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11.发明授权公开(公告)号：US10828018B2
公开(公告)日：2020-11-10
申请号：US16106278
申请日：2018-08-21
Applicant: Ethicon, Inc.
Inventor： Dennis D. Jamiolkowski , An-Min Jason Sung , Leo B. Kriksunov
Abstract: The present invention relates devices capable of continuous and simultaneous expression of components of a multi-part biomedical composition with variable mixing ratios. The device has at least two syringes that contain the inter-reactive components of the multi-part biomedical composition. At least the barrel of the first syringe has a first retention compartment having a cross-sectional area dimension that is larger than the cross-sectional area of a second retention compartment. The first piston has a cross-sectional dimension that matches the inside cross-sectional dimension of the small dimensioned retention compartment, while a ring-shaped gasket is located within the large dimensioned retention compartment and has an outside cross-sectional dimension that matches an interior dimension of the large dimension retention compartment.
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12.发明申请公开(公告)号：US20200000958A1
公开(公告)日：2020-01-02
申请号：US16021322
申请日：2018-06-28
Applicant: Ethicon, Inc.
Inventor： Dennis D. Jamiolkowski , Christopher DeFelice , Sasa Andjelic , Brian M. Kelly , Marc Wisnudel , Daniel Steiger , Gaoyuan Gavin Chen
Abstract: Novel surgical sutures and novel medical devices made from novel semi-crystalline, glycolide-rich A-B-A triblock copolymers of glycolide and lactide, wherein said B-segment is a fully amorphous random copolymer of glycolide and lactide, for long term medical applications are disclosed. The novel polymer compositions are useful for long term absorbable surgical sutures, meshes and other medical devices, especially for patients with compromised healing. The novel sutures have improved properties and improved breaking strength retention, while still substantially absorbing within about a 120-day period post-implantation.
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13.发明授权公开(公告)号：US10085729B2
公开(公告)日：2018-10-02
申请号：US14199173
申请日：2014-03-06
Applicant: Ethicon, Inc.
Inventor： Dennis D. Jamiolkowski , An-Min Jason Sung , Leo B. Kriksunov
Abstract: The present invention relates devices capable of continuous and simultaneous expression of components of a multi-part biomedical composition with variable mixing ratios. The device has at least two syringes that contain the inter-reactive components of the multi-part biomedical composition. At least the barrel of the first syringe has a first retention compartment having a cross-sectional area dimension that is larger than the cross-sectional area of a second retention compartment. The first piston has a cross-sectional dimension that matches the inside cross-sectional dimension of the small dimensioned retention compartment, while a ring-shaped gasket is located within the large dimensioned retention compartment and has an outside cross-sectional dimension that matches an interior dimension of the large dimension retention compartment.
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公开(公告)号：US09737630B2
公开(公告)日：2017-08-22
申请号：US14635215
申请日：2015-03-02
Applicant: Ethicon, Inc.
Inventor： Dennis D. Jamiolkowski , Daniel Steiger , Modesto Erneta
IPC: A61L17/12 , A61L27/26 , A61L27/54 , A61B17/064 , B29C45/00 , B29C47/00 , B29C49/00 , C08L67/04 , A61L17/00 , A61B17/06 , C08J3/00 , A61B17/00 , B29L31/00
CPC classification number: A61L17/12 , A61B17/06166 , A61B17/064 , A61B2017/00004 , A61L17/005 , A61L27/26 , A61L27/54 , A61L2300/202 , A61L2300/404 , A61L2300/606 , A61L2430/00 , B29C45/00 , B29C47/00 , B29C49/00 , B29L2031/753 , C08J3/005 , C08J2367/04 , C08J2467/04 , C08L67/04 , Y10T442/10 , Y10T442/3976 , Y10T442/40 , Y10T442/696
Abstract: Novel absorbable polymer blends are disclosed. The blends are useful for manufacturing medical devices having engineered degradation and breaking strength retention in vivo. The blends consist of a first absorbable polymeric component and a second absorbable polymeric component. The weight average molecular weight of the first polymeric component is higher than the weight average molecular weight of the second polymeric component. At least at least one of said components is at least partially end-capped by a carboxylic acid group. Further aspects are medical devices made therefrom.
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15.发明申请RIGID REINFORCING EXOSKELETAL SLEEVE FOR DELIVERY OF FLOWABLE BIOCOMPATIBLE MATERIALS 审中-公开用于输送可流动的生物成分材料的刚性增强弹性套管公开(公告)号：US20160235909A1
公开(公告)日：2016-08-18
申请号：US15137202
申请日：2016-04-25
Applicant: Ethicon, Inc.
