公开(公告)号：US20150173680A1

公开(公告)日：2015-06-25

申请号：US14139855

申请日：2013-12-23

Applicant: Google Inc.

Inventor： James Etzkorn ,  Harvey Ho ,  Zenghe Liu

IPC: A61B5/00 ,  A61B5/145 ,  A61B5/1486

CPC classification number: A61B5/6821 ,  A61B5/0002 ,  A61B5/14532 ,  A61B5/1486 ,  Y10T29/49155

Abstract: A method may involve providing a conductive pattern on a bio-compatible layer. The conductive pattern may include a first conductive layer that comprises a first metal and a second conductive layer that comprises a second metal. The second conductive layer may be over the first conductive layer, and the first metal may be more malleable than the second metal. The method may also include mounting an electrical component to the conductive pattern to provide an electrochemical sensor. The electrochemical sensor may be configured for use in a body-mountable device.

Abstract translation: 一种方法可以涉及在生物相容层上提供导电图案。 导电图案可以包括包括第一金属的第一导电层和包括第二金属的第二导电层。 第二导电层可以在第一导电层之上，并且第一金属可以比第二金属更具有延展性。 该方法还可以包括将电气部件安装到导电图案以提供电化学传感器。 电化学传感器可被配置为用于体内安装的装置。

公开(公告)号：US20150160151A1

公开(公告)日：2015-06-11

申请号：US14098790

申请日：2013-12-06

Applicant: Google Inc.

Inventor： Zenghe Liu ,  Huanfen Yao

IPC: G01N27/327

CPC classification number: G01N27/3271

Abstract: An analyte sensor and method of making are provided. The analyte sensor includes a crosslinked, hydrophilic copolymer in contact with a surface of an electrode; and an analyte sensing component embedded within the crosslinked, hydrophilic copolymer, where the analyte sensing component is surrounded by a buffer having a predetermined buffering component and pH value and where the crosslinked, hydrophilic copolymer includes: backbone chains having first methacrylate-derived units, each having a first hydrophilic side chain; second methacrylate-derived units, each having a second hydrophilic side chain, where the first and second side chains are the same or different; third methacrylate-derived units; and hydrophilic crosslinks between third methacrylate-derived units in different backbone chains. The analyte sensor may be maintained at a humidity level of less than 25% to maintain its performance during storage.

Abstract translation: 提供分析物传感器和制造方法。 分析物传感器包括与电极表面接触的交联的亲水共聚物; 和分析物感测组件，其嵌入在交联的亲水共聚物内，其中分析物感测组分被具有预定缓冲组分和pH值的缓冲液包围，并且其中交联的亲水共聚物包括：具有第一甲基丙烯酸酯衍生单元的骨架链 具有第一亲水侧链; 第二甲基丙烯酸酯衍生单元，每个具有第二亲水侧链，其中第一和第二侧链相同或不同; 第三甲基丙烯酸酯衍生单元; 和在不同主链中的第三甲基丙烯酸酯衍生单元之间的亲水交联。 分析物传感器可以保持在小于25％的湿度水平以保持其在储存期间的性能。

公开(公告)号：US20150112173A1

公开(公告)日：2015-04-23

申请号：US14056837

申请日：2013-10-17

Applicant: Google Inc.

Inventor： Huanfen Yao ,  Zenghe Liu

IPC: A61B5/00 ,  A61B5/145 ,  A61B5/1486

CPC classification number: A61B5/6821 ,  A61B5/0004 ,  A61B5/14507 ,  A61B5/14546 ,  A61B5/1477 ,  A61B5/1486 ,  A61B5/6803 ,  A61B5/742

Abstract: A body-mountable pyruvate sensing device includes an electrochemical sensor embedded in a polymeric material configured for mounting to a surface of an eye. The electrochemical sensor includes a working electrode, a reference electrode, and a reagent localized near the working electrode that selectively reacts with pyruvate. Application of a voltage between the working electrode and the reference electrode causes a current related to a concentration of pyruvate in a fluid to which the electrochemical sensor is exposed; the current is measured by the body-mountable device and wirelessly communicated.

Abstract translation: 身体安装的丙酮酸感测装置包括嵌入聚合物材料中的电化学传感器，其被配置用于安装到眼睛的表面。 电化学传感器包括工作电极，参比电极和位于工作电极附近选择性地与丙酮酸反应的试剂。 在工作电极和参比电极之间施加电压引起与电化学传感器暴露于的流体中的丙酮酸盐浓度相关的电流; 电流由身体安装装置测量并进行无线通信。

公开(公告)号：US20150005603A1

公开(公告)日：2015-01-01

申请号：US13930877

申请日：2013-06-28

Applicant: Google Inc.

