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    MEDICAL DEVICE COMPRISING A PROBE FOR MEASURING TEMPERATURE DATA IN A PATIENT'S TISSUE
    12.
    发明申请
    MEDICAL DEVICE COMPRISING A PROBE FOR MEASURING TEMPERATURE DATA IN A PATIENT'S TISSUE 审中-公开
    包含用于测量患者组织中的温度数据的探针的医疗装置

    公开(公告)号：US20110245713A1

    公开(公告)日：2011-10-06

    申请号：US13127046

    申请日：2009-11-09

    申请人： Judith Margreet Rensen ,  Jaap Haartsen ,  Mareike Klee ,  Drazenko Babic ,  Bernardus Hendrikus Wilhelmus Hendriks ,  Christianus Martinus Van Heesch ,  Bout Marcelis

    发明人： Judith Margreet Rensen ,  Jaap Haartsen ,  Mareike Klee ,  Drazenko Babic ,  Bernardus Hendrikus Wilhelmus Hendriks ,  Christianus Martinus Van Heesch ,  Bout Marcelis

    IPC分类号： A61B5/01

    CPC分类号： G01K13/002 ,  A61B5/01 ,  A61B2562/0271 ,  G01K3/14 ,  G01K7/02

    摘要： A medical device comprising a probe for measurement temperature data of tissue within a patient's body is proposed. The probe (2) comprises a flexible substrate (3) attached to a medical device core (5), the flexible substrate (3) comprising one or more thermopiles (7) and may furthermore comprise resistors for measuring an absolute temperature and heat sources for locally applying heat. The thermopiles can be processed directly on a flexible polymer carrier or, alternatively, on a silicon substrate and transferred to a flexible carrier (3) enabling both, a highly flexible substrate (3) and very small structural dimensions for the thermopiles (7) and, possibly, the resistors and heat sources. Accordingly, measurement of temperature gradients of tissue being in contact to the medical device may be performed at high resolution allowing reliable detection of temperature anomalies e.g. due to malign tissue.

    摘要翻译： 提出了包括用于测量患者身体内的组织的温度数据的探针的医疗装置。 探针（2）包括附接到医疗器件芯（5）的柔性衬底（3），柔性衬底（3）包括一个或多个热电堆（7），并且还可以包括用于测量绝对温度的电阻器和用于 局部施加热量。 可以将热电堆直接加工在柔性聚合物载体上，或者在硅衬底上进行处理，并转移到柔性载体（3）上，从而使高弹性基底（3）和热电堆（7）的非常小的结构尺寸和 ，可能是电阻和热源。 因此，可以以高分辨率执行与医疗装置接触的组织的温度梯度的测量，从而可以可靠地检测温度异常。 由于恶性组织。

    Determination of a lipid water ratio
    15.
    发明授权
    Determination of a lipid water ratio 有权
    脂质水比的测定

    公开(公告)号：US09468379B2

    公开(公告)日：2016-10-18

    申请号：US13641229

    申请日：2011-04-18

    申请人： Bernardus Hendrikus Wilhelmus Hendriks ,  Jeroen Jan Lambertus Horikx ,  Gerhardus Wilhelmus Lucassen ,  Rami Nachabe ,  Marjolein Van Der Voort

    发明人： Bernardus Hendrikus Wilhelmus Hendriks ,  Jeroen Jan Lambertus Horikx ,  Gerhardus Wilhelmus Lucassen ,  Rami Nachabe ,  Marjolein Van Der Voort

    IPC分类号： G01N21/359 ,  A61B5/00

    CPC分类号： A61B5/0059 ,  A61B5/4869 ,  G01N21/359

    摘要： The present invention relates to an apparatus, a method and a computer program for determining a lipid-water ratio and a scattering parameter of a sample. In particular, the invention relates to an apparatus comprising a light source and a detector arranged to measure an optical parameter at various wavelengths, where the wavelengths are selected so that at two of the wavelengths the absorption coefficients for both water and lipids are substantially identical. This enables determination of a scattering parameter. A further measurement at a third wavelength enables determination of a water-lipid ratio. According to a specific embodiment, the light source and the detector are arranged in relation to an interventional device, so as to be able to examine a tissue in terms of lipid-water ratio and scattering during an intervention.

