公开(公告)号：US08377867B2

公开(公告)日：2013-02-19

申请号：US12685085

申请日：2010-01-11

Applicant: Jyh-Yih Chen ,  Chia-Yu Pan

Inventor： Jyh-Yih Chen ,  Chia-Yu Pan

IPC: A61K38/16 ,  A61K38/12 ,  A61P31/04

CPC classification number: A61K38/1706 ,  A61K38/1767

Abstract: Treatments of trichomonas, propionibacterium, or yeast infection using an epinecidin-1 peptide or an anti-lipopolysaccharide factor peptide.

Abstract translation: 使用表皮素-1肽或抗脂多糖因子肽治疗毛滴虫，丙酸杆菌或酵母菌感染。

公开(公告)号：US08377436B2

公开(公告)日：2013-02-19

申请号：US12764260

申请日：2010-04-21

Applicant: Yuan-Tsong Chen ,  Wen-Hung Chung ,  Shuen-Iu Hung

Inventor： Yuan-Tsong Chen ,  Wen-Hung Chung ,  Shuen-Iu Hung

IPC: A61K39/00 ,  A61K39/395

CPC classification number: G01N33/564 ,  G01N2800/104 ,  G01N2800/245

Abstract: Disclosed are uses of granulysin in methods of diagnosing or treating autoimmune disorders.

Abstract translation: 公开了颗粒溶素在诊断或治疗自身免疫性疾病的方法中的用途。

公开(公告)号：US20130040952A1

公开(公告)日：2013-02-14

申请号：US13567355

申请日：2012-08-06

Applicant: Chi-Huey Wong ,  Ming-Daw Tsai ,  Ying-Ta Wu ,  Yih-Shyun E. Cheng ,  Yu-Hou Chen ,  Yu-Fang Shen

Inventor： Chi-Huey Wong ,  Ming-Daw Tsai ,  Ying-Ta Wu ,  Yih-Shyun E. Cheng ,  Yu-Hou Chen ,  Yu-Fang Shen

IPC: A61K31/5377 ,  C12N5/07 ,  A61P31/16 ,  G01N33/53 ,  A61K31/167 ,  A61K31/517

CPC classification number: A61K31/167 ,  A61K31/517 ,  A61K31/5377 ,  G01N33/56983

Abstract: Methods for identifying agents capable of disrupting a salt bridge in an influenza A virus nucleoprotein corresponding to the E339 . . . R416 salt bridge in SEQ ID NO:1, and thus the trimerization of the NP protein; and uses of such agents, e.g., small molecules and peptides, for inhibiting influenza virus replication and treating infection caused by influenza virus.

Abstract translation: 鉴定能够破坏对应于E339的甲型流感病毒核蛋白中的盐桥的试剂的方法。 。 。 R416盐桥，因此NP蛋白的三聚化; 以及这些药剂（例如小分子和肽）用于抑制流感病毒复制和治疗由流感病毒引起的感染的用途。

公开(公告)号：US08361483B2

公开(公告)日：2013-01-29

申请号：US13070197

申请日：2011-03-23

Applicant: Jyh-Yih Chen ,  Chang-Jer Wu

Inventor： Jyh-Yih Chen ,  Chang-Jer Wu

IPC: A61K45/00 ,  A61K39/193 ,  A61K39/12 ,  A61K39/00

CPC classification number: A61K39/12 ,  A61K39/39 ,  A61K2039/5252 ,  A61K2039/55516 ,  C12N2770/24134 ,  Y02A50/39

Abstract: A method of enhancing a mammalian immune response to a virus is disclosed. The method comprises administering a composition comprising an effective amount of epinecidin (Epi)-1 and the virus to a mammal, wherein the virus has envelope protein and is infectious to the mammal. A vaccine kit and a method for preventing Japanese encephalitis virus (JEV) infection are also disclosed.

