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公开(公告)号：US20220273365A1
公开(公告)日：2022-09-01
申请号：US17637484
申请日：2020-08-27
Applicant: Arizona Board of Regents on behalf of Arizona State University , MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH
Inventor： Kaushal Rege , Inam Ridha , Russell Urie , Pelagia Kouloumberis , Shelley Noland
Abstract: The present invention provides a method of nerve repair using localized delivery of heat. The method involves localized induction of hyperthermia for end-to-end attachment of severed peripheral nerves by delivering stimulus responsive materials and exposing them to an excitation source under conditions wherein they emit heat. The generation of heat effects the joining of the nerve ends.
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公开(公告)号：US11317968B2
公开(公告)日：2022-05-03
申请号：US16195121
申请日：2018-11-19
Inventor： Kaushal Rege , Huang-Chiao Huang
IPC: A61B18/20 , A61B18/18 , A61L24/10 , A61K38/18 , A61K38/19 , A61L24/00 , A61K41/00 , A61K38/39 , A61N5/06 , A61N5/067 , A61B18/14 , A61B18/00
Abstract: Disclosed herein are methods of connecting disrupted tissue, tissue repair, treating colorectal disorder and tissue welding. The methods comprise using a bioadhesive composition comprising ELP and light absorbing chromophores and irradiating the bioadhesive tissue.
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公开(公告)号：US20210100927A1
公开(公告)日：2021-04-08
申请号：US17065283
申请日：2020-10-07
Inventor： Kaushal Rege , Deepanjan Ghosh
IPC: A61L15/44 , A61L15/20 , A61L15/32 , A61K38/39 , A61P17/02 , A61K38/18 , A61K33/242 , A61N5/06 , A61K31/417 , A61L15/18 , A61K9/70
Abstract: A wound dressing includes: a structural material formed into a dressing; at least one immunomodulatory agent associated with the dressing; and a growth factor associated with the dressing. A wound dressing kit includes: a structural material formed into a wound dressing; an immunomodulatory agent; and a growth factor composition, wherein the structural material contains the immunomodulatory agent and/or the immunomodulatory agent is in a separate composition. A method of treating a wound in a tissue includes: applying an immunomodulatory agent to the wound; applying a wound dressing to the wound; and allowing the wound to heal with the immunomodulatory agent and wound dressing. The application of a growth factor can be before, during and/or after applying the wound dressing to the wound.
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公开(公告)号：US20190078052A1
公开(公告)日：2019-03-14
申请号：US16084415
申请日：2017-03-16
Inventor： Kaushal Rege , Taraka Sai Pavan Grandhi
Abstract: Methods and compositions involving hydrogel compositions utilized for growing, separating, isolating, and/or screening cancer cells for resistance to one or more anti-cancer cell agents, such as a drug or biologic. Some hydrogel compositions utilize the monomer aminoglycoside amikacin AM1 or aminoglycoside amikacin AM3 in combination with a variety of crosslinkers.
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公开(公告)号：US11896724B2
公开(公告)日：2024-02-13
申请号：US17065283
申请日：2020-10-07
Inventor： Kaushal Rege , Deepanjan Ghosh
IPC: A61K33/242 , A61N5/067 , A61L15/18 , A61L15/44 , A61L15/20 , A61L15/32 , A61K38/39 , A61P17/02 , A61N5/06 , A61K31/417 , A61K9/70 , A61K38/18 , A61L26/00
CPC classification number: A61L15/44 , A61K9/7007 , A61K31/417 , A61K33/242 , A61K38/1825 , A61K38/39 , A61L15/18 , A61L15/20 , A61L15/32 , A61L26/0004 , A61L26/008 , A61L26/0066 , A61L26/0095 , A61N5/0616 , A61P17/02 , A61L2300/102 , A61L2300/414 , A61L2300/426 , A61L2300/45 , A61N5/067
Abstract: A wound dressing includes: a structural material formed into a dressing; at least one immunomodulatory agent associated with the dressing; and a growth factor associated with the dressing. A wound dressing kit includes: a structural material formed into a wound dressing; an immunomodulatory agent; and a growth factor composition, wherein the structural material contains the immunomodulatory agent and/or the immunomodulatory agent in a separate composition. A method of treating a wound in a tissue includes: applying an immunomodulatory agent to the wound; applying a wound dressing to the wound; and allowing the wound to heal with the immunomodulatory agent and wound dressing. The application of a growth factor can be before, during and/or after applying the wound dressing to the wound.
