公开(公告)号：US10155725B2

公开(公告)日：2018-12-18

申请号：US14981847

申请日：2015-12-28

Applicant: MERIAL, INC.

Inventor： Charles Q. Meng ,  Alan Long ,  Scot Huber ,  Srinivas Reddy Gurrala ,  Douglas Edward Wilkinson ,  Gregory Pacofsky

IPC: A61K31/497 ,  C07D215/38 ,  A61K31/167 ,  A61K31/4704 ,  A61K31/495 ,  A61K31/496 ,  A61K31/4995 ,  A61K45/06 ,  C07D241/04 ,  C07D277/64 ,  C07D307/81 ,  C07D401/06 ,  C07D401/12 ,  C07D417/06 ,  C07D471/08 ,  C07D403/12 ,  C07D213/74 ,  C07D215/42 ,  C07D217/06 ,  C07D333/66 ,  C07D405/12 ,  C07D409/12 ,  C07D413/12 ,  C07D417/12 ,  C07D263/58 ,  C07D277/82 ,  C07D295/15 ,  C07D295/185 ,  C07D295/215 ,  C07D307/14 ,  C07D307/82 ,  C07C233/56 ,  C07C235/16 ,  A61K31/47 ,  A61K31/472 ,  C07D211/58 ,  C07D295/16 ,  C07D333/60

Abstract: The present invention relates to novel anthelmintic compounds of formula (I) below: wherein Y and Z are independently a bicyclic carbocyclic or a bicyclic heterocyclic group, or one of Y or Z is a bicyclic carbocyclic or a bicyclic heterocyclic group and the other of Y or Z is alkyl, alkenyl, alkynyl, cycloalkyl, phenyl, heterocyclyl or heteroaryl, and variables X1, X2, X3, X4, X5, X6, X7 and X8 are as defined herein. The invention also provides for veterinary compositions comprising the anthelmintic compounds of the invention, and their uses for the treatment and prevention of parasitic infections in animals.

公开(公告)号：US10098941B2

公开(公告)日：2018-10-16

申请号：US15419568

申请日：2017-01-30

Applicant: MERIAL, INC.

Inventor： Tammy (Kolander) Bremer ,  Paulraj Lawrence ,  Russell Bey

IPC: A61K39/102 ,  A61K39/00 ,  A61K45/06 ,  C12N1/38 ,  C12N1/36

Abstract: This disclosure provides attenuated Histophilus somni strains, compositions comprising same, and methods of production and use thereof. The attenuated strains may express lower or no levels of various virulence-associated genes, relative to the corresponding pathogenic bacteria Advantageously, the attenuated Histophilus somni strains may be administered orally, intranasally, intra-tracheally, or subcutaneously.

公开(公告)号：US20180271966A1

公开(公告)日：2018-09-27

申请号：US15763892

申请日：2016-10-05

Applicant: MERIAL, INC. ,  VETAGRO-SUP ,  INSTITUT PASTEUR

Inventor： Natalia Ines Bomchil ,  Lionel Pierre Cupillard ,  Celia Fontana ,  Pierre-Michel Guigal ,  Jerome Bouvet ,  Mathieu Picardeau ,  Angeli Kodjo

IPC: A61K39/02 ,  C07K14/20

CPC classification number: A61K39/0225 ,  A61K2039/522 ,  A61K2039/552 ,  C07K14/20

Abstract: The present invention provides compositions or vaccines that contain a recombinant or an attenuated Leptospira interrogans that elicit an immune response in animals against Leptospira infection, including compositions comprising said recombinant or attenuated L. interrogans, methods of vaccination against Leptospira, and kits for use with such methods and compositions.

公开(公告)号：US10080791B2

公开(公告)日：2018-09-25

申请号：US14851457

申请日：2015-09-11

Applicant: Merial Inc.

Inventor： Nicolas Pierre Yves Carboulec ,  Rene Labatut ,  Lionel Gerentes

IPC: A61L2/00 ,  A61K39/02 ,  A61K39/00

CPC classification number: A61K39/099 ,  A61K39/0225 ,  A61K39/0241 ,  A61K2039/521 ,  A61K2039/552

Abstract: The invention relates to hyperbaric devices for inactivating microorganisms and viruses while retaining their immunogenicity and for making and producing the soluble, disaggregated, refolded or active immunogenic or therapeutic proteins from inclusion bodies produced from prokaryotes or eukaryotes. The invention encompasses hyperbaric methods for inactivating pathogenic organisms, and methods for producing vaccine compositions using the inactivated pathogens. The hyperbarically inactivated microorganisms are safer and more immunogenic than chemically inactivated microorganisms. Similarly, the solubilized proteins have superior properties compared to more heavily aggregated proteins, including reduced non-specific immune reactions.

