公开(公告)号：US06448270B1

公开(公告)日：2002-09-10

申请号：US09592883

申请日：2000-06-13

Applicant: Christopher F. Bigge ,  Jonathan Wright ,  Sui Xiong Cai ,  Eckard Weber ,  Richard Woodward ,  Nancy C. Lan ,  Zhang-Lin Zhou ,  John F.W. Keana

Inventor： Christopher F. Bigge ,  Jonathan Wright ,  Sui Xiong Cai ,  Eckard Weber ,  Richard Woodward ,  Nancy C. Lan ,  Zhang-Lin Zhou ,  John F.W. Keana

IPC: A61K31445

CPC classification number: C07D401/06 ,  C07D211/14 ,  C07D211/18 ,  C07D211/42 ,  C07D211/44 ,  C07D211/46 ,  C07D211/52 ,  C07D211/54 ,  C07D211/58 ,  C07D405/06

Abstract: Novel 4-substituted piperidine analogs, pharmaceutical compositions containing the same and the method of using the 4-substituted piperidine analogs as selectively active antagonists of N-methyl-D-aspartate (NMDA) receptor subtypes for treating conditions such as cerebral ischemia, central nervous system trauma, hypoglycemia, neurodegenerative disorders, anxiety, migraine headaches, convulsions, aminoglycoside antibiotics-induced hearing loss, chronic pain, psychosis, glaucoma, CMV retinitis, opioid tolerance or withdrawal, urinary incontinence and neurodegenerative disorders such as lathyrism, Alzheimers' Disease, Parkinsonism, and Huntington's Disease are described. Also described are novel methods for preparing 4-substituted piperidine analogs and novel intermediates of the 4-substituted piperidine analogs.

Abstract translation: 新的4-取代的哌啶类似物，含有它们的药物组合物和使用4-取代的哌啶类似物作为N-甲基-D-天冬氨酸（NMDA）受体亚型的选择性活性拮抗剂的方法，用于治疗诸如脑缺血，中枢神经 系统性创伤，低血糖症，神经退行性疾病，焦虑症，偏头痛，惊厥，氨基糖苷类抗生素诱发的听力损失，慢性疼痛，精神病，青光眼，CMV视网膜炎，阿片样物质耐受或戒断，尿失禁和神经退行性疾病，如莱姆里斯，阿尔茨海默病， 描述了帕金森综合征和亨廷顿氏病。 还描述了制备4-取代的哌啶类似物和4-取代的哌啶类似物的新中间体的新方法。

公开(公告)号：US6130234A

公开(公告)日：2000-10-10

申请号：US91594

申请日：1996-12-20

Applicant: Christopher F. Bigge ,  Jonathan Wright ,  Sui Xiong Cai ,  Eckard Weber ,  Richard Woodward ,  Nancy C. Lan ,  Zhang-Lin Zhou ,  John F. W. Keana

Inventor： Christopher F. Bigge ,  Jonathan Wright ,  Sui Xiong Cai ,  Eckard Weber ,  Richard Woodward ,  Nancy C. Lan ,  Zhang-Lin Zhou ,  John F. W. Keana

IPC: A61K31/00 ,  A61K31/4427 ,  A61K31/443 ,  A61K31/445 ,  A61K31/4465 ,  A61K31/451 ,  A61K31/4523 ,  A61K31/4525 ,  A61K31/4535 ,  A61K31/4545 ,  A61K31/47 ,  A61K31/4709 ,  A61K31/495 ,  A61K31/498 ,  A61K31/505 ,  A61K31/517 ,  A61K31/529 ,  A61K31/55 ,  A61K31/551 ,  A61K31/5513 ,  A61P25/00 ,  A61P25/02 ,  A61P25/04 ,  A61P43/00 ,  C07D211/14 ,  C07D211/18 ,  C07D211/42 ,  C07D211/44 ,  C07D211/46 ,  C07D211/48 ,  C07D211/52 ,  C07D211/54 ,  C07D211/58 ,  C07D211/70 ,  C07D401/04 ,  C07D401/06 ,  C07D401/12 ,  C07D405/06 ,  C07D413/06 ,  C07D417/04 ,  C07D417/06 ,  C07D417/12 ,  C07D235/08

