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公开(公告)号：US20170158836A1
公开(公告)日：2017-06-08
申请号：US15039219
申请日：2014-11-25
Applicant: Carnegie Mellon University
Inventor： Krzysztof Matyjaszewski , Saadyah Averick , Hongkun He
CPC classification number: C08J9/26 , B01D71/40 , B01D71/44 , B01D71/52 , B01D71/82 , B01D2323/30 , C02F3/342 , C08J9/0061 , C08J9/36 , C08J2201/0462 , C08J2205/022 , C08J2205/05 , C08J2333/06 , C08J2333/12 , C08J2335/02 , C08J2489/00 , C12N9/96 , C12Y304/21004
Abstract: A three-dimensionally ordered macroporous hydrogel for immobilizing a selected bioresponsive molecule and method of making are disclosed. The three-dimensionally ordered macroporous hydrogel comprises a crosslinked polymer that has a system of interconnected pores. The interconnected pores have a uniform pore size in the range of 50 to 5000 nm, and a plurality of first pore functional groups. The plurality of first pore functional groups is selected to immobilize a selected bioresponsive molecule. Examples of bioresponsive molecules include an enzyme; a molecule for: a protein scaffold, solid phase synthesis, nucleic acid synthesis, polypeptide synthesis, analyte detection, adsorption of analytes and measuring analyte concentrations, organic synthesis, and degradation of biologically active agents in wastewater. A method includes forming a colloidal crystal template, polymerizing a hydrogel within the pores of the colloidal crystal template, and selectively removing the colloidal crystal template. The hydrogel can be polymerized using CRP, ATRP and FRP polymerization processes.
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公开(公告)号：US09533297B2
公开(公告)日：2017-01-03
申请号：US14379418
申请日：2013-02-22
Applicant: Carnegie Mellon University
Inventor： Krzysztof Matyjaszewski , Yungwan Kwak , Joanna Burdynska , Andrea Elsen , Kristin Schroeder
IPC: C08F4/40 , C08F4/44 , C08F4/80 , B01J31/22 , C08F120/18 , C08F2/38 , C08F4/10 , C08F4/26 , B01J31/18 , C08F220/18
CPC classification number: B01J31/2295 , B01J31/1815 , B01J31/2243 , B01J2231/10 , B01J2231/30 , B01J2231/42 , B01J2531/0247 , B01J2531/16 , B01J2531/842 , C08F2/38 , C08F4/10 , C08F4/26 , C08F4/40 , C08F120/18 , C08F2220/1825 , C08F2438/01 , Y02P20/52
Abstract: A series of ligands with site specific electron donating substituents that form a catalyst complex with a transition metal and are suitable for catalysis of atom transfer radical reactions, including ATRP are described. Faster catalysis rates were observed allowing for low catalyst concentrations and linear increases in molecular weight with monomer conversion, and narrow molecular weight distributions. Cyclic voltammetry revealed that increasing the strength and number of conjugated electron donating groups resulted in more stable complexes and larger ATRP equilibrium constants.
Abstract translation: 描述了一系列具有与过渡金属形成催化剂络合物并且适于催化原子转移自由基反应（包括ATRP）的位置特异性给电子取代基的配位体。 观察到更快的催化速率，使得催化剂浓度低，分子量随单体转化率的线性增加，分子量分布窄。 循环伏安法显示，增加共轭给电子基团的强度和数量导致更稳定的络合物和较大的ATRP平衡常数。
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公开(公告)号：US20230079313A1
公开(公告)日：2023-03-16
申请号：US17942952
申请日：2022-09-12
Applicant: Carnegie Mellon University
Inventor： Krzysztof Matyjaszewski , Alan Enciso Barros , Liye Fu , Alan J. Russell
IPC: C08F4/10 , C08F2/16 , C08K5/1545 , C08F4/26 , C12P7/00
Abstract: Materials and methods for conducting an atom transfer radical polymerization in the presence of oxygen by interlocking enzymatic activities are provided herein.
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公开(公告)号：US20230049990A1
公开(公告)日：2023-02-16
申请号：US17959913
申请日：2022-10-04
Applicant: CARNEGIE MELLON UNIVERSITY
Inventor： Krzysztof Matyjaszewski , Jianan Zhang , Michael R. Bockstaller
IPC: C01B32/354 , C01B32/21 , C08L33/20
Abstract: A method for preparation of mesoporous nitrogen-doped carbon includes forming a composition by solubilizing a nitrogen-containing polymer in an aqueous solution of ZnCl2 and drying the aqueous solution, the method further includes heating the composition after drying to a temperature sufficiently high to carbonize the nitrogen-containing polymer to form the mesoporous nitrogen-doped carbon.
