公开(公告)号：US20070010564A1

公开(公告)日：2007-01-11

申请号：US11477641

申请日：2006-06-29

申请人： Edward Boyd ,  Frederick Brookfield ,  Jonathan Gridley ,  Manfred Kubbies ,  Raymond Lau ,  Ulrike Reiff ,  Georg Tiefenthaler ,  Wolfgang von der Saal ,  Thomas von Hirschheydt ,  Timothy Woodcock

发明人： Edward Boyd ,  Frederick Brookfield ,  Jonathan Gridley ,  Manfred Kubbies ,  Raymond Lau ,  Ulrike Reiff ,  Georg Tiefenthaler ,  Wolfgang von der Saal ,  Thomas von Hirschheydt ,  Timothy Woodcock

IPC分类号： A61K31/44 ,  A61K31/381 ,  C07D333/22 ,  C07D213/56

CPC分类号： A61K31/38 ,  A61K31/381 ,  A61K31/44 ,  C07D213/59 ,  C07D333/24

摘要： The present invention relates to compounds of formula I wherein R1, R2 and R3 are defined herein, their pharmaceutically acceptable salts, enantiomeric forms, diastereoisomers and racemates, the preparation of the above compounds, medicaments containing them and their manufacture, as well as the use of the above compounds in the control or prevention of illnesses such as cancer.

公开(公告)号：US20070003282A1

公开(公告)日：2007-01-04

申请号：US11478492

申请日：2006-06-28

申请人： Edward Boyd ,  Ryan Hirth ,  Hung Nguyen

发明人： Edward Boyd ,  Ryan Hirth ,  Hung Nguyen

IPC分类号： H04J14/00

CPC分类号： H04J3/0638 ,  H04J3/0652 ,  H04J3/0682 ,  H04J3/07 ,  H04J3/1694 ,  H04Q11/0067 ,  H04Q2011/0079

摘要： One embodiment of the present invention provides a system that accommodates different clock frequencies in an EPON. The system receives a signal from the OLT at the ONU and derives an OLT clock. The system also maintains a local clock. The system further receives from the OLT an assignment for an upstream transmission window, during which the ONU can transmit an upstream data burst to the OLT based on the local clock. The system adjusts the number of bits of the data burst without affecting the payload data carried in the data burst, thereby allowing the data burst to fit properly within the upstream transmission window and compensating for frequency differences between the local clock and the OLT clock. The system transmits the data burst based on the local clock in the upstream transmission window.

摘要翻译： 本发明的一个实施例提供一种在EPON中适应不同时钟频率的系统。 系统从ONU接收来自OLT的信号，得到OLT时钟。 该系统还维护本地时钟。 该系统还从OLT接收用于上行传输窗口的分配，在该传输窗口期间，ONU可以基于本地时钟向OLT发送上行数据突发。 该系统调整数据脉冲串的位数，而不影响数据脉冲串中承载的有效载荷数据，从而允许数据脉冲串适配于上游传输窗口内，并补偿本地时钟与OLT时钟之间的频率差异。 系统根据上行传输窗口中的本地时钟传输数据脉冲串。

公开(公告)号：US20060089359A1

公开(公告)日：2006-04-27

申请号：US11233311

申请日：2005-09-23

申请人： Edward Boyd ,  Frederick Brookfield ,  Guy Georges ,  Bernhard Goller ,  Sabine Huensch ,  Petra Rueger ,  Matthias Rueth ,  Stefan Scheiblich ,  Christine Schuell ,  Wolfgang von der Saal ,  Justin Warne ,  Stefan Weigand

发明人： Edward Boyd ,  Frederick Brookfield ,  Guy Georges ,  Bernhard Goller ,  Sabine Huensch ,  Petra Rueger ,  Matthias Rueth ,  Stefan Scheiblich ,  Christine Schuell ,  Wolfgang von der Saal ,  Justin Warne ,  Stefan Weigand

IPC分类号： A61K31/502 ,  C07D403/02

CPC分类号： C07D403/12

摘要： Compounds of formula I their pharmaceutically acceptable salts, enantiomeric forms, diastereoisomers and racemates are disclosed. Also disclosed are methods for the preparation of the above-mentioned compounds, pharmaceutical compositions containing them, as well as the use of the above-mentioned compounds in the treatment, control or prevention of illnesses such as cancer.