    摘要翻译： 本发明涉及一种用于确定样品的脂质 - 水比和散射参数的装置，方法和计算机程序。 具体地，本发明涉及一种包括光源和检测器的设备，其被布置成测量各种波长的光学参数，其中选择波长使得在两个波长处，水和脂质的吸收系数基本相同。 这使得能够确定散射参数。 在第三波长处的进一步测量使得能够测定水 - 油比。 根据具体实施例，光源和检测器相对于介入装置布置，以便能够在干预期间根据脂质 - 水比和散射来检查组织。

    Methods and apparatuses of microbeamforming with adjustable fluid lenses
    16.
    发明授权
    Methods and apparatuses of microbeamforming with adjustable fluid lenses 失效
    具有可调节流体透镜的微波成像的方法和装置

    公开(公告)号：US08764665B2

    公开(公告)日：2014-07-01

    申请号：US12596841

    申请日：2008-04-30

    申请人： Christopher Stephen Hall ,  Chien Ting Chin ,  Jan Frederik Suijver ,  Bernardus Hendrikus Wilhelmus Hendriks ,  Stein Kuiper

    发明人： Christopher Stephen Hall ,  Chien Ting Chin ,  Jan Frederik Suijver ,  Bernardus Hendrikus Wilhelmus Hendriks ,  Stein Kuiper

    IPC分类号： A61B8/00

    CPC分类号： G10K11/30

    摘要： An acoustic probe (100, 300) includes an acoustic transducer (15, 444), and a plurality of variably-refracting acoustic lens elements (10, 210a, 210b, 442) coupled to the acoustic transducer. Each variably-refracting acoustic lens element has at least a pair of electrodes (150, 160) adapted to adjust at least one characteristic of the variably-refracting acoustic lens element in response to a selected voltage applied across the electrodes. In one embodiment, each variably-refracting acoustic lens element includes a cavity, first and second fluid media (141, 142) disposed within the cavity, and the pair of electrodes. The speed of sound of an acoustic wave in the first fluid medium is different than the speed of sound of the acoustic wave in the second fluid medium. The first and second fluid media are immiscible with respect to each other, and the first fluid medium has a substantially different electrical conductivity than the second fluid medium.

    摘要翻译： 声探针（100,300）包括声换能器（15,444）和耦合到声换能器的多个可变折射声透镜元件（10,210a，210b，442）。 每个可变折射声透镜元件具有至少一对电极（150,160），其适于响应于跨过电极施加的选定电压来调节可变折射声透镜元件的至少一个特性。 在一个实施例中，每个可变折射声透镜元件包括空腔，设置在空腔内的第一和第二流体介质（141,142）和一对电极。 第一流体介质中声波的声速不同于第二流体介质中声波的声速。 第一和第二流体介质相对于彼此是不混溶的，并且第一流体介质具有与第二流体介质基本上不同的导电性。

    Method and system for imaging samples
    17.
    发明授权
    Method and system for imaging samples 有权
    成像样本的方法和系统

    公开(公告)号：US08450703B2

    公开(公告)日：2013-05-28

    申请号：US12678781

    申请日：2008-07-23

    申请人： Ruth Wilhelmine Ireen De Boer ,  Bernardus Hendrikus Wilhelmus Hendriks

    发明人： Ruth Wilhelmine Ireen De Boer ,  Bernardus Hendrikus Wilhelmus Hendriks

    IPC分类号： G01N21/64

    CPC分类号： G01N21/6458 ,  G01N2021/6419 ,  G01N2021/6421 ,  G01N2021/6441 ,  G02B21/16 ,  G02B21/244

    摘要： The invention provides a method for imaging samples, at least comprising: —staining of a sample with a first marker material and with a second marker material; —utilizing the first marker material in a focusing step for focusing an imaging device with respect to the sample; and —utilizing the second marker material and the imaging device, which has been focused in the focusing step, in an imaging step to acquire an image of the sample. The invention also relates to a system for imaging samples.

    摘要翻译： 本发明提供了一种用于成像样品的方法，至少包括：用第一标记材料和第二标记材料染色样品; - 在聚焦步骤中利用所述第一标记材料，用于相对于所述样品聚焦成像装置; 并且在成像步骤中利用聚焦在聚焦步骤中的第二标记材料和成像装置来获取样本的图像。 本发明还涉及用于成像样本的系统。

    System for variably refracting ultrasound and/or light
    18.
    发明授权
    System for variably refracting ultrasound and/or light 失效
    用于可变地折射超声和/或光的系统

    公开(公告)号：US08422338B2

    公开(公告)日：2013-04-16

    申请号：US12376307

    申请日：2007-04-12

    申请人： Stein Kuiper ,  Bernardus Hendrikus Wilhelmus Hendriks ,  Jan Frederik Suijver

    发明人： Stein Kuiper ,  Bernardus Hendrikus Wilhelmus Hendriks ,  Jan Frederik Suijver

    IPC分类号： G10K11/30

    CPC分类号： G10K11/30

    摘要： The disclosure is directed to a system for variably refracting, and is transparent for, ultrasound as well as for light. By choosing liquids with the right optical and acoustical properties, it is possible to variably refract (including focusing and deflecting or steering) ultrasound while not affecting the refraction of light, or vice versa. Two lenses in series, or preferably one lens, allow for variably refracting ultrasound and light.

