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57 条记录 (耗时 0.043 秒)

    Touch-Sensitive Illuminated Display Apparatus and Method of Operation Thereof
    11.
    发明申请
    Touch-Sensitive Illuminated Display Apparatus and Method of Operation Thereof 审中-公开
    触敏照明显示装置及其操作方法

    公开(公告)号：US20090219261A1

    公开(公告)日：2009-09-03

    申请号：US12332860

    申请日：2008-12-11

    申请人： Joseph Jacobson ,  Serge Rutman ,  Jun-Bo Yoon

    发明人： Joseph Jacobson ,  Serge Rutman ,  Jun-Bo Yoon

    IPC分类号： G06F3/042

    CPC分类号： G06F3/0412 ,  G06F3/0416 ,  G06F3/0421

    摘要： A touch-sensitive system, and apparatus, and method of operation of the apparatus, are provided. In one embodiment, the apparatus includes a light source module configured to emit light; and a deformable waveguide coupled to the light source module and configured to transmit the light or a deflected version of the light at a situs at which pressure external to the deformable waveguide is applied. The deformable waveguide may also be illuminated by the light. The apparatus may also include one or more sensors configured to detect information indicative of the light or the deflected version of the light at the situs, and output a signal in response to the detected information.

    摘要翻译： 提供了一种触敏系统和装置，以及该装置的操作方法。 在一个实施例中，该装置包括被配置为发光的光源模块; 以及可变形波导，其耦合到所述光源模块并且被配置为在施加所述可变形波导外部的压力的位置处传输所述光或偏转版本的光。 可变形波导也可以被光照射。 该装置还可以包括一个或多个传感器，其被配置为检测指示在该位置处的光的偏转或偏转版本的信息，并响应于检测到的信息而输出信号。

    Nucleotide sequencing via repetitive single molecule hybridization
    12.
    发明申请
    Nucleotide sequencing via repetitive single molecule hybridization 失效
    通过重复单分子杂交的核苷酸测序

    公开(公告)号：US20080070798A1

    公开(公告)日：2008-03-20

    申请号：US11896897

    申请日：2007-09-06

    申请人： Joseph Jacobson

    发明人： Joseph Jacobson

    IPC分类号： C40B30/04 ,  C07H21/04 ,  G01N33/00

    CPC分类号： B82Y5/00 ,  B82Y10/00 ,  C12Q1/6869 ,  G06F19/20 ,  G06F19/22 ,  Y10T436/143333

    摘要： Methods of obtaining sequence information about target oligonucleotides by repetitive single molecule hybridization are disclosed. The methods include exposing a target oligonucleotide to one or more copies of a test oligonucleotide; measuring hybridization; dehybridizing the test oligonucleotide; and repeating until the information content from the hybridization trials equals or exceeds the information content of the target oligonucleotide.

    摘要翻译： 公开了通过重复单分子杂交获得关于靶寡核苷酸的序列信息的方法。 所述方法包括将靶寡核苷酸暴露于测试寡核苷酸的一个或多个拷贝; 测量杂交; 对测试寡核苷酸进行脱杂交; 并重复，直到来自杂交试验的信息内容等于或超过目标寡核苷酸的信息含量。

    Rapid patterning of nanostructures
    13.
    发明申请
    Rapid patterning of nanostructures 失效
    纳米结构的快速图案化

    公开(公告)号：US20070197044A1

    公开(公告)日：2007-08-23

    申请号：US11330865

    申请日：2006-01-12

    申请人： Joseph Jacobson ,  Jae-bum Joo ,  Jon Varsanik ,  Vikrant Agnihotri

    发明人： Joseph Jacobson ,  Jae-bum Joo ,  Jon Varsanik ,  Vikrant Agnihotri

    IPC分类号： H01L21/428

    CPC分类号： H01L21/28506 ,  B33Y10/00 ,  B82Y10/00 ,  C23C14/024 ,  C23C14/048 ,  C23C14/228 ,  C23C16/047 ,  C23C16/45525 ,  C23C16/45555 ,  H01L21/268 ,  H01L21/76838 ,  Y10S438/962

