公开(公告)号：US20140296434A1

公开(公告)日：2014-10-02

申请号：US14298332

申请日：2014-06-06

Applicant: EMD Millipore Corporation

Inventor： Shari Spector ,  Robert Smith ,  Joe Orlando ,  Nanying Bian

IPC: C07K14/31 ,  B01D15/38 ,  C07K1/22

CPC classification number: C07K14/31 ,  B01D15/3809 ,  B01J20/286 ,  B01J20/3272 ,  B01J20/3274 ,  C07K1/22 ,  C07K16/1271 ,  C07K2319/21

Abstract: The present invention relates to chromatography matrices including ligands based on one or more domains of immunoglobulin-binding proteins such as, Staphylococcus aureus Protein A (SpA), as well as methods of using the same.

Abstract translation: 本发明涉及包括基于免疫球蛋白结合蛋白（例如金黄色葡萄球菌蛋白A（SpA））的一个或多个结构域的配体的色谱基质，以及使用它们的方法。

公开(公告)号：US20140137386A1

公开(公告)日：2014-05-22

申请号：US14162823

申请日：2014-01-24

Applicant: EMD Millipore Corporation

Inventor： Stephane Olivier ,  Jerome Geyer ,  Gerard Muller

IPC: B23P19/04

CPC classification number: B23P19/04 ,  A61B17/3417 ,  A61B17/3421 ,  A61M5/158 ,  A61M5/162 ,  A61M25/06 ,  A61M25/065 ,  A61M2005/1623 ,  Y10T29/49826 ,  Y10T29/49892 ,  Y10T29/49895 ,  Y10T29/49897 ,  Y10T29/49899 ,  Y10T29/49947

Abstract: A take-off needle comprises a hollow lance having a distal end adapted to perform a insertion operation, said hollow lance being connected to at least one pipe provided with a spigot for it to be connected to a tube, and comprising a body for holding the hollow lance and pipe relative to each other such that the spigot projects from the holding body, said needle timber comprising two flanges held on respective sides of and spaced from the holding body by virtue of a spacer disposed between each flange and the holding body, said flanges extending in a longitudinal direction from the spigot to the vicinity of the proximal end of the hollow lance, the width of each flange being greater than the width of the portion of the holding body facing the flanges.

Abstract translation: 起飞针包括具有适于执行插入操作的远端的中空喷枪，所述中空喷枪连接到至少一个设置有插口的管子，以将其连接到管，并且包括用于保持 空心枪和管相对于彼此，使得插口从保持体突出，所述针木由包括设置在每个凸缘和保持体之间的间隔件而保持在保持体的相应侧面并与保持体间隔开的两个凸缘， 凸缘从纵向方向延伸到中空喷枪的近端附近，每个凸缘的宽度大于保持体面对凸缘的部分的宽度。

公开(公告)号：US20140105795A1

公开(公告)日：2014-04-17

申请号：US14109988

申请日：2013-12-18

Applicant: EMD Millipore Corporation

Inventor： Chris Scott ,  Rob Colonna ,  Christopher Barmore ,  Todd Taylor ,  Daniel Morgan

IPC: B01J20/281

CPC classification number: G01N1/28 ,  B01D61/18 ,  B01J20/281 ,  B01L3/50255 ,  G01N1/4077 ,  G01N30/14 ,  G01N2030/146

Abstract: Sample preparation device for receiving in sealing relation one or more filter assemblies and one or more sample containers, each container uniquely positioned within the device to receive filtered sample from a designated filter. The device includes a body, a lid disposed on the body, a container tray, a base, an integrated seal on the body, a valve and a valve actuator. The tray can be disposed in a vacuum chamber defined by the lid and the body, and one or more sample containers can be disposed in the tray. When properly positioned in the tray in the vacuum chamber, each container is in fluid communication with a single respective filter assembly disposed in sealing relation in a respective aperture in the lid. A single actuation of a valve to place the vacuum chamber under vacuum causes the lid to seal to the base and drives the simultaneous filtration of a plurality of samples.

