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公开(公告)号：US20130084596A1
公开(公告)日：2013-04-04
申请号：US13418848
申请日：2012-03-13
Applicant: Paul J. Muchowski , Susan L. Lindquist , Tiago Outeiro
Inventor： Paul J. Muchowski , Susan L. Lindquist , Tiago Outeiro
CPC classification number: C12Q1/025 , C12N15/81 , C12Q1/02 , G01N33/6896 , G01N2500/04
Abstract: Methods of screening candidate agents to identify lead compounds for the development of therapeutic agents for the treatment of a neurodegenerative disease, such as Huntington's Disease and Parkinson's Disease and methods for identifying a mutation in, or changes in expression of, a gene associated with neurodegenerative disease, such as Huntington's Disease and Parkinson's Disease, are provided.
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公开(公告)号：US20130022988A1
公开(公告)日：2013-01-24
申请号：US13521966
申请日：2011-01-11
Applicant: Kent E.S. Matlack , Susan L. Lindquist
Inventor： Kent E.S. Matlack , Susan L. Lindquist
CPC classification number: C12N15/81 , C07K14/4711
Abstract: Disclosed are yeast cells expressing a polypeptide comprising a signal sequence and a human amyloid beta protein. Also disclosed are methods of screening yeast cells to identify compounds that prevent or suppress amyloid beta-induced toxicity and genetic suppressors or enhancers of amyloid beta-induced toxicity. Compounds identified by such screens can be used to treat or prevent neurodegenerative disorders such as Alzheimer's disease.
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13.发明申请YEAST CELLS EXPRESSING TAR DNA-BINDING PROTEIN 43 AND USES THEREFOR 有权YEAST CELLS EXPRESSING TAR DNA-BINDING蛋白43及其用途公开(公告)号：US20110053857A1
公开(公告)日：2011-03-03
申请号：US12867724
申请日：2009-02-13
Applicant: Susan L. Lindquist , Aaron D. Gitler
Inventor： Susan L. Lindquist , Aaron D. Gitler
CPC classification number: C12N15/81 , C12N15/1079 , G01N33/6872 , G01N33/6896 , G01N2500/10
Abstract: Disclosed are yeast cells expressing TAR DNA-binding protein 43 (TDP-43) and methods of screening yeast cells to identify compounds that prevent or suppress TDP-43-induced toxicity, compounds that inhibit the formation or maintenance of cytoplasmic inclusions of TDP-43, genetic suppressors or enhancers of TDP-43-induced toxicity, and genetic suppressors or enhancers of the formation or maintenance of cytoplasmic inclusions of TDP-43. Compounds identified by such screens can be used to treat or prevent TDP-43 proteinopathies such as frontotemporal lobar degeneration or amyotrophic lateral sclerosis.
Abstract translation: 公开了表达TAR DNA结合蛋白43（TDP-43）的酵母细胞和筛选酵母细胞以鉴定预防或抑制TDP-43诱导的毒性的化合物的方法，抑制TDP-43细胞质内含物形成或维持的化合物 ，TDP-43诱导的毒性的遗传抑制因子或增强子，以及形成或维持TDP-43细胞质内含物的遗传抑制子或增强子。 通过这种筛选鉴定的化合物可用于治疗或预防TDP-43蛋白病，例如额颞叶变性或肌萎缩性侧索硬化。
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公开(公告)号：US20090304664A1
公开(公告)日：2009-12-10
申请号：US11914167
申请日：2006-05-12
Applicant: Susan L. Lindquist , Aaron D. Gitler , Anil Cashikar
Inventor： Susan L. Lindquist , Aaron D. Gitler , Anil Cashikar
IPC: A61K38/45 , A61K31/7088 , C12N5/02 , C12Q1/02 , C12N1/16 , A61K31/715 , C12N5/10 , C12N1/19 , A61K38/00
CPC classification number: C12N15/113 , A61K38/1709 , C12N15/1086 , G01N33/6896 , G01N2500/00 , G01N2800/2821 , G01N2800/2835
Abstract: Disclosed are genes that, when overexpressed in cells expressing alpha-synuclein, either suppress or enhance alpha-synuclein mediated cellular toxicity. Compounds that modulate expression of these genes or activity of the encoded proteins can be used to inhibit alpha-synuclein mediated toxicity and used to treat or prevent synucleinopathies such as Parkinson's disease. Also disclosed are methods of identifying inhibitors of alpha-synuclein mediated toxicity.
