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公开(公告)号：US5756472A
公开(公告)日：1998-05-26
申请号：US789349
申请日：1997-01-27
申请人： Jerrold M. Liesch , Maria S. Meinz , Janet C. Onishi , Sandra A. Morris , Robert E. Schwartz , Gerald F. Bills , Robert A. Giacobbe , Wendy S. Horn , Deborah L. Zink , Angeles Cabello , Maria T. Diez , Isabella Martin , Fernando Pelaez , Francisca Vicente
发明人： Jerrold M. Liesch , Maria S. Meinz , Janet C. Onishi , Sandra A. Morris , Robert E. Schwartz , Gerald F. Bills , Robert A. Giacobbe , Wendy S. Horn , Deborah L. Zink , Angeles Cabello , Maria T. Diez , Isabella Martin , Fernando Pelaez , Francisca Vicente
IPC分类号： C07H15/24 , A61K31/70 , C07D315/00 , C12N1/14
CPC分类号： C07H15/24 , Y10S435/911
摘要： There is disclosed a novel compound having the formula ##STR1## which exhibits antifungal activity.
摘要翻译： 公开了具有抗真菌活性的具有式（I）＆lt; IMAGE＆gt;的式的新化合物。
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公开(公告)号：US5712151A
公开(公告)日：1998-01-27
申请号：US734702
申请日：1996-10-21
申请人： Sandra A. Morris , Gerald F. Bills , James E. Curotto , Sarah J. Dreikorn , Angela Basilio , Maria Teresa Diez , Fernando Pelaez , Francisca Vicente , Bruce W. Burgess , Stanley L. Streicher , Deborah L. Zink , John R. Thompson
发明人： Sandra A. Morris , Gerald F. Bills , James E. Curotto , Sarah J. Dreikorn , Angela Basilio , Maria Teresa Diez , Fernando Pelaez , Francisca Vicente , Bruce W. Burgess , Stanley L. Streicher , Deborah L. Zink , John R. Thompson
IPC分类号： A01N37/42 , C07D207/44 , C07D207/448 , C12P17/10 , C12N5/00 , C12N5/02
CPC分类号： C07D207/448 , A01N37/42 , C12P17/10 , C12R1/645
摘要： There is disclosed a novel compound having the formula ##STR1## which exhibits antifungal activity.
摘要翻译： 公开了具有抗真菌活性的具有式（I）的化合物。
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13.发明授权Bis-aryl ethers, compositions containing such compounds and methods of treatment 失效双芳基醚，含有这些化合物的组合物和处理方法
公开(公告)号：US5994412A
公开(公告)日：1999-11-30
申请号：US110006
申请日：1998-07-02
申请人： Seok H. Lee , Maria T. Diez , Fernando Pelaez , Marina Mojena Sanchez , M. Dolores Vilella Amils , Hans E. Huber , Denis R. Patrick , Otto D. Hensens , Rosalind G. Jenkins , Leeyuan Huang , Annie Z. Zhao , Deborah L. Zink , Anne Dombrowski , Gerald F. Bills
发明人： Seok H. Lee , Maria T. Diez , Fernando Pelaez , Marina Mojena Sanchez , M. Dolores Vilella Amils , Hans E. Huber , Denis R. Patrick , Otto D. Hensens , Rosalind G. Jenkins , Leeyuan Huang , Annie Z. Zhao , Deborah L. Zink , Anne Dombrowski , Gerald F. Bills
摘要： A compound represented by the formula I is disclosed: ##STR1## or a pharmaceutically acceptable salt or hydrate thereof. The compound has inhibitory activity against the oncoprotein Raf.Also included are pharmaceutical compositions, methods of treating cancer, cultures of the producing fungal microorganism and methods of fermentative production of the compound.