Abstract translation: 用于以密封关系接收一个或多个过滤器组件和一个或多个样品容器的样品制备装置，每个容器唯一地定位在装置内以从指定的过滤器接收经过滤的样品。 该装置包括主体，设置在主体上的盖，容器托盘，基座，主体上的集成密封件，阀和阀致动器。 托盘可以设置在由盖和主体限定的真空室中，并且一个或多个样品容器可以设置在托盘中。 当适当地定位在真空室中的托盘中时，每个容器与在盖中的相应孔中以密封关系设置的单个相应的过滤器组件流体连通。 将真空室置于真空下的阀的单次致动导致盖子密封到基座并驱动多个样品的同时过滤。

公开(公告)号：US20140099705A1

公开(公告)日：2014-04-10

申请号：US14081314

申请日：2013-11-15

Applicant: EMD Millipore Corporation

Inventor： Ju-Sung Paul Hung ,  Philip J. Lee ,  Amedeo J. Cappione

IPC: C12M1/00

CPC classification number: C12M23/16 ,  B01L3/502715 ,  B01L3/502753 ,  B01L2200/027 ,  B01L2200/0647 ,  B01L2200/0694 ,  B01L2300/0681 ,  B01L2300/0877 ,  B01L2300/14 ,  C12M23/34 ,  C12M23/40 ,  C12M27/18 ,  C12M29/10 ,  C12M41/46 ,  C12Q1/02 ,  C12Q1/025

Abstract: A number of novel improved microfluidic configurations and systems and methods of manufacture and operation for a microfluidic invasion assay system.

Abstract translation: 许多新颖的改进的微流体配置和用于微流体入侵测定系统的制造和操作的系统和方法。

公开(公告)号：US20140091019A1

公开(公告)日：2014-04-03

申请号：US14080971

申请日：2013-11-15

Applicant: EMD Millipore Corporation

Inventor： Felipe Merino ,  Luis Penacho ,  Miquel Iribarren ,  Antonio Vicente ,  Angel Cabria ,  Juan Carlos Pineiro

IPC: B01D29/66

CPC classification number: B01D29/668 ,  B01D29/0077 ,  B01D29/6438 ,  B01D29/66 ,  B01D29/908 ,  B01D61/18 ,  B01D65/02 ,  B01D2201/086 ,  B01D2321/02 ,  B01D2321/04 ,  C02F1/444 ,  C02F2209/03 ,  C02F2209/40 ,  C02F2209/44 ,  C02F2301/024 ,  C02F2301/026

Abstract: A normal flow filtration system having a housing with one or more filters contained within a bowl and attached to the outlet of the system. Liquid enters the bowl, contacts the surfaces of the one or more filters. Impurities are trapped in the filter and the filtered liquid flows through to the outlet. Parameter(s) such as flow rate, transmembrane pressure drop and/or time are measured and when met, filtration ceases. A backflushing occurs through the filter(s) so as to remove the impurities from the filter. This backwashed material is directed to an outlet of the bowl that is connected to a drain. Additionally a port formed in the side of the housing adjacent an outer surface of the filter(s) can be used to provide a lateral washing of the filter(s). The system is then recirculated in a downstream manner to reestablish equilibrium and filtration is then restarted.

Abstract translation: 一种通常的流动过滤系统，具有一个壳体，一个或多个过滤器包含在一个碗内，并连接到系统的出口。 液体进入碗中，接触一个或多个过滤器的表面。 杂质被捕获在过滤器中，并且过滤的液体流过出口。 测量流量，跨膜压降和/或时间等参数，当满足时，过滤停止。 通过过滤器发生反吹，以从过滤器中除去杂质。 该反冲洗的材料被引导到连接到排水管的碗的出口。 另外，形成在壳体的与过滤器的外表面相邻的侧面中的端口可以用于提供过滤器的侧向洗涤。 然后系统以下游方式再循环以重新建立平衡，然后重新开始过滤。

