公开(公告)号：US20090112287A1

公开(公告)日：2009-04-30

申请号：US12043830

申请日：2008-03-06

申请人： Robert J. Greenberg ,  Alan Matthew Horsager ,  Mark S. Humayun ,  Kelly H. McClure ,  Matthew J. McMahon ,  Peter Meilstrup ,  Neha Jagdish Parikh ,  Arup Roy ,  James D. Weiland ,  Chunhong Zhou

发明人： Robert J. Greenberg ,  Alan Matthew Horsager ,  Mark S. Humayun ,  Kelly H. McClure ,  Matthew J. McMahon ,  Peter Meilstrup ,  Neha Jagdish Parikh ,  Arup Roy ,  James D. Weiland ,  Chunhong Zhou

IPC分类号： A61F9/08

CPC分类号： A61N1/36046 ,  A61F9/08 ,  G06K9/4604 ,  G06K9/4628 ,  G06K9/605 ,  G09B21/008

摘要： Saliency-based apparatus and methods for visual prostheses are disclosed. A saliency-based component processes video data output by a digital signal processor before the video data are input to the retinal stimulator. In a saliency-based method, an intensity stream is extracted from an input image, feature maps based on the intensity stream are developed, plural most salient regions of the input image are detected and one of the regions is selected as a highest saliency region.

摘要翻译： 公开了用于视觉假体的基于显着性的装置和方法。 基于显眼的组件在将视频数据输入到视网膜刺激器之前处理由数字信号处理器输出的视频数据。 在基于显着性的方法中，从输入图像中提取强度流，基于强度流形成特征图，检测输入图像的多个最显着区域，并选择其中一个区域作为最高显着区域。

公开(公告)号：US07480988B2

公开(公告)日：2009-01-27

申请号：US09823464

申请日：2001-03-30

申请人： Jerry Ok ,  Robert J. Greenberg

发明人： Jerry Ok ,  Robert J. Greenberg

IPC分类号： H05K3/30 ,  H01R9/00 ,  H01K3/00 ,  H01K3/10 ,  H01K3/22

CPC分类号： H05K3/4046 ,  H01L21/486 ,  H01L23/10 ,  H01L2924/0002 ,  H05K1/0306 ,  H05K2201/10287 ,  H05K2201/10416 ,  Y10T29/49139 ,  Y10T29/49146 ,  Y10T29/49147 ,  Y10T29/49162 ,  Y10T29/49163 ,  Y10T428/24926 ,  H01L2924/00

摘要： A method and apparatus suitable for forming hermetic electrical feedthroughs in a ceramic sheet having a thickness of ≦40 mils. More particularly, the method yields an apparatus including a hermetic electrical feedthrough which is both biocompatible and electrochemically stable and suitable for implantation in a patient's body. The method involves: (a) providing an unfired, ceramic sheet having a thickness of ≦40 mils and preferably comprising >99% aluminum oxide; (b) forming multiple blind holes in said sheet; (c) inserting solid wires, preferably of platinum, in said holes; (d) firing the assembly of sheet and wires to a temperature sufficient to sinter the sheet material but insufficient to melt the wires; and (e) removing sufficient material from the sheet lower surface so that the lower ends of said wires are flush with the finished sheet lower surface.

公开(公告)号：US20080275528A1

公开(公告)日：2008-11-06

申请号：US11926047

申请日：2007-10-28

申请人： Robert J. Greenberg ,  Joseph H. Sculman

发明人： Robert J. Greenberg ,  Joseph H. Sculman

IPC分类号： A61N1/05

CPC分类号： A61N1/0543 ,  A61N1/36046 ,  A61N1/37247 ,  A61N1/375 ,  H01L2224/16225 ,  Y10T29/49165

摘要： The present invention is an electrode array adapted for stimulating the retina to create the perception of vision in blind patients.