摘要翻译： 公开了由式I表示的化合物：或其药学上可接受的盐或水合物。 该化合物对癌蛋白Raf具有抑制活性。 还包括药物组合物，治疗癌症的方法，产生真菌微生物的培养物和化合物发酵生产的方法。
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14.发明授权Antifungal agent produced by arthrinium arundinis ATCC 74359 失效由arthrinium arundinis ATCC 74359生产的抗真菌剂
公开(公告)号：US5712109A
公开(公告)日：1998-01-27
申请号：US789348
申请日：1997-01-27
申请人： Jerrold M. Liesch , Maria S. Meinz , Janet C. Onishi , Robert E. Schwartz , Gerald F. Bills , Robert A. Giacobbe , Deborah L. Zink , Angeles Cabello , Maria T. Diez , Isabella Martin , Fernando Pelaez , Francisca Vicente
发明人： Jerrold M. Liesch , Maria S. Meinz , Janet C. Onishi , Robert E. Schwartz , Gerald F. Bills , Robert A. Giacobbe , Deborah L. Zink , Angeles Cabello , Maria T. Diez , Isabella Martin , Fernando Pelaez , Francisca Vicente
CPC分类号： C07J9/00
摘要： There is disclosed a compound having the formula ##STR1## which is produced by the fungus, Arthrinium arundinis ATCC 74359, and exhibits antifungal activity.
摘要翻译： 公开了由真菌Arthrinium arundinis ATCC 74359产生的具有式（I）的化合物，并表现出抗真菌活性。
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公开(公告)号：US5348970A
公开(公告)日：1994-09-20
申请号：US125432
申请日：1993-09-22
申请人： Robert E. Schwartz , Janet C. Onishi , Gerald F. Bills , Robert A. Giacobbe , Fernando Pelaez , Maria T. Diez , Francisca Vicente , Julian Gorrochategui , Gregory L. Helms , Barnali Pramanik
发明人： Robert E. Schwartz , Janet C. Onishi , Gerald F. Bills , Robert A. Giacobbe , Fernando Pelaez , Maria T. Diez , Francisca Vicente , Julian Gorrochategui , Gregory L. Helms , Barnali Pramanik
IPC分类号： C07D405/06 , A61K31/40
CPC分类号： C07D405/06
摘要： A compound of the formula 1: ##STR1## is produced via fermentation of a fungal isolate ATCC no. 74235. The organism is included herein, as well as a process for production of the compound, a pharmaceutical composition and a method of treatment.
摘要翻译： 通过真菌分离物ATCC号的发酵产生式1化合物：
1。 生物体包括在本文中，以及生产化合物的方法，药物组合物和治疗方法。 -
16.发明授权Process for forming cholesterol lowering compound using pseudodiplodia sp. 失效使用pseudipiplodia sp形成降胆固醇化合物的方法
公开(公告)号：US5284758A
公开(公告)日：1994-02-08
申请号：US929236
申请日：1992-08-14
CPC分类号： C12R1/645 , C12P17/181 , Y10S435/911
摘要： This invention relates to a fungal microorganism Pseudodiplodia sp. (MF5767) isolated from bark discs of Hibiscus sp. and useful in a fermentation process to form compounds of formula (I): ##STR1## which are squalene synthetase inhibitors and thus useful as cholesterol lowering agents.
摘要翻译： 本发明涉及真菌微生物Pseudodiplodia sp。 （MF5767）从木槿sp。 并且可用于形成式（I）化合物的发酵方法：（*化学结构*）（I），其为角鲨烯合成酶抑制剂，因此可用作降胆固醇剂。
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公开(公告)号：US5702929A
公开(公告)日：1997-12-30
申请号：US734704
申请日：1996-10-21
申请人： Sandra A. Morris , James E. Curotto , Gerald F. Bills , Sarah J. Dreikorn , Stanley L. Streicher , Deborah L. Zink , John R. Thompson , Angela Basilio , Fernando Pelaez , Maria Teresa Diez , Francisca Vicente
发明人： Sandra A. Morris , James E. Curotto , Gerald F. Bills , Sarah J. Dreikorn , Stanley L. Streicher , Deborah L. Zink , John R. Thompson , Angela Basilio , Fernando Pelaez , Maria Teresa Diez , Francisca Vicente
IPC分类号： C07D405/06 , C12P17/16 , C12N5/00 , C07D207/00
CPC分类号： C07D405/06 , C12P17/16
摘要： There is disclosed a novel compound having the formula ##STR1## which exhibits antifungal activity.