公开(公告)号：US20140048471A1

公开(公告)日：2014-02-20

申请号：US14023543

申请日：2013-09-11

Applicant: EMD Millipore Corporation

Inventor： Yves Gaignet ,  Ichiro Kano

IPC: B01D65/06 ,  B01D29/62

CPC classification number: B01D65/06 ,  A61L2/186 ,  A61L2202/16 ,  B01D29/62 ,  B01D61/025 ,  B01D61/027 ,  B01D61/04 ,  B01D61/10 ,  B01D61/145 ,  B01D61/147 ,  B01D61/16 ,  B01D61/20 ,  B01D65/00 ,  B01D65/02 ,  B01D65/022 ,  B01D2311/04 ,  B01D2311/16 ,  B01D2321/168 ,  B01F1/0027 ,  C02F1/281 ,  C02F1/283 ,  C02F1/44 ,  C02F1/50 ,  C02F5/145 ,  C02F2201/006 ,  B01D2311/12 ,  B01D2311/2626

Abstract: The invention consists in a disposable module (31) for purifying a fluid, in particular water, adapted to form part of a thud purification system and comprising fluid purification means (25, 28), a housing (35) in which the purification means are housed, and means for removably connecting the purification module (31) to the purification system to establish fluid communication between the purification system and the purification module (31), characterized in that the housing (35) contains from the outset a cleaning agent (36) disposed to come into contact with the fluid caused to circulate inside the housing (35) to clean at least a portion of the purification system, it also consists in the purification system and corresponding fabrication and cleaning methods,

Abstract translation: 本发明包括用于净化流体（尤其是水）的一次性模块（31），该流体适于形成ud净化系统的一部分，并且包括流体净化装置（25,28），其中净化装置 以及用于将净化模块（31）可移除地连接到净化系统以建立净化系统和净化模块（31）之间的流体连通的装置，其特征在于，所述壳体（35）从一开始就包含清洁剂（36） ）设置成与所述流体接触以在所述壳体（35）内循环以清洁所述净化系统的至少一部分，其还包括所述净化系统和相应的制造和清洁方法，

公开(公告)号：US20140014230A1

公开(公告)日：2014-01-16

申请号：US14032211

申请日：2013-09-20

Applicant: EMD Millipore Corporation

Inventor： Pierre Guedon

IPC: G01N35/10

CPC classification number: C12M33/07 ,  B01L3/567 ,  G01N1/10 ,  G01N35/1097 ,  G01N2001/022

Abstract: The device for the transfer of a medium comprises a magazine having two main faces (17) of which one is adapted to cooperate with a container and a lateral face (18) extending between said main faces (17) as well as at least one sliding valve (3) housed in a cavity of said magazine (2) and in which there is formed a transfer duct (59) for said medium which issues on said face (17) adapted to cooperate with said container, said valve (3) having a closed position in which it sealingly isolates said duct (59) from said container and an open position in which said duct (59) is placed in communication with said container; said valve (3) comprising a valve member (40), an isolation sleeve (41) surrounding at least partially said valve member (40) as well as spring means (58) adapted to be compressed by said valve member (40) when said valve (3) is in its open position.

Abstract translation: 用于传送介质的装置包括具有两个主表面（17）的盒，其中一个适于与容器配合，以及在所述主面（17）之间延伸的侧面（18）以及至少一个滑动 阀（3）容纳在所述盒（2）的空腔中，其中形成有用于所述介质的传送管道（59），所述传送管道（59）适于与所述容器协作的所述面（17）上，所述阀（3）具有 关闭位置，其中密封地将所述管道（59）与所述容器隔离，并且所述管道（59）放置成与所述容器连通的打开位置; 所述阀（3）包括阀构件（40），至少部分地围绕所述阀构件（40）的隔离套（41）以及适于在所述阀构件（40）被所述阀构件（40）压缩时的弹簧装置 阀（3）处于其打开位置。

公开(公告)号：US20140000753A1

公开(公告)日：2014-01-02

申请号：US14012103

申请日：2013-08-28

Applicant: EMD MILLIPORE CORPORATION

Inventor： Pierre Guedon

IPC: C12M1/26

CPC classification number: C12M33/07 ,  B01L3/567 ,  G01N1/10 ,  G01N35/1097 ,  G01N2001/022

Abstract: The device for the transfer of a medium comprises a magazine having two main faces (17) of which one is adapted to cooperate with a container and a lateral face (18) extending between said main faces (17) as well as at least one sliding valve (3) housed in a cavity of said magazine (2) and in which there is formed a transfer duct (59) for said medium which issues on said face (17) adapted to cooperate with said container, said valve (3) having a closed position in which it sealingly isolates said duct (59) from said container and an open position in which said duct (59) is placed in communication with said container; said valve (3) comprising a valve member (40), an isolation sleeve (41) surrounding at least partially said valve member (40) as well as spring means (58) adapted to be compressed by said valve member (40) when said valve (3) is in its open position.

