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11.发明申请HYDROGEL BASED ON γ-POLYGLUTAMIC ACID AND ε-POLYLYSINE CROSSLINKED POLYMER, AND PREPARATION METHOD THEREFOR 审中-公开基于γ-聚氨基酸和ε-聚亚烷基交联聚合物的水凝胶及其制备方法公开(公告)号：US20170014543A1
公开(公告)日：2017-01-19
申请号：US15100210
申请日：2013-12-28
Applicant: NANJING UNIVERSITY OF TECHNOLOGY
Inventor： Hong Xu , Bo Chi , Jun Xia , Sha Li , Xiaohai Feng
CPC classification number: A61L15/26 , A61L15/32 , A61L15/60 , C08J3/075 , C08J3/246 , C08J9/286 , C08J2201/026 , C08J2201/048 , C08J2201/054 , C08J2205/022 , C08J2205/028 , C08J2207/12 , C08J2377/04 , C08J2477/04
Abstract: A hydrogel based on a cross-linked γ-polyglutamic acid and ε-polylysine polymer is obtained by cross-linking of γ-polyglutamic acid with ε-polylysine, and it is a polymer having the following constitutional unit, wherein, m is a natural number of 15 to 45, n is a natural number of 3900 to 17000, and x is a natural number of 5 to 40. It also discloses a preparation method of as-described hydrogel and its application in preparation as a medical wound dressing.
Abstract translation: 通过γ-聚谷氨酸与ε-聚赖氨酸交联得到基于交联的γ-聚谷氨酸和ε-聚赖氨酸聚合物的水凝胶，它是具有以下结构单元的聚合物，其中m是天然的 数为15〜45，n为3900〜17000的自然数，x为5〜40的自然数。另外公开了上述水凝胶的制备方法及其作为医疗伤口敷料的制备中的应用。
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12.发明授权Use of N-acetylneuraminic acid aldolase in catalytic synthesis of N-acetylneuraminic acid 有权N-乙酰神经氨酸醛缩酶在N-乙酰神经氨酸催化合成中的应用公开(公告)号：US09512420B2
公开(公告)日：2016-12-06
申请号：US14396317
申请日：2013-11-27
Applicant: Nanjing University of Technology
Inventor： Jingjing Xie , Wenyan Ji , Hanjie Ying , Wujin Sun , Ting Guo , Yong Chen , Xiaochun Chen , Jinglan Wu
CPC classification number: C12N9/88 , C12N15/63 , C12P19/26 , C12Y401/03003 , Y02P20/52
Abstract: It discloses a use of N-acetylneuraminic acid aldolase with an amino acid sequence as shown in SEQ ID NO: 2 in catalytic synthesis of N-acetylneuraminic acid. The preparation of N-acetylneuraminic acid is to use the N-acetylneuraminic acid aldolase with the amino acid sequence as shown in SEQ ID NO: 2 as a catalyst, and N-acetylmannosamine and pyruvic acid as substrates.
Abstract translation: 其公开了N-乙酰神经氨酸醛缩酶与N-乙酰神经氨酸的催化合成中具有SEQ ID NO：2所示氨基酸序列的用途。 N-乙酰神经氨酸的制备是使用N-乙酰神经氨酸醛缩酶与SEQ ID NO：2所示的氨基酸序列作为催化剂，N-乙酰甘露糖胺和丙酮酸作为底物。
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13.发明申请Catalyst for Benzene Hydroxylation for Preparation of Phenol and Preparation Method Thereof 审中-公开用于制备苯酚的苯羟基化催化剂及其制备方法公开(公告)号：US20160250623A1
公开(公告)日：2016-09-01
申请号：US15028438
申请日：2014-09-12
Applicant: NANJING UNIVERSITY OF TECHNOLOGY
Inventor： Rizhi CHEN , Yaohui BAO , Hong JIANG , Yiqun FAN , Weihong XING
CPC classification number: B01J29/0341 , B01J29/0316 , B01J29/0325 , B01J29/0333 , B01J37/06 , B01J2229/186 , B01J2229/32 , C07C37/58 , Y02P20/52 , C07C39/04
Abstract: The invention relates to a catalyst for benzene hydroxylation for preparation of phenol and a preparation method thereof, wherein said catalyst uses a mesoporous material as carrier, and the catalyst is prepared by first modifying the surface of the carrier using aminosilane, then immersing with acetylacetonate salt of metal, and finally washing and drying. Advantage of the invention is that a reactive metal is loaded on the silane-modified mesoporous material to form a homogeneous-heterogeneous composite catalyst, wherein, the reactive metal component is present in a reaction system in a homogeneous form, which ensures high catalytic performance of the catalyst component, and it is loaded on the carrier through bridging action of aminosilane, which improves the acting force between the metal component and the carrier, enhances stability of the catalyst, and facilitates separation of the catalyst from the product. The catalyst has a simple preparation process, has excellent catalytic performance, and can be applied to the reaction system of benzene hydroxylation for preparation of phenol.