公开(公告)号：US20180243399A1

公开(公告)日：2018-08-30

申请号：US15753324

申请日：2016-08-16

Applicant: MERIAL INC.

Inventor： Herve Poulet ,  Frédéric Reynard

IPC: A61K39/125 ,  C12N7/04

Abstract: The present invention encompasses FCV vaccines or compositions. The vaccine or composition may be a vaccine or composition containing FCV antigens. The invention also encompasses recombinant vectors encoding and expressing FCV antigens, epitopes or immunogens which can be used to protect animals against FCV infection.

公开(公告)号：US20180243398A1

公开(公告)日：2018-08-30

申请号：US15961635

申请日：2018-04-24

Applicant: MERIAL INC.

Inventor： Teshome Mebatsion ,  Aemro Kassa ,  Taejoong Kim

IPC: A61K39/12 ,  C12N15/86 ,  C07K14/08 ,  C12N7/00 ,  A61K39/00

Abstract: The present invention encompasses recombinant porcine reproductive and respiratory syndrome virus (PRRSV) vaccines or compositions. In particular, the invention encompasses recombinant adenovirus vectors encoding and expressing PRRSV gp2, gp3, gp4, gp5a, gp5 and/or E antigens, proteins, epitopes or immunogens. Such vaccines or compositions can be used to protect animals from PRRSV.

公开(公告)号：US20180221338A1

公开(公告)日：2018-08-09

申请号：US15937878

申请日：2018-03-28

Applicant: MERIAL, INC.

Inventor： Mark David Soll ,  James Pate ,  Lisa A. Baker

IPC: A61K31/415 ,  A61K47/44 ,  A01N25/02 ,  A61K47/22 ,  A61K47/18 ,  A61K47/14 ,  A61K47/10 ,  A61K47/08 ,  A61K45/06 ,  A61K31/4402 ,  A61K31/216 ,  A61K31/215 ,  A61K9/00 ,  A01N53/00 ,  A01N49/00 ,  A01N47/02 ,  A01N43/56 ,  A01N43/40 ,  A01N37/38 ,  A61K31/201 ,  A01N25/22

CPC classification number: A61K31/415 ,  A01N25/02 ,  A01N25/22 ,  A01N37/38 ,  A01N43/40 ,  A01N43/56 ,  A01N47/02 ,  A01N49/00 ,  A01N53/00 ,  A61K9/0017 ,  A61K31/201 ,  A61K31/215 ,  A61K31/216 ,  A61K31/4402 ,  A61K45/06 ,  A61K47/08 ,  A61K47/10 ,  A61K47/14 ,  A61K47/18 ,  A61K47/22 ,  A61K47/44 ,  A61K2300/00 ,  A01N2300/00

Abstract: The subject matter disclosed herein is directed to stable, highly-effective topical formulations comprising permethrin, fipronil and a solvent system that is sufficient to solubilize these two active ingredients and limit degradation of fipronil to its sulfone, and their uses in topical applications on animals and the environment. Useful formulations comprise from about 30% to about 55% (w/w) permethrin and about 2 to 15% (w/w) fipronil and a solvent system that comprises N-methyl pyrrolidone and a glycol, glycol ether, glycol ester, fatty acid ester or neutral oil, wherein the N-methyl pyrrolidone and glycol, glycol ether, glycol ester, fatty acid ester or neutral oil are present in a weight:weight ratio of from about 1:2.0 to about 1:3.5, glycol, glycol ether, glycol ester, fatty acid ester or neutral oil to n-methyl pyrrolidone. These two actives when combined in the described amounts have been found to have unexpected enhanced repellent activity against stable fly. However, it is the formulations described herein that provide solvency and stability that maintain synergistic concentrations after application on an animal.

公开(公告)号：US20180169216A1

公开(公告)日：2018-06-21

申请号：US15888718

申请日：2018-02-05

Applicant: Merial Inc.