CPC classification number: C07D401/06 ,  C07D211/14 ,  C07D211/18 ,  C07D211/42 ,  C07D211/44 ,  C07D211/46 ,  C07D211/52 ,  C07D211/54 ,  C07D211/58 ,  C07D405/06

Abstract: Novel 4-substituted piperidine analogs, pharmaceutical compositions containing the same and the method of using 4-substituted piperidine analogs as selectively active antagonists of N-methyl-D-aspartate (NMDA) receptor subtypes for treating conditions such as stroke, cerebral ischemia, central nervous system trauma, hypoglycemia, anxiety, convulsions, aminoglycoside antibiotics-induced hearing loss, migraine headaches, glaucoma, CMV retinitis, chronic pain, opioid tolerance or withdrawals, or neurodegenerative disorders, such as lathyrism, Alzheimer's Disease, Parkinsonism and Huntington's Disease are described. Also described are novel methods for preparing 4-substituted piperidine analogs and novel intermediates of the 4-substituted piperidine analogs.

Abstract translation: PCT No.PCT / US96 / 20766 Sec。 371日期：1998年9月16日 102（e）1998年9月16日PCT PCT 1996年12月20日PCT公布。 公开号WO97 / 23214 PCT 日期1997年7月3日新颖的4-取代的哌啶类似物，含有它们的药物组合物和使用4-取代的哌啶类似物作为N-甲基-D-天冬氨酸（NMDA）受体亚型的选择性活性拮抗剂的方法，用于治疗诸如中风 ，脑缺血，中枢神经系统创伤，低血糖症，焦虑症，抽搐，氨基糖苷类抗生素诱发的听力损失，偏头痛，青光眼，CMV视网膜炎，慢性疼痛，阿片样物质耐受或戒断，或神经退行性疾病，如幻影，阿尔茨海默病，帕金森综合征 并描述亨廷顿氏病。 还描述了制备4-取代的哌啶类似物和4-取代的哌啶类似物的新中间体的新方法。

公开(公告)号：US5801183A

公开(公告)日：1998-09-01

申请号：US466043

申请日：1995-06-06

Applicant: John F. W. Keana ,  Sui Xiong Cai ,  Zhang-Lin Zhou ,  James M. Navratil

Inventor： John F. W. Keana ,  Sui Xiong Cai ,  Zhang-Lin Zhou ,  James M. Navratil

IPC: C07D241/44 ,  A61K31/4375 ,  A61K31/444 ,  A61K31/498 ,  A61K31/519 ,  A61P25/00 ,  A61P25/04 ,  A61P25/08 ,  A61P25/14 ,  A61P25/18 ,  A61P25/22 ,  A61P25/28 ,  A61P25/36 ,  A61P43/00 ,  C07D241/52 ,  C07D471/04 ,  C07D475/00 ,  C07D487/04 ,  A61K31/435

CPC classification number: C07D241/52 ,  C07D471/04 ,  C07D487/04

Abstract: Methods of treating or preventing neuronal loss associated with stroke, ischemia, CNS trauma, hypoglycemia and surgery, as well as treating neurodegenerative diseases including Alzheimer's disease, amyotrophic lateral sclerosis, Huntington's disease, and Down's syndrome, treating or preventing adverse consequences of the hyperactivity of the excitatory amino acids, as well as treating anxiety, chronic pain, convulsions, inducing anesthesia, and treating or preventing opiate tolerance are disclosed by administering to an animal in need of such treatment or prevention a substituted or unsubstituted pyridine and pyridine (N-oxide) analogs of 4-hydroxydihydroquinolones, tetrahydroquinoline-trione-oximes and quinoxalones, tautomers and pharmaceutically acceptable salts thereof, which have high binding to the glycine receptor.