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公开(公告)号：US11426490B2
公开(公告)日：2022-08-30
申请号：US17189144
申请日：2021-03-01
Applicant: VALORISATION RECHERCHE, LIMITED PARTNERSHIP , VALORISATION HSJ, LIMITED PARTNERSHIP , CARNEGIE MELLON UNIVERSITY
Inventor： Xavier Banquy , Jimmy Faivre , Buddha Ratna Shrestha , Krzysztof Matyjaszewski , Joanna Burdynska , Florina Moldovan
IPC: A61L27/50 , A61L27/16 , C08F265/06 , C08B37/08 , C08L51/00 , C08L5/08 , A61L31/10 , A61L31/14 , C10M107/44 , C10M107/48 , C10M173/02 , C10N40/00 , C10N50/02
Abstract: A mixture of polymers with lubricating properties is provided. The polymer can be used to produce a lubricating fluid. They can also be born on a surface or embedded in a porous material. This mixture of polymers comprises (a) a pharmaceutically acceptable bottle-brush polymer comprising a backbone with polymeric pendant chains, and (b) a pharmaceutically acceptable linear polymer. In the lubricating fluid, the bottle-brush polymer and the linear polymer are dissolved together in a pharmaceutically acceptable solvent.
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Patent Agency Ranking
公开(公告)号：US20220145291A1
公开(公告)日：2022-05-12
申请号：US17430837
申请日：2020-02-14
Applicant: Carnegie Mellon University
Inventor： Subha Ranjan Das , Phil G. Campbell , Krzysztof Matyjaszewski , Sushil Lathwal , Saigopalakrishna Saileelaprasad Yernei
Abstract: Provided herein are tethered extracellular vesicles and methods of making tethered extracellular vesicles.
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公开(公告)号：US10982266B2
公开(公告)日：2021-04-20
申请号：US15802066
申请日：2017-11-02
Applicant: CARNEGIE MELLON UNIVERSITY
Inventor： Munira F. Fouz , Krzysztof Matyjaszewski , Bruce A. Armitage , Subha Ranjan Das , Saadyah Averick
Abstract: A composition includes a polymer including extending chains, side chains, or branches. One (or more) of a plurality of a first strand of nucleic acid is attached to each of a plurality of the side chains. One (or more) of a plurality of a second strand of nucleic acid, which is complementary to the first strand of nucleic acid, is complexed to each of the plurality of the first strand of nucleic acid to form a double strand of nucleic acid on each of the plurality of the side chains. At least one fluorescent compound is associated with the double strand of nucleic acid on each of the plurality of the side chains.
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公开(公告)号：US20170145048A1
公开(公告)日：2017-05-25
申请号：US15378537
申请日：2016-12-14
Applicant: Carnegie Mellon University
Inventor： Krzysztof Matyjaszewski , Saadyah E. Averick , Antonina Simakova
IPC: C07K1/107 , C07K14/765 , C07K14/435 , C08G81/02 , C08F283/06
CPC classification number: C07K1/1077 , A61K47/60 , C07K14/43595 , C07K14/765 , C08F283/06 , C08F289/00 , C08G81/025
Abstract: Methods for conducting controlled grafting-from radical polymerizations from biomolecules under conditions that are biologically compatible are described. The methods provide biomolecule-polymer conjugates with highly controlled structures and narrow polydispersities under aqueous reaction conditions and biological temperatures. Biomolecules, such as proteins and nucleotides can be conjugated to polymers with high levels of control.
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公开(公告)号：US12065519B2
公开(公告)日：2024-08-20
申请号：US17059806
申请日：2019-06-01
Applicant: CARNEGIE MELLON UNIVERSITY
Inventor： Krzysztof Matyjaszewski , Guojun Xie , Michael R. Martinez , Thomas G. Ribelli
IPC: C08F2/46 , C08F2/48 , C08F2/50 , C08F293/00 , C08G61/04
CPC classification number: C08F2/48 , C08F293/005 , C08F2438/01 , C08F2810/20 , C08F265/06 , C08F220/1804
Abstract: A method of carrying out an atom transfer radical polymerization wherein intermolecular crosslinking can occur includes controlling an amount of crosslinking by carrying out the reaction under conditions wherein catalytic radical termination is favored over radical termination.
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公开(公告)号：US11891305B2
公开(公告)日：2024-02-06
申请号：US17959913
申请日：2022-10-04
Applicant: CARNEGIE MELLON UNIVERSITY
Inventor： Krzysztof Matyjaszewski , Jianan Zhang , Michael R. Bockstaller
IPC: C01B32/348 , C01B32/354 , C01B32/21 , C08L33/20 , C01B32/05
CPC classification number: C01B32/354 , C01B32/05 , C01B32/21 , C01B32/348 , C08L33/20 , C01P2006/12 , C01P2006/14 , C01P2006/17
Abstract: A method for preparation of mesoporous nitrogen-doped carbon includes forming a composition by solubilizing a nitrogen-containing polymer in an aqueous solution of ZnCl2 and drying the aqueous solution, the method further includes heating the composition after drying to a temperature sufficiently high to carbonize the nitrogen-containing polymer to form the mesoporous nitrogen-doped carbon.
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