Abstract translation: 公开了增强对病毒的哺乳动物免疫应答的方法。 该方法包括向哺乳动物施用包含有效量的抗坏血酸（Epi）-1和病毒的组合物，其中所述病毒具有包膜蛋白并且对哺乳动物具有感染性。 还公开了疫苗试剂盒和预防日本脑炎病毒（JEV）感染的方法。

公开(公告)号：US20130017497A1

公开(公告)日：2013-01-17

申请号：US13539520

申请日：2012-07-02

Applicant: Tahsin J. CHOW ,  Chung-Chih WU ,  Ta-Hsien CHUANG ,  Hsing-Hung HSIEH ,  Hsin-Hui HUANG

Inventor： Tahsin J. CHOW ,  Chung-Chih WU ,  Ta-Hsien CHUANG ,  Hsing-Hung HSIEH ,  Hsin-Hui HUANG

IPC: C07D317/72 ,  C07C255/56 ,  C07D493/10 ,  C07D493/20 ,  C07C49/665 ,  B05D3/00 ,  C07D333/22 ,  C07C49/683 ,  C07D409/10 ,  G03F7/20 ,  B05D3/06 ,  C07C49/675 ,  C07C49/753

CPC classification number: C07C25/22 ,  B05D1/327 ,  B05D3/0254 ,  B05D3/06 ,  C07C49/665 ,  C07C49/683 ,  C07C49/753 ,  C07C205/45 ,  C07C255/56 ,  C07C2603/86 ,  C07C2603/90 ,  C07D333/08 ,  H01L51/0003 ,  H01L51/0055 ,  H01L51/0068 ,  Y02E10/549

Abstract: The present disclosure relates to methods and systems for synthesis of bridged-hydropentacene, hydroanthracene and hydrotetracene from the precursor compounds pentacene derivatives, tetracene derivatives, and anthracene derivatives. The invention further relates to methods and systems for forming thin films for use in electrically conductive assemblies, such as semiconductors or photovoltaic devices.

Abstract translation: 本公开内容涉及从前体化合物并五苯衍生物，并四苯衍生物和蒽衍生物合成桥联 - 水合氢，氢蒽和氢化四苯的方法和系统。 本发明还涉及用于形成用于诸如半导体或光伏器件的导电组件中的薄膜的方法和系统。

公开(公告)号：US08354266B2

公开(公告)日：2013-01-15

申请号：US12621805

申请日：2009-11-19

Applicant: Wen-Hsiung Li ,  Ming-Che Shih ,  Chieh-Chen Huang ,  Jui-Jen Chang ,  Cheng-Yu Ho

Inventor： Wen-Hsiung Li ,  Ming-Che Shih ,  Chieh-Chen Huang ,  Jui-Jen Chang ,  Cheng-Yu Ho

IPC: C12N1/21 ,  C12N15/63

CPC classification number: C07K14/33 ,  C12N1/22 ,  C12N9/00 ,  C12N9/2437 ,  C12N15/63 ,  C12P19/02 ,  C12Y302/01004

Abstract: A polycistronic expression cassette encoding proteins necessary for constructing a multi-enzyme complex was developed. Also disclosed herein is a host cell containing this polycistronic expression cassette and uses thereof in degrading biomass.

Abstract translation: 开发了编码构建多酶复合物所必需的蛋白质的多顺反子表达盒。 本文还公开了含有该多顺反子表达盒的宿主细胞及其在降解生物质中的用途。

公开(公告)号：US20130005720A1

公开(公告)日：2013-01-03

申请号：US13172975

申请日：2011-06-30

Applicant: Ta-Chau CHANG ,  Zi-Fu Wang ,  Chih-Chien Cho ,  Wei-Chun Huang ,  Jen-Fei Chu

Inventor： Ta-Chau CHANG ,  Zi-Fu Wang ,  Chih-Chien Cho ,  Wei-Chun Huang ,  Jen-Fei Chu

IPC: A61K31/5383 ,  C12N5/09 ,  A61P35/02 ,  A61K31/473 ,  A61K31/4745 ,  A61P35/00 ,  A61K31/4545 ,  C12N5/071

CPC classification number: A61K31/403

Abstract: This invention relates to a pharmaceutical composition for treating cancer, comprising an effective amount of a compound represented by formula (I): wherein R is —CCOCCOCC— or —CCOCCOCCOCC—; and a pharmaceutical acceptable carrier. This invention also relates to a method for treating cancer, comprising administering a therapeutically effective amount of said compound to a subject; and a method for stabilizing G4 structure of telomere by using this compound.