Abstract translation: 公开了当在表达α-突触核蛋白的细胞中过表达时抑制或增强α-突触核蛋白介导的细胞毒性的基因。 调节这些基因表达或编码蛋白活性的化合物可用于抑制α-突触核蛋白介导的毒性，并用于治疗或预防突触核蛋白病如帕金森病。 还公开了鉴定α-突触核蛋白介导的毒性抑制剂的方法。
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15.发明申请公开(公告)号：US20080249129A1
公开(公告)日：2008-10-09
申请号：US10599513
申请日：2005-04-04
Applicant: Susan L. Lindquist , Tiago Outeiro
Inventor： Susan L. Lindquist , Tiago Outeiro
Abstract: Disclosed are compounds and conditions that either suppress or enhance toxicity in yeast cells expressing alpha synuclein or huntingtin. These compounds and conditions can be used in the development of compositions that suppress toxicity, fibril formation, and/or diseases mediated at least in part by alpha synuclein or huntingtin.
Abstract translation: 公开了抑制或增强表达α突触核蛋白或亨廷顿汀的酵母细胞毒性的化合物和条件。 这些化合物和条件可用于开发至少部分由α突触核蛋白或亨廷顿缓解的毒性，原纤维形成和/或疾病的组合物。
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Patent Agency Ranking
16.发明授权公开(公告)号：US08192986B2
公开(公告)日：2012-06-05
申请号：US11568653
申请日：2005-05-04
Applicant: Susan L. Lindquist , Martin Duennwald
Inventor： Susan L. Lindquist , Martin Duennwald
CPC classification number: G01N33/5014 , G01N33/5008 , G01N33/502 , G01N33/5058 , G01N33/6896 , G01N2500/00
Abstract: Disclosed are methods for identifying compounds that modulate huntingtin mediated impairment of protein degradation pathways. Compounds identified by such screens can be used as candidate drugs for the treatment of prevention of polyglutamine diseases such as Huntington's Disease.
Abstract translation: 公开了用于鉴定调节亨廷丁蛋白介导的蛋白质降解途径损伤的化合物的方法。 通过这种筛选鉴定的化合物可用作候选药物，用于治疗预防多谷氨酰胺疾病如亨廷顿氏病。
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公开(公告)号：US20090099069A1
公开(公告)日：2009-04-16
申请号：US11720586
申请日：2005-12-01
Applicant: Susan L. Lindquist , Aaron D. Gitler , Anil Cashikar , Antony A. Cooper , Cole M. Haynes
Inventor： Susan L. Lindquist , Aaron D. Gitler , Anil Cashikar , Antony A. Cooper , Cole M. Haynes
CPC classification number: C12Q1/6876 , G01N33/5014 , G01N33/5023 , G01N2500/00
Abstract: Disclosed are compositions and methods for modulating expression of genes that function at the step of ER of Golgi trafficking. Compounds that modulate expression of these genes of activity of the encoded proteins can be used to inhibit alpha-synuclein mediated toxicity and used to threat of prevent synucleinopathies such as Parkinson's disease. Also disclosed are methods of identifying inhibitors of alpha-synuclein mediated toxicity.