Inventor： An-Min Jason Sung , Dennis D. Jamiolkowski , Guanghui Zhang
CPC classification number: A61M5/1414 , A61B17/00491 , A61B17/34 , A61B17/3415 , A61B2017/00331 , A61B2017/00469 , A61B2017/3405 , A61B2017/347 , A61M5/1424 , A61M25/02 , A61M2005/1416
Abstract: Exoskeletal devices or sleeves that can be used with the delivery tube of an applicator device to help dispense fluids, typically flowable biocompatible materials such as hemostatic agents, adhesives, or sealants, onto specific sites in the human body for a medical reason are disclosed. The exoskeletal devices or sleeves are rigid, pre-shaped, and snappably or slidably affixed to the delivery tube. The exoskeletal devices or sleeves do not come into contact with the flowable biocompatible fluid being dispensed, and they can be placed at any position along the delivery tube to address different application situations. Once the exoskeletal device or sleeve is in place, it can optionally be locked onto the delivery tube to prevent further sliding under stresses when pushed against tissue. Multiple exoskeletal devices or sleeves can also be used to achieve more complicated shapes for hard-to-reach anatomical sites.
Abstract translation: 公开了可以与敷贴器装置的输送管一起使用的外骨骼装置或套筒，以帮助将液体（通常是可流动的生物相容性材料，例如止血剂，粘合剂或密封剂）分配到人体的特定部位，用于医学原因。 外骨骼装置或套筒是刚性的，预成形的，并且可滑动地或可滑动地固定到输送管。 外骨骼装置或套管不会与正在分配的可流动的生物相容性流体接触，并且它们可以放置在沿输送管的任何位置以解决不同的应用情况。 一旦外骨骼装置或套筒就位，它可以可选地被锁定在输送管上，以防止在压在组织上时在应力下的进一步滑动。 还可以使用多个外骨骼装置或袖子来实现难以到达的解剖部位的更复杂的形状。
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Patent Agency Ranking
16.发明申请Bioabsorbable Polymeric Compositions, Processing Methods, and Medical Devices Therefrom 审中-公开生物可吸收聚合物组合物，加工方法和医疗器械公开(公告)号：US20160040008A1
公开(公告)日：2016-02-11
申请号：US14886590
申请日：2015-10-19
Applicant: Ethicon, Inc.
Inventor： Brian M. Kelly , Dennis D. Jamiolkowski , Christopher DeFelice
CPC classification number: C08L67/04 , A61B17/0401 , A61B17/064 , A61B2017/00004 , A61B2017/00526 , A61B2017/0647 , A61L31/041 , A61L31/148 , A61L31/16 , A61L2300/404 , A61L2300/442 , C08L2205/025 , C08L2666/18
Abstract: Novel bioabsorbable polymeric blends are disclosed. The blends have a first component that is a polylactide polymer or a copolymer of lactide and glycolide and a second component that is poly(p-dioxanone) polymer. The novel polymeric blends provide medical devices having dimensional stability. Also disclosed are novel bioabsorbable medical devices made from these novel polymer blends, as well as novel methods of manufacture.
Abstract translation: 公开了新的生物可吸收聚合物共混物。 共混物具有第一组分，其是聚丙交酯聚合物或丙交酯和乙交酯的共聚物，第二组分是聚（对二恶烷酮）聚合物。 新型聚合物共混物提供具有尺寸稳定性的医疗装置。 还公开了由这些新型聚合物共混物制成的新颖的生物可吸收的医疗装置，以及新颖的制造方法。
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17.发明申请ABSORBABLE POLYMERIC BLEND COMPOSITIONS BASED ON COPOLYMERS PREPARED FROM MONO- AND DI-FUNCTIONAL POLYMERIZATION INITIATORS, PROCESSING METHODS, AND MEDICAL DEVICES THEREFROM 有权基于单功能和二功能聚合引发剂制备的共聚物的可吸收的聚合物组合物，其加工方法及其医疗设备公开(公告)号：US20150165096A1
公开(公告)日：2015-06-18
申请号：US14571371
申请日：2014-12-16
Applicant: Ethicon, Inc.
