公开(公告)号：US06174815B1

公开(公告)日：2001-01-16

申请号：US08957813

申请日：1997-10-27

Applicant: Fu-Liang Yang ,  Chau-Jen Kuo ,  Bin Liu

Inventor： Fu-Liang Yang ,  Chau-Jen Kuo ,  Bin Liu

IPC: H01L21311

CPC classification number: H01L21/31055 ,  H01L21/316 ,  H01L21/31625 ,  H01L27/10852

Abstract: A method for planarizing DRAM cells comprising the steps of providing a silicon substrate having a field oxide layer, an oxide layer and a capacitor formed thereon, then forming a first dielectric layer over the substrate. Next, portions of the first dielectric layer is etched back to form a spacer layer, and then a second dielectric layer is formed over the spacer layer. Thereafter, an insulating layer is formed over the second dielectric layer. Finally, the insulating layer is fully etched back to form a third dielectric layer.

Abstract translation: 一种用于平坦化DRAM单元的方法，包括以下步骤：提供具有场氧化物层，氧化物层和形成在其上的电容器的硅衬底，然后在衬底上形成第一介电层。 接下来，将第一电介质层的部分进行回蚀以形成间隔层，然后在隔离层上形成第二电介质层。 此后，在第二电介质层上形成绝缘层。 最后，绝缘层被完全回蚀以形成第三电介质层。

公开(公告)号：US06066732A

公开(公告)日：2000-05-23

申请号：US138354

申请日：1998-08-21

Applicant: Edward C. Taylor ,  Bin Liu

Inventor： Edward C. Taylor ,  Bin Liu

IPC: C07D487/04 ,  C07D239/47 ,  C07D239/48

CPC classification number: C07D487/04

Abstract: 4(3H)-X-7H-Pyrrolo[2,3-d]pyrimidines in which X is .dbd.O or .dbd.NH are prepared by treating a 6-amino-4(3H)-X-pyrimidine with a unsubstituted or substituted 1-nitroalk-1-ene to yield a 6-amino-4(3H)-X-pyrimidine which is substituted in the 5-position by a 1-nitroalk-2-yl group; (ii) converting the 5-(1-nitroalk-2-yl)-6-amino-4(3H)-X-pyrimidine to the corresponding 5-(1-oxoalk-2-yl)-6-amino-4(3H)-X-pyr-imidine; and (iii) removing the elements of water from the 5-(1-oxoalk-2-yl)-6-amino-4(3H)-X-pyrimidine to effect cyclization. A typical embodiment involves treating 2,6-diamino-4(3H)-pyrimidone with 1-nitro-4-(4-ethoxycarbonylphenyl)-1-butene to yield 1 -nitro-2-(2,6-diamino-4(3H)-oxopyrimidin-5-yl)-4-(4-ethoxy-carbonylphenyl)butane which is then treated sequentially with base and acid, without isolation of the intermediate aldehyde, to form 4-[2-(2-amino-4(3H)-oxo-7H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoic acid, a valuable known chemical intermediate for the preparation of N-[4-{2-(2-hydroxy-4-amino-7H-pyrrolo[2,3-d]-pyrimidin-5-yl)ethyl}benzoyl]glutamic acid.

Abstract translation: 通过用未取代的或取代的1位的6-氨基-4（3H） - 嘧啶处理制备X（= O或= NH）的4（3H） - 7H-吡咯并[2,3-d] - 硝基-1-烯，得到6-位氨基-4（3H） - 嘧啶，其在5-位被1-硝基烷基-2-基取代; （ii）将5-（1-硝基烷基-2-基）-6-氨基-4（3H） - 嘧啶转化成相应的5-（1-氧代-2-基）-6-氨基-4（ 3H）-X-吡啶亚胺; 和（iii）从5-（1-氧代-2-基）-6-氨基-4（3H）-X-嘧啶中除去水元素以进行环化。 典型的实施方案涉及用1-硝基-4-（4-乙氧基羰基苯基）-1-丁烯处理2,6-二氨基-4（3H） - 嘧啶酮，得到1-硝基-2-（2,6-二氨基-4 3H） - 氧代嘧啶-5-基）-4-（4-乙氧基 - 羰基苯基）丁烷，然后用碱和酸依次处理，而不分离中间体醛，形成4- [2-（2-氨基-4 （3H） - 氧代-7H-吡咯并[2,3-d]嘧啶-5-基）乙基]苯甲酸是一种有价值的已知化学中间体，用于制备N- [4- {2-（2-羟基-4 - 氨基-7H-吡咯并[2,3-d] - 嘧啶-5-基）乙基}苯甲酰基]谷氨酸。

