公开(公告)号：US06885965B2

公开(公告)日：2005-04-26

申请号：US10444045

申请日：2003-05-22

Applicant: Matthew Butler ,  Grant Plummer

Inventor： Matthew Butler ,  Grant Plummer

IPC: G01J3/00 ,  G01J3/28 ,  G01J3/453 ,  G01N21/35 ,  G01B9/02 ,  G06F15/00 ,  G06F15/46

CPC classification number: G01J3/453 ,  G01J3/0264 ,  G01J3/28 ,  G01N21/3518 ,  G01N2021/1793 ,  G01N2201/1211 ,  G01N2201/129

Abstract: A fourth embodiment of the present invention is a method of generating a temperature compensated absorbance spectrum. The method includes the steps of: a. providing a sample spectrum and an estimated temperature of a backdrop object; b. from a set of known temperature spectra related to a known background temperature, selecting at least two known temperature spectra representing a background temperature above and below the estimated temperature; c. comparing the sample spectrum to the known temperature spectra in order to determine a sample background spectrum; and d. calculating an absorbance spectrum from the sample spectrum and the background spectrum.

公开(公告)号：US06847447B2

公开(公告)日：2005-01-25

申请号：US09804613

申请日：2001-03-12

Applicant: Richard M. Ozanich

Inventor： Richard M. Ozanich

IPC: G01J3/02 ,  G01J3/28 ,  G01J3/36 ,  G01J3/42 ,  G01J3/51 ,  G01N21/31 ,  G01N21/35 ,  G01N33/02 ,  G01N21/25 ,  G01N21/47

CPC classification number: G01J3/02 ,  G01J3/0218 ,  G01J3/0224 ,  G01J3/28 ,  G01J3/36 ,  G01J3/42 ,  G01J3/501 ,  G01J3/51 ,  G01J3/513 ,  G01J3/524 ,  G01N21/3563 ,  G01N21/359 ,  G01N33/025 ,  G01N2021/3155 ,  G01N2021/8466 ,  G01N2201/129 ,  Y10S250/91

Abstract: This disclosure is of 1) the utilization of the spectrum from 250 nm to 1150 nm for measurement of prediction of one or more parameters, e.g., brix, firmness, acidity, density, pH, color and external and internal defects and disorders including, for example, surface and subsurface braises, scarring, sun scald, punctures, in N—H, C—H and O—H samples including fruit; 2) an apparatus and method of detecting emitted light from samples exposed to the above spectrum in at least one spectrum range and, in the preferred embodiment, in at least two spectrum ranges of 250 to 499 nm and 500 nm; 3) the use of the chlorophyl band, peaking at 690 nm, in combination with the spectrum from 700 nm and above to predict one or more of the above parameters; 4) the use of the visible pigment region, including xanthophyll, from approximately 250 nm to 499 nm and anthocyanin from approximately 500 to 550 nm, in combination with the chlorophyl band and the spectrum from 700 nm and above to predict the all of the above parameters.

Abstract translation: 本公开是1）利用250nm至1150nm的光谱来测量一种或多种参数的预测，例如白利糖度，硬度，酸度，密度，pH，颜色以及外部和内部缺陷和紊乱，包括对于 例如，包括水果在内的NH，CH和OH样品中的表面和地下辫子，疤痕，太阳烫伤，穿刺， 2）一种在至少一个光谱范围内检测暴露于上述光谱的样品的发射光的装置和方法，在优选实施例中，在250至499nm和500nm的至少两个光谱范围内; 3）使用叶绿素带，峰值在690nm，与700nm以上的光谱结合，以预测上述一个或多个参数; 4）使用约250nm至499nm的可见颜料区域（包括叶黄素）和约500至550nm的花色素苷，与叶绿素谱带和700nm及以上的光谱结合使用，以预测上述全部 参数。

公开(公告)号：US20040034292A1

公开(公告)日：2004-02-19

申请号：US10638656

申请日：2003-08-11

Inventor： James Mansfield ,  Jenny Freeman

IPC: A61B005/00

CPC classification number: G01N21/6486 ,  A61B5/0059 ,  A61B5/0071 ,  A61B5/14532 ,  A61B5/1455 ,  A61B5/441 ,  A61B5/445 ,  A61B5/7264 ,  G01J3/28 ,  G01N2201/129

Abstract: This invention relates to methods for processing in vivo skin auto-fluorescence spectra for determining blood glucose levels. The invention also relates to methods of classifying cells or tissue samples or quantifying a component of a cell or tissue using a multivariate classification or quantification model.

