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19 条记录 (耗时 0.062 秒)

    Compounds advantageous in the treatment of central nervous system diseases and disorders
    12.
    发明授权
    Compounds advantageous in the treatment of central nervous system diseases and disorders 有权
    有利于治疗中枢神经系统疾病和病症的化合物

    公开(公告)号：US09212155B2

    公开(公告)日：2015-12-15

    申请号：US12881068

    申请日：2010-09-13

    申请人： Amir Pesyan ,  Manuel F. Balandrin

    发明人： Amir Pesyan ,  Manuel F. Balandrin

    IPC分类号： A61K31/165 ,  C07C233/11 ,  C07D295/155 ,  A61K31/353 ,  A61K31/36 ,  A61K31/44 ,  A61K31/445 ,  A61K31/495 ,  A61K31/5375 ,  A61K45/06

    CPC分类号： C07D295/155 ,  A61K31/165 ,  A61K31/353 ,  A61K31/36 ,  A61K31/44 ,  A61K31/445 ,  A61K31/495 ,  A61K31/5375 ,  A61K45/06

    摘要： A series of novel compounds showing anticonvulsant, chemical countermeasure(s), and analgesic activities is described. Such pharmaceutically active compounds may also show utility in the treatment of other central nervous system (“CNS”) diseases and disorders, such as anxiety, depression, insomnia, migraine headaches, schizophrenia, Parkinson's disease, spasticity, Alzheimer's disease, and bipolar disorder. Furthermore, such compounds may additionally find utility as analgesics (e.g., for the treatment of chronic or neuropathic pain) and as neuroprotective agents useful in the treatment of stroke(s), chronic neurodegenerative diseases (such as Alzheimer's disease and Huntington's disease), and/or traumatic brain and/or spinal cord injuries. Moreover, these/such compounds may also be useful in the treatment of status epilepticus and/or as chemical countermeasures.

    摘要翻译： 描述了一系列显示抗惊厥，化学对策和止痛活性的新型化合物。 此类药物活性化合物还可用于治疗其它中枢神经系统（“CNS”）疾病和病症，例如焦虑，抑郁，失眠，偏头痛，精神分裂症，帕金森病，痉挛状态，阿尔茨海默病和双相情感障碍。 此外，这些化合物还可用作止痛剂（例如，用于治疗慢性或神经性疼痛）和用作治疗中风，慢性神经变性疾病（如阿尔茨海默病和亨廷顿疾病）的神经保护剂，以及 /或创伤性脑部和/或脊髓损伤。 此外，这些/这样的化合物也可用于治疗癫痫持续状态和/或作为化学应对措施。

    Pharmaceutical compositions comprising isovaleramide
    19.
    发明授权
    Pharmaceutical compositions comprising isovaleramide 失效
    包含异戊酰胺的药物组合物

    公开(公告)号：US5763494A

    公开(公告)日：1998-06-09

    申请号：US623691

    申请日：1996-03-29

    申请人： Manuel F. Balandrin ,  Bradford C. Van Wagenen

    发明人： Manuel F. Balandrin ,  Bradford C. Van Wagenen

    IPC分类号： A61K31/16 ,  A61P25/20 ,  A61P25/22 ,  A01N37/18 ,  A61K31/13

    CPC分类号： A61K31/16 ,  Y10S514/923

    摘要： Isovaleramide has been found to exhibit mild anxiolytic activity at low to moderate dosage levels and mildly sedative at somewhat higher dosage levels. In contrast to certain other materials thought to be anxiolytic or mildly sedative, isovaleramide is non-cytotoxic and does not paradoxically stimulate the central nervous system. Isovaleramide is therefore useful as a mild anxiolytic and mild sedative which can be made available to the general public.

    摘要翻译： 已经发现异戊酰胺在低至中等剂量水平下表现出轻度的抗焦虑活性，并且在稍高的剂量水平下轻度镇静。 与被认为是抗焦虑或轻度镇静的某些其他物质相反，异戊酰胺是非细胞毒性的，并不矛盾地刺激中枢神经系统。 因此，异戊酰胺可作为轻度抗焦虑和轻度镇静剂而使用，可向公众提供。