Abstract translation: 治疗或预防与中风，缺血，CNS创伤，低血糖和手术相关的神经元损失以及治疗神经变性疾病包括阿尔茨海默病，肌萎缩性侧索硬化，亨廷顿病和唐氏综合症的治疗或预防方法，治疗或预防多动症的不良后果 通过向需要这种治疗或预​​防的动物施用取代或未取代的吡啶和吡啶（N-氧化物）来公开兴奋性氨基酸以及治疗焦虑症，慢性疼痛，惊厥，诱导麻醉以及治疗或预防阿片剂耐受性 的类似物，其与甘氨酸受体具有高结合性的4-羟基二氢喹诺酮，四氢喹啉 - 三酮 - 肟和喹喔啉酮，其互变异构体和药学上可接受的盐。

公开(公告)号：US09366978B2

公开(公告)日：2016-06-14

申请号：US14391012

申请日：2012-06-25

Applicant: Krzysztof Nauka ,  Zhang-Lin Zhou ,  Hou T. Ng

Inventor： Krzysztof Nauka ,  Zhang-Lin Zhou ,  Hou T. Ng

IPC: G03G15/02 ,  G03G15/04 ,  G03G5/147 ,  G03G5/07 ,  G03G5/00

CPC classification number: G03G5/14791 ,  G03G5/005 ,  G03G5/07 ,  G03G5/14721 ,  G03G5/1473 ,  G03G5/14734 ,  G03G5/14739 ,  G03G5/14752 ,  G03G5/14769 ,  G03G5/14778

Abstract: The present disclosure is related to coated photoconductors. In an example, a coated photoconductor can comprise a photoconductor including a substrate having a charge generation layer and charge transport layer adhered thereto and a top coating adhered to the photoconductor. The top coating can comprise a cross-linkable polymer, a cross-linker, and a polymeric dopant having a weight average molecular weight of less than 500,000. Additionally, the top coating can have a thickness of 0.1 μm to 12 μm and the polymeric dopant can be present in the top coating at a concentration of 0.1 wt % to 10 wt %.

Abstract translation: 本公开涉及涂覆的光电导体。 在一个实例中，涂覆的光电导体可以包括光电导体，其包括具有附着到其上的电荷产生层和电荷传输层的基底和附着到光电导体的顶部涂层。 顶部涂层可以包含可交联聚合物，交联剂和重均分子量小于500,000的聚合物掺杂剂。 此外，顶部涂层可以具有0.1μm至12μm的厚度，并且聚合物掺杂剂可以以0.1wt％至10wt％的浓度存在于顶部涂层中。

公开(公告)号：US09291873B2

公开(公告)日：2016-03-22

申请号：US14124828

申请日：2011-06-10

Applicant: Zhang-Lin Zhou ,  Qin Liu ,  Mary Elizabeth Parent

Inventor： Zhang-Lin Zhou ,  Qin Liu ,  Mary Elizabeth Parent

IPC: C07D207/412 ,  G02F1/167 ,  C07D207/40 ,  C07D401/12 ,  C07D403/12 ,  C07D413/12 ,  C08G73/02 ,  C09D11/03 ,  C09D11/10

CPC classification number: G02F1/167 ,  C07D207/40 ,  C07D207/412 ,  C07D207/46 ,  C07D401/12 ,  C07D403/06 ,  C07D403/12 ,  C07D413/12 ,  C08G73/0213 ,  C09D11/03 ,  C09D11/10 ,  C09D11/52 ,  G02F2001/1678

Abstract: Surfactants are provided that have a hydrophobic tail portion and a hydrophilic head portion. The hydrophilic head portion includes a terminal dialkyl-substituted tertiary amine or a terminal cycloalkyl-substituted tertiary amine. Also provided are pigment-based inks employing the surfactant, a combination of an electronic display and the pigment-based inks, and a process for reducing conductivity in primary amine-based surfactants and improving reliability of electronic inks employing such surfactants.