Abstract translation: 本发明涉及用于处理体内皮肤自动荧光光谱以测定血糖水平的方法。 本发明还涉及使用多变量分类或定量模型分类细胞或组织样品或定量细胞或组织的组分的方法。

公开(公告)号：US06675029B2

公开(公告)日：2004-01-06

申请号：US10183660

申请日：2002-06-25

Applicant: Stephen L. Monfre ,  Timothy L. Ruchti ,  Thomas B. Blank ,  Brian J. Wenzel

Inventor： Stephen L. Monfre ,  Timothy L. Ruchti ,  Thomas B. Blank ,  Brian J. Wenzel

IPC: A61B500

CPC classification number: A61B5/444 ,  A61B5/0062 ,  A61B5/0075 ,  A61B5/1075 ,  A61B5/14532 ,  A61B5/1455 ,  A61B5/7264 ,  G01N21/3554 ,  G01N21/359 ,  G01N21/4785 ,  G01N21/49 ,  G01N2201/129

Abstract: An apparatus and method for non-destructively estimating a tissue property, such as hydration, of a living subject utilizes in vivo spectral measurements made by irradiating skin tissue with near infrared (NIR) light. The apparatus includes a spectroscopic instrument in conjunction with a subject interface. The resulting spectra are passed to an analyzer for further processing, which includes detecting and eliminating invalid spectral measurements, and preprocessing to increase the signal-to-noise ratio. Finally, an estimation model developed from an exemplary set of measurements is applied to predict the tissue hydration for the sample. The method of tissue hydration measurement provides additional information about primary sources of systematic tissue variability, namely, the water content of the epidermal layer of skin and the penetration depth of the incident light. Tissue hydration measurement is therefore suitable for further spectral analysis and quantification of biological and chemical compounds, such as analytes.

Abstract translation: 用于非破坏性地估计活体受试者的组织性质（例如水合）的装置和方法利用通过用近红外（NIR）光照射皮肤组织进行的体内光谱测量。 该装置包括结合主体界面的光谱仪器。 所得到的光谱被传递到分析器以用于进一步处理，其包括检测和消除无效光谱测量以及预处理以增加信噪比。 最后，应用从示例性测量集合开发的估计模型来预测样品的组织水合。 组织水合测量的方法提供关于系统组织变异性的主要来源的附加信息，即皮肤表皮层的水含量和入射光的穿透深度。 因此，组织水合测量适用于生物和化学化合物（如分析物）的进一步光谱分析和定量。

公开(公告)号：US20030060693A1

公开(公告)日：2003-03-27

申请号：US10183660

申请日：2002-06-25

Inventor： Stephen L. Monfre ,  Timothy L. Ruchti ,  Thomas B. Blank ,  Brian J. Wenzel

IPC: A61B005/00

CPC classification number: A61B5/444 ,  A61B5/0062 ,  A61B5/0075 ,  A61B5/1075 ,  A61B5/14532 ,  A61B5/1455 ,  A61B5/7264 ,  G01N21/3554 ,  G01N21/359 ,  G01N21/4785 ,  G01N21/49 ,  G01N2201/129

Abstract: An apparatus and method for non-destructively estimating a tissue property, such as hydration, of a living subject utilizes in vivo spectral measurements made by irradiating skin tissue with near infrared (NIR) light. The apparatus includes a spectroscopic instrument in conjunction with a subject interface. The resulting spectra are passed to an analyzer for further processing, which includes detecting and eliminating invalid spectral measurements, and preprocessing to increase the signal-to-noise ratio. Finally, an estimation model developed from an exemplary set of measurements is applied to predict the tissue hydration for the sample. The method of tissue hydration measurement provides additional information about primary sources of systematic tissue variability, namely, the water content of the epidermal layer of skin and the penetration depth of the incident light. Tissue hydration measurement is therefore suitable for further spectral analysis and quantification of biological and chemical compounds, such as analytes.