公开(公告)号：US20250121246A1

公开(公告)日：2025-04-17

申请号：US18379664

申请日：2023-10-13

Applicant: Bin Liu

Inventor： Bin Liu

IPC: A63B21/00 ,  A63B21/062

Abstract: The present invention discloses a fitness equipment comprising frame assembly, drive assembly, slide trolley and a smith system. Two base frames set opposite to each other are connected by connecting rod, and the first column and the second column are set in the vertical direction of the connecting rod which are connected by gantry frame, and the first cross beam and the second cross beam are set vertically on the connecting rod and the gantry frame, respectively, and the third column is set between them, thus forming the structure of fitness equipment, and pulley assembly is cooperated with the first wire rope, the second wire rope, and the third wire rope so that it can drive the slide car moves, realizing the alignment from the middle, which can reduce friction and increase the service life of the multifunctional fitness equipment when in use.

公开(公告)号：US20160376296A1

公开(公告)日：2016-12-29

申请号：US14934665

申请日：2015-11-06

Applicant: Yi Pang ,  Bin Liu

Inventor： Yi Pang ,  Bin Liu

IPC: C07F9/6533 ,  G01N33/58 ,  C12Q1/02

CPC classification number: A61B5/0071 ,  A61K31/713 ,  A61K49/0021 ,  C07D311/30 ,  C07F9/6533 ,  C12N15/113 ,  C12N15/1135 ,  C12N15/1137 ,  C12N2310/14 ,  C12N2310/322 ,  C12N2310/344 ,  C12N2310/3515 ,  C12N2310/531 ,  C12N2320/30 ,  C12N2320/32 ,  C12N2320/35 ,  C12N2320/53 ,  C12Q1/02 ,  G01N33/582 ,  H05K999/99 ,  C12N2310/3533 ,  C12N2310/3531 ,  C12N2310/321 ,  C12N2310/3521

Abstract: Flavonoid compounds may be prepared that are selective for certain cell organelles, and may be used as biological imaging agents. Organelles that may be imaged with flavonoid compounds include mitochondria and lysosomes. Advantageously, the flavonoids show specificity to certain organelles and may exhibit a florescence “turn-on” mechanism, where the flavonoids that have target an organelle exhibit a florescence response when excited.

Abstract translation: 可以制备对某些细胞器具有选择性的类黄酮化合物，并且可以用作生物成像剂。 可能用黄酮类化合物成像的细胞器包括线粒体和溶酶体。 有利地，类黄酮对某些细胞器显示特异性并且可能表现出荧光“开启”机制，其中靶向细胞器的类黄酮在激发时表现出荧光反应。

公开(公告)号：US09145462B2

公开(公告)日：2015-09-29

申请号：US13172759

申请日：2011-06-29

Applicant: Bin Liu ,  James D. Marks ,  Xiaodong Zhu ,  Scott Bidlingmaier

Inventor： Bin Liu ,  James D. Marks ,  Xiaodong Zhu ,  Scott Bidlingmaier

IPC: A61K39/395 ,  C07K16/28 ,  C07K16/30 ,  C12N5/095 ,  G01N33/574

CPC classification number: C07K16/18 ,  A61K47/6843 ,  A61K51/1045 ,  C07K16/2896 ,  C07K16/3053 ,  C07K2317/21 ,  C07K2317/54 ,  C07K2317/55 ,  C07K2317/622 ,  C07K2317/73 ,  C07K2317/77 ,  C07K2317/92 ,  C12N5/0695 ,  G01N33/57407

Abstract: The present disclosure is generally related to antibodies that bind specifically to glioblastoma multiforme (GBM) cells. In particular, the present disclosure provides compositions comprising human single chain or full-length antibodies that bind tumor cells. Additionally the present disclosure provides methods of using the anti-GBM antibodies.

