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    Biomimetic vascular network and devices using the same
    11.
    发明授权
    Biomimetic vascular network and devices using the same 有权

    公开(公告)号：US10327885B2

    公开(公告)日：2019-06-25

    申请号：US14615646

    申请日：2015-02-06

    申请人： David M. Hoganson ,  Howard I. Pryor ,  Ira Spool ,  Joseph P. Vacanti ,  Jeffrey T. Borenstein

    发明人： David M. Hoganson ,  Howard I. Pryor ,  Ira Spool ,  Joseph P. Vacanti ,  Jeffrey T. Borenstein

    IPC分类号： A61F2/06 ,  A61F2/04 ,  A61F2/02 ,  G01N33/50

    摘要： The invention provides method of fabricating a scaffold comprising a fluidic network, including the steps of: (a) generating an initial vascular layer for enclosing the chamber and providing fluid to the cells, the initial vascular layer having a network of channels for fluid; (b) translating the initial vascular layer into a model for fluid dynamics analysis; (c) analyzing the initial vascular layer based on desired parameters selected from the group consisting of a characteristic of a specific fluid, an input pressure, an output pressure, an overall flow rate and combinations thereof to determine sheer stress and velocity within the network of channels; (d) measuring the sheer stress and the velocity and comparing the obtained values to predetermined values; (e) determining if either of the shear stress or the velocity are greater than or less than the predetermined values, and (f) optionally modifying the initial vascular layer and repeating steps (b)-(e). The invention also provides compositions comprising a vascular layer for use in tissue lamina as well as a medical devices having a vascular layer and kits.