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公开(公告)号：US10829464B2
公开(公告)日：2020-11-10
申请号：US16461234
申请日：2017-11-17
Applicant: EAST CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY , SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES
Inventor： Jian Li , Lefu Lan , Baoli Li , Feifei Chen , Shuaishuai Ni , Yifu Liu , Hanwen Wei , Fei Mao , Jin Zhu
IPC: C07D307/81 , A61P31/04 , A61P31/10 , C07D307/82 , C07D333/58 , C07D409/12
Abstract: Disclosed are benzoheterocyclic alkylamine compounds, or a pharmaceutically acceptable salt thereof, or a stereoisomer thereof, and a preparation method thereof, and use of the same in the manufacture of an antibacterial drug as an inhibitor of staphyloxanthin synthesis in Staphylococcus aureus.
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公开(公告)号：US20200163983A1
公开(公告)日：2020-05-28
申请号：US16630309
申请日：2018-07-12
Applicant: EAST CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY , YUNNAN UNIVERSITY , SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES
Inventor： Honglin LI , Weilie XIAO , Lili ZHU , Lina QUAN , Qiao LI , Yanyan DIAO , Zhenjiang ZHAO , Hualiang JIANG
IPC: A61K31/704 , A61P35/00 , A61K31/56
Abstract: Provided are use of a saponin compound of formula (I) or (II), or a pharmaceutically acceptable salt, prodrug or solvate thereof, in the manufacture of a medicament targeting PD-1. The medicament targeting PD-1 is one which treats a disease by inhibiting PD-1 from binding to a ligand thereof. The disease may be a tumor, an infection caused by a bacterium, a virus or a fungus, or an inflammatory disease.
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公开(公告)号：US10479945B2
公开(公告)日：2019-11-19
申请号：US15742044
申请日：2016-06-21
Applicant: JIANGSU GOLDEN GATE ENERGY & EQUIPMENT CO., LTD , EAST CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY
Inventor： Benxian Shen , Changsheng Jiang , Zuhu Liu , Yun Sun
Abstract: Provided is an electric desalting and dehydration apparatus, including an oil inlet distributor of an upper electric field, wherein the oil inlet distributor includes an oil inlet distributing pipe and an oil inlet branch pipe. The oil inlet distributing pipe is arranged in a water tray of an electric desalter, and below a ground electrode of the electric desalter. The oil inlet branch pipe is connected to the oil inlet distributing pipe to supply crude oil into the oil inlet distributing pipe. The oil inlet distributing pipe is provided with oil outlets on both sides thereof in a horizontal direction. The distributor can uniformly distribute crude oil in a water tray, thus all of the crude oil is kept in an electric field for an equal time.
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公开(公告)号：US10472547B2
公开(公告)日：2019-11-12
申请号：US15537305
申请日：2015-12-16
Applicant: KUNSHAN TIANYANG HOT MELT ADHESIVE CO., LTD. , SHANGHAI TIANYANG HOT MELT ADHESIVE CO., LTD. , EAST CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY
Inventor： Zhelong Li , Wanyu Zhu , Xingquan Ma , Heji Lei , Zuoxiang Zeng , Yongjian Zhang
IPC: C09J123/06 , C09J11/04 , C09J11/06 , C09J11/08 , D01D4/02 , D01D5/084 , D01D5/088 , C08K3/26 , C08K3/34 , C08K5/13 , C08K5/134 , D01D5/08
Abstract: A composite hot-melt adhesive mesh film and preparation process thereof, in particular, a composite hot-melt adhesive mesh film and preparation process thereof for bonding metal and non-polar material are disclosed. The mesh film is compounded of a polar polyamide hot-melt adhesive and a non-polar polyolefin hot-melt adhesive mesh film containing a compatibilizer. The mesh film has a high adhesive strength and a durable and stable adhesion, and is especially suitable for bonding stainless steel, aluminum, copper or other metal materials and polyethylene, polypropylene or other non-polar polymers. Additionally, the preparation process is completed in one set of production process from raw material pretreatment to the final preparation of the hot melt adhesive mesh film product, thereby greatly reducing production failures, and providing high production efficiency and low costs.
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公开(公告)号：US10449507B2
公开(公告)日：2019-10-22
申请号：US15313855
申请日：2014-05-30
Inventor： Chongjun Zhao , Jianbo Dong , Youfu Huang , Xiuzhen Qian
IPC: B01J19/02 , B01J19/12 , C01B32/184 , C01B32/186
Abstract: Methods for converting carbon dioxide (CO2) into graphene are described. The methods include contacting a metal with gaseous carbon dioxide, and irradiating a surface of the metal with at least one laser beam to convert the gaseous carbon dioxide into graphene on the surface of the metal. Systems for converting carbon dioxide into graphene are also described.
