公开(公告)号：US10415537B2

公开(公告)日：2019-09-17

申请号：US15837885

申请日：2017-12-11

Applicant: National Technology & Engineering Solutions of Sandia, LLC ,  Michigan Technological University ,  South Dakota Board of Regents

Inventor： Ossama Abdelkhalik ,  Rush D. Robinett, III ,  Shangyan Zou ,  David G. Wilson ,  Giorgio Bacelli ,  Umesh Korde ,  Ryan G. Coe

IPC: F03B13/10 ,  F03B13/12 ,  F03B13/18 ,  F03B15/00 ,  G06F1/02 ,  F03B13/16

Abstract: A parametric excitation dynamic model is used for a three degrees-of-freedom (3-DOF) wave energy converter. Since the heave motion is uncoupled from the pitch and surge modes, the pitch-surge equations of motion can be treated as a linear time varying system, or a linear system with parametric excitation. In such case the parametric exciting frequency can be tuned to twice the natural frequency of the system for higher energy harvesting. A parametric excited 3-DOF wave energy converter can harvest more power, for both regular and irregular waves, compared to the linear 3-DOF. For example, in a Bretschneider wave, the harvested energy in the three modes is about 3.8 times the energy harvested in the heave mode alone; while the same device produces about 3.1 times the heave mode energy when using a linear 3-DOF model.

公开(公告)号：US20190206599A1

公开(公告)日：2019-07-04

申请号：US16294656

申请日：2019-03-06

Applicant: South Dakota Board of Regents

Inventor： Rajesh V. Shende

IPC: H01F1/36 ,  C01B3/06

CPC classification number: H01F1/36 ,  B82Y25/00 ,  B82Y40/00 ,  C01B3/06 ,  Y02E60/36

Abstract: The present disclosure addresses limitations in ferritic materials. In at least one aspect, the present disclosure provides core-shell nanoparticles exhibiting improved characteristics for implementations and adaptability in numerous applications. Further aspects of the disclosure provide core-shell nanoparticles for use in electronic, magnetic and electro-magnetic applications. Still, other aspects of the present disclosure provide core-shell nanoparticles for a thermochemical water-splitting reaction resulting in increased H2 volume generation during multiple thermochemical cycles.

公开(公告)号：US09981034B2

公开(公告)日：2018-05-29

申请号：US15131989

申请日：2016-04-18

Applicant: South Dakota Board of Regents

Inventor： Victor Huber ,  Ying Fang

IPC: A61K39/145 ,  A61K39/12 ,  A61K39/00

CPC classification number: A61K39/145 ,  A61K39/12 ,  A61K2039/5254 ,  A61K2039/5256 ,  A61K2039/53 ,  A61K2039/55 ,  A61K2039/552 ,  A61K2039/575 ,  C12N2760/16121 ,  C12N2760/16122 ,  C12N2760/16134 ,  C12N2760/16141

Abstract: Disclosed herein are compositions and methods useful for immunizing a subject against disease caused by influenza A. Disclosed methods comprise administering to the subject an immunoprotective dose of an immunogenic composition. In certain aspects, the immunogenic composition is a vaccine comprised of a recombinant chimeric hemagglutinin polypeptide. In certain aspects, the subject is a mammal. In further aspects, the mammal is a pig. In still further aspects, the mammal is a human.

公开(公告)号：US09809522B2

公开(公告)日：2017-11-07

申请号：US15263141

申请日：2016-09-12

Applicant: South Dakota Board of Regents

Inventor： Alevtina Smirnova ,  Chris Lynde ,  Abu Md Numan-Al-Mobin ,  Rudresh Bommadihalli Rajappagowda

IPC: C07C45/00 ,  C07C41/00 ,  C07C41/18 ,  C07C45/59 ,  C07C27/00

CPC classification number: C07C41/18 ,  C07C27/00 ,  C07C45/59 ,  Y02P20/544 ,  C07C43/23 ,  C07C47/58

Abstract: Disclosed herein are methods for selective synthesis of specific phenolic products by means biomass or biomass products liquefaction, manipulation of the said selectivity in favor of one specific phenolic compound or a mixture of specific phenolic compounds, and the synthesis of the phenolic compounds from a liquid or biomass organic fraction produced in presence of a homogeneous catalyst in supercritical state or a mixture of said homogeneous and one or several heterogeneous catalysts mixed with water in sub-critical, near-critical, or supercritical condition.

