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公开(公告)号：US06512161B1
公开(公告)日：2003-01-28
申请号：US09227701
申请日：1999-01-08
申请人： Didier Rouy , Nicolas Duverger , Florence Emmanuel , Patrice Denefle , Louis-Marie Houdebine , Celine Viglietta , Edward M. Rubin , Steven D. Hughes
发明人： Didier Rouy , Nicolas Duverger , Florence Emmanuel , Patrice Denefle , Louis-Marie Houdebine , Celine Viglietta , Edward M. Rubin , Steven D. Hughes
IPC分类号： G01N3300
CPC分类号： C07K14/775 , A01K67/0275 , A01K67/0278 , A01K2207/15 , A01K2217/00 , A01K2217/05 , A01K2227/107 , A01K2267/03 , A01K2267/0375 , A61K49/0008 , C12N15/8509 , Y10S977/924
摘要： A transgenic rabbit which has in its genomic DNA sequences that encode apolipoprotein (a) and apolipoprotein B polypeptides which are capable of combining to produce lipoprotein (a), a process for creating such a rabbit, and the use of the rabbit to identify compounds which are effective in the treatment of human diseases which are associated with, induced and/or exacerbated by Lp(a) expression.
摘要翻译： 一种转基因兔，其基因组DNA序列中编码能组合产生脂蛋白（a）的载脂蛋白（a）和载脂蛋白B多肽，一种制备这种兔子的方法，以及使用该兔子鉴定化合物 对于与Lp（a）表达相关，诱导和/或恶化的人类疾病的治疗有效。
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12.发明授权
公开(公告)号：US6033885A
公开(公告)日：2000-03-07
申请号：US702573
申请日：1996-09-12
IPC分类号： C12N15/09 , A61K9/08 , A61K35/76 , A61K38/00 , A61K38/22 , A61K38/43 , A61K38/46 , A61K48/00 , A61P9/10 , A61P25/00 , A61P25/02 , A61P25/28 , A61P31/12 , A61P35/00 , A61P37/04 , C07K14/775 , C12N5/10 , C12N7/00 , C12N7/01 , C12N7/04 , C12N15/861 , C12N15/864 , C12N15/00 , A01N63/00 , C12P1/00
CPC分类号： C12N15/86 , C07K14/775 , C12N7/00 , A61K38/00 , A61K48/00 , C12N2710/10343 , C12N2710/10344 , C12N2710/10362 , C12N2750/14143 , C12N2830/008
摘要： The present invention relates to recombinant adenoviruses having a cassette capable of integrating into the genome of infected cells, their preparation, pharmaceutical compositions containing them, and their use. In particular, the cassette contains at least one inverted terminal repeat (ITR) Sequence from AAV and a heterologous DNA Sequence.
摘要翻译： PCT No.PCT / FR95 / 00233 Sec。 371日期：1996年9月12日 102（e）日期1996年9月12日PCT提交1995年2月28日PCT公布。 第WO95 / 23867号公报 日期1995年9月8日本发明涉及具有能够整合入感染细胞的基因组的盒，其制备物，含有它们的药物组合物及其用途的重组腺病毒。 特别地，盒包含至少一个来自AAV的反向末端重复（ITR）序列和异源DNA序列。
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公开(公告)号：US5792902A
公开(公告)日：1998-08-11
申请号：US704582
申请日：1996-09-20
IPC分类号： A01K67/027 , C07K14/775 , C12N15/09 , C12N15/85 , G01N33/15 , C12N15/00 , A61K49/00
CPC分类号： C12N15/8509 , A01K67/0275 , A01K67/0278 , C07K14/775 , A01K2207/15 , A01K2217/00 , A01K2217/05 , A01K2227/107 , A01K2267/03 , A01K2267/0362
摘要： A transgenic rabbit expressing a protein capable of interfering with dyslipoproteinaemia-related diseases, a method of preparing the same, and its use as an animal model, are disclosed. Specifically, a transgenic rabbit expressing high levels of Apo-AI, is disclosed.
