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    Epinecidin-1 as a vaccine adjuvant for enhancing immune responses
    154.
    发明授权
    Epinecidin-1 as a vaccine adjuvant for enhancing immune responses 有权
    Epinecidin-1作为用于增强免疫应答的疫苗佐剂

    公开(公告)号：US08361483B2

    公开(公告)日：2013-01-29

    申请号：US13070197

    申请日：2011-03-23

    Applicant: Jyh-Yih Chen ,  Chang-Jer Wu

    Inventor： Jyh-Yih Chen ,  Chang-Jer Wu

    IPC: A61K45/00 ,  A61K39/193 ,  A61K39/12 ,  A61K39/00

    CPC classification number: A61K39/12 ,  A61K39/39 ,  A61K2039/5252 ,  A61K2039/55516 ,  C12N2770/24134 ,  Y02A50/39

    Abstract: A method of enhancing a mammalian immune response to a virus is disclosed. The method comprises administering a composition comprising an effective amount of epinecidin (Epi)-1 and the virus to a mammal, wherein the virus has envelope protein and is infectious to the mammal. A vaccine kit and a method for preventing Japanese encephalitis virus (JEV) infection are also disclosed.

    Abstract translation: 公开了增强对病毒的哺乳动物免疫应答的方法。 该方法包括向哺乳动物施用包含有效量的抗坏血酸（Epi）-1和病毒的组合物，其中所述病毒具有包膜蛋白并且对哺乳动物具有感染性。 还公开了疫苗试剂盒和预防日本脑炎病毒（JEV）感染的方法。

    Molecular ion accelerator
    158.
    发明授权
    Molecular ion accelerator 有权
    分子离子加速器

    公开(公告)号：US08344317B2

    公开(公告)日：2013-01-01

    申请号：US13365105

    申请日：2012-02-02

    Applicant: Chung-Hsuan Chen ,  Jung-Lee Lin ,  Nien-Yeen Hsu ,  Yi-Sheng Wang

    Inventor： Chung-Hsuan Chen ,  Jung-Lee Lin ,  Nien-Yeen Hsu ,  Yi-Sheng Wang

    IPC: H01J49/26 ,  H01J49/40

    CPC classification number: H05H5/047 ,  H01J49/06 ,  H01J49/40 ,  H01J49/403

    Abstract: A novel system and methods for accelerating analytes including, without limitation, molecular ions, biomolecules, polymers, nano- and microparticles, is provided. The invention can be useful for increasing detection sensitivity in applications such as mass spectrometry, performing collision-induced dissociation molecular structure analysis, and probing surfaces and samples using accelerated analyte.

    Abstract translation: 提供了一种用于加速分析物的新系统和方法，包括但不限于分子离子，生物分子，聚合物，纳米和微粒。 本发明可用于在诸如质谱法，进行碰撞诱导的解离分子结构分析和使用加速分析物的探测表面和样品等应用中提高检测灵敏度。

    MULTI-AXIS ACTUATING APPARATUS
    159.
    发明申请
    MULTI-AXIS ACTUATING APPARATUS 有权
    多轴动作装置

    公开(公告)号：US20120306317A1

    公开(公告)日：2012-12-06

    申请号：US13252842

    申请日：2011-10-04

    Applicant: En-Te Hwu ,  Ing-Shouh Hwang

    Inventor： En-Te Hwu ,  Ing-Shouh Hwang

    IPC: H01L41/00

    CPC classification number: G01Q10/04

    Abstract: A multi-axis actuating apparatus for a nano-positioning apparatus includes a movable element attached to a sample platform, a plurality of driving elements, and a plurality of actuators. The driving elements frictionally engage the movable element and are configured to selectively move the movable element along a first direction. The plurality of actuators move the plurality of driving elements when driving signals are applied to the plurality of actuators. Different driving signals may be applied to the plurality of actuators to cause different movement of the driving elements such that the movable element has different displacements in different directions along the plurality of driving elements. The movable element is titled due to the different displacements.

    Abstract translation: 用于纳米定位装置的多轴致动装置包括附接到样品平台的可移动元件，多个驱动元件和多个致动器。 驱动元件摩擦地接合可移动元件并被构造成沿着第一方向选择性地移动可移动元件。 当驱动信号被施加到多个致动器时，多个致动器移动多个驱动元件。 可以将不同的驱动信号施加到多个致动器以引起驱动元件的不同移动，使得可移动元件在沿着多个驱动元件的不同方向上具有不同的位移。 可移动元件由于不同的位移而被标题。

    Non-human animal model for frontotemporal lobar degeneration with ubiquitin-positive inclusions (FTLD-U)
    160.
    发明授权
    Non-human animal model for frontotemporal lobar degeneration with ubiquitin-positive inclusions (FTLD-U) 有权
    具有泛素阳性包涵体（FTLD-U）的额颞叶变性的非人动物模型

    公开(公告)号：US08324450B2

    公开(公告)日：2012-12-04

    申请号：US12785653

    申请日：2010-05-24

    Applicant: Che-Kun James Shen ,  Kuen-Jer Tsai

    Inventor： Che-Kun James Shen ,  Kuen-Jer Tsai

    IPC: G01N33/68 ,  A01K67/027 ,  C12N5/079

    CPC classification number: C12N15/8509 ,  A01K67/0275 ,  A01K2217/052 ,  A01K2217/206 ,  A01K2227/105 ,  A01K2267/0356 ,  C12N5/0618

    Abstract: Non-human animal models for frontotemporal lobar degeneration with ubiquitin-positive inclusions (FTLD-U) are disclosed. The invention relates to a transgenic mouse whose genome comprises a transgene operably linked to a neuronal specific promoter effective for an increased expression of the transgene in the brain of the mouse, in which the transgene comprises a nucleotide sequence encoding TAR DNA-binding protein 43 (TDP-43). The transgenic mouse exhibits reduced or impaired learning and memory capacity, and may further exhibits progressively impaired or reduced motor functions. Methods of using such animal models are also disclosed.

    Abstract translation: 公开了具有泛素阳性夹杂物（FTLD-U）的额颞叶变性的非人动物模型。 本发明涉及一种转基因小鼠，其基因组包含可操作地连接到有效增加小鼠脑中转基因表达的神经元特异性启动子的转基因，其中转基因包含编码TAR DNA结合蛋白43的核苷酸序列（ TDP-43）。 转基因小鼠表现出减少或受损的学习和记忆能力，并且可能进一步显示出逐渐受损或减少的运动功能。 还公开了使用这种动物模型的方法。

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