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    Synthesis of intermediates useful in preparing tricyclic compounds
    112.
    发明授权
    Synthesis of intermediates useful in preparing tricyclic compounds 有权
    可用于制备三环化合物的中间体的合成

    公开(公告)号：US06372909B1

    公开(公告)日：2002-04-16

    申请号：US09442512

    申请日：1999-11-18

    Applicant: Charles F. Bernard ,  Michael Casey ,  Frank Xing Chen ,  Denise C. Grogan ,  Marc Poirier ,  Robert P. Williams ,  Yee-Shing Wong ,  George G. Wu

    Inventor： Charles F. Bernard ,  Michael Casey ,  Frank Xing Chen ,  Denise C. Grogan ,  Marc Poirier ,  Robert P. Williams ,  Yee-Shing Wong ,  George G. Wu

    IPC: C07F980

    CPC classification number: C07D221/16

    Abstract: Disclosed is a process for preparing a compound having the formula: wherein R, R1, R2, R3, and R4 are independently selected from the group consisting of H, Br, Cl, F, alkyl, or alkoxy, by (A) reacting a compound having the formula  wherein RA, RC, RD, and RE are independently selected from the group consisting of H, halo, alkyl, or alkoxy, and R5 is aryl or heteroaryl, with a dehydrating agent to produce an imine having the formula: (B) hydrolyzing the imine produced in step (A) to produce the compound having formula (I). Also disclosed are novel intermediates having the formula:  wherein RA, RB, RC, RD, and RE are independently selected from the group consisting of H, halo, alkyl, or alkoxy, and R5 is aryl or heteroaryl. Also disclosed is a process for preparing a compound having the formula:  comprising: reacting a compound having the formula:  with NH2R5 in the presence of a palladium catalyst, carbon monoxide, a base, and an ether selected from the group consisting of: CH3OCH2CH2OCH3; CH3OCH2CH2OCH2CH2OCH3; and CH3OCH2CH2OCH2CH2OCH2CH2OCH3, wherein X is H, Br, Cl, or F, and R5 is aryl or heteroaryl. The compounds made by these processes are useful intermediates for preparing compounds that are antihistamines or inhibitors of farnesyl protein transferase.

    Abstract translation: 公开了一种制备具有下式的化合物的方法：其中R，R 1，R 2，R 3和R 4独立地选自H，Br，Cl，F，烷基或烷氧基，通过（A）使 具有下式的化合物其中RA，RC，RD和RE独立地选自H，卤素，烷基或烷氧基，R5是芳基或杂芳基，与脱水剂反应生成具有下式的亚胺：（B ）水解步骤（A）中产生的亚胺以制备具有式（I）的化合物。 还公开了具有下式的新型中间体：其中RA，RB，RC，RD和RE独立地选自H，卤素，烷基或烷氧基，R5是芳基或杂芳基。 还公开了制备具有下式的化合物的方法：包括：在钯催化剂，一氧化碳，碱和选自以下的醚的存在下使具有下式的化合物与NH 2 R 5反应：CH 3 OCH 2 CH 2 OCH 3; CH3OCH2CH2OCH2CH2OCH3; 和CH 3 OCH 2 CH 2 OCH 2 CH 2 OCH 2 CH 2 OCH 3，其中X是H，Br，Cl或F，R 5是芳基或杂芳基。 通过这些方法制备的化合物是制备抗组胺剂或法呢基蛋白转移酶抑制剂的化合物的有用中间体。

    Enantioselective alkylation of tricyclic compounds
    114.
    发明授权
    Enantioselective alkylation of tricyclic compounds 有权
    三环化合物的对映选择性烷基化