Abstract translation: 提供具有疏水尾部和亲水头部的表面活性剂。 亲水性头部包括末端二烷基取代的叔胺或末端环烷基取代的叔胺。 还提供了使用表面活性剂的颜料基油墨，电子显示器和颜料基油墨的组合，以及降低伯胺类表面活性剂的导电性和提高使用这种表面活性剂的电子油墨的可靠性的方法。

公开(公告)号：US09244326B2

公开(公告)日：2016-01-26

申请号：US14369301

申请日：2012-01-17

Applicant: Zhang-Lin Zhou ,  Qin Liu

Inventor： Zhang-Lin Zhou ,  Qin Liu

IPC: G02B26/00 ,  G09G3/34 ,  G02F1/167 ,  G02B26/02 ,  C09D11/10 ,  C09D11/033 ,  C09D11/037 ,  C09D11/107 ,  G02F1/1333 ,  C08L51/06

CPC classification number: G02F1/167 ,  C08L51/06 ,  C09D11/033 ,  C09D11/037 ,  C09D11/10 ,  C09D11/107 ,  G02B26/004 ,  G02B26/02 ,  G02B26/026 ,  G02F1/133348 ,  G02F2001/1678

Abstract: Pigment based inks are provided. The inks include a non-polar carrier fluid and a surface-functionalized pigment particle including a nitrogen-linked moiety to the surface of the pigment particle through a nitrogen link at one end of the nitrogen-linked moiety and a graft copolymer having two or three blocks attached at another end, the pigment particle suspended in the non-polar carrier fluid, the nitrogen-linked moiety further including an alkyl chain interposed between the nitrogen-linked moiety and the graft copolymer having the structure (I), where X is the nitrogen-linked moiety and Y is a copolymer, and the letter a is an integer between 0 and about 5,000, while the letter b is an integer of 2 or more.

Abstract translation: 提供了基于颜料的油墨。 油墨包括非极性载体流体和通过氮连接部分的一端的氮键连接到颜料颗粒表面的含氮部分的表面官能化颜料颗粒和具有两个或三个 附着在另一端的嵌段，悬浮在非极性载体流体中的颜料颗粒，氮连接的部分还包括置于氮连接部分和具有结构（I）的接枝共聚物之间的烷基链，其中X是 氮连接部分，Y为共聚物，字母a为0〜约5,000的整数，字母b为2以上的整数。

公开(公告)号：US20140322638A1

公开(公告)日：2014-10-30

申请号：US14364994

申请日：2011-12-20

Applicant: Zhang-Lin Zhou ,  Krzysztof Nauka ,  Lihua Zhao

Inventor： Zhang-Lin Zhou ,  Krzysztof Nauka ,  Lihua Zhao

IPC: G03G5/147

CPC classification number: G03G5/14717 ,  C08F220/56 ,  C08G61/02 ,  C08G61/12 ,  C08G61/122 ,  C08G61/123 ,  C08G61/124 ,  C08G2261/124 ,  C08G2261/1412 ,  C08G2261/147 ,  C08G2261/3142 ,  C08G2261/3162 ,  C08G2261/3241 ,  C08G2261/3246 ,  C08G2261/411 ,  C08G2261/512 ,  C08G2261/91 ,  C09D4/00 ,  C09D133/14 ,  C09D133/26 ,  G03G5/047 ,  G03G5/05 ,  G03G5/0507 ,  G03G5/0525 ,  G03G5/0532 ,  G03G5/0546 ,  G03G5/0575 ,  G03G5/0592 ,  G03G5/0605 ,  G03G5/0614 ,  G03G5/071 ,  G03G5/14769 ,  G03G5/14778 ,  G03G5/14786 ,  G03G5/14791 ,  H01L51/0007 ,  H01L51/0039 ,  H01L51/0043 ,  H01L51/42 ,  C08L65/00

Abstract: An alcohol-soluble organic coating including a hole transport material formed on a surface of organic photoconductor is provided. The coating comprises a cationic alternate fluorene-based copolymer with phosphonium salt terminal groups embedded in an in-situ cross-linked polymer.

