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    FEEDBACK LOOP FOR FOCUSED ULTRASOUND APPLICATION
    11.
    发明申请
    FEEDBACK LOOP FOR FOCUSED ULTRASOUND APPLICATION 审中-公开
    用于聚焦超声波应用的反馈环

    公开(公告)号：US20100041988A1

    公开(公告)日：2010-02-18

    申请号：US12442197

    申请日：2007-09-19

    Applicant: Remco H. W. Pijnenburg ,  Youri V. Ponomarev ,  Matthias Merz

    Inventor： Remco H. W. Pijnenburg ,  Youri V. Ponomarev ,  Matthias Merz

    IPC: A61B8/00 ,  A61N7/00

    CPC classification number: A61B17/2202 ,  A61B17/2256 ,  A61B2017/00106

    Abstract: A method is disclosed using a feedback loop for focused ultrasound application. The method includes the steps of determining a location of a target side within a body using ultrasound waves, applying focused ultrasound waves to the target site, determining a new location of the target site using further ultrasound waves, and adjusting the focused ultrasound waves in response to the new location of the target site.

    Abstract translation: 公开了一种使用聚焦超声应用的反馈回路的方法。 该方法包括以下步骤：使用超声波确定身体内目标侧的位置，向目标位置施加聚焦超声波，使用另外的超声波确定目标位置的新位置，以及响应于调整聚焦超声波 到目标网站的新位置。

    BRANCHING THERAPY ELEMENTS AND METHOD OF THEIR INSERTION INTO LIVING TISSUE
    12.
    发明申请
    BRANCHING THERAPY ELEMENTS AND METHOD OF THEIR INSERTION INTO LIVING TISSUE 审中-公开
    分配治疗单元及其入侵组织的方法

    公开(公告)号：US20100010550A1

    公开(公告)日：2010-01-14

    申请号：US12442528

    申请日：2007-09-20

    Applicant: Youri Ponomarev ,  Matthias Merz ,  Remco Henricus Wilhelmus Pijnenburg

    Inventor： Youri Ponomarev ,  Matthias Merz ,  Remco Henricus Wilhelmus Pijnenburg

    IPC: A61N1/05 ,  A61M31/00 ,  A61B19/00

    CPC classification number: A61N1/0529 ,  A61N1/0534

    Abstract: An implantable medical system for electrical recording and or providing therapy to a plurality of tissue sites without damage to surrounding blood vessels is disclosed comprising: an implant body having a plurality of therapy elements, the elements being hingedly attached at one end to the surface of the body and releasably extendable outward from the surface of the body at the other end; a release mechanism for each of the elements; and a coating material covering the body and the elements; wherein upon dissolution of the coating material after implantation, the release mechanism is capable of causing the elements to extend outward at one end from the surface of the body and into a plurality of tissue sites without damage to the surrounding blood vessels. The method of implanting the system into a body is also disclosed.

    Abstract translation: 公开了一种用于对多个组织部位进行电记录和/或对周围血管的损伤提供治疗的可植入医疗系统，包括：具有多个治疗元件的植入体，所述元件在一端铰接附接到 并且在另一端从主体的表面可释放地向外延伸; 用于每个元件的释放机构; 以及覆盖所述主体和所述元件的涂层材料; 其中，在植入后溶解涂层材料时，释放机构能够使元件在一端从身体的表面向外延伸并且进入多个组织部位而不损坏周围的血管。 还公开了将系统植入体内的方法。

    Implantable multi-electrode device
    15.
    发明授权
    Implantable multi-electrode device 有权
    可植入多电极装置

    公开(公告)号：US08798737B2

    公开(公告)日：2014-08-05

    申请号：US12442133

    申请日：2007-09-18

    Applicant: Matthias Merz ,  Youri V. Ponomarev ,  Remco H. W. Pijnenburg

    Inventor： Matthias Merz ,  Youri V. Ponomarev ,  Remco H. W. Pijnenburg

    IPC: A61N1/00

    CPC classification number: A61N1/0529 ,  A61B5/04001 ,  A61L31/148 ,  A61N1/0531 ,  A61N1/0534 ,  A61N1/0536 ,  A61N1/0539 ,  A61N1/0558 ,  A61N1/36082

    Abstract: The invention provides an implantable multi-electrode device (300) and related methods and apparatuses. In one embodiment, the invention includes an implantable device (300) comprising: an assembly block (320); and a plurality of leads (340 . . . 348) radiating from the assembly block (320), each of the plurality of leads (340 . . . 348) containing at least one electrode (342A), such that the electrodes are distributed within a three-dimensional space, wherein the assembly block (320) includes a barb (350) for anchoring the assembly block (320) within implanted tissue.