Inventor： Jean-Christophe Audonnet ,  Frédéric Reynard ,  Natalia Bomchil ,  Cécile Sigoillot-Claude

IPC: A61K39/135 ,  A61K39/385 ,  C07K14/005 ,  C07K14/32 ,  C12N7/00 ,  A61K39/00

CPC classification number: A61K39/135 ,  A61K39/385 ,  A61K2039/5258 ,  A61K2039/545 ,  A61K2039/552 ,  A61K2039/55566 ,  A61K2039/6075 ,  C07K14/005 ,  C07K14/32 ,  C07K2319/40 ,  C07K2319/735 ,  C12N7/00 ,  C12N2770/24222 ,  C12N2770/32122 ,  C12N2770/32134 ,  C12N2770/32171

Abstract: The present invention encompasses FMDV vaccines or compositions. The vaccine or composition may be a vaccine or composition containing FMDV antigens. The invention also encompasses recombinant vectors encoding and expressing FMDV antigens, epitopes or immunogens which can be used to protect animals, in particular ovines, bovines, caprines, or swines, against FMDV. The invention further encompasses methods of making or producing antigenic polypeptides or antigens.

公开(公告)号：US09949953B2

公开(公告)日：2018-04-24

申请号：US15248327

申请日：2016-08-26

Applicant: MERIAL, INC.

Inventor： Mark David Soll ,  James Pate ,  Lisa A. Baker

IPC: A61K31/415 ,  A61K31/215 ,  A61K45/06 ,  A61K47/14 ,  A61K47/22 ,  A01N53/00 ,  A61K9/00 ,  A61K47/08 ,  A61K47/18 ,  A01N47/02 ,  A01N25/02 ,  A01N37/38 ,  A01N43/40 ,  A01N43/56 ,  A01N49/00 ,  A61K31/201 ,  A61K31/216 ,  A61K31/4402 ,  A61K47/10 ,  A61K47/44

CPC classification number: A61K31/415 ,  A01N25/02 ,  A01N25/22 ,  A01N37/38 ,  A01N43/40 ,  A01N43/56 ,  A01N47/02 ,  A01N49/00 ,  A01N53/00 ,  A61K9/0017 ,  A61K31/201 ,  A61K31/215 ,  A61K31/216 ,  A61K31/4402 ,  A61K45/06 ,  A61K47/08 ,  A61K47/10 ,  A61K47/14 ,  A61K47/18 ,  A61K47/22 ,  A61K47/44 ,  A61K2300/00 ,  A01N2300/00

Abstract: The subject matter disclosed herein is directed to stable, highly-effective topical formulations comprising permethrin, fipronil and a solvent system that is sufficient to solubilize these two active ingredients and limit degradation of fipronil to its sulfone, and their uses in topical applications on animals and the environment. Useful formulations comprise from about 30% to about 55% (w/w) permethrin and about 2 to 15% (w/w) fipronil and a solvent system that comprises N-methyl pyrrolidone and a glycol, glycol ether, glycol ester, fatty acid ester or neutral oil, wherein the N-methyl pyrrolidone and glycol, glycol ether, glycol ester, fatty acid ester or neutral oil are present in a weight:weight ratio of from about 1:2.0 to about 1:3.5, glycol, glycol ether, glycol ester, fatty acid ester or neutral oil to n-methyl pyrrolidone. These two actives when combined in the described amounts have been found to have unexpected enhanced repellent activity against stable fly. However, it is the formulations described herein that provide solvency and stability that maintain synergistic concentrations after application on an animal.

公开(公告)号：US20180064719A1

公开(公告)日：2018-03-08

申请号：US15801109

申请日：2017-11-01

Applicant: MERIAL INC.

Inventor： Rolf Valter Attstrom ,  Hugo De Bruyn

IPC: A61K31/5377 ,  A61Q11/00 ,  A61K8/49

CPC classification number: A61K8/49 ,  A23K1/1628 ,  A61K31/5377 ,  A61K2800/74 ,  A61Q11/00 ,  C07D265/30

Abstract: Use of a compound having the formula (I) in the manufacture of a medicament for the prevention or treatment of a disease caused by oral bacteria in an animal wherein R1 is a straight or branched alkyl group containing 8 to 16 carbon atoms at the 2- or 3-position of the morpholino ring, and R2 is a straight or branched alkyl group containing 2 to 10 carbon atoms, substituted with a hydroxy group except in the alpha-position, or a pharmaceutically acceptable salt thereof. A cosmetic method of preventing or decreasing oral staining in an animal, comprising the step of exposing the oral cavity to a morpholino compound of general