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公开(公告)号：US11466241B2
公开(公告)日：2022-10-11
申请号：US15781217
申请日：2016-11-25
Applicant: CYTIVA SWEDEN AB
Inventor： Amit Kumar Singh , Klaus Gebauer , Supti Datta , Jakob Liderfelt , Nachiket Karmarkar , Ajit S. Vernekar , Mats Olsson , Rajan Thiyaga , Amit K. Sharma , Sasi Kumar Nutalapati , Fredrik Lundstrom , Jean Pierre Neff
Abstract: The invention discloses a first unit (1) for treatment of a bioprocess liquid comprising a first lateral face (2), a second lateral face (3) and a front face (4) which meets the two said lateral faces. The front face comprises: a plurality of valves (7) adapted to receive and act upon one or more legs (8) of a disposable flow path (6); optionally one or more pumps (10) adapted to receive and act upon one or more legs of the disposable flow path; optionally one or more sensors (11) adapted to receive and to measure one or more parameters in one or more legs of the disposable flow path; wherein the plurality of valves and optional pumps and sensors are vertically offset from each other to give one or more legs of a disposable flow path received by said valves and optional pumps and sensors a slope of at least 3.0 degrees from the horizontal plane (h).
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公开(公告)号：US11428558B2
公开(公告)日：2022-08-30
申请号：US16768956
申请日：2018-12-04
Applicant: Cytiva Sweden AB
Inventor： Philipp Lang , Jens Ruetten , Charles E. Seeley
Abstract: Provided is a Coriolis flow sensor assembly that includes a flow tube configured to provide a flow path through the flow tube. Further, the Coriolis flow sensor assembly includes a mechanical drive assembly configured to drive an oscillation of the flow tube while fluid is flowing via an oscillation surface. The Coriolis flow sensor assembly includes an interface fixedly coupled to the oscillation surface of the mechanical drive assembly and configured to receive the flow tube.
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153.发明申请公开(公告)号：US20220265877A1
公开(公告)日：2022-08-25
申请号：US17620617
申请日：2020-06-17
Applicant: Cytiva Sweden AB
Inventor： Hanno Ehring
Abstract: Disclosed is an ultra-violet (UV) light sterilisable fluid-guiding element (100, 200, 300, 400, 500) configurable to form a part of a normally closed bioprocessing fluid system, at least a portion of the element being formed from a material which is transmissive to UV light, said at least one portion of the element including one or more surfaces (134) configured to contact and guide fluids within the closed system. The element further includes at least one UV light emitting diode (LED) (154) mounted in, on, or adjacent the at least one portion and has sufficient light output to sterilise at least the one or more surfaces (134).
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公开(公告)号：US11415241B2
公开(公告)日：2022-08-16
申请号：US17259709
申请日：2019-07-19
Applicant: Cytiva Sweden AB
Inventor： Prashanth Hosabettu Mohan , Ajit S. Vernekar , Praveen Paul , Krishnadev Madhavan Nair , Manjunath Bhat
Abstract: A valve (100) for a bioprocess liquid apparatus (199) comprises tubular sections (101, 102, 103) inside which valve seat means (155) are arranged. A plunger arrangement (150) is configured to selectively interact with the valve seat means to close and open the tubular sections in response to a magnetic field provided by solenoid arrangements (104, 105), the solenoid arrangements being arranged at the bioprocess liquid apparatus. A flow path device comprising such a valve and a bioprocess liquid apparatus and a method of handling a bioprocess liquid are also disclosed.
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公开(公告)号：US20220242903A1
公开(公告)日：2022-08-04
申请号：US17616577
申请日：2020-06-11
Applicant: CYTIVA SWEDEN AB
Inventor： Niklas JUNGNELIUS , Andreas CASTAN
Abstract: The present disclosure is directed to method (100) for separating a biomolecule from a fluid (2), wherein the biomolecule is produced by biological cells in a perfusion bioreactor (3), the method comprising: forwarding (110) a product fluid comprising the biomolecule and biological cells from the perfusion bioreactor (3) during a bioreactor product output time period; loading (210) a first separation device (4) with the product fluid obtained in step (110) during a first separation loading time period, which constitutes a first part of a first separation cycle time period; pausing (130) the forwarding of the product fluid from the perfusion bioreactor during a bioreactor non-product output time period; and pausing (220) the loading of the first separation device (4) during a second part of the first separation cycle time period. Also disclosed are a computer-implemented method performed by a controller configured to control a separation of a biomolecule from a fluid (2), and further a controller, a computer program, and a computer program product.
