公开(公告)号：US20090105777A1

公开(公告)日：2009-04-23

申请号：US12249856

申请日：2008-10-10

申请人： Yanting Dong ,  Xuan Wei ,  Ankur Garg ,  Quan Ni

发明人： Yanting Dong ,  Xuan Wei ,  Ankur Garg ,  Quan Ni

IPC分类号： A61N1/39 ,  A61N1/365 ,  A61N1/08

CPC分类号： A61N1/365 ,  A61N1/36585 ,  A61N1/37211 ,  A61N1/37264 ,  A61N1/37282 ,  G06F19/00 ,  G06F19/3418 ,  G06F19/3481

摘要： A remote external interface for an implantable cardiac function management device is configured to be communicatively coupled to the implantable cardiac function management device via a network to a local external interface and via telemetry between the local external interface and the implantable cardiac function management device. The remote external interface includes a communication circuit and a processor circuit. The communication circuit is configured to communicate with the implantable cardiac function management device. The processor circuit is configured to perform an analysis of physiologic data received from the implantable cardiac function management device in response to operation of the implantable cardiac function management device using a plurality of therapy control parameter sets. The processor circuit can be further configured to select a particular therapy control parameter set using the analysis.

摘要翻译： 用于可植入心脏功能管理装置的远程外部接口被配置为通过网络通信地耦合到可植入心脏功能管理装置到本地外部接口并且经由本地外部接口和可植入心脏功能管理装置之间的遥测。 远程外部接口包括通信电路和处理器电路。 通信电路被配置为与可植入心脏功能管理装置进行通信。 处理器电路被配置为响应于使用多个治疗控制参数组的可植入心脏功能管理装置的操作来执行从可植入心脏功能管理装置接收的生理数据的分析。 处理器电路可以进一步配置为使用分析来选择特定的治疗控制参数集。

公开(公告)号：US20090048637A1

公开(公告)日：2009-02-19

申请号：US12254631

申请日：2008-10-20

申请人： Quan Ni ,  Jiang Ding ,  Yinghong Yu ,  Douglas R. Daum ,  Julio C. Spinelli ,  Jeffrey E. Stahmann

发明人： Quan Ni ,  Jiang Ding ,  Yinghong Yu ,  Douglas R. Daum ,  Julio C. Spinelli ,  Jeffrey E. Stahmann

IPC分类号： A61N1/365

CPC分类号： A61N1/3627 ,  A61B5/053 ,  A61N1/36521 ,  A61N1/3682 ,  A61N1/3684

摘要： This document discusses, among other things, systems, devices, and methods measure an impedance and, in response, adjust an atrioventricular (AV) delay or other cardiac resynchronization therapy (CRT) parameter that synchronizes left and right ventricular contractions. A first example uses parameterizes a first ventricular volume against a second ventricular volume during a cardiac cycle, using a loop area to create a synchronization fraction (SF). The CRT parameter is adjusted in closed-loop fashion to increase the SF. A second example measures a septal-freewall phase difference (PD), and adjusts a CRT parameter to decrease the PD. A third example measures a peak-to-peak volume or maximum rate of change in ventricular volume, and adjusts a CRT parameter to increase the peak-to-peak volume or maximum rate of change in the ventricular volume.

摘要翻译： 本文件还讨论了系统，设备和方法测量阻抗，并作为响应调整房室（AV）延迟或同步左心室收缩和右心室收缩的其他心脏再同步治疗（CRT）参数。 第一个例子是使用循环区域创建同步分数（SF），在心动周期中使用第一心室容积对第二心室容积进行参数化。 CRT参数以闭环方式调整以增加SF。 第二个例子是测量隔层相位差（PD），并调整CRT参数以减少PD。 第三个例子测量峰 - 峰体积或最大心室容积变化率，并调整CRT参数以增加心室容积的峰 - 峰体积或最大变化率。

