公开(公告)号：US07884301B2

公开(公告)日：2011-02-08

申请号：US11921360

申请日：2006-06-02

申请人： Uwe Kirstein ,  Klaus Lennartz

发明人： Uwe Kirstein ,  Klaus Lennartz

IPC分类号： B07C5/00 ,  B01L1/00

CPC分类号： G01N15/1459 ,  G01N2001/2223 ,  G01N2015/0019 ,  G01N2015/149 ,  G01N2035/00277

摘要： A device and method for sorting microparticles including a nozzle for a separating stream, with a vibration generator for the dispersion of the separation flow into a droplet flow with a deflector device for separation of the droplet flow into a through flow and at least one side flow depending on signals from an analytical device configured to analyze the microparticles (s) contained in the droplets and to control the deflector device. Also provided is a protective chamber in which at least the nozzle, the oscillation generator and the deflector device are arranged. The analytical device is outside the safety cabinet wherein the protective chamber is part of the safety cabinet with a clean chamber and a monitoring device through which the signals of the microparticles arising from the separating stream are supplied to the detectors of the analytical device, arranged outside the safety cabinet.

摘要翻译： 一种用于分选包括用于分离流的喷嘴的微粒的装置和方法，具有用于将分离流分散到液滴流中的振动发生器，该偏转装置用于将液滴流分离成通流和至少一个侧流 取决于来自分析装置的信号，其被配置为分析包含在液滴中的微粒并且控制偏转器装置。 还设置有至少安装喷嘴，振荡发生器和偏转器装置的保护室。 分析装置在安全柜之外，其中保护室是安全柜的一部分，具有清洁室和监测装置，通过该装置将从分离流产生的微粒的信号提供给分布装置的检测器，布置在外部 安全柜。

公开(公告)号：US07731898B2

公开(公告)日：2010-06-08

申请号：US11523842

申请日：2006-09-20

申请人： Claudius Burkhardt ,  Gottlieb Schacher ,  Renato Belz

发明人： Claudius Burkhardt ,  Gottlieb Schacher ,  Renato Belz

IPC分类号： G01N35/00 ,  G01N35/10

CPC分类号： G01N35/025 ,  G01N2035/00277 ,  G01N2035/00455 ,  G01N2035/0443 ,  Y10T436/11 ,  Y10T436/111666 ,  Y10T436/114998

摘要： A reagent container assembly adapted for being installed in a cavity of an analyzer. The reagent container assembly comprises a housing having an upper opening and defining at least one circular array of chambers, each chamber being adapted for receiving a reagent container, a cover for closing the upper opening of the housing, and a locking mechanism arranged within the housing. The locking mechanism is adapted for locking the cover and for preventing rotation thereof. The locking mechanism is further adapted for locking the housing and thereby preventing rotation thereof when the reagent container assembly is removed from its position in the analyzer. The locking mechanism is further adapted for cooperating with a pin arranged at the bottom of the cavity of the analyzer when the reagent container assembly is installed in the analyzer, the housing being unlocked by the cooperation and thereby allowed to be rotated within the cavity of the analyzer.

摘要翻译： 一种适于安装在分析器的空腔中的试剂容器组件。 试剂容器组件包括具有上开口并限定至少一个圆形阵列的壳体的壳体，每个腔室适于容纳试剂容器，用于封闭壳体的上部开口的盖子以及设置在壳体内的锁定机构 。 锁定机构适于锁定盖并防止其旋转。 锁定机构还适于锁定外壳，从而当试剂容器组件从分析器中的位置移除时防止其旋转。 锁定机构进一步适用于当试剂容器组件安装在分析器中时与配置在分析器的空腔底部的销配合，壳体通过协作解锁，从而允许在壳体内的空腔内旋转 分析仪

公开(公告)号：US20100028986A1

公开(公告)日：2010-02-04

申请号：US12529536

申请日：2007-10-16

申请人： Nobuhiro Hanafusa

发明人： Nobuhiro Hanafusa

IPC分类号： C12M1/34 ,  B01J19/00 ,  C12M1/00 ,  B01J10/00

CPC分类号： B01L3/502738 ,  B01J2219/00315 ,  B01J2219/00364 ,  B01J2219/00391 ,  B01L3/0268 ,  B01L3/5025 ,  B01L2200/0605 ,  B01L2200/0684 ,  B01L2300/041 ,  B01L2300/046 ,  B01L2300/0829 ,  B01L2300/0864 ,  B01L2400/0478 ,  B01L2400/0481 ,  B01L2400/0487 ,  B01L2400/0605 ,  B01L2400/0611 ,  B01L2400/0622 ,  B01L2400/0644 ,  G01N2035/00277

