公开(公告)号：US20060247384A9

公开(公告)日：2006-11-02

申请号：US11221123

申请日：2005-09-06

Applicant: Guillermo Bazan ,  Bin Liu

Inventor： Guillermo Bazan ,  Bin Liu

IPC: C08F297/02

CPC classification number: C08G61/123 ,  C08F8/44 ,  C08F257/00 ,  C08F279/02 ,  C08F287/00 ,  C08F289/00 ,  C08F291/00 ,  C08G61/02 ,  C08G61/124 ,  C08G61/125 ,  C08G61/126 ,  C08G73/00 ,  C08G73/06 ,  C08G73/08 ,  C08L51/006 ,  C08L51/04 ,  H01L51/0034 ,  H01L51/0035 ,  H01L51/0036 ,  H01L51/0037 ,  H01L51/0038 ,  H01L51/0039 ,  H01L51/0043 ,  H01L51/5048 ,  C08L2666/02

Abstract: Methods, compositions and articles of manufacture involving soluble conjugated polymers are provided. The conjugated polymers have a sufficient density of polar substituents to render them soluble in a polar medium, for example water and/or methanol. The conjugated polymer may desirably comprise monomers which alter its conductivity properties. In some embodiments, the inventors have provided cationic conjugated polymers (CCPs) comprising both solubilizing groups and conductive groups, resulting in conductive conjugated polymers soluble in polar media. The different solubility properties of these polymers allow their deposition in solution in multilayer formats with other conjugated polymers. Also provided are articles of manufacture comprising multiple layers of conjugated polymers having differing solubility characteristics. Embodiments of the invention are described further herein.

Abstract translation: 提供涉及可溶性共轭聚合物的方法，组合物和制品。 共轭聚合物具有足够的极性取代基密度，使其可溶于极性介质，例如水和/或甲醇。 共轭聚合物可以理想地包括改变其导电性能的单体。 在一些实施方案中，本发明人提供了包含增溶基团和导电基团的阳离子共轭聚合物（CCPs），导致可溶于极性介质的导电共轭聚合物。 这些聚合物的不同溶解度特性允许它们以多层形式沉积在其它共轭聚合物中。 还提供了包含具有不同溶解度特性的多层共轭聚合物的制品。 本文进一步描述本发明的实施例。

公开(公告)号：US20060216734A1

公开(公告)日：2006-09-28

申请号：US11329861

申请日：2006-01-10

Applicant: Guillermo Bazan ,  Bin Liu

Inventor： Guillermo Bazan ,  Bin Liu

IPC: C12Q1/68 ,  G06F19/00

CPC classification number: C12Q1/6818 ,  C12Q2563/119 ,  C12Q2565/101 ,  C12Q2565/519 ,  C12Q2565/607 ,  C12Q2523/313

Abstract: The invention further relates to polycationic multichromophores, which may be conjugated polymers, and methods, articles and compositions employing them as described herein. In some aspects, the invention relates to methods, articles and compositions for the detection and analysis of biomolecules in a sample. Provided assays include those determining the presence of a target biomolecule in a sample or its relative amount, or the assays may be quantitative or semi-quantitative. The methods can be performed on a substrate. The methods can be performed in an array format on a substrate, which can be a sensor. In some embodiments, detection assays are provided employing sensor biomolecules that do not comprise a fluorophore that can exchange energy with the cationic multichromophore. In some aspects biological assays are provided in which energy is transferred between one or more of the multichromophore, a label on the target biomolecule, a label on the sensor biomolecule, and/or a fluorescent dye specific for a polynucleotide, in all permutations. The multichromophore may interact at least in part electrostatically with the sensor and/or the target, and an increase in energy transfer with the polymer may occur upon binding of the sensor and the target. Other variations of the inventions are described further herein.

Abstract translation: 本发明还涉及可以是共轭聚合物的阳离子多色素，以及如本文所述使用它们的方法，制品和组合物。 在一些方面，本发明涉及用于检测和分析样品中生物分子的方法，制品和组合物。 提供的测定包括确定样品中靶生物分子的存在或其相对量的那些，或者测定可以是定量或半定量的。 该方法可以在衬底上进行。 这些方法可以以阵列格式在基底上进行，其可以是传感器。 在一些实施方案中，使用不包含能够与阳离子多重色素交换能量的荧光团的传感器生物分子来提供检测测定。 在一些方面，提供生物测定，其中在所有置换中，能量在一个或多个多色素，目标生物分子上的标记，传感器生物分子上的标记和/或多核苷酸特异的荧光染料之间转移。 多重色淀可以至少部分地与传感器和/或靶相互作用，并且当传感器和目标物结合时，聚合物的能量传递的增加可能发生。 本文进一步描述了本发明的其它变型。