Abstract translation: 用于非破坏性地估计活体受试者的组织性质（例如水合）的装置和方法利用通过用近红外（NIR）光照射皮肤组织进行的体内光谱测量。 该装置包括结合主体界面的光谱仪器。 所得到的光谱被传递到分析器以用于进一步处理，其包括检测和消除无效光谱测量以及预处理以增加信噪比。 最后，应用从示例性测量集合开发的估计模型来预测样品的组织水合。 组织水合测量的方法提供关于系统组织变异性的主要来源的附加信息，即皮肤表皮层的水含量和入射光的穿透深度。 因此，组织水合测量适用于生物和化学化合物（如分析物）的进一步光谱分析和定量。

公开(公告)号：US06456955B1

公开(公告)日：2002-09-24

申请号：US09730126

申请日：2000-12-05

Applicant: Richard Wayne Andrews ,  Virginia L. Corbin

Inventor： Richard Wayne Andrews ,  Virginia L. Corbin

IPC: G01N3700

CPC classification number: G01N30/88 ,  G01N2030/8804 ,  G01N30/02 ,  G01N2201/129

Abstract: A method and apparatus for automating the qualification process for chromatographic systems. Automation technology and regression analysis are used for qualifying a chromatography system. The trained operator prepares the chromatography system to ensure that the samples, solvents, and the separation column are ready for analysis. The qualification of the detector, the solvent delivery system, the sample manager, the gradient proportioning system, the column heater, and the delay volume of the chromatography system are completed without the necessity of operator intervention. Regression analysis is performed to compute performance statistics that demonstrate the accuracy, linearity, and precision of the chromatographic system and quantify its suitability for chromatographic analysis.

Abstract translation: 用于自动化色谱系统鉴定过程的方法和设备。 自动化技术和回归分析用于对色谱系统进行鉴定。 经过培训的操作人员准备色谱系统，以确保样品，溶剂和分离柱准备好进行分析。 完成了检测器，溶剂输送系统，样品管理器，梯度配比系统，色谱柱加热器和色谱系统的延迟体积的鉴定，无需操作员干预。 进行回归分析以计算性能统计，显示色谱系统的准确度，线性和精度，并量化其色谱分析的适用性。

公开(公告)号：US20010034477A1

公开(公告)日：2001-10-25

申请号：US09785531

申请日：2001-02-20

Inventor： James Mansfield ,  Jenny Freeman

IPC: A61B005/00

CPC classification number: G01N21/6486 ,  A61B5/0059 ,  A61B5/0071 ,  A61B5/14532 ,  A61B5/1455 ,  A61B5/441 ,  A61B5/445 ,  A61B5/7264 ,  G01J3/28 ,  G01N2201/129

Abstract: This invention relates to methods for processing in vivo skin auto-fluorescence spectra for determining blood glucose levels. The invention also relates to methods of classifying cells or tissue samples or quantifying a component of a cell or tissue using a multivariate classification or quantification model.

Abstract translation: 本发明涉及用于处理体内皮肤自动荧光光谱以测定血糖水平的方法。 本发明还涉及使用多变量分类或定量模型分类细胞或组织样品或定量细胞或组织的组分的方法。

公开(公告)号：US06271518B1

公开(公告)日：2001-08-07

申请号：US09222720

申请日：1998-12-29

Applicant: Claudine Boehm ,  Jean-Bernard Berrut

Inventor： Claudine Boehm ,  Jean-Bernard Berrut

IPC: G01V500

CPC classification number: G01N21/64 ,  G01N33/241 ,  G01N2201/129

Abstract: The present invention relates to the exploration for and exploitation of formation hydrocarbons. According to the invention, a sample of material, representative of the impregnation with hydrocarbons of the rocks passed through, is taken during a drilling operation, with which sample a value of an emission flux, representative of the concentration of the fluorescent elements in the sample, and a value of a fluorescence quotient, which reflects the nature of the hydrocarbons present in the sample, are determined by spectrofluorimetry. The invention finds its application in analytical laboratories and on the drilling sites of petroleum production fields.

