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    High speed sample transportation apparatus in a superconducting magnet and transporting method thereof
    113.
    发明授权
    High speed sample transportation apparatus in a superconducting magnet and transporting method thereof 有权

    公开(公告)号：US09696391B2

    公开(公告)日：2017-07-04

    申请号：US13887405

    申请日：2013-05-06

    Applicant: Academia Sinica

    Inventor： Tai-Huang Huang ,  Ching-Yu Chou ,  Ming-Lee Chu ,  Chi-Fon Chang

    IPC: G01R33/30 ,  G01R33/44

    CPC classification number: G01R33/307 ,  G01R33/445

    Abstract: A precision high-speed shuttle device for transporting samples between different positions of a superconducting magnet with different magnetic field strength is provided. The sample equilibrated at the center of the magnet, where the magnetic field is the highest and homogeneous, is shuttled to a higher position above, where the fringe field is lower, for a defined period of time and shuttled back to the center for detection. By shuttling the sample to different positions in the magnet in different experiments one can obtain a field-dependent profile of particular physical parameters. The position and timing of the sample are precisely under the experimental controlled. In this way various magnetic field-dependent nuclear magnetic resonance (NMR) experiments can be conducted in a single high-field NMR spectrometer.

    MULTI-DRUG DELIVERY SYSTEM AND USE THEREOF
    114.
    发明申请
    MULTI-DRUG DELIVERY SYSTEM AND USE THEREOF 审中-公开

    公开(公告)号：US20170173154A1

    公开(公告)日：2017-06-22

    申请号：US15325346

    申请日：2015-07-10

    Applicant: Academia Sinica

    Inventor： Patrick Ch HSIEH ,  Pei-Jung WU ,  Steve ROFFLER ,  Bill CHENG

    IPC: A61K39/395 ,  C07K16/44 ,  A61K9/00 ,  A61K47/36 ,  A61K47/42

    CPC classification number: A61K39/39583 ,  A61K9/0019 ,  A61K9/0024 ,  A61K9/06 ,  A61K38/00 ,  A61K47/36 ,  A61K47/42 ,  A61K47/60 ,  A61K47/6891 ,  C07K16/44

    Abstract: Disclosed herein is a multiple drugs delivery system and its uses in treating diseases. The multiple drugs delivery system includes, an anti-PEG antibody for directing the PEGylated therapeutic to the treatment site; and a hydrogel for retaining the anti-PEG antibody and/or the PEGylated therapeutic at the treatment site for at least 3 days. The hydrogel is selected from the group consisting of hyaluronan (HA) or a derivative of HA, collagen, gelatin, fibronectin, fibrinogen, alginate, chitosan, and a synthetic biocompatible polymer. The anti-PEG antibody and the hydrogel are present in the mixture in a ratio from about 1:1 (v/v) to 1:100 (v/v). At least two dosages of the PEGylated therapeutic, which may be the same or different, are administered to the subject, with each dosage being given at about 1 hour to about 1 week apart. Accordingly, a novel method of treating a subject having cancer or ischemic disease is also provided.

    Cooling system for an electronic rack
    117.
    发明授权
    Cooling system for an electronic rack 有权

    公开(公告)号：US09609786B2

    公开(公告)日：2017-03-28

    申请号：US14468869

    申请日：2014-08-26

    Applicant: Academia Sinica

    Inventor： Shih-Chang Lee ,  Ming-Lee Chu ,  Chih-Hsun Lin

    IPC: H05K7/20

    CPC classification number: H05K7/2039 ,  H05K7/20409 ,  H05K7/20445 ,  H05K7/20545 ,  H05K7/20709

    Abstract: The present invention discloses a cooling system for an electronic rack, comprising: an electronic rack comprising at least one side wall; at least one electronic chassis comprising a top wall and at least one side wall and disposed inside the electronic rack for housing at least one modular electronics equipment comprising a plurality of electronic components and at least one stationary thermal interface arranged above the plurality of electronic components; a first detachable thermal interface arranged between the top wall of the at least one electronic chassis and the at least one modular electronic equipment; and at least one second detachable thermal interface arranged between the at least one side wall of the electronic rack and the at least one side wall of the at least one electronic chassis.

    PHAGE-DISPLAYED ANTIBODY LIBRARIES AND USES THEREOF
    119.
    发明申请
    PHAGE-DISPLAYED ANTIBODY LIBRARIES AND USES THEREOF 审中-公开
    PHAGE显示的抗体库及其用途

    公开(公告)号：US20170044239A1

    公开(公告)日：2017-02-16

    申请号：US15232819

    申请日：2016-08-10

    Applicant: Academia Sinica

    Inventor： An-Suei YANG ,  Ing-Chien CHEN ,  Chao-Ping TUNG ,  Chung-Ming YU

    IPC: C07K16/00 ,  C12N15/10 ,  C12N15/85 ,  C07K16/10

    CPC classification number: C07K16/005 ,  C07K16/1018 ,  C07K2317/33 ,  C07K2317/34 ,  C07K2317/565 ,  C07K2317/622 ,  C07K2317/76 ,  C07K2317/92 ,  C12N15/1037

    Abstract: Disclosed herein are phage-displayed single-chain variable fragment (scFv) libraries, which comprised a plurality of scFvs with a specific sequence in each CDR. The present scFv libraries could be used to efficiently produce different antibodies with high binding affinity to H1 hemagglutinin of influenza virus. Accordingly, the present disclosure provides a potential means to generate different antigen-specific antibodies promptly in accordance with the need in experimental researches and/or clinical applications.

    Abstract translation: 本文公开了噬菌体展示的单链可变片段（scFv）文库，其包含在每个CDR中具有特定序列的多个scFv。 目前的scFv文库可用于有效地产生具有高流感病毒H1血凝素的高结合亲和力的不同抗体。 因此，本公开提供了根据实验研究和/或临床应用中的需要迅速产生不同抗原特异性抗体的潜在手段。

    METHOD FOR PRODUCING AVENACIOLIDES AND USES THEREOF
    120.
    发明申请
    METHOD FOR PRODUCING AVENACIOLIDES AND USES THEREOF 审中-公开
    生产环糊精的方法及其用途

    公开(公告)号：US20160297829A1

    公开(公告)日：2016-10-13

    申请号：US14681553

    申请日：2015-04-08

    Applicant: Academia Sinica

    Inventor： Shih-Hsiung WU ,  Ching-Ming CHANG

    IPC: C07D493/08 ,  C07D307/33 ,  A61K45/06 ,  A61K31/365

    CPC classification number: C07D493/08 ,  A61K31/365 ,  A61K36/06 ,  A61K45/06 ,  C07D307/33 ,  Y02A50/469 ,  Y02A50/473 ,  A61K2300/00

    Abstract: Disclosed herein are novel uses of avenaciolide derivatives and the preparation method of producing the same. The avenaciolide derivatives may suppress or inhibit the growth of gram-positive bacteria, including the notorious methicillin-resistant Staphylococcus aureus. Accordingly, the avenaciolides derivatives are potential lead compounds for the development of next generation antibiotics for the treatment of disease and/or disorders related to infection caused by gram-positive bacteria.

    Abstract translation: 本文公开了一种新戊烯衍生物的新用途及其制备方法。 阿维菌素衍生物可抑制或抑制革兰氏阳性菌的生长，包括臭名昭着的耐甲氧西林金黄色葡萄球菌。 因此，阿维菌素衍生物是用于开发用于治疗与由革兰氏阳性菌引起的感染相关的疾病和/或病症的下一代抗生素的潜在的铅化合物。

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