摘要： Disclosed herein is a reaction container plate which prevents the entry of foreign matter from the outside and the pollution of an outside environment. A reaction container plate (1) includes a sealed reaction container (5), a reaction container channel (15) connected to the reaction container (5), a sealed container (17) provided separately from the reaction container (5), a sealed container channel (17a) connected to the sealed container (17), a syringe (33) for sending a liquid, a switching valve (47) for connecting the syringe (33) to the introduction channel (15) or the sealed container channel (17a), and a sealed container air vent channel (17b) of which one end is connected to the sealed container (17). When the syringe (33) is connected to the sealed container (17) via the switching valve (47) to inject a liquid contained in the syringe (33) into the sealed container (17) and to suck a liquid contained in the sealed container (17) into the syringe (33), a gas contained in the sealed container (17) is moved between the sealed container (17) and the sealed container air vent channel (17b).

摘要翻译： 本文公开了一种反应容器板，其防止异物从外部进入和外部环境的污染。 反应容器板（1）包括密封的反应容器（5），与反应容器（5）连接的反应容器通道（15），与反应容器（5）分开设置的密封容器（17） 连接到密封容器（17）的容器通道（17a），用于送出液体的注射器（33），用于将注射器（33）连接到引入通道（15）或密封容器通道（ 17a）和密封容器排气通道（17b），其一端连接到密封容器（17）。 当注射器（33）经由切换阀（47）与密封容器（17）连接以将包含在注射器（33）中的液体注入到密封容器（17）中并且吸收容纳在密封容器 （17）进入注射器（33）时，密封容器（17）中容纳的气体在密封容器（17）和密封容器排气通道（17b）之间移动。

公开(公告)号：US07651856B2

公开(公告)日：2010-01-26

申请号：US10596438

申请日：2004-11-11

申请人： Raimund Schuetze ,  Bernd Saegmueller ,  Kurt Harms ,  Yilmaz Niyaz

发明人： Raimund Schuetze ,  Bernd Saegmueller ,  Kurt Harms ,  Yilmaz Niyaz

IPC分类号： C12N5/00 ,  G01N1/00

CPC分类号： G01N1/2813 ,  G01N2001/284 ,  G01N2001/2886 ,  G01N2035/00277

摘要： To enable contactless laser microdissection in a closed container (10, 11), for example in the form of a Petri dish, it is proposed according to the invention to use a holding device which comprises a receiving portion (4) for arrangement in the container (10, 11) and a holding portion (1) for arrangement externally of the container (10, 11). The receiving portion (4) serves to receive at least one receiving means (9), which serves in turn to receive or collect at least one biological specimen obtained by laser microdissection from biological material (15) located in the container (10, 11). The holding portion (1) is coupled to the receiving portion (4) in contactless manner, for example by means of magnetic coupling, in such a way that, by moving the holding portion (1), the receiving portion (4), together with the receiving means (9) held thereby, may be positioned in the closed container (10, 11) precisely over the biological specimen in each case to be received.

摘要翻译： 为了使得非接触式激光显微切割在密闭容器（10,11）中，例如以培养皿的形式，根据本发明，提出使用一种保持装置，该保持装置包括用于配置在容器中的容纳部分（4） （10,11）和用于在容器（10,11）的外部配置的保持部分（1）。 接收部分（4）用于容纳至少一个接收装置（9），所述接收装置依次用于接收或收集由位于容器（10,11）中的生物材料（15）通过激光显微切割获得的至少一个生物样本， 。 保持部分（1）以例如通过磁耦合的非接触方式联接到接收部分（4），使得通过使保持部分（1），接收部分（4）一起移动 在其中保持的接收装置（9）可以在每种情况下精确地定位在密封容器（10,11）中以便接收。