公开(公告)号：US20170182700A1

公开(公告)日：2017-06-29

申请号：US15307196

申请日：2016-08-11

Applicant: SOUTH DAKOTA BOARD OF REGENTS

Inventor： Andrew T. Brady ,  Bert D. Mannhalter ,  David R. Salem

IPC: B29C47/12 ,  B32B27/06 ,  B32B15/04 ,  B32B37/14

CPC classification number: B29C48/30 ,  B29B7/005 ,  B29B7/007 ,  B29B7/46 ,  B29B7/603 ,  B29B7/726 ,  B29B7/82 ,  B29B7/845 ,  B29B7/90 ,  B29C43/24 ,  B29C48/0018 ,  B29C48/0022 ,  B29C48/05 ,  B29C48/08 ,  B29C48/21 ,  B29C48/2886 ,  B29C48/35 ,  B29C48/402 ,  B29C48/475 ,  B29C48/625 ,  B29C48/761 ,  B29C48/92 ,  B29L2007/002 ,  B32B5/02 ,  B32B5/08 ,  B32B5/26 ,  B32B7/02 ,  B32B15/04 ,  B32B15/14 ,  B32B27/06 ,  B32B27/12 ,  B32B37/1018 ,  B32B37/142 ,  B32B2260/021 ,  B32B2260/023 ,  B32B2260/046 ,  B32B2262/02 ,  B32B2262/0269 ,  B32B2262/101 ,  B32B2262/105 ,  B32B2262/106 ,  B32B2262/14 ,  B32B2305/22 ,  B32B2307/202 ,  B32B2307/302 ,  B32B2307/54 ,  B32B2307/546 ,  B32B2605/00 ,  B32B2607/00 ,  C08K7/02 ,  C08K7/06 ,  C08K7/14 ,  C08L23/12 ,  C08L51/06 ,  C08L77/02

Abstract: The invention relates to compositions comprising composite materials comprised of discontinuous fibers and one or more polymers and/or oligomers. The invention relates to methods of making the same. The composite materials can be in the form of compositions, composite sheets, laminates, pellets, and/or shaped composite products.

公开(公告)号：US09556113B2

公开(公告)日：2017-01-31

申请号：US14699946

申请日：2015-04-29

Applicant: The South Dakota Board of Regents ,  Sanford Research

Inventor： Xiangming Guan ,  Chandrahar Dwivedi ,  Yinghong Li ,  Yang Yang ,  John H. Lee ,  Wilson Keith Miskimins

IPC: C07C235/74 ,  A61K45/06 ,  A61N5/10 ,  A61K31/225 ,  C07C233/56 ,  A61K33/24 ,  A61K9/00 ,  A61K47/02 ,  A61K47/10 ,  A61K47/14 ,  A61K47/18 ,  A61K47/26 ,  A61K9/06 ,  A61K47/32 ,  A61K9/08 ,  A61K47/38 ,  A61K47/44 ,  A61K9/20 ,  A61K9/48

CPC classification number: C07C235/74 ,  A61K9/0019 ,  A61K9/008 ,  A61K9/06 ,  A61K9/08 ,  A61K9/2018 ,  A61K9/2027 ,  A61K9/2054 ,  A61K9/2059 ,  A61K9/4858 ,  A61K9/4866 ,  A61K31/225 ,  A61K33/24 ,  A61K45/06 ,  A61K47/02 ,  A61K47/10 ,  A61K47/14 ,  A61K47/18 ,  A61K47/26 ,  A61K47/32 ,  A61K47/38 ,  A61K47/44 ,  A61N5/10 ,  A61N2005/1098 ,  C07C233/56 ,  A61K2300/00