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Patent Agency Ranking
16.发明申请公开(公告)号：US20220411360A1
公开(公告)日：2022-12-29
申请号：US17775372
申请日：2020-11-09
Inventor： Abhinav Acharya , Kaushal Rege
IPC: C07C53/126 , A61K47/69
Abstract: The present invention provides polymers, particles, and compositions thereof that selectively and efficiently deliver various therapeutic agents, such as metabolites, to a cell. The present invention further relates to methods relating to the said polymers, particles, and compositions for enhancing biological tissue growth (e.g. biological tissue regeneration in wound healing) in a subject. The present invention additionally provides kits that find use in the practice of the methods of the invention.
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17.发明申请公开(公告)号：US20220018826A1
公开(公告)日：2022-01-20
申请号：US17357138
申请日：2021-06-24
Inventor： Kaushal Rege , Karthik Subramaniam Pushpavanam , Eshwaran Narayanan , Stephen Sapareto , John C. Chang
Abstract: An apparatus includes a solution including a metallic compound, a surfactant, and an acid. The solution is substantially colorless. A container holds the solution. A radiated solution is formed when the solution receives a low dose of ionizing radiation
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18.发明申请公开(公告)号：US20180021753A1
公开(公告)日：2018-01-25
申请号：US15547173
申请日：2016-02-12
Inventor： Kaushal Rege , Taraka Sai Pavan Grandhi , Thrimoorthy Potta
IPC: B01J20/285 , B01D15/20 , C12N15/10 , B01J20/28
CPC classification number: B01J20/285 , B01D15/20 , B01J20/267 , B01J20/28052 , C12N15/101 , G01N2030/528
Abstract: Methods and materials for the generation of amikacin antibiotic-derived microbeads, (FIG. 3). These beads may function as anion-exchange resins for use in pDNA purification as well as in situ capture of DNA from mammalian cells. New microresin and macroporous monolith based materials also are disclosed and may function for plasmid DNA binding and purification, mammalian whole cell genomic DNA extraction, and in-vitro cell culture.
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公开(公告)号：US20170232157A1
公开(公告)日：2017-08-17
申请号：US15430234
申请日：2017-02-10
Inventor： Kaushal Rege , Taraka Sai Pavan Grandhi , Jerry Crum , Russell Urie
IPC: A61L31/12 , A61L31/16 , A61L31/14 , A61B17/06 , A61B17/064
CPC classification number: A61L31/128 , A61B17/00491 , A61B17/06166 , A61B17/064 , A61B18/00 , A61B2017/00004 , A61B2017/00526 , A61B2017/00876 , A61B2017/00884 , A61B2018/00005 , A61B2018/00619 , A61B2018/0063 , A61L31/14 , A61L31/148 , A61L31/16
Abstract: A tissue closure device can include a structural material and a stimulus responsive material on or in the structural material. The structural material can be biodegradable and/or bioabsorbable (e.g., biocompatible natural and/or semi-natural and/or synthetic polymer). The stimulus responsive material can be a particle, such as a nanoparticle. The structural material is shaped as a suture, staple, screw, patch, adhesive, sealant, or the like. A biologically active agent can be included. A method of promoting wound healing can include: approximating tissue portions; and stimulating the stimulus responsive material with a stimulus to cause the tissue portions of the wound to adhere to each other. The stimulus is selected from optical, electrical, thermal, chemical, mechanical, magnetic, acoustic, pressure, shear, biological, or enzymatic sources.
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20.发明申请公开(公告)号：US20170212037A1
公开(公告)日：2017-07-27
申请号：US15398590
申请日：2017-01-04
Inventor： Kaushal Rege , Karthik Subramaniam Pushpavanam , Eshwaran Narayanan , Stephen Sapareto , John C. Chang
CPC classification number: A61N5/1071
Abstract: An apparatus includes a solution including a metallic compound, a surfactant, and an acid. The solution is substantially colorless. A container holds the solution. A radiated solution is formed when the solution receives a low dose of ionizing radiation.
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