摘要翻译： 公开了式I化合物的药学上可接受的盐，对映体形式，非对映异构体和外消旋体。 还公开了制备上述化合物的方法，含有它们的药物组合物，以及上述化合物在治疗，控制或预防诸如癌症等疾病中的用途。

公开(公告)号：US20060039390A1

公开(公告)日：2006-02-23

申请号：US11223487

申请日：2005-09-08

申请人： Edward Boyd ,  Thyagarajan Subramanian ,  Lawrence Davis

发明人： Edward Boyd ,  Thyagarajan Subramanian ,  Lawrence Davis

IPC分类号： H04L12/28

CPC分类号： H04L47/10 ,  H04L12/4641 ,  H04L41/5003 ,  H04L41/5022 ,  H04L47/15 ,  H04L47/2408 ,  H04L47/2425 ,  H04L47/2491

摘要： One embodiment of the present invention provides a system for forwarding packets in an Ethernet passive optical network (EPON) which includes a central node and at least one remote node. During operation, the system associates a logical link identifier (LLID) to a logical link between the central node and a remote node, wherein the logical link corresponds to a priority level based on a certain service level agreement (SLA). After receiving a packet to be forwarded to a remote node, the system then determines the value of one or more fields within the packet which is used to indicate a priority level for the packet. Subsequently, the system assigns an LLID to the packet based on the value of the one or more fields, thereby facilitating differentiated service qualities within the EPON.

摘要翻译： 本发明的一个实施例提供了一种用于在包括中央节点和至少一个远程节点的以太网无源光网络（EPON）中转发分组的系统。 在操作期间，系统将逻辑链路标识符（LLID）与中心节点和远程节点之间的逻辑链路相关联，其中逻辑链路基于特定服务级别协议（SLA）对应于优先级。 在接收到要转发到远程节点的分组之后，系统然后确定用于指示分组的优先级的分组内的一个或多个字段的值。 随后，系统基于一个或多个字段的值向该分组分配LLID，从而促进EPON内的差异化服务质量。

公开(公告)号：US20050058135A1

公开(公告)日：2005-03-17

申请号：US10663608

申请日：2003-09-15

申请人： John Sisto ,  Edward Boyd

发明人： John Sisto ,  Edward Boyd

IPC分类号： H04L12/56

CPC分类号： H04L12/5695 ,  H04L47/22 ,  H04L47/2425 ,  H04L47/70 ,  H04L47/788 ,  H04L47/805 ,  H04L47/828

摘要： One embodiment of the present invention provides a system that facilitates dynamic allocation of upstream bandwidth in a passive optical network which includes a central node and at least one remote node. Each remote node is coupled to at least one logical entity, which corresponds to a device or a user, that transmits upstream data to the central node and receives downstream data from the central node. The central node is coupled to an external network outside of the passive optical network through a shared out-going uplink.

摘要翻译： 本发明的一个实施例提供了一种有助于在包括中央节点和至少一个远程节点的无源光网络中动态分配上行带宽的系统。 每个远程节点耦合到至少一个对应于设备或用户的逻辑实体，该逻辑实体将上行数据发送到中央节点并从中央节点接收下游数据。 中央节点通过共享的外向上行链路耦合到无源光网络外部的外部网络。

公开(公告)号：USD458919S1

公开(公告)日：2002-06-18

申请号：US29129997

申请日：2000-09-25

申请人： Hamid Arjomand ,  Edward Boyd

设计人： Hamid Arjomand ,  Edward Boyd

公开(公告)号：US07208506B2

公开(公告)日：2007-04-24

申请号：US11477641

申请日：2006-06-29

申请人： Edward Boyd ,  Frederick Brookfield ,  Jonathan Gridley ,  Manfred Kubbies ,  Raymond Lau ,  Ulrike Reiff ,  Georg Tiefenthaler ,  Wolfgang von der Saal ,  Thomas von Hirschheydt ,  Timothy Woodcock