公开(公告)号：US20060204984A1

公开(公告)日：2006-09-14

申请号：US11344942

申请日：2006-01-31

Applicant: Guillermo Bazan ,  Bin Liu

Inventor： Guillermo Bazan ,  Bin Liu

IPC: C12Q1/68 ,  G01N33/53 ,  C08G63/91 ,  C08G63/48

CPC classification number: G01N21/6486 ,  C08G61/02 ,  C08G61/123 ,  C12Q1/6818 ,  C12Q1/6825 ,  G01N33/542 ,  G01N33/54373 ,  Y10T436/143333 ,  C12Q2565/113 ,  C12Q2563/173 ,  C12Q2565/101

Abstract: This invention relates to an aggregation sensor useful for the detection and analysis of aggregants in a sample, and methods, articles and compositions relating to such a sensor. The sensor comprises first and second optically active units, where energy may be transferred from an excited state of the first optically active unit to the second optically active unit. The second optically active unit is present in a lesser amount, but its relative concentration is increased upon aggregation, increasing its absorption of energy from the first optically active units. This increase in energy transfer can be detected in variety of formats to produce an aggregation sensing system for various aggregants, including for quantitation. Other variations of the inventions are described further herein.

Abstract translation: 本发明涉及可用于检测和分析样品中的聚集体的聚集传感器，以及与这种传感器相关的方法，制品和组合物。 传感器包括第一和第二光学有源单元，其中能量可以从第一光学活性单元的激发状态转移到第二光学活性单元。 第二光学活性单元以较小的量存在，但是其聚集时其相对浓度增加，从而增加其从第一光学活性单元的能量吸收。 可以以各种格式检测能量转移的这种增加，以产生用于各种聚合物的聚集感测系统，包括用于定量。 本文进一步描述了本发明的其它变型。

公开(公告)号：US20060167247A1

公开(公告)日：2006-07-27

申请号：US11295638

申请日：2005-12-07

Applicant: Enrique Michelotti ,  Eric Springman ,  Duyan Nguyen ,  Rupa Shetty ,  Younghee Lee ,  Kristofer Moffett ,  Jennifer Ludington ,  Ted Fujimoto ,  Zenon Konteatis ,  Bin Liu ,  Frank Hollinger ,  Bruce Dorsey

Inventor： Enrique Michelotti ,  Eric Springman ,  Duyan Nguyen ,  Rupa Shetty ,  Younghee Lee ,  Kristofer Moffett ,  Jennifer Ludington ,  Ted Fujimoto ,  Zenon Konteatis ,  Bin Liu ,  Frank Hollinger ,  Bruce Dorsey

IPC: C07D417/02 ,  C07D413/02 ,  C07D409/02

CPC classification number: C07D333/38 ,  C07D231/40 ,  C07D243/08 ,  C07D277/48 ,  C07D277/56 ,  C07D295/192 ,  C07D333/36 ,  C07D403/06 ,  C07D405/06 ,  C07D409/04 ,  C07D409/06 ,  C07D409/12 ,  C07D413/12 ,  C07D413/14 ,  C07D417/06 ,  C07D417/14 ,  C07D495/04

Abstract: The present invention is directed to a compound having the formula wherein R1, R2, G, and Q are defined herein. The compounds of the present invention are useful as inhibitors of protein kinases such as MAP kinases, in particular p38 kinases. The present invention is also directed to compositions comprising a compound according to the above formula. The compounds and compositions described herein are useful for treating and preventing an inflammatory condition or disease. The present invention is also directed to a method of treating or preventing a protein kinase-mediated condition.

Abstract translation: 本发明涉及具有下式的化合物：其中R 1，R 2，G和Q在本文中定义。 本发明的化合物可用作蛋白激酶如MAP激酶，特别是p38激酶的抑制剂。 本发明还涉及包含根据上式的化合物的组合物。 本文所述的化合物和组合物可用于治疗和预防炎性疾病或疾病。 本发明还涉及治疗或预防蛋白激酶介导的病症的方法。

公开(公告)号：US20060009186A1

公开(公告)日：2006-01-12

申请号：US10887657

申请日：2004-07-08

Applicant: Bin Liu ,  Xi Huang

Inventor： Bin Liu ,  Xi Huang

IPC: H04B1/10 ,  H04B1/18

CPC classification number: H04B1/30 ,  H04B1/123

Abstract: Signal processing for a receiver, such as a radio receiver within a cellular telephone, includes providing frequency conversion, preferentially passing a desired signal following the conversion, and introducing both phase-based filtering and equalization to the band-filtered signal. In one embodiment, the band filtering is provided by a low pass filter and the compensation occurs following operations by a polyphase filter, which implements the phase-based filtering. In many applications, the frequency conversion is a down conversion to either a zero intermediate frequency or a low intermediate frequency. The low pass filter reduces out-of-band interference and blocking signal strength, but may introduce phase-related distortions. The polyphase filtering and equalization cooperate to control the phase-related distortions.