公开(公告)号：US07050854B2

公开(公告)日：2006-05-23

申请号：US10178277

申请日：2002-06-24

申请人： Douglas R. Daum ,  Quan Ni

发明人： Douglas R. Daum ,  Quan Ni

IPC分类号： A61N1/365

CPC分类号： A61N1/365

摘要： Calibration of adaptive-rate pacing by a cardiac rhythm management system using an intrinsic chronotropic response. The cardiac rhythm management system may include an adaptive-rate pacing device. The adaptive-rate pacing device may include an adaptive-rate sensor module for measuring an activity level of the individual. A monitor module may be coupled to the adaptive-rate sensor module, the monitor module monitoring an intrinsic chronotropic response. A calculator module may be coupled to the monitor module, the calculator module calculating a calibrated parameter for the adaptive-rate pacing device based on the intrinsic chronotropic response. An adjuster module may be coupled to the calculator module, wherein the adjuster module adjusts the adaptive-rate pacing device based on the calibrated parameter. The parameters of the adaptive-rate pacing device adjusted by the adjuster module may include a sensor rate target, a maximum sensor rate, and a response factor.

公开(公告)号：US20050197674A1

公开(公告)日：2005-09-08

申请号：US10795126

申请日：2004-03-05

申请人： Aaron McCabe ,  Avram Scheiner ,  Geng Zhang ,  Quan Ni ,  Douglas Daum

发明人： Aaron McCabe ,  Avram Scheiner ,  Geng Zhang ,  Quan Ni ,  Douglas Daum

IPC分类号： A61B5/0402 ,  A61N1/365 ,  A61N1/375 ,  A61N1/362

CPC分类号： A61B5/0402 ,  A61N1/365 ,  A61N1/3756

摘要： An implantable medical device such as an implantable pacemaker or implantable cardioverter/defibrillator includes a programmable sensing circuit providing for sensing of a signal approximating a surface electrocardiogram (ECG) through implanted electrodes. With various electrode configurations, signals approximating various standard surface ECG signals are acquired without the need for attaching electrodes with cables onto the skin. The various electrode configurations include, but are not limited to, various combinations of intracardiac pacing electrodes, portions of the implantable medical device contacting tissue, and electrodes incorporated onto the surface of the implantable medical device.

摘要翻译： 诸如可植入起搏器或植入式心律转复/除颤器的可植入医疗装置包括可编程感测电路，用于通过植入电极感测接近表面心电图（ECG）的信号。 通过各种电极配置，获取近似各种标准表面ECG信号的信号，而不需要将电极与电缆连接在皮肤上。 各种电极配置包括但不限于心脏内起搏电极，可植入医疗器械接触组织的部分和结合到可植入医疗装置的表面上的电极的各种组合。

公开(公告)号：US09888864B2

公开(公告)日：2018-02-13

申请号：US13634333

申请日：2011-03-10

申请人： John Rondoni ,  Mark A. Christopherson ,  Quan Ni

发明人： John Rondoni ,  Mark A. Christopherson ,  Quan Ni

IPC分类号： A61B5/053 ,  A61B5/04 ,  A61B5/0488 ,  A61B5/11 ,  A61B5/00 ,  A61N1/372 ,  A61B5/08 ,  A61B34/20 ,  A61N1/36 ,  A61B34/00

CPC分类号： A61B5/0536 ,  A61B5/04001 ,  A61B5/0488 ,  A61B5/08 ,  A61B5/1104 ,  A61B5/4519 ,  A61B5/4818 ,  A61B5/4893 ,  A61B5/6814 ,  A61B5/682 ,  A61B5/6822 ,  A61B5/6839 ,  A61B5/6843 ,  A61B5/6849 ,  A61B5/7425 ,  A61B5/7435 ,  A61B34/20 ,  A61B34/25 ,  A61B2034/2065 ,  A61B2505/05 ,  A61B2562/043 ,  A61N1/36 ,  A61N1/372 ,  A61N1/37241 ,  A61N1/37247

摘要： A system and method for identifying a stimulation location on a nerve is disclosed. The system includes an image-based navigation interface used to facilitate advancing a stimulation element within a patient body toward a target nerve stimulation site. Using the system one determines, separately for each potential target nerve stimulation site, a neuromuscular response of muscles produced upon applying a stimulation signal at the respective separate potential target stimulation sites. The image-based navigation interface is configured to display a graphic identification of which muscles were activated for each respective potential target nerve stimulation site upon applying the stimulation signal.

