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    Treatment of tissue in the digestive circulatory respiratory urinary and reproductive systems
    132.
    发明授权
    Treatment of tissue in the digestive circulatory respiratory urinary and reproductive systems 有权
    消化循环呼吸泌尿和生殖系统中组织的处理

    公开(公告)号：US06425877B1

    公开(公告)日：2002-07-30

    申请号：US09307348

    申请日：1999-05-06

    Applicant: Stuart D. Edwards

    Inventor： Stuart D. Edwards

    IPC: A61N130

    CPC classification number: A61B18/1477 ,  A61B17/1617 ,  A61B18/1492 ,  A61B18/1815 ,  A61B18/20 ,  A61B2017/4216 ,  A61B2018/00214 ,  A61B2018/00553

    Abstract: Apparatus for creating a controlled pattern of ablation throughout the interior of an organ or body cavity while minimizing thermal damage to collateral tissue includes a microporous balloon mounted on a catheter. The balloon, bearing electrodes embedded in the surface, is inserted into the target body region and inflated, whereupon the electrodes come into contact with the interior of the targeted organ. Because of its microporous nature, fluids for cooling or various therapeutic purposes may pass through the surface of the balloon to the target site. Sensors monitor conditions such as temperature and impedance at the site, providing required feedback for delivery of RF energy for ablation, and administration of cooling and hydrating fluids. A second balloon or other means isolates the treatment area and controls the flow and accumulation of body fluids and treatment fluids minimizing adverse treatment effects from fluid accumulations, and anchoring the catheter in place.

    Abstract translation: 用于在整个器官或体腔内部产生受控消融模式的装置，同时最小化对侧支组织的热损伤，包括安装在导管上的微孔气球。 将嵌入表面的承载电极的球囊插入目标体区域并膨胀，于是电极与目标器官的内部接触。 由于其微孔性质，用于冷却的流体或各种治疗目的可以通过气囊的表面到达靶位点。 传感器监测现场的温度和阻抗等情况，提供用于消除RF能量的所需反馈，以及冷却和保湿流体的管理。 第二气球或其他手段隔离治疗区域并控制体液和治疗液体的流动和积聚使流体积聚的不利治疗效果最小化，并将导管锚定到位。

    Treating body tissue by applying energy and substances
    136.
    发明授权
    Treating body tissue by applying energy and substances 有权
    通过施加能量和物质来治疗身体组织

    公开(公告)号：US06409723B1

    公开(公告)日：2002-06-25

    申请号：US09285575

    申请日：1999-04-02

    Applicant: Stuart D. Edwards

    Inventor： Stuart D. Edwards

    IPC: A61B1818

    CPC classification number: A61B18/1477 ,  A61B17/1617 ,  A61B18/1492 ,  A61B2017/4216 ,  A61B2018/00214 ,  A61B2018/00261 ,  A61B2018/00267 ,  A61B2018/00517 ,  A61B2018/00523 ,  A61B2018/00553 ,  A61B2218/007

    Abstract: A method and apparatus for treatment for body structures, especially internal body structures involving disorders involving unwanted features or other disorders, that does not require relatively invasive surgery, and is not subject to other drawbacks noted with regard to the known art. A relatively minimally invasive catheter is inserted into the body, treatment of the body structures is applied using the catheter, and the unwanted features or disorders are relatively cured using the applied treatments. The applied treatments can include application of energy or substances, including application of energy (such as of radio frequency energy, microwave energy, or laser or other electromagnetic energy) or substances (such as collagen or other bulking, plumping, or shaping agents; saline or other energy-receiving electrolytes; astringents or other debulking, reducing, or shaping agents; antibiotics or other bioactive, chemoactive, or radioactive compounds). More than one applied treatment can be performed, either in conjunction, in parallel, or seriatim, so as to achieve a combined effect more substantial than any one individual such applied treatment.