Abstract translation: 用于诸如蜂窝电话中的无线电接收机的接收机的信号处理包括提供频率转换，优先地通过转换之后的期望信号，并将两个基于相位的滤波和均衡引入带通滤波信号。 在一个实施例中，频带滤波由低通滤波器提供，并且补偿发生在实现基于相位的滤波的多相滤波器的操作之后。 在许多应用中，频率转换是向零转换到零中频或低中频。 低通滤波器降低了带外干扰和阻塞信号强度，但可能引入相位相关的失真。 多相滤波和均衡协调控制相位相位失真。

公开(公告)号：US06963251B2

公开(公告)日：2005-11-08

申请号：US10992426

申请日：2004-11-18

Applicant: Bin Liu

Inventor： Bin Liu

IPC: H03F3/45 ,  H03F3/72 ,  H03K3/0231 ,  H03K5/00 ,  H03K5/13 ,  H03L7/099 ,  H03B5/02

CPC classification number: H03F3/45183 ,  H03F3/4565 ,  H03F3/72 ,  H03F2203/7203 ,  H03K3/0231 ,  H03K3/0322 ,  H03K5/133 ,  H03K2005/00208 ,  H03L7/0995

Abstract: A ring oscillator circuit, such as a VCO, with a relatively high level of noise rejection for noise originating from both the voltage supply and ground. The ring oscillator circuit is composed of a plurality of differential delay circuits, each differential delay circuit generating a differential output signal that is a delayed (and preferably inverted) version of a differential input signal. ‘Each differential delay circuit includes first and second input transistors for receiving the differential input signal. Each differential delay circuit also includes first and second load transistors coupled in parallel with the respective first and second input transistors. Each differential delay circuit further includes a first current source coupled between the first input transistor and a first power supply terminal (e.g., a voltage supply terminal), a second current source coupled between the second input transistor and the first power supply terminal and a third current source coupled between the first and second input transistors and a second power supply terminal (e.g., a ground terminal). The first and second current sources reduce the coupling of noise from the first power supply terminal to the output. The third current source reduces the coupling of noise from the second power supply terminal to the output.

Abstract translation: 环路振荡器电路，例如VCO，对于源自电压源和地的噪声具有较高的噪声抑制水平。 环形振荡器电路由多个差分延迟电路组成，每个差分延迟电路产生作为差分输入信号的延迟（最好是反向）版本的差分输出信号。 “每个差分延迟电路包括用于接收差分输入信号的第一和第二输入晶体管。 每个差分延迟电路还包括与相应的第一和第二输入晶体管并联耦合的第一和第二负载晶体管。 每个差分延迟电路还包括耦合在第一输入晶体管和第一电源端子（例如，电压源端子）之间的第一电流源，耦合在第二输入晶体管和第一电源端子之间的第二电流源， 耦合在第一和第二输入晶体管之间的电流源和第二电源端子（例如，接地端子）。 第一和第二电流源减少了从第一电源端子到输出端的噪声耦合。 第三电流源减少了从第二电源端子到输出端的噪声耦合。

公开(公告)号：US20050135010A1

公开(公告)日：2005-06-23

申请号：US10745205

申请日：2003-12-23

Applicant: Bin Liu ,  Dieter Weller

Inventor： Bin Liu ,  Dieter Weller

IPC: G11B5/62 ,  G11B5/012 ,  G11B5/82 ,  G11B5/02 ,  G11B7/24 ,  G11B23/03

CPC classification number: G11B5/82 ,  G11B5/012 ,  G11B2005/0021 ,  Y10S977/778

Abstract: Heat assisted magnetic recording systems with composite recording films are disclosed. The magnetic recording films include superparamagnetic nanoparticles dispersed in an antiferromagnetic or ferrimagnetic matrix. The matrix provides antiferromagnetic coupling with the superparamagnetic nanoparticles, and minimizes exchange interactions between adjacent nanoparticles.

