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公开(公告)号：US20240316112A1
公开(公告)日：2024-09-26
申请号：US18674990
申请日：2024-05-27
Applicant: Ramot at Tel-Aviv University Ltd.
Inventor： Tal DVIR , Reuven EDRI , Lior WERTHEIM
IPC: A61K35/30 , A61K35/12 , A61L31/14 , C12N5/071 , C12N5/0793
CPC classification number: A61K35/30 , A61K35/12 , A61L31/145 , C12N5/0619 , C12N5/0679 , A61L2300/64 , A61L2430/38 , A61L2430/40 , C12N2501/999 , C12N2506/45
Abstract: A composition is disclosed which comprises a plurality of fibrous particles fabricated from decellularized omentum, the fibrous particles being between 750 microns-3 mm in diameter, wherein the fibrous particles comprise a network of mature neurons. Uses thereof and methods of generating same are also disclosed.
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公开(公告)号：US12070597B2
公开(公告)日：2024-08-27
申请号：US16766978
申请日：2018-11-26
Applicant: RAMOT AT TEL-AVIV UNIVERSITY LTD. , UNIVERSITAET LINZ
Inventor： Yael Hanein , Niyazi Serdar Sariciftci , Eric Daniel Glowacki , David Rand , Gur Lubin , Marie Jakesova
CPC classification number: A61N1/0543 , A61N1/36046 , H10K30/20 , A61N1/0551 , A61N1/36062 , H10K85/311 , H10K85/621
Abstract: An efficient nanoscale semiconducting optoelectronic system, containing a P/N acceptor donor organic hetrojunction which is optimized for neuronal stimulation—an organic electrolytic photocapacitor. The devices comprise a thin (80 nm) trilayer of metal and p-n semiconducting organic nanocrystals. When illuminated in physiological solution, these metal-semiconductor devices charge up, transducing light pulses into localized displacement currents that are strong enough to electrically stimulate neurons with safe light intensities.
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公开(公告)号：US20240271066A1
公开(公告)日：2024-08-15
申请号：US18570211
申请日：2022-06-29
Applicant: RAMOT AT TEL AVIV UNIVERSITY LTD.
Inventor： Ben Meir MAOZ , Anna HERLAND , Shay DIVALD , Yuval OLIEL
CPC classification number: C12M21/08 , C12M23/16 , C12M23/34 , C12M23/42 , C12M25/04 , C12M29/06 , C12M41/46
Abstract: Provided herein is a modular organ-on-a-chip platform, configured for cultivating cells, tissues, organoids and organelles and capable of performing high throughput analyses, including pharmacokinetic evaluations.
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公开(公告)号：US20240245613A1
公开(公告)日：2024-07-25
申请号：US18433057
申请日：2024-02-05
Applicant: RAMOT AT TEL AVIV UNIVERSITY LTD.
Inventor： Ayala LAMPEL , Avigail-Elah BARUCH LESHEM , Amit BEN-AMAR
CPC classification number: A61K9/5052 , A61K47/42 , C07K7/06 , C07K7/08
Abstract: The invention provides a peptide liquid droplet a composition the same and methods for the delivery of an active ingredient, as disclosed herein. The composition comprises a peptide liquid droplet and an active agent encapsulated in the peptide liquid droplet. Further provided are a method for encapsulation of an active agent in a peptide liquid droplet; method for manufacturing an active ingredient in the peptide liquid droplet and a method for the delive
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公开(公告)号：US20240216510A1
公开(公告)日：2024-07-04
申请号：US18556172
申请日：2022-04-13
Applicant: RAMOT AT TEL-AVIV UNIVERSITY LTD. , ICHILOV TECH LTD. , YEDA RESEARCH & DEVELOPMENT CO. LTD.
Inventor： Vered PADLER-KARAVANI , Ron AMON , Lihi NINIOMANY , Moran RAWET SLOBODKIN , Anat GLOBERSON LEVIN , Tova WAKS , Zelig ESHHAR
IPC: A61K39/00 , A61P35/00 , C07K14/705 , C07K14/725 , C07K16/30 , C12N5/0783
CPC classification number: A61K39/4631 , A61K39/4611 , A61K39/4613 , A61K39/464474 , A61P35/00 , C07K14/7051 , C07K14/70517 , C07K14/70521 , C07K14/70532 , C07K14/70575 , C07K14/70578 , C07K16/30 , C12N5/0636 , A61K2039/505 , C07K2317/622 , C07K2319/03 , C07K2319/30 , C12N2510/00
Abstract: The present invention discloses chimeric antigen receptors that specifically recognize and bind to Sialyl Tn carbohydrate antigen with high specificity and selectivity. The invention further provides lymphocytic cells, such as T cells, comprising said CARs, compositions comprising said cells or CARs as well as uses thereof.
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Patent Agency Ranking
公开(公告)号：US20240204251A1
公开(公告)日：2024-06-20
申请号：US18288837
申请日：2022-04-15
Applicant: Ramot at Tel-Aviv University Ltd.