公开(公告)号：US20130334450A1

公开(公告)日：2013-12-19

申请号：US13972301

申请日：2013-08-21

Applicant: EMD Millipore Corporation

Inventor： Stephen Proulx ,  Joseph Almasian ,  Naren Renganath ,  Stephen Tingley ,  Martin Morrissey

IPC: F16K5/00

CPC classification number: F16K5/00 ,  A61M39/10 ,  A61M39/16 ,  A61M39/18 ,  A61M39/22 ,  A61M2039/1027 ,  A61M2039/222 ,  F16K3/265 ,  F16K13/04 ,  F16K15/18 ,  F16L37/107

Abstract: The present invention relates to a process for the sterile transfer of fluids, be they liquids or gases. It uses a presterilized device comprised of a body having a bore formed through at least a portion of its interior. Contained within the bore is a movable plunger. The body has a first and a second end. The first end contains a face designed to be attached to the upstream component. The second end is connected to a downstream component such as a filter, pipeline, sample bag and the like. The plunger has corresponding first and second ends. The first end of the plunger when it the closed position is in alignment with the face of the body which combined form a steamable surface and a sterile barrier against the environment to the rest of the interior of the body, the plunger and downstream components. The device is attached to an upstream component and the face and the first end of the plunger are steam sterilized in place.

Abstract translation: 本发明涉及一种无菌转移流体（无论是液体还是气体）的方法。 它使用由具有通过其内部的至少一部分形成的孔的主体构成的预灭菌装置。 孔内包含一个可移动的柱塞。 身体有第一和第二端。 第一端包含设计成连接到上游部件的面。 第二端连接到诸如过滤器，管道，样品袋等的下游部件。 柱塞具有相应的第一和第二端。 柱塞在其关闭位置时的第一端与主体的表面对齐，该表面组合形成一个可蒸汽表面，并且一个无菌隔离物抵抗环境的内部其余部分，柱塞和下游部件。 该装置连接到上游部件，柱塞的表面和第一端被蒸汽灭菌就位。

公开(公告)号：US20130312492A1

公开(公告)日：2013-11-28

申请号：US13956428

申请日：2013-08-01

Applicant: EMD Millipore Corporation

Inventor： Brian Hillier ,  Martin Szyk ,  Aaron Burke ,  Joseph Almasian

IPC: G01N15/08

CPC classification number: F16K31/50 ,  F16K1/12 ,  F16K11/22 ,  F16K31/445 ,  F16K31/60 ,  G01N15/0826 ,  Y10T137/0318 ,  Y10T137/7932 ,  Y10T137/794 ,  Y10T137/85938 ,  Y10T137/87885

Abstract: Fluid transfer apparatus including a body having a bore formed through at least a portion of its interior. Contained within the bore is a movable plunger that moves without changing the axial dimensions of the body. A first end of the body contains a face designed to be attached to an upstream component. A second end of the body is connected to a downstream component such as a filter, pipeline, etc. A first end of the plunger, when it is in the closed position, is in alignment with the face of the body, which combined form a steamable surface and a sterile barrier against the environment to the remainder of the interior of the body, the plunger and downstream components. An outer annular collar is rotatable relative to the body and causes the plunger to move axially within the bore from an open to a closed position.

Abstract translation: 流体输送装置包括具有通过其内部的至少一部分形成的孔的主体。 包含在孔内的是可移动的柱塞，其移动而不改变主体的轴向尺寸。 身体的第一端包含设计成连接到上游部件的面。 主体的第二端连接到诸如过滤器，管道等的下游部件。当处于关闭位置时，柱塞的第一端与主体的表面对准，其结合形成一个 可蒸发的表面和抵抗环境的无菌屏障到身体内部的其余部分，柱塞和下游部件。 外环形套环可相对于主体旋转并使柱塞在孔内轴向移动，从开放到闭合位置。