Abstract translation: 本公开通常涉及特异性结合多形性胶质母细胞瘤（GBM）细胞的抗体。 特别地，本公开提供了包含结合肿瘤细胞的人单链或全长抗体的组合物。 另外，本公开提供了使用抗GBM抗体的方法。

公开(公告)号：US20140328764A1

公开(公告)日：2014-11-06

申请号：US14342074

申请日：2012-09-03

Applicant: Benzhong Tang ,  Wei Qin ,  Jianzhao Liu ,  Sijie Chen ,  Tsz Kin Kwok ,  Bin Liu ,  Kai Li ,  Dan Ding ,  Haibin Shi ,  Jun Long Geng ,  Jingzhi Sun ,  Anjun Qin ,  Qiuli Zhao

Inventor： Benzhong Tang ,  Wei Qin ,  Jianzhao Liu ,  Sijie Chen ,  Tsz Kin Kwok ,  Bin Liu ,  Kai Li ,  Dan Ding ,  Haibin Shi ,  Jun Long Geng ,  Jingzhi Sun ,  Anjun Qin ,  Qiuli Zhao

IPC: G01N33/58 ,  A61K49/00 ,  G01N33/574 ,  C12Q1/37

CPC classification number: G01N33/582 ,  A61K49/0021 ,  A61K49/0054 ,  A61K49/0093 ,  C09K11/06 ,  C12Q1/37 ,  G01N33/574 ,  G01N2333/96466

Abstract: The development of fluorescent bioprobes comprising organic fluorescent compounds that exhibit aggregation induced emission (AIE) properties, methods of producing the same, and their practical applications for in vitro and in vivo bioimaging.

Abstract translation: 荧光生物探针的发展包括显示聚集诱导发射（AIE）性质的有机荧光化合物，其生产方法及其在体外和体内生物成像中的实际应用。

公开(公告)号：US20130225747A1

公开(公告)日：2013-08-29

申请号：US13881373

申请日：2010-12-30

Applicant: Bin Liu ,  Huayan Xing

Inventor： Bin Liu ,  Huayan Xing

IPC: C09D115/02

CPC classification number: C09D115/02 ,  C08K5/54 ,  C09D5/08 ,  C09D127/12 ,  C08K13/02 ,  C08K3/04 ,  C08K3/22 ,  C08K5/544

Abstract: A fluorine-containing anti-corrosive coating is prepared by using fluororubber as basic film-forming substance, adding auxiliary agent, reinforcing agent and additive, kneading to obtain fluorine mixed compound, dissolving in organic solvent to obtain component A solution of the mixed compound; and while using it, mixing the component A solution with silane coupling agent as component B at a certain proportion, curing at low temperature and obtaining the fluorine-containing coating.

Abstract translation: 通过使用氟橡胶作为基本成膜物质，添加助剂，增强剂和添加剂，捏合以获得氟混合物，溶解在有机溶剂中以得到混合化合物的组分A溶液，制备含氟防腐涂料; 在使用时，以一定比例混合组分A溶液与硅烷偶联剂作为组分B，在低温下固化并获得含氟涂层。

公开(公告)号：US08522348B2

公开(公告)日：2013-08-27

申请号：US12846541

申请日：2010-07-29

Applicant: Yan Chen ,  Zhichun Li ,  Gao Xia ,  Bin Liu

Inventor： Yan Chen ,  Zhichun Li ,  Gao Xia ,  Bin Liu

IPC: G06F11/00

CPC classification number: H04L63/1416 ,  H04L63/1433 ,  H04L69/22

Abstract: Systems, methods, and apparatus are provided for vulnerability signature based Network Intrusion Detection and/or Prevention which achieves high throughput comparable to that of the state-of-the-art regex-based systems while offering improved accuracy. A candidate selection algorithm efficiently matches thousands of vulnerability signatures simultaneously using a small amount of memory. A parsing transition state machine achieves fast protocol parsing. Certain examples provide a computer-implemented method for network intrusion detection. The method includes capturing a data message and invoking a protocol parser to parse the data message. The method also includes matching the parsed data message against a plurality of vulnerability signatures in parallel using a candidate selection algorithm and detecting an unwanted network intrusion based on an outcome of the matching.