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Patent Agency Ranking
公开(公告)号：US20220229052A1
公开(公告)日：2022-07-21
申请号：US17437118
申请日：2020-03-23
Applicant: Cytiva Sweden AB
Inventor： Ola Lind , Nils Norrman , Sara Häggblad Sahlberg , Ronnie Palmgren
IPC: G01N33/543 , G01N30/92
Abstract: The present disclosure is directed to a method for separating a biomolecule from a cell culture or from a biological solution, comprising the steps of: (a) providing magnetic particles comprising ligands capable of binding the biomolecule; (b) contacting a cell culture or a biological solution comprising the biomolecule with the magnetic particles to obtain magnetic particles comprising the bound biomolecule; (c) retaining the magnetic particles with a magnetic field in a magnetic separator; (d) optionally washing the magnetic particles with a washing liquid; (e1) providing a flow of an elution liquid through the magnetic separator to elute the bound biomolecule from the magnetic particles while retaining the magnetic particles with the magnetic field in the magnetic separator; (f1) forwarding the biomolecule eluted from the magnetic separator to a membrane chromatography device; (g1) separating the biomolecule from impurities and/or contaminants by membrane chromatography.
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公开(公告)号：US20220205960A1
公开(公告)日：2022-06-30
申请号：US17690975
申请日：2022-03-09
Applicant: Cytiva Sweden AB
Inventor： Klaus Gebauer
Abstract: The invention relates to containers or bags for chromatographic media and methods of packing chromatography columns using such containers. The bags may be used for storing and/or transporting chromatographic media and can be inserted directly into the chamber of a chromatography column in readiness for
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158.发明申请公开(公告)号：US20220137039A1
公开(公告)日：2022-05-05
申请号：US17577138
申请日：2022-01-17
Applicant: CYTIVA SWEDEN AB
Inventor： Olof Karlsson
IPC: G01N33/543 , G01N33/557
Abstract: The present invention relates to a method for evaluation of an interaction between an analyte in a fluid sample and a ligand immobilized on a sensor surface of a biosensor, comprising the steps of providing (101) a plurality of fluid samples, each containing known concentrations of analyte providing (102) a plurality of needles and a plurality of sensor surfaces or detection spots, at least some of the sensor surfaces or detection spots having a known amount of ligand immobilized thereon, and each needle being configured to inject a fluid sample to a sensor surface or detection spots dividing (103) said plurality of fluid samples into at least two groups injecting (104) the fluid samples of a first of said groups to the sensor surfaces or detection spots by means of the needles to permit association of the analyte to the ligand monitoring (104) each sensor surface or detection spot and collecting binding data, and repeating (105) the steps of injecting fluid samples and monitoring detection spots and collecting binding data for each group of fluid samples, wherein the steps above are performed sequentially, without intermediate regeneration or renewal of the immobilized ligand. The invention also relates to a biosensor system for evaluation of an interaction between an analyte in a fluid sample and a ligand immobilized on a sensor surface, to software for performing the steps of the method and to a computer readable medium for storing said software.
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公开(公告)号：US11255829B2
公开(公告)日：2022-02-22
申请号：US15763520
申请日：2016-09-29
Applicant: Cytiva Sweden AB
Inventor： Helena Skoglar , Bjorn Olovsson
Abstract: The present invention relates to a chromatography system and a method therefor. The chromatography system comprising an inlet port (102) for receiving a sample, an outlet port (106) for delivering the sample, a detector (201), a column (104), and a valve (202) in fluid communication with the inlet port, the outlet port, the detector, and the column. The valve (202) comprises a first position (304) wherein the inlet port is in fluid communication with the outlet port via a first fluid path comprising the detector and the column, wherein the detector is arranged upstream the column. The valve comprises a second position (404) wherein the inlet port is in fluid communication with the outlet port via a second fluid path comprising the detector and the column, wherein the detector is arranged downstream the column.
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公开(公告)号：US20220034748A1
公开(公告)日：2022-02-03
申请号：US17276981
申请日：2019-09-09
Applicant: Cytiva Sweden AB
Inventor： Sameera Simha Hindupur , Manoj Kumar Ramakrishna , Andreas Castan , Swapnil Puranik , Klaus Gebauer
Abstract: The present invention relates to a computer implemented method for determining a weld integrity test result performed by a system configured to aseptically transferring cells to a container (BR), the method comprising welding (710) a vial to a connector to obtain a fluid-tight seal between the vial (V) and a connector (C), the connector being provided with a pair of conduits each having one end protruding through the connector and into the vial, sealing (720) an opposite end of one of the conduits, generating (730) a fluid pressure different to an ambient fluid pressure at an opposite end of the other conduit, measuring (740) a fluid pressure within at least one of the conduits, determining (750) a fluid pressure change based on the ambient pressure and the measured fluid pressure, determining (760) the weld integrity test result as pass or as fail based on the fluid pressure change.
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