Abstract translation: 公开了用于调节在高尔基体运输的ER步骤中起作用的基因表达的组合物和方法。 调节这些编码蛋白质活性基因表达的化合物可用于抑制α-突触核蛋白介导的毒性，并用于预防突触核蛋白病如帕金森病的威胁。 还公开了鉴定α-突触核蛋白介导的毒性抑制剂的方法。
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公开(公告)号：US08399241B2
公开(公告)日：2013-03-19
申请号：US11720586
申请日：2005-12-01
Applicant: Susan L. Lindquist , Aaron D. Gitler , Anil Cashikar , Antony A. Cooper , Cole M. Haynes
Inventor： Susan L. Lindquist , Aaron D. Gitler , Anil Cashikar , Antony A. Cooper , Cole M. Haynes
IPC: C12N1/16
CPC classification number: C12Q1/6876 , G01N33/5014 , G01N33/5023 , G01N2500/00
Abstract: Disclosed are compositions and methods for modulating expression of genes that function at the step of ER of Golgi trafficking. Compounds that modulate expression of these genes of activity of the encoded proteins can be used to inhibit alpha-synuclein mediated toxicity and used to threat of prevent synucleinopathies such as Parkinson's disease. Also disclosed are methods of identifying inhibitors of alpha-synuclein mediated toxicity.
Abstract translation: 公开了用于调节在高尔基体运输的ER步骤中起作用的基因表达的组合物和方法。 调节这些编码蛋白质活性基因表达的化合物可用于抑制α-突触核蛋白介导的毒性，并用于预防突触核蛋白病如帕金森病的威胁。 还公开了鉴定α-突触核蛋白介导的毒性抑制剂的方法。
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公开(公告)号：US20130045483A1
公开(公告)日：2013-02-21
申请号：US13538089
申请日：2012-06-29
Applicant: SEBASTIAN TREUSCH , KENT E.S. MATLACK , SUSAN L. LINDQUIST
Inventor： SEBASTIAN TREUSCH , KENT E.S. MATLACK , SUSAN L. LINDQUIST
CPC classification number: C12Q1/6883 , C07K14/4711 , C12Q2600/136 , C12Q2600/158 , G01N33/5017 , G01N33/5023 , G01N33/6896 , G01N2800/2821
Abstract: Disclosed are yeast cells expressing a polypeptide comprising a signal sequence and a human amyloid beta protein. Also disclosed are methods of screening yeast cells to identify compounds that prevent or suppress amyloid beta-induced toxicity and genetic suppressors or enhancers of amyloid beta-induced toxicity. Compounds identified by such screens can be used to treat or prevent neurodegenerative disorders such as Alzheimer's disease.
Abstract translation: 公开了表达包含信号序列和人淀粉样蛋白β蛋白的多肽的酵母细胞。 还公开了筛选酵母细胞以鉴定预防或抑制淀粉样蛋白β-诱导的毒性的化合物和淀粉样蛋白β-诱导的毒性的遗传抑制剂或增强子的方法。 通过这种筛选鉴定的化合物可用于治疗或预防神经变性疾病如阿尔茨海默氏病。
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公开(公告)号：US08343913B1
公开(公告)日：2013-01-01
申请号：US11175515
申请日：2005-07-05
Applicant: Leah Cowen , Susan L. Lindquist
Inventor： Leah Cowen , Susan L. Lindquist
IPC: A01N37/18 , A01N43/64 , A61K38/00 , A61K31/41 , A61K45/00 , A61K47/44 , A61P31/10 , C07D293/00 , C07D421/00 , C07D517/00 , C07D291/00 , C07D419/00 , C07D515/00 , C07D285/00 , C07D417/00 , C07D513/00 , C07D273/00 , C07D413/00 , C07D498/00 , C07D277/04 , C07D277/08 , C07D275/02 , C07D249/08 , C07D233/00 , C07D233/02 , C07D231/00
CPC classification number: A61K45/06 , A01N37/46 , A61K31/336 , A61K31/395 , A61K31/41 , A61K38/12 , A61K2300/00
Abstract: A method of reducing antifungal drug resistance in which Hsp inhibitors, such as Hsp90 inhibitors, are used.
Abstract translation: 降低抗真菌药物耐药性的方法，其中使用Hsp抑制剂，如Hsp90抑制剂。
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