Inventor： Emanuel PELED , Tzach MUKRA , Evelina FAKTOROVICH SIMON , Roy MARRACHE , Tamir ASSA , Niv ALONI
IPC: H01M10/0567 , H01M4/02 , H01M4/38 , H01M10/0525 , H01M10/0562 , H01M10/0568 , H01M10/0569
CPC classification number: H01M10/0567 , H01M4/381 , H01M10/0525 , H01M10/0562 , H01M10/0568 , H01M10/0569 , H01M2004/027 , H01M2004/028 , H01M2300/0028 , H01M2300/0065
Abstract: An electrochemical cell is described herein, which comprises an anode, cathode and liquid electrolyte, as well as a rechargeable alkali metal ion battery comprising at least one such electrochemical cell. The anode comprises an alkali metal and/or a conductive solid suitable for deposition of the alkali metal thereupon; the cathode comprises a substance capable of reversibly absorbing and releasing ions of the alkali metal; and the liquid electrolyte comprises at least one additive selected from the group consisting of a nanoparticle dispersed in the liquid electrolyte and a polymer dissolved and/or dispersed in the liquid electrolyte. Further described herein is a process for preparing the electrochemical cell by contacting the liquid electrolyte with the cathode and/or said conductive solid, wherein the conductive solid is substantially devoid of the alkali metal, or the conductive solid is coated with a layer of the alkali metal.
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公开(公告)号：US20240181070A1
公开(公告)日：2024-06-06
申请号：US18285394
申请日：2022-04-07
Applicant: Ramot at Tel-Aviv University Ltd.
Inventor： Ronit SATCHI-FAINARO , Helena FLORINDO
IPC: A61K47/64 , A61K39/00 , A61K39/215 , A61K47/69
CPC classification number: A61K47/646 , A61K39/215 , A61K47/6455 , A61K47/6937 , A61K2039/6093
Abstract: A polymeric nanoparticle is disclosed which comprises: (i) at least one SARS-CoV-2 derived antigen which is capable of producing a T-cell and/or B cell response: and (ii) an antigen presenting cell targeting moiety which is attached to the outer surface of the nanoparticle. Use of the nanoparticle for treating COVID-19 is also disclosed.
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18.发明公开公开(公告)号：US20240167001A1
公开(公告)日：2024-05-23
申请号：US18424988
申请日：2024-01-29
Applicant: Ramot at Tel-Aviv University Ltd.
Inventor： Ronit SATCHI-FAINARO , Lena NEUFELD
IPC: C12N5/071
CPC classification number: C12N5/0697 , C12N2503/02 , C12N2513/00
Abstract: A three dimensional (3D) model of a glioblastoma tumor made of a synthetic material and a plurality of cell types, including malignant cells and non-malignant cells of the tumor. Methods of forming the 3D tumor model are also provided, as well as systems in which the 3D tumor model can be perfused and fluidly connected to a medium containing immune cells and/or other cells and factors present in the tumor's microenvironment. Methods utilizing the 3D tumor model or the system in, for example, personalized therapy, are also provided.
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19.发明公开公开(公告)号：US20240164696A1
公开(公告)日：2024-05-23
申请号：US18283085
申请日：2022-03-24
Applicant: RAMOT AT TEL-AVIV UNIVERSITY LTD. , ICHILOV TECH LTD.
Inventor： Ari DEROWE , Tal Yehuda BARKAI , Linor KLEIN , Mickey SCHEINOWITZ , Amir DAGAN
CPC classification number: A61B5/383 , A61B5/291 , A61B5/372 , A61B5/381 , A61B5/682 , A61B2503/06 , A61N1/0548
Abstract: Systems and methods for diagnosis of Acute Otitis Media (AOM) with a monopolar probe in a territory innervated by a chorda tympani nerve (CTN) by applying a stimulus by the monopolar, measuring a response to the stimulus, changing the strength of the stimulus applied based on the measured response until the measured response reaches a threshold value, determining a first stimulus strength at the threshold value, repeating these steps for another predefined location in a territory innervated by the CTN associated with a second ear, to determine a second stimulus strength at the threshold value for the second predefined location; and diagnosing AOM based on a difference between the determined first and second stimulus strengths for the first and second locations.
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公开(公告)号：US20240151517A1
公开(公告)日：2024-05-09
申请号：US18548939
申请日：2022-05-15
Applicant: RAMOT AT TEL-AVIV UNIVERSITY LTD.
Inventor： Avishay Eyal , Alon Bahabad , Daniel Marima , Barak Hadad , Nadav Magal
CPC classification number: G01B11/2441 , A61B34/20 , A61B2034/2061 , A61B2090/3735
Abstract: A method for estimating a geometrical shape of an optical fiber (106) includes transmitting (102) into the optical fiber an input optical signal that excites in the optical fiber multiple propagation modes. An output optical signal, which is output from the optical fiber in response to the input optical signal, is recombined with a reference signal derived from the input optical signal, so as to produce a recombined optical signal. The recombined optical signal is detected (108), and the geometrical shape of the optical fiber (106) is estimated based on the detected recombined optical signal.
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