Abstract translation: 本发明涉及一种用于制备苯酚的苯羟基化催化剂及其制备方法，其中所述催化剂使用介孔材料作为载体，催化剂通过首先用氨基硅烷改性载体的表面，然后用乙酰丙酮盐 的金属，最后洗涤和干燥。 本发明的优点是将反应性金属负载在硅烷改性介孔材料上以形成均相 - 非均相复合催化剂，其中反应性金属组分以均匀形式存在于反应体系中，这确保了高的催化性能 催化剂组分，并通过氨基硅烷的桥接作用负载在载体上，改善了金属组分与载体之间的作用力，提高了催化剂的稳定性，有利于催化剂与产物的分离。 该催化剂具有简单的制备方法，具有优异的催化性能，可应用于苯羟基化反应体系制备苯酚。
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14.发明申请PREPARATION METHOD OF LYCOPENE INTERMEDIATE 3-METHYL-4,4-DIALKOXY-1-BUTALDEHYDE 审中-公开中间体3-甲基-4,4-二甲氧基-1-苯甲醛的制备方法公开(公告)号：US20140357900A1
公开(公告)日：2014-12-04
申请号：US14369137
申请日：2012-12-10
Applicant: NANJING UNIVERSITY OF TECHNOLOGY , ZHEJIANG MEDICINE CO., LTD. XINCHANG PHARMACEUTICAL FACTORY
Inventor： Chunlei Lv , Shiqing Pl , Jianhui Chen , Dingqiang Lu , Pingkai Ouyang
CPC classification number: C07C45/30 , C07C41/22 , C07C45/00 , C07C45/516 , C07C47/198
Abstract: Disclosed is a preparation method of the lycopene intermediate 3-methyl-4,4-dialkoxy-1-butaldehyde. The preparation method comprises the following steps: (1) reacting 2-methyl-3,3-dialkoxy-1-halopropane with magnesium powder in the solvent of anhydrous tetrahydrofuran at a temperature of 45˜65° C. to generate a mixture of Grignard reagents under the protection of an inert gas; and (2) adding N,N-disubstituted carboxamide to the mixture of Grignard reagents and reacting at a temperature of 10° C.˜35° C. to obtain 3-methyl-4,4-dialkoxy-1-butaldehyde. The process route of the present invention is simple and direct, the operation is easy, the conditions are mild and the yield is good, and thus the invention has commercial value.
Abstract translation: 公开了番茄红素中间体3-甲基-4,4-二烷氧基-1-丁醛的制备方法。 制备方法包括以下步骤：（1）在45〜65℃的温度下，将2-甲基-3,3-二烷氧基-1-卤代丙烷与镁粉末在无水四氢呋喃的溶剂中反应，生成格利雅 在惰性气体保护下的试剂; 和（2）将N，N-二取代的甲酰胺加入到格氏试剂混合物中，并在10℃〜35℃的温度下反应，得到3-甲基-4,4-二烷氧基-1-丁醛。 本发明的工艺路线简单直接，操作容易，条件温和，产量好，因此本发明具有商业价值。
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15.发明申请CHEMICALLY DEFINED CULTURE MEDIUM FOR FERMENTATION TO PRODUCE SUCCINIC ACID AND APPLICATION THEREOF 审中-公开化学定义的培养基，用于发酵生产酸性和应用公开(公告)号：US20140242673A1
公开(公告)日：2014-08-28
申请号：US14352320
申请日：2012-09-14
Applicant: NANJING UNIVERSITY OF TECHNOLOGY
Inventor： Min Jiang , Yongian Xi , Jiuhua Zhang , Rong Xu , Wenyu Dai , Kequan Chen , Ping Wei
IPC: C12N1/20
Abstract: This invention belongs to the technical field of industrial microorganism fermentation and relates to a type of chemical defined medium used for succinic acid production by fermentation and its application. The chemical defined medium of this invention used for succinic acid production by fermentation includes conventional compositions and critical growth factor compositions. Said critical growth factor compositions include biotin or 5-ALA, niacin, amino acid, and methionine. This formula determines four critical growth factors of succinic acid fermentation through reasonable technical means. The culture medium is free of complicated and expensive nutritious compositions such as yeast powder and peptone. Reliance on expensive vitamin by production of succinic acid through fermentation in defined medium is avoided, so that production cost of succinic acid can be greatly lowered, and subsequent separation process can be simplified, constituting a key step of industrial production of succinic acid using chemical defined medium.