公开(公告)号：US20090127167A1

公开(公告)日：2009-05-21

申请号：US11921360

申请日：2006-06-02

申请人： Uwe Kirstein ,  Klaus Lennartz

发明人： Uwe Kirstein ,  Klaus Lennartz

IPC分类号： B07B7/00 ,  B01L1/00

CPC分类号： G01N15/1459 ,  G01N2001/2223 ,  G01N2015/0019 ,  G01N2015/149 ,  G01N2035/00277

摘要： The invention relates to the separation of microparticles by means of a nozzle (12) for the release of a separating stream (20), comprising at least one enveloping fluid and microparticles entrained Therein, with a vibration generator (18), for the dispersion of the separation flow (20) into a droplet flow (20′), with a deflector device (24), for separation of the droplet flow (20′) into a through flow (20A) and at least one side flow (20B, 20C, . . . ), depending on signals from an analytical device (38). Said analytical device (38) is provided for the analysis of the microparticles(s) contained in the droplets and to control the deflector device (24). Also provided is a protective chamber for product and personnel protection, in which at least the nozzle (12), the oscillation generator (18) and the deflector device (24) are arranged. The analytical device is arranged essentially outside the microbiological safety cabinet (200), whereby, according to the invention, the protective chamber is part of a microbiological safety cabinet (MSW 200), in particular with a laminar throughflow, with a clean chamber (34) and with a monitoring device (22), provided in a side wall, in particular in the back wall (32) of the microbiological safety cabinet (200), through which the signals of the microparticles arising from the separating stream (20) are supplied to the detectors of the analytical device (38), arranged outside the microbiological safety cabinet (200).

摘要翻译： 本发明涉及通过用于释放分离流（20）的喷嘴（12）分离微粒，包括至少一个包裹流体和其中夹带的微粒与振动发生器（18），用于分散 分离流（20）转换成具有偏转器装置（24）的液滴流（20'），用于将液滴流（20'）分离成通流（20A）和至少一个侧流（20B，20C ，...），取决于来自分析装置（38）的信号。 所述分析装置（38）被提供用于分析包含在液滴中的微粒并控制偏转器装置（24）。 还提供了一种用于产品和人员保护的保护室，其中至少布置有喷嘴（12），振荡发生器（18）和偏转器装置（24）。 分析装置基本上布置在微生物安全柜（200）的外部，根据本发明，保护室是微生物安全柜（MSW 200）的一部分，特别是具有层流通流的清洁室（34） ）和设置在微生物安全柜（200）的后壁（32）的侧壁中的监视装置（22），通过该监视装置从分离流（20）产生的微粒的信号是 供应到布置在微生物安全柜（200）外部的分析装置（38）的检测器。

公开(公告)号：US20090100942A1

公开(公告)日：2009-04-23

申请号：US12254717

申请日：2008-10-20

申请人： Yoshiaki Maeda ,  Takaaki Fujita

发明人： Yoshiaki Maeda ,  Takaaki Fujita

IPC分类号： G01N35/10

CPC分类号： G01N35/1079 ,  G01N2035/00277

摘要： After a sampling needle is moved to a position above a sample container, the sampling needle is moved down so that the tip of the sampling needle penetrates a septum, and is then preferably moved down to a position at which the tip of the sampling needle is not brought into contact with a sample contained in the sample container, and then, the sampling needle is once elevated until the sampling needle is pulled out of the septum, and is then again moved down to penetrate the septum until the tip of the sampling needle is inserted into the sample to suck the sample through a suction port of the sampling needle, and then, the sampling needle is moved to a sample injection port of an analyzer to inject the sample into the analyzer.

摘要翻译： 在将取样针移动到样品容器上方的位置之后，采样针向下移动，使得采样针的尖端穿过隔膜，然后优选地向下移动到采样针的尖端为 不与样品容器中包含的样品接触，然后，采样针一旦升高直到取样针从隔膜中拉出，然后再次向下移动以穿透隔膜直到采样针的尖端 插入到样品中以通过取样针的吸入口吸取样品，然后将采样针移动到分析器的样品注入口，将样品注入分析器。

公开(公告)号：US20090029476A1

公开(公告)日：2009-01-29

申请号：US12237757

申请日：2008-09-25

申请人： Hidekazu ISHII

发明人： Hidekazu ISHII

IPC分类号： G01N33/00 ,  B01J19/00

CPC分类号： G01N21/03 ,  B01L3/508 ,  B01L3/50857 ,  B01L2300/042 ,  B01L2300/0838 ,  G01N21/11 ,  G01N2021/0325 ,  G01N2021/151 ,  G01N2035/00277 ,  G01N2035/0403

摘要： A reaction vessel includes a storage space extending from a first end to a second ends the reaction vessel being configured to retain at least one of a reagent and a specimen in the storage space when the at least one of the reagent and the specimen is dispensed from the first end, and to discharge the at least one of the reagent and the specimen outside the storage space from the second end when a discharge operation is performed from outside.

