公开(公告)号：US20170345523A1

公开(公告)日：2017-11-30

申请号：US15605507

申请日：2017-05-25

Applicant: Ion Beam Applications, S.A.

Inventor： Benoît Nactergal ,  Frédéric Stichelbaut

IPC: G21G1/10 ,  H05H13/00

CPC classification number: G21G1/10 ,  G21F1/12 ,  H05H7/00 ,  H05H13/005 ,  H05H2277/116

Abstract: The present disclosure relates to an isotope production apparatus. In one implementation, the apparatus may include a cyclotron for producing a particle beam, a shielding surrounding the cyclotron, and a target system within the shielding. The shielding may include a first layer having a hydrogen content of at least 100 kg/m3 and a second layer having at least 4900 kg/m3 of material having an atomic number equal to or higher than 26, and at least 29 kg/m3 of hydrogen.

公开(公告)号：US20170332474A1

公开(公告)日：2017-11-16

申请号：US15594538

申请日：2017-05-12

Applicant: Ion Beam Applications, S.A.

Inventor： Michel Abs ,  Sébastien De Neuter

IPC: H05H7/04 ,  H05H13/00

CPC classification number: H05H7/10 ,  H01F3/10 ,  H01F7/02 ,  H01F7/20 ,  H05H7/001 ,  H05H7/04 ,  H05H13/005 ,  H05H13/08 ,  H05H2007/002 ,  H05H2007/043

Abstract: The present disclosure relates to compact isochronous sector-focused cyclotrons having reduced dimensions and weight compared with state of the art cyclotrons of same energies. In one implementation, a cyclotron may include two pole magnets facing each other in a chamber defined by a yoke having base plates and flux return yokes forming a lateral wall of the chamber. The magnet poles may include between three and eight hill sectors alternating with a same number of valley sectors distributed about a central axis. The lip of the abyssal opening may be positioned at a distance from the corresponding valley peripheral edge. The flux return yoke may have a thickness in the portions facing valley sectors, such that the ratio of the product of the distance times the thickness to the square of the distance of the peripheral edge to the central axis is less than 5%.

公开(公告)号：US20170332471A1

公开(公告)日：2017-11-16

申请号：US15594534

申请日：2017-05-12

Applicant: Ion Beam Applications, S.A.

Inventor： Willem Kleeven ,  Szymon Zaremba

IPC: H05H7/00 ,  H05H7/04 ,  H05H7/10 ,  H05H13/00 ,  H05H13/08

CPC classification number: H05H7/10 ,  H01F3/10 ,  H01F7/02 ,  H01F7/20 ,  H05H7/001 ,  H05H7/04 ,  H05H13/005 ,  H05H13/08 ,  H05H2007/002 ,  H05H2007/043

Abstract: The present disclosure relates to a magnet pole for an isochronous sector-focused cyclotron having hill and valley sectors alternatively distributed around a central axis, Z, each hill sector having an upper surface bounded by four edges: an upper peripheral edge, an upper central edge, a first and a second upper lateral edges, and a peripheral surface extending from the upper peripheral edge to a lower peripheral line. The upper peripheral edge of at least one hill sector may further include a concave portion with respect to the central axis defining a recess extending at least partially over a portion of the peripheral surface of the corresponding hill sector.

公开(公告)号：US09818573B2

公开(公告)日：2017-11-14

申请号：US14594852

申请日：2015-01-12

Applicant: Ion Beam Applications S.A.

Inventor： Michel Abs ,  Szymon Zaremba ,  Willem Kleeven

IPC: H01J37/10 ,  A61L2/08 ,  A61N5/10 ,  G21K1/08 ,  G21K5/04 ,  G21K5/10 ,  H05G2/00 ,  H01J37/30 ,  H01J37/317 ,  H01J37/147 ,  H01J37/304

CPC classification number: H01J37/10 ,  A61L2/087 ,  A61L2202/122 ,  A61N5/1043 ,  A61N2005/1087 ,  G21K1/08 ,  G21K5/04 ,  G21K5/10 ,  H01J37/147 ,  H01J37/1474 ,  H01J37/3002 ,  H01J37/3005 ,  H01J37/304 ,  H01J37/3045 ,  H01J37/317 ,  H01J2237/103 ,  H01J2237/12 ,  H01J2237/14 ,  H01J2237/2602 ,  H01J2237/30 ,  H01J2237/31701 ,  H05G2/00

Abstract: The present invention is related to an apparatus for transporting a charged particle beam. The apparatus may include means for scanning the charged particle beam on a target, a dipole magnet arranged upstream of the means for scanning, at least three quadrupole lenses arranged between the dipole magnet and the means for scanning and means for adjusting the field strength of said at least three quadrupole lenses in function of the scanning angle of the charged particle beam. The apparatus can be made at least single achromatic.

公开(公告)号：US20160045769A1

公开(公告)日：2016-02-18

申请号：US14779790

申请日：2014-03-26

Applicant: ION BEAM APPLICATIONS S.A.