Abstract translation: 公开了具有复合记录膜的热辅助磁记录系统。 磁记录膜包括分散在反铁磁性或亚铁磁性基质中的超顺磁性纳米粒子。 该矩阵提供与超顺磁性纳米粒子的反铁磁耦合，并最小化相邻纳米粒子之间的交换相互作用。

公开(公告)号：US20050091306A1

公开(公告)日：2005-04-28

申请号：US10677881

申请日：2003-10-02

Applicant: Charbel Khawand ,  Jean Khawand ,  Jyh-Han Lin ,  Bin Liu ,  Jianping Miller ,  Chin Wong

Inventor： Charbel Khawand ,  Jean Khawand ,  Jyh-Han Lin ,  Bin Liu ,  Jianping Miller ,  Chin Wong

IPC: G06F20060101 ,  G06F15/16

CPC classification number: H04L67/12 ,  H04L69/327

Abstract: An IPC network (1900) allows for the dynamic composition of services. An IPC client (1902) can for example request a service, such as a new photo service, and teach the IPC network what service components comprise the service. The IPC server (1908) will wait until all of the required service components (1914, 1916) have registered with the IPC network (1900) prior to allowing the IPC client (1902) the go ahead to use the service. The dynamic composition of services allows clients/components operating in the IPC network (1900) to change service definitions without affecting the interprocessor communications between applications operating in the network (1900). Also, the IPC network (1900) learns dynamically the new service and is able to identify the availability of the service within the network (1900).

Abstract translation: IPC网络（1900）允许服务的动态组合。 IPC客户端（1902）可以例如请求诸如新照片服务的服务，并且教授IPC网络什么服务组件构成服务。 IPC服务器（1908）将等待所有必需的服务组件（1914,1916）在IPC客户端（1902）继续使用该服务之前已经向IPC网络（1900）注册。 服务的动态组合允许在IPC网络（1900）中操作的客户端/组件改变服务定义，而不影响在网络中运行的应用程序之间的处理器间通信（1900）。 此外，IPC网络（1900）动态地学习新服务，并且能够识别网络内的服务的可用性（1900）。

公开(公告)号：US06681473B1

公开(公告)日：2004-01-27

申请号：US10078066

申请日：2002-02-15

Applicant: Bin Liu ,  R. Kehl Sink ,  David Welsh ,  Yuanjian Xu

Inventor： Bin Liu ,  R. Kehl Sink ,  David Welsh ,  Yuanjian Xu

IPC: G02B600

CPC classification number: G02B6/3644 ,  G02B6/3676 ,  G02B6/3688 ,  G02B6/3692 ,  Y10T29/49885 ,  Y10T29/49982 ,  Y10T29/49993

Abstract: A method and apparatus hermetically sealing a fiber array block is described. In one embodiment, a fiber array plate is fabricated and an array of tapered holes formed therein. An adhering metal layer, such as a titanium, nickel and gold multilayer, is deposited upon the fiber array plate. A solder preform is positioned on the fiber array plate so that the array of holes in the solder preform corresponds to the array of holes in the array plate. Fibers having an adhering metal layer deposited thereon, are then inserted through the fiber array plate. The tapered holes make the fiber insertion process easier. The fiber array plate is then heated such that the solder preform melts causing the solder to fill any gaps between the fiber array plates and the fiber. When the solder cools a hermetic seal is formed while the fibers remain accurately positioned.

Abstract translation: 描述了密封光纤阵列块的方法和设备。 在一个实施例中，制造了光纤阵列板，并且形成了一组锥形孔。 附着的金属层，例如钛，镍和金多层，沉积在纤维阵列板上。 焊料预制件位于纤维阵列板上，使得焊料预制件中的孔阵列对应于阵列板中的孔阵列。 然后将其上沉积有附着金属层的纤维插入穿过纤维阵列板。 锥形孔使纤维插入过程更容易。 然后加热纤维阵列板，使​​得焊料预制件熔化，导致焊料填充纤维阵列板和纤维之间的任何间隙。 当焊料冷却时，在纤维保持精确定位的同时形成气密密封。

公开(公告)号：US06657503B2

公开(公告)日：2003-12-02

申请号：US10131963

申请日：2002-04-25

Applicant: Bin Liu

Inventor： Bin Liu

IPC: H03B2700

CPC classification number: H03F3/45183 ,  H03F3/4565 ,  H03F3/72 ,  H03F2203/7203 ,  H03K3/0231 ,  H03K3/0322 ,  H03K5/133 ,  H03K2005/00208 ,  H03L7/0995

Abstract: A ring oscillator circuit, such as a VCO, with a relatively high level of noise rejection for noise originating from both the voltage supply and ground. The ring oscillator circuit is composed of a plurality of differential delay circuits, each differential delay circuit generating a differential output signal that is a delayed (and preferably inverted) version of a differential input signal. Each differential delay circuit includes first and second input transistors for receiving the differential input signal. Each differential delay circuit also includes first and second load transistors coupled in parallel with the respective first and second input transistors. Each differential delay circuit further includes a first current source coupled between the first input transistor and a first power supply terminal (e.g., a voltage supply terminal), a second current source coupled between the second input transistor and the first power supply terminal and a third current source coupled between the first and second input transistors and a second power supply terminal (e.g., a ground terminal). The first and second current sources reduce the coupling of noise from the first power supply terminal to the output. The third current source reduces the coupling of noise from the second power supply terminal to the output.