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11.再颁专利公开(公告)号：USRE42315E1
公开(公告)日：2011-05-03
申请号：US11825298
申请日：2007-07-05
IPC分类号： B01D15/34
CPC分类号： G01N27/44773 , B82Y30/00 , G01N30/00 , G01N30/88 , G01N2030/8813 , Y10S977/717 , Y10S977/845 , Y10T436/25375 , Y10T436/255
摘要： The present invention provides a nanostructured device comprising a substrate including nanotroughs therein; and a lipid bilayer suspended on or supported in the substrate. A separation method is also provided comprising the steps of supporting or suspending a lipid bilayer on a substrate; wherein the substrate comprises nanostructures and wherein the lipid bilayer comprises at least one membrane associated biomolecule; and applying a driving force to the lipid bilayer to separate the membrane associated biomolecule from the lipid bilayer and to drive the membrane associated biomolecule into the nanostructures.
摘要翻译： 本发明提供一种纳米结构装置，其包括其中包括纳沟的基板; 和悬浮在或支撑在基底中的脂质双层。 还提供了一种分离方法，包括以下步骤：在基质上支持或悬浮脂质双层; 其中所述底物包含纳米结构，并且其中所述脂质双层包含至少一个膜缔合的生物分子; 并将驱动力施加到脂质双层以将膜相关生物分子与脂质双层分离并将膜相关联的生物分子驱动到纳米结构中。
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12.再颁专利公开(公告)号：USRE41762E1
公开(公告)日：2010-09-28
申请号：US12215893
申请日：2008-06-30
IPC分类号： C02F1/00
CPC分类号： G01N27/44773 , B82Y30/00 , G01N30/00 , G01N30/88 , G01N2030/8813 , Y10S977/717 , Y10S977/845 , Y10T436/25375 , Y10T436/255
摘要： The present invention provides a nanostructured device comprising a substrate including nanotroughs therein; and a lipid bilayer suspended on or supported in the substrate. A separation method is also provided comprising the steps of supporting or suspending a lipid bilayer on a substrate; wherein the substrate comprises nanostructures and wherein the lipid bilayer comprises at least one membrane associated biomolecule; and applying a driving force to the lipid bilayer to separate the membrane associated biomolecule from the lipid bilayer and to drive the membrane associated biomolecule into the nanostructures.
摘要翻译： 本发明提供一种纳米结构装置，其包括其中包括纳沟的基板; 和悬浮在或支撑在基底中的脂质双层。 还提供了一种分离方法，包括以下步骤：在基质上支持或悬浮脂质双层; 其中所述底物包含纳米结构，并且其中所述脂质双层包含至少一个膜缔合的生物分子; 并将驱动力施加到脂质双层以将膜相关生物分子与脂质双层分离并将膜相关联的生物分子驱动到纳米结构中。
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公开(公告)号：US06685841B2
公开(公告)日：2004-02-03
申请号：US10073935
申请日：2002-02-14
IPC分类号： B01D5700
CPC分类号： B01L3/502746 , B01L3/502753 , B01L2300/0636 , B01L2300/0822 , B01L2300/0877 , B01L2300/0896 , B01L2400/086 , B82Y15/00 , B82Y30/00 , G01N27/44791 , G01N30/02 , G01N30/6065 , G01N30/6095 , G01N2030/525 , Y10T137/2224 , Y10T428/249953 , Y10T428/249961 , Y10T436/2575 , B01D15/3833 , B01D15/327 , B01D15/3804 , B01D15/34
摘要： The present invention provides a matrix comprising an array of nanostructures that exhibit a variation (gradient) in physical properties (such as size or pitch) in at least one direction of the plane containing said array. A method for forming an array having a gradient property is also provided. In addition, a separation method is provided comprising the steps of: providing a matrix comprising an array of nanostructures arranged so that the array has the property of a gradient; and conducting at least one biomolecule separation process to separate biomolecules in a composition containing a plurality of biomolecules using the matrix.
摘要翻译： 本发明提供一种包含纳米结构阵列的矩阵，其在包含所述阵列的平面的至少一个方向上表现出物理性质（例如尺寸或间距）的变化（梯度）。 还提供了一种形成具有梯度特性的阵列的方法。 另外，提供了一种分离方法，其包括以下步骤：提供包括纳米结构阵列的矩阵，所述纳米结构的阵列被布置成使得阵列具有梯度的性质; 并进行至少一个生物分子分离过程以使用该基质分离含有多个生物分子的组合物中的生物分子。
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公开(公告)号：US20180231512A1
公开(公告)日：2018-08-16
申请号：US15883386
申请日：2018-01-30
申请人： Aaron Neumann , Linnea K. Ista
发明人： Aaron Neumann , Linnea K. Ista
CPC分类号： G01N30/8631 , C12Q1/04 , G01N30/7233 , G01N30/8675 , G01N2030/8813 , G01N2333/21 , G01N2333/40 , G01N2430/00 , G01N2800/26 , B01D15/40
摘要： A method for rapid differential diagnosis of infection using supercritical fluid chromatographic separation of quorum sensing molecules as biomarkers for infection agents.
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15.发明申请公开(公告)号：US20100255266A1
公开(公告)日：2010-10-07
申请号：US11682396
申请日：2007-03-06
申请人： Quiang Fu , Venkata R. Goparaju , Linnea K. Ista , Yang Wu , Brett P. Andrzejewski , Yunfeng Lu , Larry A. Sklar , Timothy L. Ward , Gabriel Lopez
发明人： Quiang Fu , Venkata R. Goparaju , Linnea K. Ista , Yang Wu , Brett P. Andrzejewski , Yunfeng Lu , Larry A. Sklar , Timothy L. Ward , Gabriel Lopez
CPC分类号： C01B39/02 , C01B37/00 , C01B37/02 , C01F7/02 , C01P2006/16 , Y10T428/24694 , Y10T428/249955 , Y10T428/249956 , Y10T428/268
摘要： The present subject matter relates generally to design, synthesis, and characterization of materials with well-defined porous networks of molecular dimensions in which the size and surface energy of the pores can be externally and reversibly controlled to dynamically modulate the adsorption and transport of molecular species.
摘要翻译： 本主题一般涉及具有明确的分子尺寸多孔网络的材料的设计，合成和表征，其中孔的尺寸和表面能可以被外部和可逆地控制以动态调节分子种类的吸附和运输 。
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公开(公告)号：US11360062B2
公开(公告)日：2022-06-14
申请号：US15883386
申请日：2018-01-30
申请人： Aaron Neumann , Linnea K. Ista
发明人： Aaron Neumann , Linnea K. Ista
摘要： A method for rapid differential diagnosis of infection using supercritical fluid chromatographic separation of quorum sensing molecules as biomarkers for infection agents.
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公开(公告)号：US20170298339A1
公开(公告)日：2017-10-19
申请号：US15481600
申请日：2017-04-07
CPC分类号： C12N11/04 , C02F3/005 , C02F3/322 , C02F3/325 , C02F3/341 , C02F3/345 , C02F3/348 , C02F2303/10 , C12N1/12 , C12N1/20 , H01M4/90 , H01M8/16 , Y02E60/527 , Y02W10/30
摘要： Engineered stable multi-organism (or multi-cell type) communities encapsulated in a media that slows or prohibits certain metabolic functions such as cell division, but maintains other metabolic functions.
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