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11.发明授权公开(公告)号：US07553653B2
公开(公告)日：2009-06-30
申请号：US11230374
申请日：2005-09-19
申请人： Emilio Kakkis , Daniel Oppenheimer , Paul Fitzpatrick , Robert Heft , Alejandra Gamez , Lin Wang , Woomi Kim , Mary Straub , Marianne Patch , Raymond C. Stevens
发明人： Emilio Kakkis , Daniel Oppenheimer , Paul Fitzpatrick , Robert Heft , Alejandra Gamez , Lin Wang , Woomi Kim , Mary Straub , Marianne Patch , Raymond C. Stevens
IPC分类号： C12N9/88
CPC分类号： C12N9/88 , C07K2299/00 , Y02A90/26
摘要： The present invention pertains to the use of the protein phenylalanine ammonia-lyase, as well as the biologically-active derivatives of the said protein for preventing or treating diseases associated with a phenylalanine imbalance in a human or animal body. More particularly, the present invention relates to the therapeutic use of the above-cited molecules for preventing or treating a phenylalanine imbalance in vivo. This invention also deals with therapeutic compositions comprising a pharmaceutically active amount of the above-described therapeutic molecules as well as with therapeutic methods using the said therapeutic compositions. Finally, the present invention relates to processes for selecting more therapeutically-effective variants of said protein as well as to the selected variants themselves.
摘要翻译： 本发明涉及蛋白质苯丙氨酸氨裂解酶的用途，以及所述蛋白质的生物活性衍生物用于预防或治疗与人或动物体内苯丙氨酸不平衡有关的疾病。 更具体地说，本发明涉及上述分子用于预防或治疗体内苯丙氨酸失衡的治疗用途。 本发明还涉及包含药物活性量的上述治疗分子以及使用所述治疗组合物的治疗方法的治疗组合物。 最后，本发明涉及用于选择所述蛋白质的更多治疗上有效的变体以及所选择的变体本身的方法。
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公开(公告)号：US06387614B1
公开(公告)日：2002-05-14
申请号：US09608788
申请日：2000-06-30
申请人： Quan Cheng , Raymond C. Stevens
发明人： Quan Cheng , Raymond C. Stevens
IPC分类号： C12Q100
CPC分类号： G01N33/56916 , C12Q1/005 , Y10S436/801 , Y10S436/806 , Y10S436/904
摘要： The present invention provides methods and compositions for detecting the presence of biologically-important analytes by using redox liposome biosensors. In particular, the present invention provides liposome/sol-gel electrodes suitable for the detection of a wide variety of organic molecules, including but not limited to bacterial toxins.
摘要翻译： 本发明提供了通过使用氧化还原脂质体生物传感器检测生物重要分析物的存在的方法和组合物。 特别地，本发明提供了适用于检测多种有机分子的脂质体/溶胶 - 凝胶电极，包括但不限于细菌毒素。
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13.发明授权Methods and compositions for obtaining high-resolution crystals of membrane proteins 有权用于获得膜蛋白的高分辨率晶体的方法和组合物公开(公告)号：US08252899B2
公开(公告)日：2012-08-28
申请号：US12739134
申请日：2008-10-22
CPC分类号： C07K14/723 , C07K14/705 , C07K14/70571 , C07K2299/00 , C12N9/2462 , C12N9/96
摘要： The invention describes compositions and method useful for the crystallization of membrane proteins.
摘要翻译： 本发明描述了可用于膜蛋白结晶的组合物和方法。
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公开(公告)号：US07049152B2
公开(公告)日：2006-05-23
申请号：US10096569
申请日：2002-03-12
申请人： Raymond C. Stevens , Quan Cheng , Jie Song
发明人： Raymond C. Stevens , Quan Cheng , Jie Song
IPC分类号： G01N33/545 , G01N33/547 , G01N33/544 , G01N33/92 , G01N21/63 , A61K9/127
CPC分类号： G01N31/221 , B82Y5/00 , B82Y10/00 , G01N33/52 , Y10S436/805 , Y10S436/811 , Y10S436/817 , Y10S436/829
摘要： The present invention herein provides the design, synthesis and characterization of compositions comprising asymmetric bolaamphiphilic lipids that form extended polymeric ribbons and wide sheets. These compositions may be doped, or interspersed, with various compounds to fine-tune the fluidity and rigidity of the bolaamphiphilic lipid composition, and promote other morphologies of the composition, including fluid vesicles and truncated flat sheets. Upon an increase in pH these compositions undergo a calorimetric and morphological transformation.