摘要翻译： 公开了具有抗真菌活性的具有式（I）的化合物。
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公开(公告)号：US5461071A
公开(公告)日：1995-10-24
申请号：US326986
申请日：1994-10-21
申请人： Evon A. Bolessa , Robert E. Schwartz , Gerald F. Bills , Robert A. Giacobbe , Fernando Pelaez Perez , Angeles Cabello Arroyo , Teresa Diez Matas , Isabel Martin Fernandez , Francisca Vincente Perez , Suzanne M. Mandala , Deborah L. Zink , Rosemary Thornton , John R. Thompson , James E. Curotto
发明人： Evon A. Bolessa , Robert E. Schwartz , Gerald F. Bills , Robert A. Giacobbe , Fernando Pelaez Perez , Angeles Cabello Arroyo , Teresa Diez Matas , Isabel Martin Fernandez , Francisca Vincente Perez , Suzanne M. Mandala , Deborah L. Zink , Rosemary Thornton , John R. Thompson , James E. Curotto
IPC分类号： C07D207/12 , A61K31/40 , A61K31/445 , C07D211/40
CPC分类号： C07D207/12
摘要： A compound having the formula ##STR1## which is an anti-fungal agent is described. The producing organism Colletotricum accutatum is also described, along with a method of production.
摘要翻译： 描述了具有抗真菌剂的式“IMAGE”的化合物。 还描述了生产菌Colletotricum accutatum以及生产方法。
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19.发明授权Gamma-pyrone-3-acetic acid as an inhibitor or interleukin-1 .beta. inventory enzyme 失效γ - 吡喃酮-3-乙酸作为抑制剂或白细胞介素-1β库存酶
公开(公告)号：US5411985A
公开(公告)日：1995-05-02
申请号：US62881
申请日：1993-05-17
申请人： Gerald F. Bills , Otto D. Hensens , Jerrold M. Liesch , Russel B. Lingham , Jon D. Polishook , Michael J. Salvatore , Susan L. Raghoobar
发明人： Gerald F. Bills , Otto D. Hensens , Jerrold M. Liesch , Russel B. Lingham , Jon D. Polishook , Michael J. Salvatore , Susan L. Raghoobar
IPC分类号： A61K31/35 , C07D309/38 , C12P17/06
CPC分类号： C12R1/645 , A61K31/35 , C07D309/38 , C12P17/06
摘要： Novel peptidyl derivatives of formula I are found to be potent inhibitors of interleukin-1.beta. converting enzyme (ICE). Compounds of formula I may be useful in the treatment of inflammatory or immune-based diseases of the lung and airways; central nervous system and surrounding membranes; the eyes and ears; joints, bones, and connective tissues; cardiovascular system including the pericardium; the gastrointestinal and urogenital systems; the skin and mucosal membranes. Compounds of formula I are also useful in treating the complications of infection (e.g., gram negative shock) and tumors in which IL 1 functions as an autocrine growth factor or as a mediator of cachexia. ##STR1##
摘要翻译： 发现式I的新型肽基衍生物是白细胞介素-1β转换酶（ICE）的有效抑制剂。 式I化合物可用于治疗肺和气道炎性或免疫性疾病; 中枢神经系统和周围膜; 眼睛和耳朵 关节，骨骼和结缔组织; 包括心包的心血管系统; 胃肠道和泌尿生殖系统; 皮肤和粘膜。 式I化合物也可用于治疗感染（例如，革兰氏阴性休克）的并发症和其中IL1作为自分泌生长因子或作为恶病质介质的肿瘤。
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20.发明授权Biologically pure culture of Cytospora useful as angiotensin II antagonist 失效作为血管紧张素II拮抗剂的细胞生物学纯培养物
公开(公告)号：US5278068A
公开(公告)日：1994-01-11
申请号：US961958
申请日：1992-10-16
申请人： Gerald F. Bills
发明人： Gerald F. Bills
IPC分类号： C07D311/74 , C07D491/10 , C12P17/02 , C12P17/06 , C12R1/645 , C12P17/08
CPC分类号： C07D491/10 , C07D311/74 , C12P17/02 , C12P17/06 , C12R1/645 , Y10S435/911
摘要： An organism of the Cytospora species produces substituted hexahydrobenzopyran compounds of the Formulas A, B, or C which are useful as angiotensin II antagonists: ##STR1##
摘要翻译： Cytospora物种的生物产生用作血管紧张素II拮抗剂的式A，B或C的取代的六氢苯并吡喃化合物：（*化学结构*）A（*化学结构*）B（*化学结构*）C
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