摘要翻译： 本发明是适用于刺激视网膜以产生盲患者视力感知的电极阵列。

公开(公告)号：US20080262569A1

公开(公告)日：2008-10-23

申请号：US11875724

申请日：2007-10-19

申请人： Robert J. Greenberg ,  Mark S. Humayun ,  Kelly H. McClure ,  Matthew J. McMahon

发明人： Robert J. Greenberg ,  Mark S. Humayun ,  Kelly H. McClure ,  Matthew J. McMahon

IPC分类号： A61N1/00

CPC分类号： A61N1/36046 ,  A61N1/37247

摘要： A method for stimulating a subject's retina. The method comprising selecting at least a first and a second electrode each configured to apply current to a subject's retina, determining impedance for the at least first electrode and second electrode, and applying current to the subject's retina through the at least first and second electrode, wherein current to be applied by the first electrode and the second electrode is configured to be higher for the first electrode when the first electrode has an impedance lower than a second electrode's impedance.

摘要翻译： 刺激受试者视网膜的方法。 所述方法包括选择至少第一和第二电极，每个电极被配置为向对象的视网膜施加电流，确定至少第一电极和第二电极的阻抗，以及通过至少第一和第二电极将电流施加到对象的视网膜， 其中，当所述第一电极具有比所述第二电极的阻抗低的阻抗时，由所述第一电极和所述第二电极施加的电流被配置为高于所述第一电极。

公开(公告)号：US20080221653A1

公开(公告)日：2008-09-11

申请号：US12044830

申请日：2008-03-07

申请人： Rajat Agrawal ,  Robert J. Greenberg ,  Mark S. Humayun ,  James Singleton Little ,  Brian V. Mech ,  Jordan Matthew Neysmith ,  Neil Hamilton Talbot ,  Dao Min Zhou

发明人： Rajat Agrawal ,  Robert J. Greenberg ,  Mark S. Humayun ,  James Singleton Little ,  Brian V. Mech ,  Jordan Matthew Neysmith ,  Neil Hamilton Talbot ,  Dao Min Zhou

IPC分类号： A61N1/00

CPC分类号： A61N1/05 ,  A61N1/0541 ,  A61N1/0543 ,  A61N1/36046

摘要： A flexible circuit electrode array comprising: a polymer base layer; metal traces deposited on said polymer base layer, including electrodes suitable to stimulate neural tissue; a polymer top layer deposited on said polymer base layer and said metal traces; and a central opening in the area of the metal traces. A flexible circuit electrode array comprising: a polymer base layer; metal traces deposited on said polymer base layer, including electrodes suitable to stimulate neural tissue; a polymer top layer deposited on said polymer base layer and said metal traces; and a soft polymer filling an attachment point. A flexible circuit electrode array comprising: a polymer base layer; metal traces deposited on said polymer base layer, including electrodes suitable to stimulate neural tissue; a polymer top layer deposited on said polymer base layer and said metal traces; and a hump to avoid a touching of the flexible electrode array and the optic nerve.

摘要翻译： 一种柔性电路电极阵列，包括：聚合物基层; 沉积在所述聚合物基层上的金属痕迹，包括适于刺激神经组织的电极; 沉积在所述聚合物基底层和所述金属迹线上的聚合物顶层; 和金属痕迹区域的中心开口。 一种柔性电路电极阵列，包括：聚合物基层; 沉积在所述聚合物基层上的金属痕迹，包括适于刺激神经组织的电极; 沉积在所述聚合物基底层和所述金属迹线上的聚合物顶层; 和填充附着点的软质聚合物。 一种柔性电路电极阵列，包括：聚合物基层; 沉积在所述聚合物基层上的金属痕迹，包括适于刺激神经组织的电极; 沉积在所述聚合物基底层和所述金属迹线上的聚合物顶层; 和一个驼峰以避免触摸柔性电极阵列和视神经。

公开(公告)号：US20080154336A1

公开(公告)日：2008-06-26

申请号：US11893260

申请日：2007-08-15

申请人： Kelly H. McClure ,  Richard Agustin Castro ,  Sanjay Gaikwad ,  Da-Yu Chang ,  Scott M. Loftin ,  Rongqing Dai ,  Robert J. Greenberg