摘要翻译： 本发明提供了组合物的设计，合成和表征，所述组合物包含形成延伸的聚合物带和宽片材的不对称胶体脂质。 这些组合物可以用各种化合物掺杂或散布，以微调泡沫脂质组合物的流动性和刚性，并促进组合物的其它形态，包括流体囊泡和截短的平片。 当pH升高时，这些组合物进行量热和形态转化。
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15.发明申请NOVEL FUSION PARTNERS FOR THE PURPOSE OF CRYSTALLIZING G-PROTEIN COUPLED RECEPTORS 审中-公开用于结晶G蛋白偶联受体的目的的新型融合合作伙伴公开(公告)号：US20120288913A1
公开(公告)日：2012-11-15
申请号：US13470104
申请日：2012-05-11
申请人： Michael A. HANSON , Christopher B. Roth , Raymond C. Stevens , Joshua M. Kunken , Mark T. Griffith , Aaron A. Thompson , Wei Liu , Fei Xu , Vsevolod Katritch
发明人： Michael A. HANSON , Christopher B. Roth , Raymond C. Stevens , Joshua M. Kunken , Mark T. Griffith , Aaron A. Thompson , Wei Liu , Fei Xu , Vsevolod Katritch
CPC分类号： C07K14/723 , C07K14/195 , C07K14/47 , C07K14/721 , C07K14/80 , C07K2319/00 , C07K2319/02 , C07K2319/03 , C07K2319/21 , C07K2319/43 , C12N9/2434 , C12N9/2462 , C12N9/2482 , C12Y302/01008 , G16B30/00
摘要： GPCR-fusion partner proteins comprising G protein coupled receptors (GPCRs) of GPCRs and fusion partners such as rubredoxin, cytochrome b562 RIL (Bril, bRIL, BRIL), T4 lysozyme C-terminal fragment (Cterm-T4L), flavodoxin, or xylanase either substituted for some or all of the third intracellular loop of the GPCR between the fifth and sixth helix of the GPCR are described or attached to an terminus or C terminus of the GPCR. GPCR-fusion partner proteins in crystalline form, optionally of a quality suitable for x-ray crystallographic structure determination of the GPCR, are described. Methods of using fusion partners in GPCR-fusion partner proteins to support crystallization of GPCR-fusion partner proteins for x-ray crystallographic structure determination of the GPCR, are described. Methods of identifying other suitable fusion partners through screening of protein data banks are also described.
摘要翻译： GPCR-融合配偶体蛋白包含GPCR和融合配偶体的G蛋白偶联受体（GPCR），例如rubredoxin，细胞色素b562 RIL（Bril，bRIL，BRIL），T4溶菌酶C-末端片段（Cterm-T4L），黄素氧还蛋白或木聚糖酶 代替GPCR的第五和第六螺旋之间的GPCR的第三细胞内环的一些或全部被描述或附着于GPCR的末端或C末端。 描述了结晶形式的GPCR-融合伴侣蛋白，任选地具有适合于GPCR的x射线晶体结构确定的质量。 描述了在GPCR-融合配偶体蛋白中使用融合配偶体以支持GPCR-融合配偶体蛋白质结合用于GPCR的X射线晶体结构测定的方法。 还描述了通过筛选蛋白质数据库识别其他合适的融合伙伴的方法。
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公开(公告)号：US20120123092A1
公开(公告)日：2012-05-17
申请号：US13121923
申请日：2009-10-01
IPC分类号： C07K14/705
CPC分类号： C07K14/705 , C07K2299/00 , C07K2319/00 , C12N9/2462 , C12Y302/01017 , G01N33/566 , G01N2333/705 , G01N2500/00
摘要： The invention provides the structure of human A2A adenosine receptor protein bound to an antagonist. Methods of using one or more binding sites and other features of this G-protein coupled receptor to develop new therapeutics are also disclosed.