摘要翻译： 反应容器包括从第一端延伸到第二端的存储空间，反应容器构造成当试剂和样品中的至少一种从试剂和试样中分离出时将试剂和样品中的至少一种保留在储存空间中 第一端，并且当从外部执行排放操作时，将所述试剂和样本中的至少一个从所述第二端排出所述存储空间。

公开(公告)号：US20080115885A1

公开(公告)日：2008-05-22

申请号：US11601121

申请日：2006-11-17

申请人： Sharon Eileen Silveri

发明人： Sharon Eileen Silveri

IPC分类号： B29C65/00

CPC分类号： B29C66/8612 ,  B01L3/5025 ,  B01L2200/12 ,  B01L2300/044 ,  B29C65/18 ,  B29C65/7841 ,  B29C66/1122 ,  B29C66/53461 ,  B29C66/652 ,  B29C66/836 ,  B29C66/91421 ,  B29C66/91431 ,  B29C66/91641 ,  B29C66/91645 ,  B29C66/919 ,  B29K2705/00 ,  B29K2995/0067 ,  G01N2035/00277

摘要： A heat sealer with a base unit and a mobile unit containing a heating element with a substantially flat heating surface. The mobile unit is heated and then used to apply heat to a sealing medium disposed over an assay plate. Heat may be applied by moving the mobile unit in a substantially horizontal plane, while the heating element is in contact with the sealing medium, thus annealing the sealing medium to a top surface of an assay plate. Heat may also be applied using a vertical motion, or any combination of motions, and may be applied to individual wells of the assay plate.

摘要翻译： 具有基座单元的热封机和包含具有基本上平坦的加热表面的加热元件的移动单元。 移动单元被加热，然后用于向设置在测定板上的密封介质施加热量。 可以通过在基本上水平的平面中移动移动单元，同时加热元件与密封介质接触，从而将密封介质退火到测定板的顶表面来施加热量。 也可以使用垂直运动或运动的任何组合施加热量，并且可以将其应用于分析板的各个孔。

公开(公告)号：US07337654B2

公开(公告)日：2008-03-04

申请号：US11648640

申请日：2007-01-03

申请人： Masami Tomita ,  Yoshiaki Maeda

发明人： Masami Tomita ,  Yoshiaki Maeda

IPC分类号： G01N1/12

CPC分类号： G01N35/1097 ,  B01L3/0275 ,  B01L2300/161 ,  G01N30/24 ,  G01N35/1004 ,  G01N2035/00277 ,  Y10T29/49391 ,  Y10T29/49982

摘要： In a method of forming a needle for an auto-sampler successively collecting liquid samples from plural sample containers, a parent material forming the needle is coated with a coating material having a chemical activity small than that of the needle. Then, the coated parent material is polished so that the surface has an average roughness of 10 to 20 nm.

摘要翻译： 在从多个样品容器中连续收集液体样品的自动采样器的针形成方法中，形成针的母材涂覆有比针的化学活性小的涂料。 然后，对涂覆的母材进行抛光，使得表面的平均粗糙度为10〜20nm。

公开(公告)号：US07273759B2

公开(公告)日：2007-09-25

申请号：US10236953

申请日：2002-09-09

申请人： Jonathan L. Coffman ,  Hong Lu ,  Ernest J. Wodds, III

发明人： Jonathan L. Coffman ,  Hong Lu ,  Ernest J. Wodds, III

IPC分类号： G01N1/10

CPC分类号： B01L3/50255 ,  B01L3/5025 ,  G01N1/405 ,  G01N35/1095 ,  G01N2001/388 ,  G01N2035/00237 ,  G01N2035/00277 ,  G01N2035/00485 ,  Y10T436/2575

摘要： Device and method for processing samples are provided. A first multiwell plate is stacked atop a second multiwell plate. The first multiwell plate has x wells arranged in an array, each well is capable of receiving a sample and has an outlet. The second multiwell plate has y wells arranged in an array, each well being capable of receiving a separate sample. y>x. The outlets of the first multiwell plate register with inlets of a subset of wells of the second multiwell plate when the first plate is stacked atop the second plate. Also provided are a mechanism for aligning the plates and transfer indicia for tracking transfer of sample from the first to the second plate. A mechanism for sealing the first plate to the second plate is provided so that samples can be directly transferred between the plates without cross-contamination occurring in open wells of the second plate.

摘要翻译： 提供了处理样品的装置和方法。 第一多孔板堆叠在第二多孔板上。 第一个多孔板具有排列成阵列的x个孔，每个孔能够接收样品并具有出口。 第二个多孔板具有以阵列排列的y个孔，每个孔能够接收单独的样品。 y> x。 当第一板堆叠在第二板顶上时，第一多孔板的出口对准第二多孔板的孔子集的入口。 还提供了用于对准板和传送标记以跟踪样品从第一板到第二板的转移的机构。 提供了将第一板密封到第二板的机构，使得样品可以在板之间直接传递，而不会在第二板的开放井中发生交叉污染。