摘要翻译： PCT No.PCT / FR95 / 00318 Sec。 371日期：1996年9月20日 102（e）1996年9月20日PCT 1995年3月16日PCT公布。 WO95 / 25793 PCT出版物 日期1995年9月28日公开了一种表达能够干扰血脂异常相关疾病的蛋白质的转基因兔，其制备方法及其作为动物模型的用途。 具体地说，公开了表达高水平Apo-AI的转基因兔。
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公开(公告)号：US08642739B2
公开(公告)日：2014-02-04
申请号：US13157815
申请日：2011-06-10
申请人： Patrice Denefle , Thomas F. Haws , June M. Kaplow , Marie Rosier
发明人： Patrice Denefle , Thomas F. Haws , June M. Kaplow , Marie Rosier
IPC分类号： C07K14/00
CPC分类号： C07K14/4705 , A61K38/00 , A61K48/00
摘要： The present invention is directed to nuclear factor κB (NFκB)-inducing factor polypeptides (NFIF polypeptides) which are capable of inducing NFκB. The present invention includes within its scope NFIF polypeptides, including NFIF-14b and NFIF-7a, DNA, including cDNA, encoding these polypeptides, and expression vectors capable of expressing NFIF polypeptides. Also included are methods and compositions for increasing NFκB induction in a patient, methods and compositions for lowering NFκB induction in a patient, methods for inhibiting inflammation, and methods for manufacture of a medicament intended for the treatment and/or prevention of an NFκB-regulated inflammatory response. In addition, methods for determining whether a test compound inhibits or enhances the activity of NFIF polypeptides are provided.
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15.发明申请Recombinant Viruses and their Use for Treatment of Atherosclerosis and Othe Forms of Coronary Artery Disease and Method, Reagent, and Kit for Evaluating Susceptibiity to Same 审中-公开重组病毒及其用于治疗动脉粥样硬化和冠状动脉疾病形式的方法，试剂和评估易感性的试剂盒公开(公告)号：US20130164262A1
公开(公告)日：2013-06-27
申请号：US13584203
申请日：2012-08-13
IPC分类号： C12N7/00
CPC分类号： C12Q1/6883 , A61K38/00 , A61K48/00 , A61K2039/51 , C12N9/20 , C12N15/86 , C12N2710/10343 , C12N2740/13043 , C12N2800/108 , C12N2830/42 , C12N2840/20 , C12N2840/44 , C12Q1/6858 , C12Q2600/156 , C12Y301/01034 , C12Q2535/131 , C12Q2525/131
摘要： Recombinant viruses comprising a heterologous DNA sequence coding for a lipase involved in lipoprotein metabolism. The invention also concerns the preparation and use in therapy of said recombinant viruses, especially for the treatment or prevention of dyslipoproteinemia-related pathologies.
摘要翻译： 包含编码参与脂蛋白代谢的脂肪酶的异源DNA序列的重组病毒。 本发明还涉及在所述重组病毒的治疗中的制备和用途，特别是用于治疗或预防与脂蛋白血症相关的病症。
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16.发明申请Recombinant viruses and their use for treatment of atherosclerosis and other forms of coronary artery disease and method, reagent, and kit for evaluating susceptibility to same 审中-公开重组病毒及其用于治疗动脉粥样硬化和其他形式的冠状动脉疾病的方法，试剂和试剂盒，用于评估与之相似的易感性公开(公告)号：US20050163754A1
公开(公告)日：2005-07-28
申请号：US10831268
申请日：2004-04-26
CPC分类号： C12Q1/6883 , A61K38/00 , A61K48/00 , A61K2039/51 , C12N9/20 , C12N15/86 , C12N2710/10343 , C12N2740/13043 , C12N2800/108 , C12N2830/42 , C12N2840/20 , C12N2840/44 , C12Q1/6858 , C12Q2600/156 , C12Y301/01034 , C12Q2535/131 , C12Q2525/131
摘要： Recombinant viruses comprising a heterologous DNA sequence coding for a lipase involved in lipoprotein metabolism. The invention also concerns the preparation and use in therapy of said recombinant viruses, especially for the treatment or prevention of dyslipoproteinemia-related pathologies.
摘要翻译： 包含编码参与脂蛋白代谢的脂肪酶的异源DNA序列的重组病毒。 本发明还涉及在所述重组病毒的治疗中的制备和用途，特别是用于治疗或预防与脂蛋白血症相关的病症。
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公开(公告)号：US06410011B1
公开(公告)日：2002-06-25
申请号：US08633769
申请日：1996-06-20
申请人： Didier Branellec , Jean-François Dedieu , Patrice Denefle , Laurent Feldman , Michel Perricaudet , Philippe Gabriel Steg
发明人： Didier Branellec , Jean-François Dedieu , Patrice Denefle , Laurent Feldman , Michel Perricaudet , Philippe Gabriel Steg
IPC分类号： A61K4800
CPC分类号： A61K48/00 , A61K38/45 , A61K38/50 , C12N15/86 , C12N2710/10343 , C12N2830/00 , C12N2830/15 , C12N2830/60 , C12Y207/01021 , C12Y305/04001
摘要： A method for treating restenosis by gene therapy is disclosed, said method comprising delivering a recombinant suicide-gene-containing adenovirus.