Inventor： Jean-Claude AMELIA ,  Thomas COLMANT ,  Sven DE ROECK

IPC: A61N5/10

CPC classification number: A61N5/1083 ,  A61N5/1042 ,  A61N5/1043 ,  A61N5/1077 ,  A61N2005/1074 ,  A61N2005/1087 ,  A61N2005/1095

Abstract: The present disclosure relates to an accessory holder attachable to or integrated in the nozzle of an apparatus for particle beam irradiation treatment. The accessory may be an aperture piece, a range shifter or any other element that can be placed in the beam path between the outer end of the nozzle and the irradiated target. The accessory holder may be equipped with first displacement means for moving the accessory away from or towards the nozzle, thereby moving the accessory forwards and backwards in the direction of the beam and second displacement means for moving the accessory into or out of the beam path. Measurements or treatment steps may be performed with and without the accessory in the beam path, without interrupting the treatment.

Abstract translation: 本公开涉及一种可附接到或集成在用于粒子束照射处理的装置的喷嘴中的附件保持器。 附件可以是孔径片，范围移位器或可以放置在喷嘴的外端和被照射的靶之间的光束路径中的任何其它元件。 附件保持器可以配备有用于将附件远离或朝向喷嘴移动的第一移位装置，从而沿着梁的方向向前和向后移动附件和用于将附件移入或移出光束路径的第二移位装置。 测量或处理步骤可以在束道中具有和不具有附件，而不中断处理。

公开(公告)号：US20150246245A1

公开(公告)日：2015-09-03

申请号：US14426913

申请日：2013-09-10

Applicant: ION BEAM APPLICATIONS S.A.

Inventor： Alexandre Debatty ,  Jean-Claude Amélia ,  Sébastien De Neuter

IPC: A61N5/10 ,  A61B6/00 ,  A61B6/03

CPC classification number: A61N5/1048 ,  A61B6/032 ,  A61B6/035 ,  A61B6/105 ,  A61B6/4085 ,  A61B6/4429 ,  A61B6/487 ,  A61B6/547 ,  A61N5/1049 ,  A61N5/1081 ,  A61N2005/1061 ,  A61N2005/1087

Abstract: The invention relates to a hadron therapy installation that comprises an irradiation unit (1) supported by a rotary support structure, so as to be able to rotate around a target volume (15) centered on the axis of rotation (22), to deliver a treatment beam (17) from different angles on the target volume (15). An imaging device (3, 4) is secured in rotation with the irradiation unit (1) and translatable relative to the irradiation unit (1) between a retracted position at the irradiation unit (1) and a lateral deployed position relative to the target volume (15), such that in its deployed position, the imaging device (3, 4) can rotate around the target volume (15) together with the irradiation unit (1). Such an installation can be used for a cone beam computed tomography method and/or a fluoroscopic imaging method on a patient to be treated in the hadron therapy installation.

Abstract translation: 本发明涉及一种强子治疗装置，其包括由旋转支撑结构支撑的照射单元（1），以便能够围绕以旋转轴线（22）为中心的目标体积（15）旋转，以便将 处理束（17）从目标体积（15）上的不同角度。 成像装置（3,4）与照射单元（1）旋转固定，并且相对于照射单元（1）在照射单元（1）的缩回位置和相对于目标体积的横向展开位置之间可平移 （15），使得在其展开位置，成像装置（3,4）可以与照射单元（1）一起围绕目标体积（15）旋转。 这样的安装可以用于在强子治疗装置中待治疗的患者的锥形束计算机断层摄影方法和/或透视成像方法。

公开(公告)号：US09093209B2

公开(公告)日：2015-07-28

申请号：US14376100

申请日：2013-02-01

Applicant: Ion Beam Applications S.A.

Inventor： Yves Jongen

IPC: H01F6/02 ,  H05H13/00 ,  H01F6/06 ,  H05H7/04 ,  A61N5/10

CPC classification number: H01F6/06 ,  A61N5/1077 ,  H05H7/04 ,  H05H13/005 ,  H05H2007/043

Abstract: The invention relates to a magnet structure for a superconducting isochronous cyclotron for use in particle therapy. The cyclotron according to the invention is using two sets of three or more superconducting sector coil elements for generating an azimuthally varying magnetic field across the acceleration region. In this way, high-field (e.g. above 4 T) isochronous cyclotrons are provided which do not suffer the problem of a low flutter amplitude.

Abstract translation: 本发明涉及一种用于粒子治疗的超导同步回旋加速器的磁体结构。 根据本发明的回旋加速器使用两组三个或更多个超导扇形线圈元件，用于在加速区域上产生方位角变化的磁场。 以这种方式，提供了高场（例如高于4T）同步回旋加速器，其不遭受低颤振振幅的问题。

公开(公告)号：US20150133713A1

公开(公告)日：2015-05-14

申请号：US14399477

申请日：2013-05-10

Applicant: Ion Beam Applications S.A.