Abstract translation: 本发明涉及地层烃的勘探和开采。 根据本发明，在钻井操作期间取代代表通过的岩石中碳氢化合物浸渍的材料样品，其中样品的排放通量值代表样品中荧光元素的浓度 ，并且通过分光荧光法测定反映样品中存在的烃的性质的荧光商值。 本发明适用于分析实验室和石油生产领域的钻井现场。

公开(公告)号：US5945675A

公开(公告)日：1999-08-31

申请号：US819144

申请日：1997-03-17

Applicant: Donald C. Malins

Inventor： Donald C. Malins

IPC: C12N15/09 ,  C12Q1/68 ,  G01J3/45 ,  G01N21/35 ,  G01N33/15 ,  G01N33/566 ,  A61B6/00

CPC classification number: G01N21/35 ,  G01J3/45 ,  C12Q1/6886 ,  C12Q2600/112 ,  G01N2021/3595 ,  G01N2201/129 ,  G06F19/24

Abstract: Methods of screening for a tumor or tumor progression to the metastatic state are a provided. The screening methods are based on the characterization of DNA by principal components analysis of spectral data yielded by Fourier transform-infrared spectroscopy of DNA samples. The methods are applicable to a wide variety of DNA samples and cancer types.

Abstract translation: 提供筛选肿瘤或肿瘤进展至转移状态的方法。 筛选方法基于通过DNA样品的傅立叶变换红外光谱产生的光谱数据的主成分分析对DNA的表征。 该方法适用于各种DNA样品和癌症类型。

公开(公告)号：US5817007A

公开(公告)日：1998-10-06

申请号：US591663

申请日：1996-04-26

Applicant: Henrik Fodgaard ,  Rolf Singer ,  Paul Erik Fabricius

Inventor： Henrik Fodgaard ,  Rolf Singer ,  Paul Erik Fabricius

IPC: G01J3/28 ,  G01N21/05 ,  G01N21/359 ,  G01N33/487 ,  A61B5/00

CPC classification number: G01N21/359 ,  A61B5/14551 ,  A61M1/367 ,  A61B5/14535 ,  A61B5/14539 ,  A61B5/14542 ,  A61B5/14546 ,  A61M1/14 ,  A61M1/3609 ,  A61M2205/3313 ,  G01J3/2803 ,  G01N2021/058 ,  G01N2201/129

Abstract: A method and an apparatus for determining the content of a constituent of blood of an individual are disclosed. In the method a whole blood stream is extracted from a blood vessel of said individual, the stream being directed through a path defining a substantially non-varying flow-through area wherein is provided a flow-through measuring cuvette including opposite first and second optical transparent surface parts defining an optical transmission path of the order of 0.5-2.0 mm. The whole blood stream flowing through the measuring cuvette is irradiated by irradiating the first optical transparent surface part of the measuring cuvette with multi-wavelength near infrared light. The near infrared absorption spectrum is detected and the content of the constituent is quantified on the basis of the detected near infrared absorption data. The method is particularly suited for measuring constituents of whole blood in an extracorporeal loop, for example in hemodialysis.

Abstract translation: PCT No.PCT / DK94 / 00297 Sec。 371日期：1996年4月26日 102（e）日期1996年4月26日PCT 1994年8月1日PCT PCT。 出版物WO95 / 04266 日期：1995年2月9日公开了一种用于确定个体血液成分含量的方法和装置。 在该方法中，从所述个体的血管中提取全血流，所述流被引导通过限定基本上不变的流通区域的路径，其中设置有流通测量比色皿，其包括相对的第一和第二光学透明 表面部件限定0.5-2.0mm的光传输路径。 通过用多波长近红外光照射测量反应杯的第一光学透明表面部分来照射流过测量杯的全部血液。 检测近红外吸收光谱，并根据检测到的近红外吸收数据量化成分的含量。 该方法特别适用于测量体外循环中全血的成分，例如在血液透析中。