    摘要： A process for forming nanostructures comprises generating charged nanoparticles with an electrospray system in a vacuum chamber and introduction of the charged nanoparticles to a region proximate to a charge pattern, so that the particles adhere to the charge pattern in order to form the feature. Two- or three-dimensional nanostructures may be formed by rapidly creating a charge pattern of nanoscale dimensions on a substrate using a normal electron beam or a microcolumn electron beam, generating high purity nanoscale or molecular size scale building blocks of a first type that image the charge pattern using the electrospray system, and then optionally sintering the building blocks to form the feature.

    摘要翻译： 用于形成纳米结构的方法包括在真空室中用电喷雾系统产生带电荷的纳米颗粒，并将带电荷的纳米粒子引入靠近电荷图案的区域，使得颗粒粘附到电荷图案上以形成特征。 可以通过使用普通电子束或微柱电子束在衬底上快速产生纳米级尺寸的电荷图案来形成二维或三维纳米结构，产生第一类型的高纯度纳米尺度或分子尺寸刻度构建块， 使用电喷雾系统的电荷模式，然后可选地烧结构建块以形成特征。

    ELECTROPHORETIC MEDIUM AND PROCESS FOR THE PRODUCTION THEREOF
    14.
    发明申请
    ELECTROPHORETIC MEDIUM AND PROCESS FOR THE PRODUCTION THEREOF 失效
    电泳介质及其生产工艺

    公开(公告)号：US20060007527A1

    公开(公告)日：2006-01-12

    申请号：US11160364

    申请日：2005-06-21

    申请人： Richard Paolini ,  David Miller ,  Barrett Comiskey ,  Joseph Jacobson ,  Bin Wu ,  Charles Honeyman ,  Jian Lin

    发明人： Richard Paolini ,  David Miller ,  Barrett Comiskey ,  Joseph Jacobson ,  Bin Wu ,  Charles Honeyman ,  Jian Lin

    IPC分类号： G02B26/00

    CPC分类号： G02F1/167

    摘要： A two-phase electrophoretic medium comprises a continuous phase and a discontinuous phase. The discontinuous phase comprises a plurality of droplets, each of which comprises a suspending fluid and at least one particle disposed within the suspending fluid and capable of moving through the fluid upon application of an electric field to the electrophoretic medium. The continuous phase surrounds and encapsulates the discontinuous phase. To reduce the humidity sensitivity of the medium, a non-ionizable or crystalline polymer may be used as the continuous phase.

    摘要翻译： 两相电泳介质包括连续相和不连续相。 不连续相包括多个液滴，每个液滴包括悬浮流体和设置在悬浮流体内的至少一个颗粒，并且在向电泳介质施加电场时能够移动通过流体。 连续相围绕并封装不连续相。 为了降低介质的湿度敏感性，可以使用不可离子化或结晶的聚合物作为连续相。

    Protein arrays and methods of using and making the same
    17.
    发明授权
    Protein arrays and methods of using and making the same 有权

    公开(公告)号：US10457935B2

    公开(公告)日：2019-10-29

    申请号：US13884446

    申请日：2011-11-10

    申请人： Joseph Jacobson ,  Michael E. Hudson ,  Larry Li-Yang Chu

    发明人： Joseph Jacobson ,  Michael E. Hudson ,  Larry Li-Yang Chu

    IPC分类号： C12N15/10 ,  C40B50/14 ,  B01J19/00

    摘要： Methods and devices are provided for preparing a protein array having a plurality of proteins. In one embodiment, the method includes providing a plurality of nucleic acids each having a predefined sequence and expressing in vitro a plurality of proteins from the plurality of nucleic acids. In another embodiment, protein arrays having a solid surface and a microvolume are also provided. The solid surface can have a plurality of anchor oligonucleotides capable of hybridizing with a plurality of nucleic acids. The microvolume can cover each of the plurality of anchor oligonucleotides and can be configured to produce a polypeptide from each of the plurality of nucleic acids.