发明人： Edward Boyd ,  Frederick Brookfield ,  Jonathan Gridley ,  Manfred Kubbies ,  Raymond Lau ,  Ulrike Reiff ,  Georg Tiefenthaler ,  Wolfgang von der Saal ,  Thomas von Hirschheydt ,  Timothy Woodcock

IPC分类号： A61K31/38 ,  A61K31/42 ,  A61K31/425 ,  A61K31/44

CPC分类号： A61K31/38 ,  A61K31/381 ,  A61K31/44 ,  C07D213/59 ,  C07D333/24

摘要： The present invention relates to compounds of formula I wherein R1, R2 and R3 are defined herein, their pharmaceutically acceptable salts, enantiomeric forms, diastereoisomers and racemates, the preparation of the above compounds, medicaments containing them and their manufacture, as well as the use of the above compounds in the control or prevention of illnesses such as cancer.

摘要翻译： 本发明涉及式I化合物，其中R 1，R 2和R 3 3定义为其药学上可接受的盐，对映体形式 ，非对映异构体和外消旋物，上述化合物的制备，含有它们的药物及其制备，以及上述化合物在控制或预防诸如癌症等疾病中的用途。

公开(公告)号：US20050256170A1

公开(公告)日：2005-11-17

申请号：US11055724

申请日：2005-02-11

申请人： Alexander Oxford ,  Richard Davis ,  Robert Coleman ,  Kenneth Clark ,  David Clark ,  Neil Harris ,  Garry Fenton ,  George Hynd ,  Keith Stuttle ,  Jonathan Sutton ,  Mark Ashton ,  Edward Boyd ,  Shirley Brunton

发明人： Alexander Oxford ,  Richard Davis ,  Robert Coleman ,  Kenneth Clark ,  David Clark ,  Neil Harris ,  Garry Fenton ,  George Hynd ,  Keith Stuttle ,  Jonathan Sutton ,  Mark Ashton ,  Edward Boyd ,  Shirley Brunton

IPC分类号： A61K31/4178 ,  A61K31/422 ,  A61K31/427 ,  A61K31/4439 ,  C07C233/75 ,  C07C233/81 ,  C07C235/84 ,  C07D213/81 ,  C07D233/90 ,  C07D257/04 ,  C07D277/24 ,  C07D277/26 ,  C07D277/56 ,  C07D307/46 ,  C07D307/68 ,  C07D307/91 ,  C07D333/38 ,  C07D401/12 ,  C07D405/04 ,  C07D405/12 ,  C07D409/12 ,  C07D413/02 ,  C07D417/02 ,  C07D43/02

CPC分类号： C07D213/81 ,  C07C233/75 ,  C07C233/81 ,  C07C235/84 ,  C07D233/90 ,  C07D257/04 ,  C07D277/24 ,  C07D277/26 ,  C07D277/56 ,  C07D307/46 ,  C07D307/68 ,  C07D307/91 ,  C07D333/38 ,  C07D401/12 ,  C07D405/04 ,  C07D405/12 ,  C07D409/12

