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公开(公告)号：US3806420A
公开(公告)日：1974-04-23
申请号：US24958872
申请日：1972-05-02
发明人： HOLZ G , GRAMSALL J , NELBOECK HOCHSTETTER M , BERGMEYER H
CPC分类号： C12Q1/34 , C12N9/78 , C12N9/86 , C12Q1/50 , G01N2333/9123 , G01N2333/978 , G01N2333/986 , Y10S435/815 , Y10S435/816 , Y10S435/824 , Y10S435/829 , Y10S435/933
摘要： CREATININE AMIDOHYDROLASE AND CREATINE AMIDINOHYDROLASE ARE PREPARED BY A PROCESS COMPRISING CULTURING (A) ALCALIGENCE SPEC. WS 51400 OR (B) PENICILLIUM WS 90001; IN A CREATININE-CONTAINING MEDIUM, DIGESTING SAME, OBTAINING THE CREATININE AMIDIODOHYDROLASE IN SUBSTANTIALLY PURE FORM FROM THE WATER-SOLUBLE DIGESTION FRACTION AND, OPTIONALLY SEPARATING BY ION EXCHANGE CHROMATOGRAPHY ANY CREATININE AMIDINOHYDROSALE PRESENT.
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公开(公告)号：US3802842A
公开(公告)日：1974-04-09
申请号：US23231572
申请日：1972-03-02
发明人： LANGE H , RITTERSDORF W , REY H , RIECKMANN P
CPC分类号： C12Q1/28 , C12Q1/54 , G01N33/525 , Y10S435/805 , Y10T436/144444 , Y10T436/146666 , Y10T436/173076
摘要： Test strips for the detection of components in liquids, especially in body fluids, comprising a holder and at least one indicator layer containing detection reagents wherein one surface of the layer is attached to the holder and the other surface is covered with a fine meshwork.
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公开(公告)号：US3793365A
公开(公告)日：1974-02-19
申请号：US3793365D
申请日：1970-04-10
发明人： WINTER W , THIEL M , STACH K , DIETMANN K , BARTSCH W
IPC分类号： A41B3/00 , A61K31/195 , C07C237/00 , C07D265/32 , C07D295/12 , C07C101/08
CPC分类号： C07D295/12 , A41B3/00 , A61K31/195 , C07C237/00 , C07D265/32
摘要： NEW AMINO ACID DERIVATIVES OF THE FORMULA
R1-O-CH2-CH(-OH)-CH2-N(-R2)-A-CO-R3
WHEREIN R1 IS ARYL, SUCH AS NAPHTHYL OR PHENYL, WHICH MAY BE SUBSTITUTED BY HALOGEN OR HYDROXYL, ALKOXY, ALKENYL, ALKENYLOXY, ALKYL, ALKOXYALKYL, TRIFLUOROALKYL, ALKYLMERCAPTO, ALKENYLMERCAPTO, AMINO, ALKYLSULFONYLAMINO, OR ACYLAMINO; R1 MAY ALSO BE INDENYL OR HYDROGENATED INDENYL OR HYDROGENATED NAPHTHYL; R2 IS HYDROGEN OR LOWER ALKYL OR ARALKYL; R3 IS HYDROXYL OR AMINO OT ALKOXY, ALKYLAMINO OR DIALKYLAMINO, OR AN N-PIPERAZYL RADICAL, WHICH MAY BE N''-SUBSTITUTED; AND A IS AN ALKYLATED, OR ARYLATED LOWER ALKYLENE CHAIN, WHICH CAN CARRY A FURTHER CARBOXYL OR CARBALKOXY RADICAL; AND THE PHYSIOLOGICALLY COMPATIBLE SALTS THEREOF; ARE OUTSTANDINGLY EFFECTIVE AS B-ADRENERGIC AGENTS.-
公开(公告)号：US3787317A
公开(公告)日：1974-01-22
申请号：US3787317D
申请日：1971-04-15
发明人： JAWOREK D
摘要： Mixtures of substances are resolved into their components by use of molecular sieve and/or ion exchangers wherein at least two different molecular sieve chromatographic separation materials, and optionally an ion exchange chromatographic separation material; are arranged directly behind one another, at least one ion exchange material and/or molecular sieve material being followed by at least one molecular sieve material. Examples of materials separated are dextran blue (A), catalase (B), haemoglobin (C), chymotrypsin (D), cytochrome C (E), and dinitrophenyl-asparaginic acid (F).
