉冲聚焦到样品上而产生的受激拉曼散射强度调制的第二光脉冲。 第二光脉冲发生器将以第二脉冲周期发射的每个原始光脉冲分成两个光脉冲，将两个光脉冲中的一个相对于另一个脉冲延迟，并将从一个原始光脉冲分离的一个光脉冲和延迟的一个光脉冲与 另一个光脉冲从在一个原始光脉冲之后发射的另一原始光脉冲中分离，以产生第二光脉冲。

公开(公告)号：US09103714B2

公开(公告)日：2015-08-11

申请号：US12924831

申请日：2010-10-06

Applicant: Patrick Treado ,  Matthew Nelson ,  Charles W. Gardner, Jr.

Inventor： Patrick Treado ,  Matthew Nelson ,  Charles W. Gardner, Jr.

IPC: G01J3/02 ,  G01J3/44 ,  G01N21/359 ,  G01N33/00

CPC classification number: G01J3/02 ,  G01J3/0218 ,  G01J3/027 ,  G01J3/0278 ,  G01J3/44 ,  G01N21/359 ,  G01N33/0057

Abstract: A system and method for detecting explosives and explosive residues. A region of interest is surveyed using a video capture device to thereby identify a target area wherein the target area comprises an unknown material. The target area is interrogated using SWIR spectroscopic methods to form a SWIR hyperspectral image of the target area. The SWIR hyperspectral image is analyzed to thereby identify the unknown material.

Abstract translation: 爆炸物和爆炸物残留物的检测系统和方法。 使用视频捕获装置测量感兴趣的区域，从而识别目标区域，其中目标区域包括未知材料。 使用SWIR光谱方法询问目标区域以形成目标区域的SWIR高光谱图像。 分析SWIR高光谱图像，从而识别未知物质。

公开(公告)号：US20150185154A1

公开(公告)日：2015-07-02

申请号：US14576699

申请日：2014-12-19

Applicant: Nuctech Company Limited

Inventor： Zhiqiang CHEN ,  Ziran ZHAO ,  Jianhong ZHANG ,  Hongqiu WANG ,  Yumin YI

IPC: G01N21/65

CPC classification number: G01N21/65 ,  G01J3/28 ,  G01J3/44 ,  G01J3/4412 ,  G01N2201/06113 ,  G01N2201/12

Abstract: An embodiment of the present invention provides a Raman spectroscopic detection method for detecting a sample in a vessel, comprising the steps of: (a) measuring a Raman spectrum of the vessel to obtain a first Raman spectroscopic signal; (b) measuring a Raman spectrum of the sample through the vessel to obtain a second Raman spectroscopic signal; (c) removing an interference caused by the Raman spectrum of the vessel from the second Raman spectroscopic signal on basis of the first Raman spectroscopic signal to obtain a third Raman spectroscopic signal of the sample itself; and (d) identifying the sample on basis of the third Raman spectroscopic signal. By means of the above method, the Raman spectrum of the sample in the vessel may be detected correctly so as to identify the sample to be detected efficiently.

Abstract translation: 本发明的一个实施方案提供一种用于检测容器中的样品的拉曼光谱检测方法，包括以下步骤：（a）测量容器的拉曼光谱以获得第一拉曼光谱信号; （b）通过容器测量样品的拉曼光谱，以获得第二拉曼光谱信号; （c）基于所述第一拉曼光谱信号从所述第二拉曼光谱信号中除去由所述容器的拉曼光谱引起的干扰，以获得所述样品本身的第三拉曼光谱信号; 和（d）基于第三拉曼光谱信号鉴定样品。 通过上述方法，可以正确地检测容器中的样品的拉曼光谱，以便有效地鉴定要检测的样品。

公开(公告)号：US20150185076A1

公开(公告)日：2015-07-02

申请号：US14577748

申请日：2014-12-19

Applicant: NUCTECH COMPANY LIMITED

Inventor： Ziran ZHAO ,  Jianhong ZHANG ,  Hongqiu WANG ,  Weiwei WANG ,  Zhiming WANG ,  Yumin YI

IPC: G01J3/02 ,  G01N21/65

CPC classification number: G01J3/0297 ,  G01J3/28 ,  G01J3/44 ,  G01J2003/4424 ,  G01N21/65 ,  G01N2201/06113 ,  G01N2201/12

Abstract: Embodiments of the present invention provide a Raman spectroscopic inspection method, comprising the steps of: measuring a Raman spectrum of an object to be inspected successively to collect a plurality of Raman spectroscopic signals; superposing the plurality of Raman spectroscopic signals to form a superposition signal; filtering out a florescence interfering signal from the superposition signal; and identifying the object to be inspected on basis of the superposition signal from which the florescence interfering signal has been filtered out. By means of the above method, a desired Raman spectroscopic signal may be acquired by removing the interference caused by a florescence signal from a Raman spectroscopic inspection signal of the object. It may inspect correctly the characteristics of the Raman spectrum of the object so as to identify the object effectively.

Abstract translation: 本发明的实施例提供一种拉曼光谱检查方法，包括以下步骤：连续测量待检测物体的拉曼光谱，以收集多个拉曼光谱信号; 叠加多个拉曼光谱信号以形成叠加信号; 从叠加信号滤除荧光干扰信号; 并且根据已经滤除了荧光干扰信号的重叠信号来识别待检查的对象。 通过上述方法，可以通过从对象的拉曼光谱检查信号中去除由荧光信号引起的干扰来获得所需的拉曼光谱信号。 它可以正确地检查物体的拉曼光谱的特征，以有效地识别物体。