发明人： Kelly H. McClure ,  Richard Agustin Castro ,  Sanjay Gaikwad ,  Da-Yu Chang ,  Scott M. Loftin ,  Rongqing Dai ,  Robert J. Greenberg

IPC分类号： A61N1/00

CPC分类号： A61N1/36046 ,  A61N1/0543

摘要： A visor for retinal stimulation of visually impaired subjects is shown. The visor comprises a frame, an external coil, a camera and a mounting system. A connector allows the external coil to be positioned along a first direction. A sliding device allows the external coil to be positioned along a second direction. Positioning of the visor on a subject's nose allows the external coil to be positioned along a third direction. Positioning of the external coil along the first, second or third direction is useful to maximize coupling RF coupling between the external coil and an internal coil implanted on a subject wearing the visor.

摘要翻译： 显示视网膜刺激视力障碍受试者的遮阳板。 遮阳板包括框架，外部线圈，照相机和安装系统。 连接器允许外部线圈沿第一方向定位。 滑动装置允许外部线圈沿第二方向定位。 遮阳板在被检者的鼻子上的定位允许外部线圈沿第三方向定位。 外部线圈沿着第一，第二或第三方向的定位对于使外部线圈和植入戴着遮阳板的物体上的内部线圈之间的耦合RF耦合最大化是有用的。

公开(公告)号：US20080082143A1

公开(公告)日：2008-04-03

申请号：US11529809

申请日：2006-09-29

申请人： Rongqing Dai ,  Dao Min Zhou ,  Robert J. Greenberg ,  John Gord

发明人： Rongqing Dai ,  Dao Min Zhou ,  Robert J. Greenberg ,  John Gord

IPC分类号： A61N1/00

CPC分类号： A61N1/37229 ,  A61N1/36046 ,  A61N1/3787

摘要： Methods and devices for inductively coupled implants on the human or animal body are disclosed. An external coil assembly to be used with the implant has a transmitting coil and one or more receiving coils. The number of the receiving coils, their distance from the transmitting coil and their shape is chosen to reduce the influence of a noise signal received by the external coil assembly.

摘要翻译： 公开了用于人体或动物体上的电感耦合植入物的方法和装置。 与植入物一起使用的外部线圈组件具有发射线圈和一个或多个接收线圈。 选择接收线圈的数量，它们与发射线圈的距离及其形状，以减少由外部线圈组件接收的噪声信号的影响。

公开(公告)号：US20070207569A1

公开(公告)日：2007-09-06

申请号：US11517859

申请日：2006-09-07

申请人： Robert J. Greenberg ,  Jerry Ok

发明人： Robert J. Greenberg ,  Jerry Ok

IPC分类号： H01L21/00

CPC分类号： A61N1/0543 ,  A61N1/36046 ,  A61N1/3752 ,  H01L23/057 ,  H01L23/10 ,  H01L23/4985 ,  H01L2224/05573 ,  H01L2224/16225 ,  H01L2224/73204 ,  H01L2224/92125 ,  H01L2924/01079 ,  H01L2924/1461 ,  H05K1/0306 ,  H05K3/321 ,  H05K3/328 ,  H05K3/361 ,  H05K3/4015 ,  H05K3/423 ,  H05K3/4652 ,  H05K3/4691 ,  H05K2201/09127 ,  H05K2201/10287 ,  H05K2201/10295 ,  H05K2201/10977 ,  H05K2203/0733 ,  H05K2203/1446 ,  H01L2924/00

摘要： The invention is directed to a method of bonding a hermetically sealed electronics package to an electrode or a flexible circuit and the resulting electronics package that is suitable for implantation in living tissue, such as for a retinal or cortical electrode array to enable restoration of sight to certain non-sighted individuals. The hermetically sealed electronics package is directly bonded to the flex circuit or electrode by electroplating a biocompatible material, such as platinum or gold, effectively forming a plated rivet-shaped connection, which bonds the flex circuit to the electronics package. The resulting electronic device is biocompatible and is suitable for long-term implantation in living tissue.