公开(公告)号：US20110295136A1

公开(公告)日：2011-12-01

申请号：US13205387

申请日：2011-08-08

申请人： Greg Zhang ,  Douglas R. Daum ,  James O. Gilkerson ,  Quan Ni

发明人： Greg Zhang ,  Douglas R. Daum ,  James O. Gilkerson ,  Quan Ni

IPC分类号： A61N1/365 ,  A61B5/0452 ,  A61N1/37

CPC分类号： A61N1/371 ,  A61N1/3621 ,  A61N1/3756

摘要： An implantable pacemaker is provided with a far-field sensing channel which requires a reduced refractory period during the time when pacing pulses are delivered as compared with sensing channels using intra-cardiac electrodes. The far-field sensing channel may use the conductive housing of the implantable device or can and an indifferent electrode mounted on the device header as the electrodes for its differential inputs. Such a far-field sensing channel is able to sense activity occurring in either the atria or the ventricles for the purposes of arrhythmia detection and/or capture verification.

摘要翻译： 植入式心脏起搏器设置有远场感测通道，与使用心脏内电极的感测通道相比，在进行起搏脉冲的时间期间需要减少的不应期。 远场感测通道可以使用可植入装置的导电外壳或者可以将安装在设备头上的无关电极用作其差分输入的电极。 为了心律失常检测和/或捕获验证的目的，这种远场感测通道能够感测在心房或心室中发生的活动。

公开(公告)号：US20100010556A1

公开(公告)日：2010-01-14

申请号：US12487266

申请日：2009-06-18

申请人： Weiying Zhao ,  Quan Ni ,  Stephen Ruble ,  Jason J. Hamann

发明人： Weiying Zhao ,  Quan Ni ,  Stephen Ruble ,  Jason J. Hamann

IPC分类号： A61N1/36

CPC分类号： A61N1/36114 ,  A61N1/0551 ,  A61N1/36053 ,  A61N1/36117 ,  A61N1/36592 ,  A61N1/3712

摘要： According to various method embodiments, a person is indicated for a therapy to treat a cardiovascular disease, and the therapy is delivered to the person to treat the cardiovascular disease. Delivering the therapy includes delivering a vagal stimulation therapy (VST) to a vagus nerve of the person at a therapeutically-effective intensity for the cardiovascular disease that is below an upper boundary at which upper boundary the VST would lower an intrinsic heart rate during the VST.

摘要翻译： 根据各种方法实施例，指示一个人用于治疗心血管疾病的治疗，并且将该治疗递送给该人以治疗心血管疾病。 提供治疗包括将迷走神经刺激治疗（VST）以对于心血管疾病的治疗有效强度的人的迷走神经递送，所述心血管疾病低于VST在VST期间的上边界降低内在心率的上边界 。

公开(公告)号：US07606616B2

公开(公告)日：2009-10-20

申请号：US11276530

申请日：2006-03-03

申请人： Douglas R. Daum ,  Quan Ni

发明人： Douglas R. Daum ,  Quan Ni

IPC分类号： A61N1/365

CPC分类号： A61N1/365

摘要： Calibration of adaptive-rate pacing by a cardiac rhythm management system using an intrinsic chronotropic response. The cardiac rhythm management system may include an adaptive-rate pacing device. The adaptive-rate pacing device may include an adaptive-rate sensor module for measuring an activity level of the individual. A monitor module may be coupled to the adaptive-rate sensor module, the monitor module monitoring an intrinsic chronotropic response. A calculator module may be coupled to the monitor module, the calculator module calculating a calibrated parameter for the adaptive-rate pacing device based on the intrinsic chronotropic response. An adjuster module may be coupled to the calculator module, wherein the adjuster module adjusts the adaptive-rate pacing device based on the calibrated parameter. The parameters of the adaptive-rate pacing device adjusted by the adjuster module may include a sensor rate target, a maximum sensor rate, and a response factor.