Inventor： Zenghe Liu ,  Jeffrey George Linhardt ,  Huanfen Yao

IPC: A61B5/1486 ,  A61B5/145

CPC classification number: A61B5/1486 ,  A61B5/14507 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/682 ,  A61B5/6821

Abstract: An analyte sensor for the continuous or semi-continuous monitoring of physiological parameters and a method for making the analyte sensor are disclosed. The analyte sensor includes a crosslinked copolymer network in contact with a surface of an electrode. The copolymer network has voids formed by the removal of a porogen, and an analyte sensing component is immobilized within the network. The method involves forming a solution of the precursors of the copolymer, depositing the mixture on a surface of an electrode, and curing the deposited mixture to provide the analyte sensor.

Abstract translation: 公开了用于连续或半连续监测生理参数的分析物传感器和用于制备分析物传感器的方法。 分析物传感器包括与电极表面接触的交联共聚物网络。 共聚物网络具有通过去除致孔剂形成的空隙，并且分析物感测组分固定在网络内。 该方法包括形成共聚物的前体溶液，将混合物沉积在电极的表面上，并固化沉积的混合物以提供分析物传感器。

公开(公告)号：US20140371558A1

公开(公告)日：2014-12-18

申请号：US13919764

申请日：2013-06-17

Applicant: Google Inc.

Inventor： James Etzkorn ,  Zenghe Liu

IPC: A61B3/10

CPC classification number: A61B5/1486 ,  A61B3/101 ,  A61B5/0002 ,  A61B5/0004 ,  A61B5/002 ,  A61B5/14507 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/1477 ,  A61B5/6821 ,  A61B5/7264 ,  A61B2560/0214 ,  G01N27/30 ,  G01N27/3271 ,  G01N27/4166 ,  G02C7/04

Abstract: An eye-mountable device includes an electrochemical sensor embedded in a polymeric material configured for mounting to a surface of an eye. The electrochemical sensor includes a working electrode, a reference electrode, and a reagent that selectively reacts with an analyte to generate a sensor measurement related to a concentration of the analyte in a fluid to which the eye-mountable device is exposed. The working electrode can have a first side edge and a second side edge. The reference electrode can be situated such that at least a portion of the first and second side edges of the working electrode are adjacent respective sections of the reference electrode.

Abstract translation: 一种可眼睛安装的装置包括嵌入聚合物材料中的电化学传感器，其被配置用于安装到眼睛的表面。 电化学传感器包括工作电极，参比电极和选择性地与分析物反应以产生与可眼睛安装的装置暴露于的流体中的分析物的浓度相关的传感器测量的试剂。 工作电极可以具有第一侧边缘和第二侧边缘。 参考电极可以被设置为使得工作电极的第一和第二侧边缘的至少一部分与参考电极的相应部分相邻。

公开(公告)号：US20140107444A1

公开(公告)日：2014-04-17

申请号：US13650418

申请日：2012-10-12

Applicant: Google Inc.

Inventor： Zenghe Liu

IPC: A61B5/1477

CPC classification number: A61B5/1468 ,  A61B5/0002 ,  A61B5/0004 ,  A61B5/14507 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/1473 ,  A61B5/1486 ,  A61B5/6821 ,  A61B5/6867 ,  G01N27/3271 ,  G02C7/04

Abstract: An eye-mountable device includes an electrochemical sensor embedded in a polymeric material configured for mounting to a surface of an eye. The electrochemical sensor includes a working electrode, a reference electrode, and a reagent that selectively reacts with an analyte to generate a sensor measurement related to a concentration of the analyte in a fluid to which the eye-mountable device is exposed. The working electrode can have at least one dimension less than 25 micrometers. The reference electrode can have an area at least five times greater than an area of the working electrode. A portion of the polymeric material can surround the working electrode and the reference electrode such that an electrical current conveyed between the working electrode and the reference electrode is passed through the at least partially surrounding portion of the transparent polymeric material.

Abstract translation: 一种可眼睛安装的装置包括嵌入聚合物材料中的电化学传感器，其被配置用于安装到眼睛的表面。 电化学传感器包括工作电极，参比电极和选择性地与分析物反应以产生与可眼睛安装的装置暴露于的流体中的分析物的浓度相关的传感器测量的试剂。 工作电极可具有至少一个小于25微米的尺寸。 参考电极可以具有比工作电极的面积大至少五倍的面积。 聚合物材料的一部分可围绕工作电极和参考电极，使得在工作电极和参比电极之间输送的电流通过透明聚合材料的至少部分环绕的部分。

公开(公告)号：US20160262670A1

公开(公告)日：2016-09-15

申请号：US14657909

申请日：2015-03-13

Applicant: Google Inc.

