摘要:
A log-in resource release system includes a set of lists for managing log-in requests to a processing cluster input/output port from host server input/output ports. Host servers that have been granted memory structures within a memory storage device (“configured hosts”) are granted priority access to a storage processing device's input/output port (“cluster port”). If the cluster port has exhausted its log-in resources, log-on requests from non-configured hosts will be not be accepted. New log-in requests from configured hosts will cause a host connected at a link or transport layer but not an upper layer to be logged off. If no hosts are connected only at the link or transport layer, a non-configured host connected at an upper layer will be logged off. If only configured hosts are connected and only at the upper layer, the log-on request by the configured host will be denied.
摘要:
Methods are provided for identifying anti-HIV therapeutic compounds substituted with carboxyl ester or phosphonate ester groups. Libraries of such compounds are screened optionally using the novel enzyme GS-7340 Ester Hydrolase. Compositions and methods relating to GS-7340 Ester Hydrolase also are provided.
摘要:
The present invention is drawn to methods for photodynamic therapy (PDT) of a target cell, target tissue or target composition in a mammalian subject, using a therapeutically effective amount of a targeted substance, which is either a targeted photosensitizing agent, or a photosensitizing agent delivery system, or a targeted prodrug. This targeted substance preferably selectively binds to the target cell, target tissue or target composition. Light at a wavelength or waveband corresponding to that which is absorbed by the targeted substance is then administered. The light intensity is relatively low, but a high total fluence is employed to ensure the activation of the targeted photosensitizing agent or targeted prodrug product.
摘要:
A method for variable velocity printing includes printing a first swath at a first velocity, and printing a second swath at a second velocity. Thus, different swaths of a single print job can be printed at different swath velocities. By varying the swath velocity between swaths, mechanical vibrations that can degrade or negatively impact the quality of the resulting printed product can be ameliorated.
摘要:
Methods are provided for identifying anti-HIV therapeutic compounds substituted with carboxyl ester or phosphonate ester groups. Libraries of such compounds are screened optionally using the novel enzyme GS-7340 Ester Hydrolase. Compositions and methods relating to GS-7340 Ester Hydrolase also are provided.
摘要:
The invention is related to phosphorus substituted compounds with activity for treating metabolic diseases and/or disorders, e.g., diabetes and hypercholesterolemia, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.
摘要:
Phosphorus-substituted imidazole compounds with anti-HIV properties having use as therapeutics and for other industrial purposes are disclosed. The compositions inhibit reverse transcriptase activity and are useful therapeutically for the inhibition of such enzymes, as well as in assays for the detection of such enzymes.
摘要:
An apparatus, system, and method are disclosed for fastload code update on a communications adapter. The apparatus includes an image load module, a memory initialization module, and an image overlay module. The image load module is configured to load a copy of a new code image in a memory on the communications adapter. The memory also concurrently stores a copy of an old code image used by the communications adapter. The memory initialization module is configured to invoke the new code image to perform a memory initialization operation. The memory initialization module may perform the memory initialization operation concurrently with ongoing I/O requests possibly accepted, but not necessarily processed, by the old code image. The image overlay module is configured to overlay the old code image with the new code image. The fastload code update minimizes the time that the communications adapter is off-line to overlay the old code image with the new code image and reinitialize the communications adapter.
摘要:
Methods, system and computer program product are provided to improve the efficiency of data transfers in a PPRC environment. A block of data to be transferred is divided into tracks. Each track is allocated to a data mover task control block (TCB) with a master TCB being assigned to supervise the data mover TCBs. The tracks are then transferred from the primary storage controller to the secondary controller in a piped fashion over a link coupling the primary and secondary storage controllers. However, the usage of resources is monitored by a resource management algorithm and, if too many TCBs are being used for a transfer or if the supply of data mover TCBs is exhausted, the transfer is automatically switched to a serial, non-piped transfer with the master TCB serving as the data mover TCB for the remaining tracks. In addition, the various links coupling the primary and secondary storage controllers is monitored to determine which link will provide the fastest transfer. If, during a transfer of tracks over one link, a faster link is identified, the transfer may be switched to the second, faster link.
摘要:
Ortho-sulfonamido aryl hydroxamic acids are provided which are useful, inter alia, for the inhibition of matrix metalloproteinases and the treatment of conditions associated with overexpression of MMPs.