Inventor： Sasa Andjelic , Dennis D. Jamiolkowski , Brian M. Kelly , Christopher DeFelice , Daniel Steiger
CPC classification number: A61L31/041 , A61B17/064 , A61B17/0642 , A61B2017/00004 , A61B2017/00889 , A61B2017/00893 , A61L17/12 , A61L27/18 , A61L29/06 , A61L31/06 , A61L31/148 , C08G63/664 , C08L67/04 , C08L2205/025 , C08L2205/03
Abstract: Novel absorbable polymeric blends made from components wherein at least one of the components is synthesized using mixtures of mono- and di-functional initiators are disclosed. The blends have a first component that is a polylactide polymer or a copolymer of lactide and glycolide and a second component that is either poly(p-dioxanone) homopolymer, or a poly(p-dioxanone-co-glycolide) copolymer. The novel polymeric blends provide medical devices having dimensional stability. Also disclosed are novel absorbable medical devices made from these novel polymer blends, as well as novel methods of manufacture.
Abstract translation: 公开了由组分制成的新型可吸收聚合物共混物，其中使用单官能和二官能引发剂的混合物合成至少一种组分。 共混物具有第一组分，其是聚丙交酯聚合物或丙交酯和乙交酯的共聚物，第二组分是聚（对二恶烷酮）均聚物或聚（对 - 二恶烷酮 - 共 - 乙交酯）共聚物。 新型聚合物共混物提供具有尺寸稳定性的医疗装置。 还公开了由这些新型聚合物共混物制成的新型可吸收医疗器件以及新颖的制造方法。
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公开(公告)号：US11058792B2
公开(公告)日：2021-07-13
申请号：US16021322
申请日：2018-06-28
Applicant: Ethicon, Inc.
Inventor： Dennis D. Jamiolkowski , Christopher DeFelice , Sasa Andjelic , Brian M. Kelly , Marc Wisnudel , Daniel Steiger , Gaoyuan Gavin Chen
Abstract: Novel surgical sutures and novel medical devices made from novel semi-crystalline, glycolide-rich A-B-A triblock copolymers of glycolide and lactide, wherein said B-segment is a fully amorphous random copolymer of glycolide and lactide, for long term medical applications are disclosed. The novel polymer compositions are useful for long term absorbable surgical sutures, meshes and other medical devices, especially for patients with compromised healing. The novel sutures have improved properties and improved breaking strength retention, while still substantially absorbing within about a 120-day period post-implantation.
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公开(公告)号：US10086109B2
公开(公告)日：2018-10-02
申请号：US14728177
申请日：2015-06-02
Applicant: Ethicon, Inc.
Inventor： Sasa Andjelic , Dennis D. Jamiolkowski , Jackie Donners , Mark Timmer
IPC: A61L24/04 , C08J5/18 , C08L67/04 , A61L24/00 , C08G63/08 , C08J9/04 , C08J9/26 , A61L27/18 , A61L27/56 , A61L27/58 , A61L31/06 , A61L31/14 , C08G101/00
Abstract: Absorbable medical devices based on novel foams and films made from semi-crystalline, segmented copolymers of lactide and epsilon-caprolactone exhibiting long term absorption characteristics are disclosed. Also disclosed are methods of producing said foams and films, and useful polymer solutions.
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20.发明申请Absorbable Medical Devices Based on Novel Films and Foams Made From Semi-Crystalline, Segmented Copolymers of Lactide and Epsilon-Caprolactone Exhibiting Long Term Absorption Characteristics 审中-公开基于新型薄膜和由半乳状态和ε-己内酯的分段共聚物制成的泡沫的可吸收医疗器械展示长期吸收特性公开(公告)号：US20160354510A1
公开(公告)日：2016-12-08
申请号：US14728177
申请日：2015-06-02
Applicant: Ethicon, Inc.
Inventor： Sasa Andjelic , Dennis D. Jamiolkowski , Jackie Donners , Mark Timmer
CPC classification number: A61L24/046 , A61L24/001 , A61L24/0036 , A61L27/18 , A61L27/56 , A61L27/58 , A61L31/06 , A61L31/146 , A61L31/148 , C08G63/08 , C08G2101/00 , C08J5/18 , C08J9/04 , C08J9/26 , C08J2201/03 , C08J2201/0482 , C08J2205/02 , C08J2300/16 , C08J2367/04 , C08L67/04
Abstract: Absorbable medical devices based on novel foams and films made from semi-crystalline, segmented copolymers of lactide and epsilon-caprolactone exhibiting long term absorption characteristics are disclosed. Also disclosed are methods of producing said foams and films, and useful polymer solutions.
Abstract translation: 公开了基于由具有长期吸收特性的丙交酯和ε-己内酯的半结晶分段共聚物制成的新型泡沫和薄膜的可吸收医疗器械。 还公开了制备所述泡沫和膜以及有用的聚合物溶液的方法。
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