摘要： A compound of formula (I): or a salt, solvate and chemically protected form thereof, wherein: R5is an optionally substituted C5-20 aryl or C4-20 alkyl group; A is selected from the group consisting of: wherein X and Y are selected from the group consisiting of: O and CR3; S and CR3; NH and CR3; NH and N; O and N; S and N; N and S; and N and O., and where the dotted lines indicate a double bond in the appropriate location, and where Q is either N or CH; R3 is selected from H, F, Cl and optionally substituted C1-4 alkyl, C1-4 alkoxy, C5-7 aryl and C5-7 aryl-C1-4 alkyl groups; R4 is selected from H, F, Cl and optionally substituted C1-4 alkyl, C1-4 alkoxy, C5-7 aryl and C5-7 aryl-C1-4 alkyl groups; R6 is selected from H, F, Cl and optionally substituted C1-4 alkyl, C1-4 alkoxy, C5-7 aryl and C5-7 aryl-C1-4 alkyl groups; D is selected from: B is selected from the group consisting of: where RN′ is selected from H and C1-4 alkyl; where one of RP3 and RP4 is —Cm alkylene-R2 and the other of RP3 and RP4 is H, m and n can be 0 or 1, and m+n=1 or 2; and additionally when RP3 is —Cm alkylene-R2, m can also be 2 or 3, and m+n=1, 2, 3 or 4, and when R2 is tetrazol-5-yl, m+n may be 0; or where one of RP3 and RP4 is —O—CH2—R2, and the other of RP3 and RP4 is H, n is 0; RN is H or optionally substituted C1-4 alkyl; R2 is either: —CO2H (carboxy); —CONH2; —CH2-OH; or tetrazol-5-yl.

公开(公告)号：US20050220129A1

公开(公告)日：2005-10-06

申请号：US10814929

申请日：2004-03-30

申请人： Edward Boyd

发明人： Edward Boyd

IPC分类号： H04L12/28 ,  H04L12/46 ,  H04L12/56 ,  H04Q11/00

CPC分类号： H04L47/6215 ,  H04L12/4641 ,  H04L47/2408 ,  H04L47/50 ,  H04Q11/0066 ,  H04Q11/0067 ,  H04Q11/0071

摘要： One embodiment of the present invention provides a system that performs packets switching in a passive optical network which includes a central node and at least one remote node. After receiving a packet, the system obtains a first set of results by performing a first lookup based on a first set of values derived from the packet. The system also obtains a second set of results by performing a second lookup based on a second set of values derived from the packet. Next, the system merges the first set of results and the second set of results, and produces a merged value. The system then obtains a subsequent result by performing a subsequent lookup with the merged value. If the packet is a downstream packet, the system derives a logical identifier corresponding to one or more remote nodes from the subsequent result. The system then incorporates the logical identifier into the packet and transmits the packet to one or more remote nodes.

摘要翻译： 本发明的一个实施例提供一种在包括中央节点和至少一个远程节点的无源光网络中执行分组交换的系统。 在接收到分组之后，系统通过基于从分组导出的第一组值执行第一查找来获得第一组结果。 系统还通过基于从分组导出的第二组值执行第二查找来获得第二组结果。 接下来，系统将第一组结果和第二组结果合并，并产生合并值。 然后，系统通过执行具有合并值的后续查找来获得后续结果。 如果分组是下行分组，则系统从随后的结果中导出与一个或多个远程节点对应的逻辑标识符。 然后，系统将逻辑标识符合并到分组中，并将分组发送到一个或多个远程节点。

公开(公告)号：US06949528B1

公开(公告)日：2005-09-27

申请号：US09646599

申请日：1999-03-17

申请人： John G. Goddard ,  Donald H. Picker ,  Samull R. Umansky ,  Steven Price ,  Jac Wijkmans ,  Edward Boyd ,  Anthony Baxter

发明人： John G. Goddard ,  Donald H. Picker ,  Samull R. Umansky ,  Steven Price ,  Jac Wijkmans ,  Edward Boyd ,  Anthony Baxter

IPC分类号： A61K31/66

CPC分类号： C07F9/091

摘要： The invention provides anti-apoptotic compositions lysophosphatidic acids and methods for making and using the compositions. Such compositions can also contain LPA potentiating agents, including proteins, lipid membrane structures and polymers such as polyethylene glycols. The compositions can additionally contain other pharmaceutically effective agents such as drugs, antibiotics, wound healing agents and antioxidants.

摘要翻译： 本发明提供抗凋亡组合物溶血磷脂酸及其制备和使用方法。 此类组合物还可以含有LPA增效剂，包括蛋白质，脂质膜结构和聚合物如聚乙二醇。 组合物可另外含有其它药学上有效的试剂，例如药物，抗生素，伤口愈合剂和抗氧化剂。