    公开(公告)号：US06288233B1

    公开(公告)日：2001-09-11

    申请号：US09667411

    申请日：2000-09-21

    Applicant: Shen-Chun Kuo ,  Frank Xing Chen

    Inventor： Shen-Chun Kuo ,  Frank Xing Chen

    IPC: C07D22106

    CPC classification number: C07D401/04 ,  C07D401/14 ,  Y02P20/55

    Abstract: Disclosed is a process for preparing a compound of the formula: wherein X1, X2, X3, X4, and X5 are independently selected from the group consisting of H, halo, alkyl, alkoxy, aryl, and aryloxy, and R is a protecting group, in which a compound having the formula wherein X1, X2, X3, X4, and X5 are as defined above, is treated with the following, in any sequence: (a) a non-nucleophilic strong base; (b) a chiral amino alcohol; and (c) a compound having the formula wherein L is a leaving group and R is as defined above. The compounds made by this process are useful intermediates for preparing compounds that are inhibitors of farnesyl protein transferase. Also disclosed is a compound having the formula:

    Abstract translation: 公开了一种制备下式化合物的方法：其中X 1，X 2，X 3，X 4和X 5独立地选自H，卤素，烷基，烷氧基，芳基和芳氧基，R是保护基 其中具有如下定义的具有如下定义的化合物：（a）非亲核性强碱;（b）手性氨基醇（其中R 1，R 2，R 3，X 4， ; 和（c）具有甲醛的化合物L是离去基团，R如上定义。 通过该方法制备的化合物是制备法呢基蛋白转移酶抑制剂的化合物的有用中间体。 还公开了具有下式的化合物：

    Toroidal low-field reactive gas source
    116.
    发明授权
    Toroidal low-field reactive gas source 失效
    环形低场反应气源

    公开(公告)号：US6150628A

    公开(公告)日：2000-11-21

    申请号：US883281

    申请日：1997-06-26

    Applicant: Donald K. Smith ,  Xing Chen ,  William M. Holber ,  Eric Georgelis

    Inventor： Donald K. Smith ,  Xing Chen ,  William M. Holber ,  Eric Georgelis

    IPC: H05H1/46 ,  H01J27/16 ,  H01J37/32 ,  H01L21/205 ,  H01L21/302 ,  H01L21/3065 ,  B23K10/00

    CPC classification number: H01J37/32009 ,  H01J27/16 ,  H01J37/321 ,  H01J37/32357 ,  H01J37/32862

    Abstract: An apparatus for dissociating gases includes a plasma chamber that may be formed from a metallic material and a transformer having a magnetic core surrounding a portion of the plasma chamber and having a primarily winding. The apparatus also includes one or more switching semiconductor devices that are directly coupled to a voltage supply and that have an output coupled to the primary winding of the transformer. The one or more switching semiconductor devices drive current in the primary winding that induces a potential inside the chamber that forms a plasma which completes a secondary circuit of the transformer.

    Abstract translation: 用于解离气体的装置包括可以由金属材料形成的等离子体室和具有围绕等离子体室的一部分并具有主要绕组的磁芯的变压器。 该装置还包括直接耦合到电压源并且具有耦合到变压器的初级绕组的输出的一个或多个开关半导体器件。 一个或多个开关半导体器件驱动初级绕组中的电流，其引起室内的电位，其形成等离子体，其完成变压器的次级电路。

    Focused beam spectroscopic ellipsometry method and system
    117.
    发明授权
    Focused beam spectroscopic ellipsometry method and system 失效
    聚焦光束椭偏仪的方法和系统

    公开(公告)号：US5910842A

    公开(公告)日：1999-06-08

    申请号：US753696

    申请日：1996-11-27

    Applicant: Timothy R. Piwonka-Corle ,  Xing Chen ,  Lloyd J. Lacomb, Jr. ,  Jean-Louis Stehle ,  Dorian Zahorski

    Inventor： Timothy R. Piwonka-Corle ,  Xing Chen ,  Lloyd J. Lacomb, Jr. ,  Jean-Louis Stehle ,  Dorian Zahorski