Abstract translation: 本发明属于工业微生物发酵技术领域，涉及一种用于通过发酵生产琥珀酸的化学定义培养基及其应用。 用于通过发酵生产琥珀酸的本发明的化学定义的培养基包括常规组合物和临界生长因子组合物。 所述临界生长因子组合物包括生物素或5-ALA，烟酸，氨基酸和甲硫氨酸。 该公式通过合理的技术手段确定了琥珀酸发酵的四个关键生长因子。 培养基不含复杂且昂贵的营养成分如酵母粉和蛋白胨。 避免通过在定义的培养基中发酵生产琥珀酸来维持昂贵的维生素，从而大大降低了琥珀酸的生产成本，并且可以简化随后的分离过程，构成了使用化学定义的工业生产琥珀酸的关键步骤 中。
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Patent Agency Ranking
公开(公告)号：US11278846B2
公开(公告)日：2022-03-22
申请号：US16470230
申请日：2017-06-09
Applicant: Nanjing University of Technology
Inventor： Xuehong Gu , Lin Wang , Chun Zhang
Abstract: Provided is a method for preparing a defect-free DDR molecular sieve membrane. Sigma-1 molecular sieve is used as an inducing seed crystal to prepare and obtain a continuous and compact DDR molecular sieve membrane on the surface of a porous ceramic support. An ozone atmosphere or an external field assisted technology is used to remove a template in the pores of the molecular sieve membrane at a low temperature. The invention avoids the formation of intercrystal defects and cracks, an activated DDR molecular sieve membrane has a good selectivity for separating CO2, and the membrane preparation time is significantly reduced.
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17.发明授权公开(公告)号：US11033884B2
公开(公告)日：2021-06-15
申请号：US15028438
申请日：2014-09-12
Applicant: NANJING UNIVERSITY OF TECHNOLOGY
Inventor： Rizhi Chen , Yaohui Bao , Hong Jiang , Yiqun Fan , Weihong Xing
Abstract: The invention relates to a catalyst for benzene hydroxylation for preparation of phenol and a preparation method thereof, wherein said catalyst uses a mesoporous material as carrier, and the catalyst is prepared by first modifying the surface of the carrier using aminosilane, then immersing with acetylacetonate salt of metal, and finally washing and drying. Advantage of the invention is that a reactive metal is loaded on the silane-modified mesoporous material to form a homogeneous-heterogeneous composite catalyst, wherein, the reactive metal component is present in a reaction system in a homogeneous form, which ensures high catalytic performance of the catalyst component, and it is loaded on the carrier through bridging action of aminosilane, which improves the acting force between the metal component and the carrier, enhances stability of the catalyst, and facilitates separation of the catalyst from the product. The catalyst has a simple preparation process, has excellent catalytic performance, and can be applied to the reaction system of benzene hydroxylation for preparation of phenol.
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公开(公告)号：US20160137557A1
公开(公告)日：2016-05-19
申请号：US14898471
申请日：2014-05-09
Applicant: NANJING UNIVERSITY OF TECHNOLOGY
Inventor： Xuehong GU , Zhenzhou SHI , Yuanyuan CHEN , Chun ZHANG , Nanping XU
IPC: C04B35/622 , B01D69/08 , B01D67/00 , B01D71/02
CPC classification number: C04B35/6225 , B01D67/0041 , B01D69/081 , B01D69/082 , B01D71/024 , B01D71/025 , B01D2325/04 , B01D2325/24 , C04B2235/3246 , C04B2235/6021
Abstract: The Invention relates to a method for preparing a multichannel hollow fiber membrane. According to a certain ratio, ceramic powder, a macromolecular polymer, an organic solvent, and a dispersant are mixed evenly to prepare a membrane casting solution; and after bubble removing processing is performed on the membrane casting solution, a membrane green body is formed with the cooperation of a multichannel hollow fiber die and phase inversion. After the membrane green body is roasted at a high temperature, a multichannel ceramic hollow fiber membrane is formed. The multichannel ceramic hollow fiber membrane has an asymmetric structure and a skeleton structure in an inner cavity and can meet the strength and flux requirements of a ceramic hollow fiber membrane.