摘要翻译： 本发明涉及一种将气密密封的电子封装结合到电极或柔性电路的方法，以及所得的电子封装，其适于植入生物组织，例如用于视网膜或皮层电极阵列，以使视力恢复到 某些非目标人士。 密封电子封装通过电镀生物相容性材料（例如铂或金）直接结合到柔性电路或电极上，有效地形成电镀铆钉形连接，其将柔性电路连接到电子封装。 所得到的电子装置是生物相容的并且适合长期植入生物体组织。

公开(公告)号：US06920358B2

公开(公告)日：2005-07-19

申请号：US09851268

申请日：2001-05-07

申请人： Robert J. Greenberg ,  Richard P. Williamson ,  Joseph H. Schulman ,  Reza P. Rassool ,  Lee J. Mandell ,  Abraham N. Seidman

发明人： Robert J. Greenberg ,  Richard P. Williamson ,  Joseph H. Schulman ,  Reza P. Rassool ,  Lee J. Mandell ,  Abraham N. Seidman

IPC分类号： A61N1/05 ,  A61N1/36 ,  G06T3/40 ,  A61N1/08

CPC分类号： A61N1/36046 ,  G06T3/40

摘要： A method and apparatus for improving visual acuity when providing a visual image from a “high” resolution input device to a “low” resolution output device. The described invention is of particular use when the output device is an array of electrodes as part of a retinal prosthesis used to restore vision to a visually-impaired patient. In that various limitations may, within the foreseeable future, limit the density of such an electrode array (and thus the resolution of the output image), the present invention teaches techniques to assign processed pixel subsets of a higher resolution image to a single electrode. By varying the pixel subsets, e.g., by jittering, and/or altering the processing criteria, the perceived visual acuity may be further improved. Alternatively and additionally, such processing may be further extended to drive neighboring electrodes in combination to thus stimulate virtual electrode sites and thus further enhance visual acuity.

摘要翻译： 当从“高”分辨率输入装置向“低”分辨率输出装置提供视觉图像时，用于提高视力的方法和装置。 当输出设备是用作将视力恢复到视觉障碍患者的视网膜假体的一部分的电极阵列时，所描述的本发明是特别有用的。 因此，在可预见的将来可能会限制这种电极阵列的密度（因此输出图像的分辨率）的各种限制，本发明教导了将更高分辨率图像的经处理的像素子集分配给单个电极的技术。 通过例如通过抖动和/或改变处理标准来改变像素子集，可以进一步改善感知的视敏度。 另外地和另外地，这样的处理可以进一步延伸以组合驱动相邻电极，从而刺激虚拟电极位置，从而进一步提高视敏度。

公开(公告)号：US10159832B2

公开(公告)日：2018-12-25

申请号：US11924763

申请日：2007-10-26

申请人： Dao Min Zhou ,  Jerry Ok ,  Neil Hamilton Talbot ,  Brian V. Mech ,  James Singleton Little ,  Robert J. Greenberg

发明人： Dao Min Zhou ,  Jerry Ok ,  Neil Hamilton Talbot ,  Brian V. Mech ,  James Singleton Little ,  Robert J. Greenberg

IPC分类号： C25D5/02 ,  A61N1/05 ,  A61N1/36

摘要： The present invention provides an implantable electrode with increased stability wherein the surface is of the electrode comprises mesh grids which are filled with sticks which are filed with a conducting or insulating material. The present invention further provides a method of manufacturing an electrode with increased stability, comprising: depositing a metal layer on an base layer; applying photoresist layer on the metal layer; patterning the photoresist layer providing openings; electroplating the openings with metal; removing the photoresist layer leaving spaces; and filling the spaces with polymer.