Abstract translation: 提供了包含在有机感光体的表面上形成的空穴传输材料的醇溶性有机涂层。 涂层包含阳离子交替芴基共聚物，其中鏻盐末端基团嵌入原位交联聚合物中。

公开(公告)号：US08841053B2

公开(公告)日：2014-09-23

申请号：US13552940

申请日：2012-07-19

Applicant: Zhang-Lin Zhou ,  Krzysztof Nauka ,  Lihua Zhao ,  Hou T. Ng

Inventor： Zhang-Lin Zhou ,  Krzysztof Nauka ,  Lihua Zhao ,  Hou T. Ng

IPC: G03G5/00 ,  G03G5/147

CPC classification number: G03G5/14708 ,  G03G5/0592 ,  G03G5/0596 ,  G03G5/0603 ,  G03G5/0605 ,  G03G5/0609 ,  G03G5/0612 ,  G03G5/0618 ,  G03G5/062 ,  G03G5/075 ,  G03G5/14734 ,  G03G5/14786 ,  G03G5/14791

Abstract: An organic photoconductor includes: a conductive substrate; a charge generation layer on the conductive substrate; and a charge transport layer on the charge generation layer. An overcoat layer is formed on the charge transport layer. The overcoat layer is a latex polymer in which a charge transport material is dispersed.

Abstract translation: 有机光电导体包括：导电基板; 导电基板上的电荷产生层; 和电荷产生层上的电荷输送层。 在电荷输送层上形成覆盖层。 外涂层是其中分散有电荷输送材料的胶乳聚合物。

公开(公告)号：US20130344425A1

公开(公告)日：2013-12-26

申请号：US14000642

申请日：2011-02-24

Applicant: Krzystof Nauka ,  Zhang-Lin Zhou ,  Lihua Zhao

Inventor： Krzystof Nauka ,  Zhang-Lin Zhou ,  Lihua Zhao

IPC: G03G5/147

CPC classification number: G03G5/14769 ,  G03G5/14708 ,  G03G5/14734 ,  G03G5/14791 ,  G03G5/14795

Abstract: A doped protective coating for extending a lifetime of an organic photoconductor is provided. The coating includes an in-situ cross-linked polymer matrix and a substantially uniformly distributed dopant therein. The dopant comprises a charge transport molecular species. A process for coating the organic photoconductor and a coated organic photoconductor are also disclosed.

Abstract translation: 提供了用于延长有机感光体寿命的掺杂保护涂层。 涂层包括原位交联的聚合物基质和其中基本均匀分布的掺杂剂。 掺杂剂包括电荷传输分子种类。 还公开了涂覆有机光电导体和涂覆的有机光电导体的方法。

公开(公告)号：US08540359B2

公开(公告)日：2013-09-24

申请号：US13386329

申请日：2009-10-16

Applicant: Zhang-Lin Zhou ,  Jeffrey Todd Mabeck ,  Richard H. Henze

Inventor： Zhang-Lin Zhou ,  Jeffrey Todd Mabeck ,  Richard H. Henze

IPC: C09D11/00

CPC classification number: C09D11/36 ,  C08K3/013 ,  C08K9/08 ,  C09D7/68 ,  C09D7/70 ,  C09D11/322

Abstract: Electronic inks are disclosed herein. The electronic ink includes a non-polar carrier fluid, a plurality of positively charged colorant particles dispersed in the non-polar carrier fluid, and a plurality of reverse co-micelles including a basic charge director and an acidic charge controlling agent. The basic charge director has a molecular weight that is within 5000 of a molecular weight of the acidic charge controlling agent.

Abstract translation: 电子油墨在此公开。 电子墨水包括非极性载体流体，分散在非极性载体流体中的多个带正电荷的着色剂颗粒，以及包括碱性电荷导向剂和酸性电荷控制剂的多个反向共胶束。 碱性电荷导向剂的分子量在酸性电荷控制剂的分子量的5000以内。