Abstract translation: 本发明涉及一种制备多通道中空纤维膜的方法。 按照一定的比例，将陶瓷粉末，高分子聚合物，有机溶剂和分散剂均匀混合以制备膜浇铸溶液; 并且在膜浇铸溶液进行气泡去除处理之后，通过多通道中空纤维管芯的配合形成膜生坯并进行相转化。 在高温下烘烤膜生坯后，形成多孔陶瓷中空纤维膜。 多通道陶瓷中空纤维膜在内腔中具有不对称结构和骨架结构，可以满足陶瓷中空纤维膜的强度和通量要求。
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19.发明申请PREPARATION METHOD OF YEAST CELL IMMOBILIZATION MEDIUM AND APPLICATION THEREOF 审中-公开YEAST细胞固定培养基的制备方法及其应用公开(公告)号：US20160032272A1
公开(公告)日：2016-02-04
申请号：US14651071
申请日：2012-12-13
Applicant: NANJING UNIVERSITY OF TECHNOLOGY
Inventor： Hanjie YING , Yong CHEN , Qingguo LIU , Jinglan WU , Xiaochun CHEN , Jingjing XIE
CPC classification number: C12N11/08 , C12N11/02 , C12N11/12 , C12P7/06 , D06M13/123 , D06M13/332 , D06M13/418 , D06M15/59 , Y02E50/17
Abstract: Provided is a preparation method of a yeast cell immobilization medium, which comprises the following steps: (1) boiling a fiber material in boiling water and drying the fiber material; (2) soaking the fiber material in a surface modified aqueous solution with a concentration of 1-100 g/L, using hydrochloric acid to adjust a PH of the solution to 7.0, fully rinsing the fiber material in deionized water and drying the fiber material; (3) soaking the fiber material in a cross-linking agent aqueous solution with a concentration of 1-100 g/L, fully rinsing the fiber material in deionized water and drying the fiber material; and (4) attaching the fiber material to supporting framework. Also provided is the yeast cell immobilization medium prepared using the preparation method and a method for producing ethanol using the yeast cell immobilization medium.
Abstract translation: 提供酵母细胞固定培养基的制备方法，其包括以下步骤：（1）在沸水中煮沸纤维材料并干燥纤维素材料; （2）将纤维材料浸泡在浓度为1-100g / L的表面改性水溶液中，使用盐酸将溶液的PH调节至7.0，将去离子水中的纤维材料充分漂洗并干燥纤维材料 ; （3）将纤维材料浸泡在浓度为1-100g / L的交联剂水溶液中，在去离子水中充分漂洗纤维材料并干燥纤维材料; 和（4）将纤维材料连接到支撑框架上。 还提供了使用制备方法制备的酵母细胞固定培养基和使用酵母细胞固定培养基生产乙醇的方法。
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公开(公告)号：US10427107B2
公开(公告)日：2019-10-01
申请号：US14898472
申请日：2014-05-09
Applicant: NANJING UNIVERSITY OF TECHNOLOGY
Inventor： Xuehong Gu , Dezhong Liu , Zhenzhou Shi , Chun Zhang , Xuerui Wang
Abstract: The invention relates to a high-strength hollow fiber zeolite membrane and its preparation method, characterized in that the support of the high-strength zeolite membrane has a multi-channel hollow fiber configuration. The preparation method comprises first preparing a crystal seed solution, then immersing the dry support with the multi-channel hollow fiber configuration in the crystal seed solution, and extracting and drying the support to obtain a crystal-seeded support; and finally placing the crystal-seeded support in a zeolite membrane synthetic fluid, performing hydrothermal synthesis, and taking out, washing and drying the product to obtain the high-strength hollow fiber zeolite membrane. The multi-channel hollow fiber support can provide high mechanical property, which greatly reduces the depreciation rate of the hollow fiber zeolite membrane equipment during use. Meanwhile, the multi-channel hollow fiber zeolite membrane prepared by the Invention possesses high loading density of permeation flux and membrane module and can reduce the production cost and improve the separation efficiency significantly, and thus lays the foundation for promoting the industrial application of the hollow fiber zeolite membrane.
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