    Abstract translation: 本发明提供一种可植入式多电极装置（300）及其相关方法和装置。 在一个实施例中，本发明包括可植入装置（300），包括：组装块（320）; 以及从所述组装块（320）辐射的多个引线（340 ... 348），所述多个引线（340 ... 348）中的每一个包含至少一个电极（342A），使得所述电极分布在 三维空间，其中组装块（320）包括用于将组装块（320）固定在植入的组织内的倒钩（350）。

    SENSOR
    16.
    发明申请
    SENSOR 有权
    传感器

    公开(公告)号：US20120260732A1

    公开(公告)日：2012-10-18

    申请号：US13382726

    申请日：2010-07-16

    Applicant: Aurelie Humbert ,  Youri Victorovitch Ponomarev ,  Roel Daamen ,  Matthias Merz

    Inventor： Aurelie Humbert ,  Youri Victorovitch Ponomarev ,  Roel Daamen ,  Matthias Merz

    IPC: G01N27/12 ,  H01B13/00 ,  B05D5/12

    CPC classification number: G01N27/223 ,  G01N33/004

    Abstract: A sensor (2) for sensing a first substance and a second substance, the sensor comprising first (3) and second (5) sensor components each comprising a first material (20), the first material being sensitive to both the first substance and the second substance, the sensor further comprising a barrier (18) for preventing the second substance from passing into the second sensor component (5).

    Abstract translation: 一种用于感测第一物质和第二物质的传感器（2），所述传感器包括第一（3）和第二（5）个传感器部件，每个传感器部件包括第一材料（20），所述第一材料对第一物质和 第二物质，传感器还包括用于防止第二物质进入第二传感器部件（5）的阻挡层（18）。

    ELECTROCHEMICAL POTENTIOMETRIC SENSING WITHOUT REFERENCE ELECTRODE
    18.
    发明申请
    ELECTROCHEMICAL POTENTIOMETRIC SENSING WITHOUT REFERENCE ELECTRODE 有权
    无参考电极的电化学电位感测

    公开(公告)号：US20110208457A1

    公开(公告)日：2011-08-25

    申请号：US13061110

    申请日：2009-08-24

    Applicant: Matthias Merz ,  Youri Victorovitch Ponomarev ,  Gilberto Curatola

    Inventor： Matthias Merz ,  Youri Victorovitch Ponomarev ,  Gilberto Curatola

    IPC: G06F19/00

    CPC classification number: G01N27/4148 ,  G01N27/4145

    Abstract: The invention relates to a method of determining a charged particle concentration in an analyte (100), the method comprising steps of: i) determining at least two measurement points of a surface-potential versus interface-temperature curve (c1, c2, c3, c4), wherein the interface temperature is obtained from a temperature difference between a first interface between a first ion-sensitive dielectric (Fsd) and the analyte (100) and a second interface between a second ion-sensitive dielectric (Ssd) and the analyte (100), and wherein the surface-potential is obtained from a potential difference between a first electrode (Fe) and a second electrode (Se) onto which said first ion-sensitive dielectric (Fsd) and said second ion-sensitive dielectric (Ssd) are respectively provided, And ii) calculating the charged particle concentration from locations of the at least two measurement points of said curve (c1, c2, c3, c4). This method, which still is a potentiometric electrochemical measurement, exploits the temperature dependency of a surface-potential of an ion-sensitive dielectric in an analyte. The invention further provides an electrochemical sensor deny for determining a charged particle concentration in an analyte. The invention also provides various sensors which can be used to determine the charged particle concentration, i.e. EGFET's and EIS capacitors.

    Abstract translation: 本发明涉及一种测定分析物（100）中带电粒子浓度的方法，所述方法包括以下步骤：i）确定表面电位对界面温度曲线（c1，c2，c3，c3）的至少两个测量点， c4），其中所述界面温度是由第一离子敏感电介质（Fsd）和分析物（100）之间的第一界面与第二离子敏感电介质（Ssd）与分析物之间的第二界面 （100），并且其中所述表面电位由所述第一离子敏感电介质（Fsd）和所述第二离子敏感电介质（Ssd）上的第一电极（Fe）和第二电极（Se）之间的电位差获得， ），和ii）从所述曲线（c1，c2，c3，c4）的至少两个测量点的位置计算带电粒子浓度。 这种仍然是电位电化学测量的方法利用分析物中离子敏感电介质的表面电位的温度依赖性。 本发明还提供了一种用于确定分析物中带电粒子浓度的电化学传感器。 本发明还提供可用于确定带电粒子浓度的各种传感器，即EGFET和EIS电容器。

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