    IPC: G01N21/21

    CPC classification number: G01N21/211 ,  G01N2021/213

    Abstract: A method and system for spectroscopic ellipsometry employing reflective optics to measure a small region of a sample by reflecting radiation (preferably broadband UV, visible, and near infrared radiation) from the region. The system preferably has an autofocus assembly and a processor programmed to determine from the measurements the thickness and/or complex refractive index of a thin film on the sample. Preferably, only reflective optics are employed along the optical path between the polarizer and analyzer, a sample beam reflects with low incidence angle from each component of the reflective optics, the beam is reflectively focused to a small, compact spot on the sample at a range of high incidence angles, and an incidence angle selection element is provided for selecting for measurement only radiation reflected from the sample at a single, selected angle (or narrow range of angles). The focusing mirror preferably has an elliptical shape to reduce off-axis aberrations in the focused beam. Some embodiments include both a spectrophotometer and an ellipsometer integrated together as a single instrument. In such instrument, the spectrophotometer and ellipsometer share a radiation source, and radiation from the source can be focused by either the spectrophotometer or the ellipsometer to the same focal point on a sample. Preferred embodiments of the ellipsometer employ a rotating, minimal-length Rochon prism as a polarizer, and include a spectrometer with an intensified photodiode array to measure reflected radiation from the sample, and a reference channel (in addition to a sample channel which detects radiation reflected from the sample).

    Abstract translation: 使用反射光学器件的光谱椭偏仪的方法和系统通过从该区域反射辐射（优选宽带UV，可见光和近红外辐射）来测量样品的小区域。 该系统优选地具有自动对焦组件和被编程用于根据测量结果确定样品上薄膜的厚度和/或复合折射率的处理器。 优选地，沿着偏振器和分析器之间的光路仅采用反射光学元件，样品光束以反射光学器件的每个分量以低入射角反射，光束被反射聚焦到样品上的小的紧密斑点 并且提供入射角选择元件用于仅选择仅以单个选定角度（或窄范围的角度）从样品反射的辐射。 聚焦镜优选具有椭圆形以减少聚焦光束中的离轴像差。 一些实施例包括作为单个仪器集成在一起的分光光度计和椭偏仪。 在这种仪器中，分光光度计和椭偏仪共享一个辐射源，来自源的辐射可以通过分光光度计或椭偏仪聚焦到样品上的同一焦点。 椭偏仪的优选实施例采用旋转的，最小长度的Rochon棱镜作为偏振器，并且包括具有增强的光电二极管阵列的光谱仪，以测量来自样品的反射辐射，以及参考通道（除了检测辐射的样品通道 从样品）。

    Method of detecting nucleic acids with enhanced signal using dual-functional capture particles
    119.
    发明授权
    Method of detecting nucleic acids with enhanced signal using dual-functional capture particles 有权

    公开(公告)号：US09890418B1

    公开(公告)日：2018-02-13

    申请号：US15083086

    申请日：2016-03-28

    Applicant: Hai Xing Chen

    Inventor： Hai Xing Chen

    IPC: C12Q1/68

    CPC classification number: C12Q1/682 ,  C12Q2537/143 ,  C12Q2563/107 ,  C12Q2563/149 ,  C12Q2565/519

    Abstract: A method of enhancing signal in detection of nucleic acid sequences utilizes dual-functional capture particles for capturing a target sequence and for binding with enhancement probes coupled to a reporter. The method includes hybridizing a target sequence with a capture sequence on dual-functional capture particles; hybridizing a pair of enhancement probes to the bounded target sequence through a linker to form a staggered chain of enhancement probes; triggering a chemical reaction between a chemical binding group on the dual-functional capture particles and a first binding moiety on the enhancement probes to bind the enhancement probes covalently to dual-functional capture particles; binding a reporter to the bounded enhancement probes through another chemical reaction between a second binding moiety on the enhancement probes and a binding functional group on the reporter; and detecting the signal from a signal generating molecule on bounded reporter, thereby amplifying signal through enhancement probes coupled to reporters.

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