Abstract: The invention novel compounds, pharmaceutical compositions and methods useful for preventing or treating cancer in animals and humans. Also, the invention provides novel prodrugs useful for reducing tumor size, and inhibiting the growth of cancers, inhibiting tumor cell growth and tumor cell proliferation, and promoting apoptosis of tumor cells. When used in combination with chemoradiation therapy, the novel compounds, compositions and prodrugs provided herein can improve the effectiveness of chemoradiation therapy. The novel compounds, compositions and prodrugs of the invention inhibit PDK and LDH in unique and effective ways.

Abstract translation: 本发明的新颖化合物，药物组合物和可用于预防或治疗动物和人类癌症的方法。 此外，本发明提供了可用于减少肿瘤大小，抑制癌细胞生长，抑制肿瘤细胞生长和肿瘤细胞增殖以及促进肿瘤细胞凋亡的新型前体药物。 当与放化疗联合使用时，本文提供的新型化合物，组合物和前药可以提高放化疗方案的有效性。 本发明的新颖化合物，组合物和前药以独特和有效的方式抑制PDK和LDH。

公开(公告)号：US09478361B2

公开(公告)日：2016-10-25

申请号：US14477344

申请日：2014-09-04

Applicant: South Dakota Board of Regents

Inventor： Brian A. Logue ,  Mahdi Farrakh Baroughi ,  Venkataiah Mallam

IPC: H01G9/20 ,  B05D1/00 ,  C23C16/448 ,  C23C14/12 ,  B05D1/18

CPC classification number: H01G9/2059 ,  B05D1/185 ,  B05D1/60 ,  C23C14/12 ,  C23C16/4485 ,  H01G9/2031 ,  Y02E10/542

Abstract: Self-assembled monolayer hybrid materials having a modified carboxylic acid deposited from the gas-phase onto a metal oxide substrate, methods of using targeted α-carbon modified carboxylic acids to rapidly deposit activated organic molecules into a self-assembled monolayer on metal oxide substrates, and the self-assembled monolayer hybrid materials capable of being used in various industries, such as optoelectronics and separation science.

Abstract translation: 具有从气相沉积到金属氧化物基底上的改性羧酸的自组装单层混合材料，使用目标α-碳改性羧酸将激活的有机分子快速沉积到金属氧化物基底上的自组装单层中的方法， 以及能够用于各种行业的自组装单层混合材料，如光电子学和分离科学。

公开(公告)号：US20160153117A1

公开(公告)日：2016-06-02

申请号：US14900426

申请日：2014-06-20

Applicant: SOUTH DAKOTA BOARD OF REGENTS

Inventor： Guojian Wang ,  Dongming Mei

IPC: C30B15/28 ,  C30B29/08 ,  C30B15/10

CPC classification number: C30B15/28 ,  C30B15/10 ,  C30B29/08

Abstract: In accordance with the present invention, taught is a high purity germanium crystal growth method utilizing a quartz shield inside a steel furnace. The quartz shield is adapted for not only guiding the flow of an inert gas but also preventing the germanium melt from contamination by insulation materials, graphite crucible, induction coil and stainless steel chamber. A load cell provides automatic control of crystal diameter and helps to ensure exhaustion of the germanium melt. The method is both convenient and effective at producing high purity germanium crystals by relatively low skilled operators.