    Methods and microfluidic devices for the manipulation of droplets in high fidelity polynucleotide assembly
    18.
    发明授权
    Methods and microfluidic devices for the manipulation of droplets in high fidelity polynucleotide assembly 有权

    公开(公告)号：US10207240B2

    公开(公告)日：2019-02-19

    申请号：US13505646

    申请日：2010-11-03

    申请人： Joseph Jacobson ,  Larry Li-Yang Chu ,  Senthil Ramu

    发明人： Joseph Jacobson ,  Larry Li-Yang Chu ,  Senthil Ramu

    IPC分类号： C40B60/14 ,  C40B60/00 ,  C40B40/06 ,  B01J19/00 ,  B01L3/00 ,  B82Y30/00 ,  C12Q1/68 ,  B01L3/02 ,  B01L7/00

    摘要： Methods and devices are provided for manipulating droplets on a support using surface tension properties, moving the droplets along a predetermined path and merging two droplets together enabling a number of chemical reactions. Disclosed are methods for controlling the droplets volumes. Disclosed are methods and devices for synthesizing at least one oligonucleotide having a predefined sequence. Disclosed are methods and devices for synthesizing and/or assembling at least one polynucleotide product having a predefined sequence from a plurality of different oligonucleotides having a predefined sequence. In exemplary embodiments, the methods involve synthesis and/or amplification of different oligonucleotides immobilized on a solid support, release of synthesized/amplified oligonucleotides in solution to form droplets, recognition and removal of error-containing oligonucleotides, moving or combining two droplets to allow hybridization and/or ligation between two different oligonucleotides, and further chain extension reaction following hybridization and/or ligation to hierarchically generate desired length of polynucleotide products.

    Methods and Apparatuses for Chip-Based DNA Error Reduction
    19.
    发明申请
    Methods and Apparatuses for Chip-Based DNA Error Reduction 有权
    基于芯片的DNA错误减少的方法和设备

    公开(公告)号：US20120028843A1

    公开(公告)日：2012-02-02

    申请号：US13164045

    申请日：2011-06-20

    申请人： Senthil Ramu ,  Joseph Jacobson

    发明人： Senthil Ramu ,  Joseph Jacobson

    IPC分类号： C40B50/06 ,  C07H21/00 ,  C12P19/34

    CPC分类号： C12N15/1058 ,  C12Q1/6848 ,  C12Q2521/514 ,  C12Q2565/537

    摘要： Methods and apparatus relate to reduction of sequence errors generated during synthesis of nucleic acids on a microarray chip. The error reduction can include synthesis of complementary stands (to template strands), using a short universal primer complementary to the template strands and polymerase. Heteroduplex can be formed be melting and re-annealing complementary stands and template strands. The heteroduplexes containing a mismatch can be recognized and cleaved by a mismatch endonuclease. The mismatch-containing cleaved heteroduplexes can be removed from the microarray chip using a global buffer exchange. The error free synthetic nucleic acids generated therefrom can be used for a variety of applications, including synthesis of biofuels and value-added pharmaceutical products.

    摘要翻译： 方法和装置涉及减少在微阵列芯片上的核酸合成期间产生的序列错误。 错误减少可以包括使用与模板链和聚合酶互补的短通用引物来合成互补基团（模板链）。 Heteroduplex可以形成为熔化和重新退火互补架和模板链。 含有不匹配的异源双链可以被不匹配的内切核酸酶识别和切割。 可以使用全局缓冲液交换从微阵列芯片去除包含错配的切割的异源双链体。 由此产生的无错误的合成核酸可用于各种应用，包括合成生物燃料和增值药物产品。