Abstract translation: 提供了基于漏洞签名的网络入侵检测和/或预防的系统，方法和装置，其实现了与现有技术的基于正则表达式的系统相当的高吞吐量，同时提供了更高的精度。 候选者选择算法使用少量内存同时有效地匹配数千个漏洞签名。 解析过渡状态机实现快速协议解析。 某些示例提供用于网络入侵检测的计算机实现的方法。 该方法包括捕获数据消息并调用协议解析器来解析数据消息。 该方法还包括使用候选选择算法并行地解析解析的数据消息与多个脆弱性签名并且基于匹配的结果来检测不需要的网络入侵。

公开(公告)号：US20130182259A1

公开(公告)日：2013-07-18

申请号：US13513052

申请日：2010-12-01

Applicant: Mark Brezinski ,  Bin Liu ,  Ehsan Azimi

Inventor： Mark Brezinski ,  Bin Liu ,  Ehsan Azimi

IPC: G01B9/02

CPC classification number: G01B9/02091 ,  A61B5/0066 ,  A61B5/7257 ,  G01B9/02044 ,  G01B9/02074 ,  G01N21/4795 ,  G01N2021/1787

Abstract: Systems and methods for enhancing spectral domain optical coherence tomography (OCT] are provided. In particular, a system and method for calibration of spectral interference signals using an acquired calibration signal are provided. The calibration signal may be logarithmically amplified to further improve the accuracy of the calibration. From the calibration signal, a series of more accurate calibration data are calculated. An acquired spectral interference signal is calibrated using these calibration data. Moreover, systems that include logarithmic amplification of the spectral interference signal and variable band-pass filtering of the spectral interference signal are provided. Such systems increase the dynamic range and visualization capabilities relative to conventional spectral domain OCT systems.

Abstract translation: 提供了增强频域光学相干断层扫描（OCT）的系统和方法，特别提供了一种使用采集的校准信号校准光谱干扰信号的系统和方法，校准信号可以对数放大，以进一步提高 校准，从校准信号中计算出一系列更准确的校准数据，采用这些校准数据对采集到的光谱干涉信号进行校准，而且包括频谱干扰信号的对数放大和可变带通滤波的系统 提供了光谱干扰信号，相对于常规光谱域OCT系统，这种系统增加了动态范围和可视化能力。

公开(公告)号：US08338532B2

公开(公告)日：2012-12-25

申请号：US13038378

申请日：2011-03-01

Applicant: Guillermo C. Bazan ,  Bin Liu

Inventor： Guillermo C. Bazan ,  Bin Liu

IPC: C08G63/91 ,  C08G63/00 ,  C12Q1/68

CPC classification number: C08G61/02 ,  C08G61/122 ,  C08G61/123 ,  C12Q1/6818 ,  C12Q1/6837 ,  G01N21/6428 ,  G01N21/6452 ,  G01N2021/6419 ,  G01N2021/6439 ,  C12Q2563/131 ,  C12Q2537/119 ,  C12Q2525/107

Abstract: The invention further relates to multichromophores, which may be conjugated polymers, and methods, articles and compositions employing them as described herein. In some aspects, the invention relates to methods, articles and compositions for the detection and analysis of biomolecules in a sample. Provided assays include those determining the presence of a target biomolecule in a sample or its relative amount, or the assays may be quantitative or semi-quantitative. The methods can be performed on a substrate. The methods can be performed in an array format on a substrate, which can be a sensor. In some embodiments, detection assays are provided employing sensor biomolecules that do not comprise a fluorophore that can exchange energy with the cationic multichromophore. In some aspects biological assays are provided in which energy is transferred between one or more of the multichromophore, a label on the target biomolecule, a label on the sensor biomolecule, and/or a fluorescent dye specific for a polynucleotide, in all permutations. The multichromophore may interact at least in part electrostatically with the sensor and/or the target, and an increase in energy transfer with the polymer may occur upon binding of the sensor and the target. Other variations of the inventions are described further herein.

Abstract translation: 本发明还涉及可以是共轭聚合物的多色素，以及如本文所述使用它们的方法，制品和组合物。 在一些方面，本发明涉及用于检测和分析样品中生物分子的方法，制品和组合物。 提供的测定包括确定样品中靶生物分子的存在或其相对量的那些，或者测定可以是定量或半定量的。 该方法可以在衬底上进行。 这些方法可以以阵列格式在基底上进行，其可以是传感器。 在一些实施方案中，使用不包含能够与阳离子多重色素交换能量的荧光团的传感器生物分子来提供检测测定。 在一些方面，提供生物测定，其中在所有置换中，能量在一个或多个多色素，目标生物分子上的标记，传感器生物分子上的标记和/或多核苷酸特异的荧光染料之间转移。 多重色淀可以至少部分地与传感器和/或靶相互作用，并且当传感器和目标物结合时，聚合物的能量传递的增加可能发生。 本文进一步描述了本发明的其它变型。