Abstract translation: 根据本发明，教导了在钢炉内使用石英屏蔽的高纯度锗晶体生长方法。 石英屏蔽适用于不仅引导惰性气体的流动，而且还防止锗熔体受绝缘材料，石墨坩埚，感应线圈和不锈钢室的污染。 称重传感器可自动控制晶体直径，有助于确保锗熔体的耗尽。 该方法既方便又有效地通过相对低的熟练操作者生产高纯锗晶体。

公开(公告)号：US20150139888A1

公开(公告)日：2015-05-21

申请号：US14551348

申请日：2014-11-24

Applicant: Hao Fong ,  Lifeng Zhang ,  Yong Zhao ,  Zhengtao Zhu

Inventor： Hao Fong ,  Lifeng Zhang ,  Yong Zhao ,  Zhengtao Zhu

IPC: C01B31/30 ,  D01D5/00

CPC classification number: D04H1/728 ,  B82Y30/00 ,  B82Y40/00 ,  C01B32/921 ,  C01P2004/16 ,  C04B35/5611 ,  C04B35/62277 ,  C04B35/634 ,  C04B2235/3843 ,  C04B2235/422 ,  C04B2235/425 ,  C04B2235/441 ,  C04B2235/5264 ,  C04B2235/77 ,  C04B2235/781 ,  C04B2235/80 ,  D01D5/0007 ,  D01F9/12 ,  D04H1/4209 ,  D04H1/4382 ,  D10B2101/14 ,  H01G11/36 ,  Y10T442/50

Abstract: A method of synthesizing mechanically resilient titanium carbide (TiC) nanofibrous felts comprising continuous nanofibers or nano-ribbons with TiC crystallites embedded in carbon matrix, comprising: (a) electrospinning a spin dope for making precursor nanofibers with diameters less than 0.5 J·Lm; (b) overlaying the nanofibers to produce a nano-fibrous mat (felt); and then (c) heating the nano-felts first at a low temperature, and then at a high temperature for making electrospun continuous nanofibers or nano-ribbons with TiC crystallites embedded in carbon matrix; and (d) chlorinating the above electrospun nano-felts at an elevated temperature to remove titanium for producing carbide derived carbon (CDC) nano-fibrous felt with high specific surface areas.

Abstract translation: 一种合成机械弹性的碳化钛（TiC）纳米纤维毡的方法，包括连续的纳米纤维或具有嵌入碳基体中的TiC微晶的纳米带，其包括：（a）静电纺丝纺丝原液以制备直径小于0.5J·Lm的前体纳米纤维; （b）覆盖纳米纤维以产生纳米纤维垫（毡）; 然后（c）首先在低温下，然后在高温下加热纳米毡，以使电纺丝连续纳米纤维或纳米带与嵌入碳基体中的TiC微晶; 和（d）在升高的温度下氯化上述电纺丝纳米毡以除去钛，以生产具有高比表面积的碳化物衍生碳（CDC）纳米纤维毡。

公开(公告)号：US08623156B1

公开(公告)日：2014-01-07

申请号：US13091385

申请日：2011-04-21

Applicant: Christopher Haines ,  Deepak Kapoor ,  Jan Puszynski ,  Rajesh Shende ,  Zac Doorenbos ,  Lori Groven

Inventor： Christopher Haines ,  Deepak Kapoor ,  Jan Puszynski ,  Rajesh Shende ,  Zac Doorenbos ,  Lori Groven

IPC: C06B45/00 ,  C06B45/18 ,  C06B45/30 ,  D03D23/00 ,  D03D43/00

CPC classification number: C06C15/00 ,  C06B45/14

Abstract: An improved method for the production of pyrophoric materials which does not employ hot NaOH and produces pyrophoric materials on various types of ceramic, metal, nanomaterial substrates. The method impregnates the substrate materials with pyrophoric iron or other materials resulting in materials that are “tunable” with respect to its pyrophoric output as determined by its temperature, rise time sustenance etc through selective variation of particle size, morphology, and diluents or reactive materials.

Abstract translation: 一种用于生产不使用热NaOH并且在各种类型的陶瓷，金属，纳米材料基底上产生自发性材料的自燃材料的改进方法。 该方法用自燃铁或其他材料浸渍基材，导致相对于其自燃输出“可调谐”的材料，通过其温度，上升时间维持等通过颗粒尺寸，形态和稀释剂或反应性材料的选择性变化来确定 。