    Abstract translation: 用于治疗身体结构的方法和装置，特别是涉及不想要的特征或其它障碍的疾病的内部身体结构，其不需要相对侵入性的手术，并且不会受到关于已知技术的其它缺点的影响。 将相对较小的侵入性导管插入体内，使用导管施加身体结构的治疗，并且使用所施用的治疗相对固化不想要的特征或障碍。 所应用的处理方法可包括能量或物质的应用，包括能量的应用（如射频能量，微波能量或激光或其他电磁能）或物质（如胶原蛋白或其他膨胀，膨胀或成型剂;盐水 或其他能量接收电解质;收敛剂或其它减压剂，还原剂或成型剂;抗生素或其它生物活性，化学活性或放射性化合物）。 可以一起，并行或连续地进行多于一个的施用治疗，以便实现比任何一个个体更加实质的组合效果。

    Treating urinary and other body strictures
    138.
    发明授权
    Treating urinary and other body strictures 失效
    治疗尿液和其他身体狭窄

    公开(公告)号：US06338726B1

    公开(公告)日：2002-01-15

    申请号：US08795656

    申请日：1997-02-06

    Applicant: Stuart D. Edwards ,  Muta M. Issa

    Inventor： Stuart D. Edwards ,  Muta M. Issa

    IPC: A61M2900

    CPC classification number: A61F2/82 ,  A61B17/00491 ,  A61B18/14 ,  A61B18/1485 ,  A61B18/1492 ,  A61B2017/005 ,  A61B2018/0022 ,  A61B2018/00404 ,  A61B2018/00553 ,  A61F2/07 ,  A61F2/90 ,  A61F2/94 ,  A61F2/958 ,  A61F2002/3008 ,  A61F2002/5015 ,  A61F2002/5052 ,  A61F2250/0098

    Abstract: The invention provides a method and system for treatment of body strictures to restore luminal diameter to within a normal diameter range, in which the stricture is dilated to stretch its lumen to a desired diameter, collagen is exuded near to existing tissue of the stricture so as to be absorbed by that tissue or adhere to that tissue, making a collagen-enhanced tissue structure, and energy is emitted to affect the collagen-enhanced tissue, such as by ablation or by hardening. Ablation and hardening may be repeated so as to create a set of layers of hardened collagen in the form of a supporting frame, preferably having a hollow cylindrical shape. Dilation of the stricture is achieved by expanding one or more balloons, or by the pressure of exuded collagen, until the stricture is larger than a normal diameter range. When energy is emitted into the collagen, the stricture contracts back to the normal diameter range, either by ablation of excess tissue or by plating of the stricture wall. The stricture's tissue is also isolated by a set of balloons at either or both ends of the stricture, so as to isolate the stricture and restrict the collagen to the stricture's tissue. The stricture's tissue is also supported by a stent, which is preferably tackwelded onto the stricture's tissue using collagen. Collagen adheres to the stent, which supports the stricture's tissue until the stent is absorbed into that tissue.

    Abstract translation: 本发明提供了一种用于治疗身体狭窄的方法和系统，以将管腔直径恢复到正常直径范围内，其中狭窄被扩张以将其内腔拉伸至期望的直径，胶原蛋白渗透到狭窄的现有组织附近，以便 被该组织吸收或粘附到该组织，形成胶原增强的组织结构，并且发射能量以影响胶原增强组织，例如通过消融或硬化。 可以重复消融和硬化，以便产生一组支撑框架形式的硬化胶原层，优选具有中空圆柱形状。 通过扩张一个或多个气囊或通过渗出的胶原的压力来扩张狭窄，直到狭窄大于正常直径范围为止。 当能量发射到胶原中时，通过消融多余的组织或通过电镀狭窄壁，狭窄可缩回到正常直径范围。 狭窄的组织也通过一组气囊在狭窄的两端或两端分离，以隔离狭窄并将胶原限制在狭窄的组织上。 狭窄的组织也由支架支撑，支架优选使用胶原粘合到狭窄组织上。 胶原蛋白粘附到支架上，其支持狭窄的组织，直到支架被吸收到该组织中。

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