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Patent Agency Ranking
公开(公告)号：US20190315703A1
公开(公告)日：2019-10-17
申请号：US16461234
申请日：2017-11-17
Applicant: EAST CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY , SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES
Inventor： Jian LI , Lefu LAN , Baoli LI , Feifei CHEN , Shuaishuai NI , Yifu LIU , Hanwen WEI , Fei MAO , Jin ZHU
IPC: C07D307/81 , C07D333/58 , C07D409/12 , A61P31/04 , A61P31/10 , C07D307/82
Abstract: Disclosed are benzoheterocyclic alkylamine compounds, or a pharmaceutically acceptable salt thereof, or a stereoisomer thereof, and a preparation method thereof, and use of the same in the manufacture of an antibacterial drug as an inhibitor of staphyloxanthin synthesis in Staphylococcus aureus.
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公开(公告)号：US20190292162A1
公开(公告)日：2019-09-26
申请号：US16302564
申请日：2017-05-17
Inventor： Honglin LI , Yufang XU , Rui WANG , Zhenjiang ZHAO , Wenlin SONG , Liuxin XU
IPC: C07D277/50 , A61P19/02
Abstract: A thiazole derivative serving as a DHODH inhibitor, and applications thereof. The present invention specifically relates to a compound represented by formula I, a pharmaceutical composition containing the compound represented by formula (I), and applications of the compound in the preparation of drugs for treating diseases mediated by the DHODH or drugs for inhibiting the DHODH.
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公开(公告)号：US20190187144A1
公开(公告)日：2019-06-20
申请号：US16318868
申请日：2017-07-18
Inventor： Linyong Zhu , Yi Yang , Dasheng Zhang , Zengmin Du , Bingkun Bao , Qiuning Lin , Xianjun Chen , Lipeng Yang , Chunyan Bao , Yihui Ge , Renmei Liu , Zhengda Chen , Sitong Zhang , Ningfeng Li , Xin Hua
IPC: G01N33/58 , G01N33/533 , C09K11/06 , A61K49/00 , G01N21/64 , C07D487/04 , C07D263/56 , C07D277/64 , C07D495/04 , C07F7/08 , C07D409/14
CPC classification number: G01N33/582 , A61K49/00 , A61K49/0017 , C07D263/56 , C07D277/64 , C07D409/14 , C07D473/18 , C07D487/04 , C07D495/04 , C07F7/0816 , C09K11/06 , G01N21/6428 , G01N33/533
Abstract: Provided are a fluorescent probe and a preparation process and the use thereof. The fluorescent probe is sensitive and specific to viscosity, and can be used for specific fluorescent labeling of proteins, and can also be used for quantification, detection or kinetic studies of proteins, and the imaging of cells, tissues and living bodies.
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公开(公告)号：US10308764B2
公开(公告)日：2019-06-04
申请号：US15542602
申请日：2015-07-13
Inventor： Liming Zhao , Jie Wei , Jun Qian , Juan Ma , Xiaofeng Tang , Yingyang Wu , Yongjun Qiu
Abstract: The invention relates to a preparation method of green nylon poly butyrolactams, the biological materials of GABA in vacuum under the condition of high temperature melt decomposition and purified butyrolactams, then by vacuum polymerization of green nylon poly butyrolactams. Compared with the prior art, the invention is prepared by biological method for the synthesis of a wide range of sources, to solve the problem of raw material supply PA4 for mass production, reduce the cost of reaction, and the reaction condition is simple, easy to implement simplified synthesis steps, from the laboratory to the transformation of industrial production.
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公开(公告)号：US10294479B2
公开(公告)日：2019-05-21
申请号：US15307455
申请日：2015-03-04
Inventor： Jianhe Xu , Yujun Zhang , Gaowei Zheng , Jiang Pan
IPC: C12N9/04 , C12N9/88 , C12N9/10 , C12N15/00 , C12P7/62 , C12P7/04 , C12N15/52 , C12R1/72 , C12N1/16 , C12P7/42 , C12N9/02 , C12N15/81
Abstract: Disclosed herein is Candida parapsilosis CGMCC 9630, the carbonyl reductase expressed by said strain and the encoding gene and amino acid sequence thereof, the recombinant expression vector and recombinant expression transformant containing said gene sequence, and use of whole cells of Candida parapsilosis, carbonyl reductase or corresponding recombinant transformant thereof as catalyst in catalyzing asymmetric reduction of prochiral carbonyl compounds, particularly reduction of 6-carbonyl-8-halogenocaprylate to prepare the synthetic precursor of (R)-α-lipoic acid, (R)-6-hydroxy-8-halogenocaprylate. In comparison to other methods of asymmetric reduction for preparing (R)-6-hydroxy-8-halogenocaprylate, the disclosure has advantages of high substrate concentration, mild reaction conditions, environmental friendship, high yield, and high optical purity of the product, and thus has good prospect in industrial production of (R)-α-α-lipoic acid.
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