摘要翻译： 通过使用分子筛和/或离子交换剂将物质的混合物分解成其组分，其中至少两种不同的分子筛色谱分离材料和任选的离子交换色谱分离材料; 彼此直接排列，至少一种离子交换材料和/或分子筛材料之后是至少一种分子筛材料。 分离的材料的实例是葡聚糖蓝（A），过氧化氢酶（B），血红蛋白（C），糜蛋白酶（D），细胞色素C（E）和二硝基苯基 - 天冬酰胺酸（F）。
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公开(公告)号：US3781328A
公开(公告)日：1973-12-25
申请号：US3781328D
申请日：1972-09-07
IPC分类号： A61K31/215 , A61K20060101 , A61K31/16 , A61K31/19 , A61K31/195 , A61K31/22 , C07C20060101 , C07C67/00 , C07C231/00 , C07C231/02 , C07C231/12 , C07C233/73 , C07C235/48 , C07C103/30
CPC分类号： Y02P20/55 , Y10S514/824
摘要： NOVEL PHENOXY-ALKYL-CARBOXYLIC ACID COMPOUNDS OF THE FORMULA:
(R1,R2-PHENYL)-CO-NH-(CH2)N-(1,4-PHENYLENE)-O-C(-R3)(-R4)-
AND THE PHARMACOLOGICAL COMPATIBLE SALTS THEREOF, ARE REMARKABLY EFFECTIVE IN LOWERING THE SERUM LIPID LEVEL AND CHOLESTEROL LEVEL WITHOUT INDUCING UNDESIRABLE SIDE EFFECTS.
R1 AND R2, WHICH MAY BE THE SAME OR DIFFERENT, ARE HYDROGEN, HALOGEN, LOWER ALKYL OR LOWER ALKOXY; R3 AND R4, WHICH MAY BE THE SAME OR DIFFERENT, ARE HYDROGEN OR LOWER ALKYL; N IS 1, 2 OR 3; AND Z IS HYDROXYL OR LOWER ALKOXY;
WHEREIN
CO-Z-
16.发明授权
公开(公告)号：US3751408A
公开(公告)日：1973-08-07
申请号：US3751408D
申请日：1971-05-21
发明人： BERGMEYER H , STORK H , WEIMANN G , MICHAEL G , NELBOECK HOCHSTETTER M
IPC分类号： A61K31/70 , A61K31/7042 , A61K31/7052 , A61K31/7056 , A61P3/06 , C07H19/052 , C07D51/52
CPC分类号： C07H19/052
摘要： CERTAIN NOVEL IMIDAZOLE-RIBOSYL CYCLOPHOSPHATE COMPOUNDS OF THE GENERAL FORMULA:
1-(3-HO,4,5-(-O-P(=O)(-OH)-O-CH2-)TETRAHYDROFUR-2-YL),
WHEREIN R IS A HYDROGEN ATOM OR A (CH2)N-A RADICAL, IN WHICH N IS 2 OR 3 A IS A SULFO OR COR'' GROUP AND R'' IS HYDROXYL, ALKOXY CONTAINING FROM 1 TO 6 CARBON ATOMS OR PROPIONAMIDO; AND THE SALTS THERREOF ARE OUTSTANDINGLY EFFECTIVE ANTI-HYPERLIPEMIC AGENTS AND, PARTICULARLY, AS ANTI-CHOLESTEROL AGENTS.
4-(R-NH-CO-),5-NH2-IMIDAZOLE-
17.发明授权
公开(公告)号：US3749724A
公开(公告)日：1973-07-31
申请号：US3749724D
申请日：1970-11-25
发明人： WIEDEMANN F , ROESCH E , HARDEBECK K , THIEL M , STACH K
IPC分类号： C07D471/04 , C07D57/20
CPC分类号： C07D471/04 , Y10S514/869
摘要： NEW 2 - MERCAPTO-PYRIDO(2,3-D)PYRIMIDIN-4(3H)-ONE COMPOUNDS OF THE FORMULA
AND PHYSIOLOGICALLY COMPATIBLE SALTS THEREOF, POSSESS EXCEPTIONAL DIURETIC AND NATRIURETIC ACTIVITY.