摘要翻译： 使用内在的时间延迟响应通过心律管理系统校准自适应起搏。 心律管理系统可以包括自适应速率起搏装置。 自适应速率起搏装置可以包括用于测量个人的活动水平的自适应速率传感器模块。 监视器模块可以耦合到自适应速率传感器模块，监视器模块监视固有的时间变化响应。 计算器模块可以耦合到监视器模块，计算器模块基于固有的时间变化响应来计算自适应速率起搏装置的校准参数。 调节器模块可以耦合到计算器模块，其中调节器模块基于校准参数来调整自适应速率起搏装置。 由调节器模块调整的自适应速率起搏装置的参数可以包括传感器速率目标，最大传感器速率和响应因子。

公开(公告)号：US20080234774A1

公开(公告)日：2008-09-25

申请号：US11687957

申请日：2007-03-19

申请人： Tamara Colette Baynham ,  Quan Ni ,  Shelley Cazares ,  Kevin J. Stalsberg

发明人： Tamara Colette Baynham ,  Quan Ni ,  Shelley Cazares ,  Kevin J. Stalsberg

IPC分类号： A61N1/368

CPC分类号： A61N1/3627 ,  A61N1/36585 ,  A61N1/368 ,  A61N1/3682 ,  A61N1/3684

摘要： Cardioprotective pre-excitation pacing may be applied to stress or de-stress a particular myocardial region delivering of pacing pulses in a manner that causes a dyssynchronous contraction. Such dyssynchronous contractions are responsible for the desired cardioprotective effects of pre-excitation pacing but may also be hazardous. Described herein is a method and system that uses measures of ventricular dyssynchrony or a patient's physiological response to ventricular dyssynchrony to control the delivery of cardioprotective pre-excitation pacing in closed-loop fashion.

摘要翻译： 心脏保护性预激发起搏可用于以导致同步收缩的方式对起搏脉冲递送的特定心肌区域应力或去应激。 这种异常收缩负责预激励起搏的所需心脏保护作用，但也可能是危险的。 本文描述了一种方法和系统，其使用心室不同步或患者对心室不同步的生理反应的测量来控制以闭环方式递送心脏保护性预激发起搏。

公开(公告)号：US20080234773A1

公开(公告)日：2008-09-25

申请号：US11690700

申请日：2007-03-23

申请人： Quan Ni ,  Christopher Hartemink ,  Andres Belalcazar ,  Allan C. Shuros ,  Loell Boyce Moon

发明人： Quan Ni ,  Christopher Hartemink ,  Andres Belalcazar ,  Allan C. Shuros ,  Loell Boyce Moon

IPC分类号： A61N1/05

CPC分类号： A61N1/36521 ,  A61B5/0031 ,  A61B5/053 ,  A61B5/0538 ,  A61B5/11 ,  A61B5/686 ,  A61B5/6869 ,  A61N1/3627 ,  A61N1/3684

摘要： An apparatus comprises a first impedance sensing circuit, a second sensing circuit, and an impedance-based cardiac dyssynchrony detector. The impedance sensing circuit senses an intracardiac local impedance signal that is indicative of a cardiac local wall motion of a first cardiac region from an implantable first bipolar pair of impedance sensing electrodes. The second sensing circuit is configured to produce a second sensor signal indicative of cardiovascular activity. The impedance-based cardiac dyssynchrony detector is configured for detecting cardiac dyssynchrony using a relationship between the first intracardiac local impedance signal and the second sensor signal. Other apparatuses and methods are disclosed.

摘要翻译： 一种装置包括第一阻抗感测电路，第二感测电路和基于阻抗的心脏不同步检测器。 阻抗感测电路感测指示来自可植入的第一双极对阻抗感测电极的第一心脏区域的心脏局部壁运动的心内局部阻抗信号。 第二感测电路被配置为产生指示心血管活动的第二传感器信号。 基于阻抗的心脏不同步检测器被配置为使用第一心内局部阻抗信号和第二传感器信号之间的关系来检测心脏不同步。 公开了其他装置和方法。