Inventor： Olivier Vierlinck ,  Michel Closset ,  David Wikler

IPC: A61N5/10

CPC classification number: A61N5/1067 ,  A61N5/1043 ,  A61N5/1045 ,  A61N5/1065 ,  A61N5/1075 ,  A61N5/1081 ,  A61N2005/1057 ,  A61N2005/1087 ,  A61N2005/1096

Abstract: The present invention relates to a method for compensating the deviation of an energetic beam of hadrons delivered by an irradiation unit of a hadron-therapy installation, with respect to an isocentre of a rotatable gantry supporting said irradiation unit, said irradiation unit comprising a collimator comprising an opening for the passage of said beam. The present invention also relates to a program comprising an algorithm for calculation of a correction to be applied to the position of an opening of a collimator of an irradiation unit of a hadron-therapy installation. The invention finally also relates to a hadron therapy installation.

Abstract translation: 本发明涉及一种用于补偿由强子治疗装置的照射单元输送的强子的能量束相对于支撑所述照射单元的可旋转机架的等中心的偏离的方法，所述照射单元包括准直器，该准直器包括： 用于通过所述梁的开口。 本发明还涉及包括用于计算要应用于强子治疗装置的照射单元的准直器的开口的位置的校正的算法的程序。 本发明最终还涉及强子治疗装置。

公开(公告)号：US20150064071A1

公开(公告)日：2015-03-05

申请号：US14389505

申请日：2013-03-29

Applicant: Ion Beam Applications S.A.

Inventor： Bernard Lambert ,  Michel Guyette ,  Christophe Sauvage

IPC: B01J4/00 ,  B32B37/12 ,  B32B38/06

CPC classification number: B01J4/00 ,  B01J19/004 ,  B01J19/0093 ,  B01J2219/00792 ,  B01J2219/00799 ,  B01J2219/00833 ,  B01J2219/0086 ,  B01J2219/00889 ,  B01J2219/00952 ,  B01J2219/00986 ,  B32B37/12 ,  B32B38/06 ,  C07B59/00 ,  Y10T29/49826 ,  Y10T156/1039

Abstract: The present invention relates to a disposable module (100) for use in a device (300) for synthesizing radiopharmaceutical products starting with chemical reagents, said disposable module (100) comprising: a supporting plate (101) comprising rigid connection means (114) to at least one flask of chemical reagents (102, 103, 104, 105) in solution in a solvent, and a reactor (106); interface means (115) with a fixed module of said synthesis device (300), in contact with or integrated into said supporting plate (101), said interface means comprising at least one valve (V1-V8) and/or at least one fluid inlet (E1, E2) and/or at least one fluid outlet (O1, O2, O3); at least one conduit (1-20) connected to said at least one valve (V1-V8) or to said at least one fluid inlet (E1, E2) or to said at least one fluid outlet (O1, O2, O3), characterized in that at least one of said conduits (1-20) is integrated into the body of the disposable module (100).

Abstract translation: 本发明涉及用于从化学试剂开始合成放射性药物产品的装置（300）中的一次性模块（100），所述一次性模块（100）包括：支撑板（101），包括刚性连接装置 在溶剂中的溶液中的至少一个化学试剂瓶（102,103,104,105）和反应器（106）; 接口装置（115）与所述合成装置（300）的固定模块接触或集成到所述支撑板（101）中，所述接口装置包括至少一个阀（V1-V8）和/或至少一种流体 入口（E1，E2）和/或至少一个流体出口（O1，O2，O3）; 连接到所述至少一个阀（V1-V8）或所述至少一个流体入口（E1，E2）或至少一个流体出口（O1，O2，O3）的至少一个导管（1-20） 其特征在于，至少一个所述导管（1-20）被集成到所述一次性模块（100）的主体中。

公开(公告)号：US20140357930A1

公开(公告)日：2014-12-04

申请号：US14366541

申请日：2012-12-21

Applicant: Ion Beam Applications S.A.

Inventor： Jean-Claude Amélia

IPC: A61N5/10

CPC classification number: A61N5/1081 ,  A61N2005/1087

Abstract: A gantry structure (16) designed for pivoting about an axis of rotation (18) and for delivering a hadron beam on a target comprises a beam delivery line (24) receiving the hadron beam in a direction essentially parallel to the axis of rotation (18), deviating it away from said axis of rotation (18) and delivering it so that the axis of the beam intersects the axis of rotation (18). The beam delivery line (24) is a self-supporting structure supported by a pivotable support arm (32) in proximity of the center of gravity of the beam delivery line (24). A counterweight (42) is supported by a support arm extension (40) on the other side of the axis of rotation (18) for compensating the moment of force due to the weight of the beam delivery line (24) and the support arm (32).

Abstract translation: 设计用于围绕旋转轴线（18）枢转并用于在目标上输送强子束的龙门架结构（16）包括沿基本上平行于旋转轴线（18）的方向接收强子束的射束输送线（24） ），使其偏离所述旋转轴线（18）并将其输送，使得光束的轴线与旋转轴线（18）相交。 束输送管线（24）是由靠近梁输送管线（24）的重心的可枢转支撑臂（32）支撑的自支撑结构。 配重（42）由旋转轴线（18）的另一侧的支撑臂延伸部（40）支撑，用于补偿由于梁输送线（24）和支撑臂（24）的重量而产生的力矩 32）。