4-(O=),2-(R-S-)-3,4-DIHYDROPYRIDO(2,3-D)PYRIMIDINE-
公开(公告)号：US3749709A
公开(公告)日：1973-07-31
申请号：US3749709D
申请日：1969-03-11
发明人： NELBOECK HOCHSTETTER M , BEAUCAMP K
CPC分类号： C07H19/16
摘要： PROCESS FOR THE CHROMATOGRAPHIC PURIFICATION OF REDUCED PYRIDINE COENZYMES WHICH COMPRISES UTILIZING COLUMNS CHARGED WITH WEAKLY BASIC ANION EXCHANGE RESINS WHICH ARE NOT PRESENT IN THE HYDROXYL FORM AND CARRYING OUT THE ELUTION WITH AN ALKALINE ELUTION AGENT HAVING A PH GREATER THAN 7.5.
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公开(公告)号：US3736334A
公开(公告)日：1973-05-29
申请号：US3736334D
申请日：1971-01-19
IPC分类号： C07D311/86 , C07D313/12 , C07D337/12 , C07D7/42
CPC分类号： C07D311/86 , C07C2603/18 , C07D313/12 , C07D337/12
摘要： WHEREIN X IS A VALENCY BOND, A SULFUR OR OXYGEN ATOM, A SATURATED OR UNSATURATED ALKYLENE RADICAL OR AN OXAMETHYLENE OR THIAMETHYLENE RADICAL, R1 AND R2, WHICH MAY BE THE SAME OR DIFFERENT, ARE HYDROGEN ATOMS OR METHYL RADICALS, AND R3 IS A HYDROGEN OR HALOGEN ATOM, WHICH COMPOUNDS SERVE TO REDUCE THE CHOLESTEROL LEVEL IN BLOOD. THE PROCESS OF MAKING AND USING THE COMPOUNDS ARE ALSO COVERED.
PHENYLENE)-)
X
PHENOXYACETIC ACID ESTERS OF THE FORMULA-
公开(公告)号：US3725465A
公开(公告)日：1973-04-03
申请号：US3725465D
申请日：1971-08-03
发明人： STOECK G , GRADEL W , BUDKA H , TOPFMEIER F
IPC分类号： C07C101/08
摘要： To an aqueous solution of D,L-N-benzoyl-3,4-dimethoxy-phenylalanine there is added at least one amine selected from the group consisting of D(-)-threo-1-m-nitrophenyl-2-amino-propanediol-1,3, D(-)-threo-1-p-nitrophenyl-2-amino-propanediol-1,3 and D(-)threo-1-phenyl-2-amino-propanediol-1,3 selectively to precipitate the amine salt of the L-stereoisomer which is separated, dissolved and acidified to precipitate the free L-stereoisomer which is saponified to L-3,4-dihydroxy-phenyl-alanine. The mother liquor from the initial precipitation containing the amine salt of the D-stereoisomer and some L-stereoisomer is acidified to precipitate the free stereoisomers, leaving the amine in the acidified solution. The precipitated free stereoisomers are racemized and recycled for recovery of additional L-stereoisomer. The acidified solution of amine is rendered alkaline and steps are taken to regenerate and recycle the free amine.
摘要翻译： 向D，LN-苯甲酰基-3,4-二甲氧基 - 苯基 - 丙氨酸的水溶液中加入至少一种选自D（ - ） - 苏氨基-1-间硝基苯基-2-氨基 - 丙二醇-1,3，D（ - ） - 苏式-1-对硝基苯基-2-氨基 - 丙二醇-1,3和D（ - ） - 苏式-1-苯基-2-氨基 - 丙二醇-3,3选择性 以沉淀L-立体异构体的胺盐，其被分离，溶解并酸化以沉淀被皂化成L-3,4-二羟基 - 苯基 - 丙氨酸的游离L-立体异构体。 将含有D-立体异构体的胺盐和一些L-立体异构体的初始沉淀的母液酸化以沉淀游离的立体异构体，使胺在酸化溶液中。 沉淀的游离立体异构体被外消旋化并再循环用于回收另外的L-立体异构体。 胺的酸化溶液呈碱性，并采取步骤来再生和再循环游离胺。
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