摘要翻译： 公开了通过基因治疗治疗再狭窄的方法，所述方法包括递送含重组自杀基因的腺病毒。
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公开(公告)号：US07972844B2
公开(公告)日：2011-07-05
申请号：US11354560
申请日：2006-02-15
申请人： June Kaplow , Thomas Haws , Marie Rosier , Patrice Denefle
发明人： June Kaplow , Thomas Haws , Marie Rosier , Patrice Denefle
CPC分类号： C07K14/4705 , A61K38/00 , A61K48/00
摘要： The present invention is directed to nuclear factor κB (NFκB)-inducing factor polypeptides (NFIF polypeptides) which are capable of inducing NFκB. The present invention includes within its scope NFIF polypeptides, including NFIF-14b and NFIF-7a, DNA, including cDNA, encoding these polypeptides, and expression vectors capable of expressing NFIF polypeptides. Also included are methods and compositions for increasing NFκB induction in a patient, methods and compositions for lowering NFκB induction in a patient, methods for inhibiting inflammation, and methods for manufacture of a medicament intended for the treatment and/or prevention of an NFκB-regulated inflammatory response. In addition, methods for determining whether a test compound inhibits or enhances the activity of NFIF polypeptides are provided.
摘要翻译： 本发明涉及能够诱导NF＆B的诱导因子多肽（NFIF）的核因子B（NF＆kgr; B）诱导因子多肽（NFIF）。 本发明在其范围内包括NFIF多肽，包括NFIF-14b和NFIF-7a，包括编码这些多肽的cDNA，以及能够表达NFIF多肽的表达载体。 还包括用于增加患者中NF和κB诱导的方法和组合物，用于降低患者中NF＆kgr B诱导的方法和组合物，用于抑制炎症的方法和用于制备用于治疗和/或预防 NF和kgr B调节的炎症反应。 此外，提供了用于确定测试化合物是否抑制或增强NFIF多肽的活性的方法。
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19.发明申请Recombinant viruses and their use for treatment of atherosclerosis and other forms of coronary artery disease and method, reagent, and kit for evaluating susceptibility to same 审中-公开重组病毒及其用于治疗动脉粥样硬化和其他形式的冠状动脉疾病的方法，试剂和试剂盒，用于评估与之相似的易感性公开(公告)号：US20090257981A1
公开(公告)日：2009-10-15
申请号：US11802679
申请日：2007-05-24
CPC分类号： C12Q1/6883 , A61K38/00 , A61K48/00 , A61K2039/51 , C12N9/20 , C12N15/86 , C12N2710/10343 , C12N2740/13043 , C12N2800/108 , C12N2830/42 , C12N2840/20 , C12N2840/44 , C12Q1/6858 , C12Q2600/156 , C12Y301/01034 , C12Q2535/131 , C12Q2525/131
摘要： Recombinant viruses comprising a heterologous DNA sequence coding for a lipase involved in lipoprotein metabolism. The invention also concerns the preparation and use in therapy of said recombinant viruses, especially for the treatment or prevention of dyslipoproteinemia-related pathologies.
摘要翻译： 包含编码参与脂蛋白代谢的脂肪酶的异源DNA序列的重组病毒。 本发明还涉及在所述重组病毒的治疗中的制备和用途，特别是用于治疗或预防与脂蛋白血症相关的病症。
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公开(公告)号：US20060223771A1
公开(公告)日：2006-10-05
申请号：US11354560
申请日：2006-02-15
申请人： June Kaplow , Thomas Haws , Marie Rosier , Patrice Denefle
发明人： June Kaplow , Thomas Haws , Marie Rosier , Patrice Denefle
CPC分类号： C07K14/4705 , A61K38/00 , A61K48/00
摘要： The present invention is directed to nuclear factor κB (NFκB)-inducing factor polypeptides (NFIF polypeptides) which are capable of inducing NFκB. The present invention includes within its scope NFIF polypeptides, including NFIF-14b and NFIF-7a, DNA, including cDNA, encoding these polypeptides, and expression vectors capable of expressing NFIF polypeptides. Also included are methods and compositions for increasing NFκB induction in a patient, methods and compositions for lowering NFκB induction in a patient, methods for inhibiting inflammation, and methods for manufacutre of a medicament intended for the treatment and/or prevention of an NFκB-regulated inflammatory response. In addition, methods for determining whether a test compound inhibits or enhances the activity of NFIF polypeptides are provided.
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