    摘要翻译： 本公开涉及用于可变折射并且对于超声波以及用于光的透明系统。 通过选择具有正确光学和声学特性的液体，可以可变地折射（包括聚焦和偏转或转向）超声波，同时不影响光的折射，反之亦然。 串联的两个镜片，或者优选地，一个透镜允许可变地折射超声波和光。

    Imaging system with two imaging modalities
    19.
    发明授权
    Imaging system with two imaging modalities 失效
    具有两种成像方式的成像系统

    公开(公告)号：US08360963B2

    公开(公告)日：2013-01-29

    申请号：US12519766

    申请日：2007-12-17

    申请人： Bernardus Hendrikus Wilhelmus Hendriks ,  Gert T Hooft ,  Stein Kuiper

    发明人： Bernardus Hendrikus Wilhelmus Hendriks ,  Gert T Hooft ,  Stein Kuiper

    IPC分类号： A61B1/06

    CPC分类号： A61B5/0059 ,  A61B5/0035 ,  A61B5/0068 ,  A61B2562/0242 ,  G02B3/14 ,  G02B21/0028 ,  G02B23/243 ,  G02B23/26

    摘要： An imaging system with two modalities has a catheter with an optical lens system situated at an end of the catheter and optically connected to optical guide. The lens system has a numerical aperture which is changeable between a first aperture and a second larger numerical aperture. The imaging system also has an imaging unit for optical imaging with the catheter. First and second imaging modalities are optically connectable with the optical lens system of the catheter. The imaging system can change between imaging in two modes: (1) the first numerical aperture of the optical lens system and the first imaging modality of the imaging unit, and (2) the second numerical aperture of the optical lens system and the second imaging modality of the imaging unit.

    摘要翻译： 具有两种模式的成像系统具有导管，其具有位于导管的端部处并且光学连接到光导的光学透镜系统。 透镜系统具有可在第一孔径和第二较大数值孔径之间变化的数值孔径。 成像系统还具有用于与导管进行光学成像的成像单元。 第一和第二成像模式可与导管的光学透镜系统光学连接。 成像系统可以以两种模式在成像之间改变：（1）光学透镜系统的第一数值孔径和成像单元的第一成像模态，以及（2）光学透镜系统的第二数值孔径和第二成像 成像单元的模态。

    Hydrogel based sensor probe for detecting an environmental state
    20.
    发明授权
    Hydrogel based sensor probe for detecting an environmental state 失效
    用于检测环境状态的基于水凝胶的传感器探头

    公开(公告)号：US08244078B2

    公开(公告)日：2012-08-14

    申请号：US12600881

    申请日：2008-05-22

    申请人： Bernardus Hendrikus Wilhelmus Hendriks ,  Szabolcs Deladi ,  Ralph Kurt ,  Jan Frederik Suijver

    发明人： Bernardus Hendrikus Wilhelmus Hendriks ,  Szabolcs Deladi ,  Ralph Kurt ,  Jan Frederik Suijver

    IPC分类号： G02B6/00

    CPC分类号： G01N21/7703 ,  A61B5/0084 ,  A61B5/14539 ,  G01N2021/772 ,  G01N2021/7723 ,  G01N2021/773 ,  G01N2021/7779

    摘要： A sensor probe for detecting an environmental state within a bodily lumen includes an elongated body having an optical guide with an outcoupling surface, which is part of an end surface of the elongated body, facing a reflective surface of an overhanging part. The sensor probe further includes a photodetector which detects a property of light which is composed of light in the optical guide that is reflected from the outcoupling surface of the optical guide and of light in the optical guide that is reflected from the overhanging part. The sensor probe also includes a hydrogel material having a property that changes when getting into contact with an environmental material and/or when detecting an environmental change. The hydrogel material is provided between the end surface of the elongated body and the overhanging part.

    摘要翻译： 用于检测身体腔内的环境状态的传感器探针包括细长体，其具有带有外耦合表面的光导，所述光耦合器是细长体的端表面的一部分，面向突出部分的反射表面。 传感器探头还包括光电检测器，其检测由光导中的光构成的光的特性，所述光从光导的输出耦合表面反射，以及从突出部反射的光导中的光。 传感器探头还包括具有在与环境材料接触和/或当检测到环境变化时变化的性质的水凝胶材料。 水凝胶材料设置在细长体的端面与突出部之间。