摘要翻译： 本发明提供了与拮抗剂结合的人A2A腺苷受体蛋白的结构。 还公开了使用该G-蛋白偶联受体的一个或多个结合位点和其它特征开发新治疗剂的方法。
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17.发明申请METHODS AND COMPOSITIONS FOR OBTAINING HIGH-RESOLUTION CRYSTALS OF MEMBRANE PROTEINS 有权用于获得膜蛋白高分辨率晶体的方法和组合物公开(公告)号：US20110031438A1
公开(公告)日：2011-02-10
申请号：US12739134
申请日：2008-10-22
IPC分类号： C09K3/00 , C07K1/00 , G01N23/207
CPC分类号： C07K14/723 , C07K14/705 , C07K14/70571 , C07K2299/00 , C12N9/2462 , C12N9/96
摘要： The invention describes compositions and method useful for the crystallization of membrane proteins.
摘要翻译： 本发明描述了可用于膜蛋白结晶的组合物和方法。
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公开(公告)号：US08536306B2
公开(公告)日：2013-09-17
申请号：US13121923
申请日：2009-10-01
IPC分类号： C07K14/705
CPC分类号： C07K14/705 , C07K2299/00 , C07K2319/00 , C12N9/2462 , C12Y302/01017 , G01N33/566 , G01N2333/705 , G01N2500/00
摘要： The invention provides the structure of human A2A adenosine receptor protein bound to an antagonist. Methods of using one or more binding sites and other features of this G-protein coupled receptor to develop new therapeutics are also disclosed.
摘要翻译： 本发明提供了与拮抗剂结合的人A2A腺苷受体蛋白的结构。 还公开了使用该G-蛋白偶联受体的一个或多个结合位点和其它特征开发新治疗剂的方法。
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公开(公告)号：US08440204B2
公开(公告)日：2013-05-14
申请号：US12769754
申请日：2010-04-29
申请人： Eric A. Johnson , Mark Joseph Jacobson , Guangyun Lin , Raymond C. Stevens , Jerome Dupuy , P{dot over (a)}l Erik Gustav Stenmark , William H. Tepp
发明人： Eric A. Johnson , Mark Joseph Jacobson , Guangyun Lin , Raymond C. Stevens , Jerome Dupuy , P{dot over (a)}l Erik Gustav Stenmark , William H. Tepp
IPC分类号： C07K14/33 , C07K16/12 , C07H21/00 , A61K39/40 , A61K38/16 , C12P21/08 , C12P21/00 , G01N33/68 , A61P25/00 , A61P21/00
CPC分类号： C07K14/33 , A61K39/08 , A61K2039/505 , C07K16/1282 , Y02A50/469
摘要： A novel subtype of type A botulinum neurotoxin (BoNT/A) is disclosed in the application. Methods to purify the neurotoxin as well as uses thereof are also disclosed.
摘要翻译： 应用中公开了A型肉毒杆菌神经毒素（BoNT / A）的新型亚型。 还公开了纯化神经毒素的方法及其用途。
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公开(公告)号：US20120100593A1
公开(公告)日：2012-04-26
申请号：US13199611
申请日：2011-09-02
IPC分类号： C12N9/96
CPC分类号： C07K14/723 , C07K14/705 , C07K14/70571 , C07K2299/00 , C12N9/2462 , C12N9/96
摘要： A polypeptide in crystalline form comprises a G-protein coupled receptor (GPCR) with an IC3 loop substituted by an amino acid residue sequence of lysozyme.
摘要翻译： 结晶形式的多肽包含具有由溶菌酶的氨基酸残基序列取代的IC3环的G蛋白偶联受体（GPCR）。
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