Abstract translation: 本发明涉及一种治疗癌症的药物组合物，其包含有效量的由式（I）表示的化合物：其中R是-CCOCCOCC-或-COCOCCOCOCOCC-; 和药物可接受的载体。 本发明还涉及一种治疗癌症的方法，包括向受试者施用治疗有效量的所述化合物; 以及通过使用该化合物稳定端粒的G4结构的方法。

公开(公告)号：US08344317B2

公开(公告)日：2013-01-01

申请号：US13365105

申请日：2012-02-02

Applicant: Chung-Hsuan Chen ,  Jung-Lee Lin ,  Nien-Yeen Hsu ,  Yi-Sheng Wang

Inventor： Chung-Hsuan Chen ,  Jung-Lee Lin ,  Nien-Yeen Hsu ,  Yi-Sheng Wang

IPC: H01J49/26 ,  H01J49/40

CPC classification number: H05H5/047 ,  H01J49/06 ,  H01J49/40 ,  H01J49/403

Abstract: A novel system and methods for accelerating analytes including, without limitation, molecular ions, biomolecules, polymers, nano- and microparticles, is provided. The invention can be useful for increasing detection sensitivity in applications such as mass spectrometry, performing collision-induced dissociation molecular structure analysis, and probing surfaces and samples using accelerated analyte.

Abstract translation: 提供了一种用于加速分析物的新系统和方法，包括但不限于分子离子，生物分子，聚合物，纳米和微粒。 本发明可用于在诸如质谱法，进行碰撞诱导的解离分子结构分析和使用加速分析物的探测表面和样品等应用中提高检测灵敏度。

公开(公告)号：US20120306317A1

公开(公告)日：2012-12-06

申请号：US13252842

申请日：2011-10-04

Applicant: En-Te Hwu ,  Ing-Shouh Hwang

Inventor： En-Te Hwu ,  Ing-Shouh Hwang

IPC: H01L41/00

CPC classification number: G01Q10/04

Abstract: A multi-axis actuating apparatus for a nano-positioning apparatus includes a movable element attached to a sample platform, a plurality of driving elements, and a plurality of actuators. The driving elements frictionally engage the movable element and are configured to selectively move the movable element along a first direction. The plurality of actuators move the plurality of driving elements when driving signals are applied to the plurality of actuators. Different driving signals may be applied to the plurality of actuators to cause different movement of the driving elements such that the movable element has different displacements in different directions along the plurality of driving elements. The movable element is titled due to the different displacements.

Abstract translation: 用于纳米定位装置的多轴致动装置包括附接到样品平台的可移动元件，多个驱动元件和多个致动器。 驱动元件摩擦地接合可移动元件并被构造成沿着第一方向选择性地移动可移动元件。 当驱动信号被施加到多个致动器时，多个致动器移动多个驱动元件。 可以将不同的驱动信号施加到多个致动器以引起驱动元件的不同移动，使得可移动元件在沿着多个驱动元件的不同方向上具有不同的位移。 可移动元件由于不同的位移而被标题。

公开(公告)号：US08324450B2

公开(公告)日：2012-12-04

申请号：US12785653

申请日：2010-05-24

Applicant: Che-Kun James Shen ,  Kuen-Jer Tsai

Inventor： Che-Kun James Shen ,  Kuen-Jer Tsai

IPC: G01N33/68 ,  A01K67/027 ,  C12N5/079

CPC classification number: C12N15/8509 ,  A01K67/0275 ,  A01K2217/052 ,  A01K2217/206 ,  A01K2227/105 ,  A01K2267/0356 ,  C12N5/0618

Abstract: Non-human animal models for frontotemporal lobar degeneration with ubiquitin-positive inclusions (FTLD-U) are disclosed. The invention relates to a transgenic mouse whose genome comprises a transgene operably linked to a neuronal specific promoter effective for an increased expression of the transgene in the brain of the mouse, in which the transgene comprises a nucleotide sequence encoding TAR DNA-binding protein 43 (TDP-43). The transgenic mouse exhibits reduced or impaired learning and memory capacity, and may further exhibits progressively impaired or reduced motor functions. Methods of using such animal models are also disclosed.

Abstract translation: 公开了具有泛素阳性夹杂物（FTLD-U）的额颞叶变性的非人动物模型。 本发明涉及一种转基因小鼠，其基因组包含可操作地连接到有效增加小鼠脑中转基因表达的神经元特异性启动子的转基因，其中转基因包含编码TAR DNA结合蛋白43的核苷酸序列（ TDP-43）。 转基因小鼠表现出减少或受损的学习和记忆能力，并且可能进一步显示出逐渐受损或减少的运动功能。 还公开了使用这种动物模型的方法。