Inventor： Jaclyn Leverett Wasson ,  Zenghe Liu ,  Brian Otis ,  William James Biederman

IPC: A61B5/145 ,  A61B5/00 ,  A61B5/11 ,  A61B5/01 ,  A61B5/024

CPC classification number: A61B5/14503 ,  A61B5/0002 ,  A61B5/0022 ,  A61B5/01 ,  A61B5/02438 ,  A61B5/11 ,  A61B5/1125 ,  A61B5/1451 ,  A61B5/14532 ,  A61B5/14865 ,  A61B5/150022 ,  A61B5/150969 ,  A61B5/6801 ,  A61B5/6823 ,  A61B5/6824 ,  A61B5/6833 ,  A61B5/6843 ,  A61B5/7405 ,  A61B5/742 ,  A61B5/7455 ,  A61B2560/0412 ,  A61B2562/164

Abstract: A body-mountable device includes a flexible substrate configured for mounting to a skin surface. The device includes an input component configured to receive inputs from a user, e.g., finger presses, swipes, motions of the sensing platform, or gestures. Received inputs could include calibration data, for example, known values of a sensed property to compare with corresponding values obtained by a sensor of the device. The device can additionally include an output component configured to provide outputs to a user. Outputs could include indications of sensor readings, medical alerts, or operational states of the device. The flexible substrate of the device is configured to be adhered or otherwise mounted to the skin in a manner that minimally impacts activities of the body.

Abstract translation: 身体安装装置包括被配置为安装到皮肤表面的柔性基底。 该设备包括被配置为接收来自用户的输入的输入组件，例如手指按压，滑动，感测平台的运动或手势。 接收的输入可以包括校准数据，例如，感测属性的已知值，以与由装置的传感器获得的对应值进行比较。 该设备还可以包括被配置为向用户提供输出的输出组件。 输出可能包括传感器读数，医疗警报或设备运行状态的指示。 该装置的柔性基底被构造成以最小程度地影响身体的活动的方式粘附或以其它方式安装到皮肤上。

公开(公告)号：US20150362752A1

公开(公告)日：2015-12-17

申请号：US14701360

申请日：2015-04-30

Applicant: Google Inc.

Inventor： Jeffrey G. Linhardt ,  Zenghe Liu ,  Scott B. Kennedy

IPC: G02C7/08 ,  G02C9/00 ,  G02C7/04

CPC classification number: G02C7/083 ,  B29D11/00817 ,  G02C7/04 ,  G02F1/133305 ,  G02F1/13439

Abstract: An eye-mountable device includes a flexible lens enclosure, anterior and posterior flexible conductive electrodes, and an accommodation actuator element. The flexible lens enclosure includes anterior and posterior layers that are sealed together. The anterior flexible conductive electrode is disposed within the flexible enclosure and across a center region of the flexible lens enclosure on a concave side of the anterior layer. The posterior flexible conductive electrode is disposed within the flexible enclosure and across the center region on a convex side of the posterior layer. The accommodation actuator element is disposed between the first and second flexible conductive electrodes. The anterior and posterior flexible conductive electrodes are transparent and electrically manipulate the accommodation actuator element.

Abstract translation: 眼睛安装装置包括柔性透镜外壳，前后柔性导电电极和调节致动元件。 柔性透镜罩包括密封在一起的前层和后层。 前柔性导电电极设置在柔性外壳内并穿过柔性透镜外壳的位于前层的凹侧的中心区域。 后柔性导电电极设置在柔性外壳内并穿过后层的凸面侧的中心区域。 调节致动器元件设置在第一和第二柔性导电电极之间。 前后柔性导电电极是透明的并且电操纵调节致动元件。

公开(公告)号：US09101309B1

公开(公告)日：2015-08-11

申请号：US14091092

申请日：2013-11-26

Applicant: Google Inc.

Inventor： Zenghe Liu ,  Douglas Weibel

IPC: A61B5/00 ,  A61B5/1486 ,  A61B5/145

CPC classification number: A61B5/1486 ,  A61B5/0004 ,  A61B5/002 ,  A61B5/14507 ,  A61B5/14546 ,  A61B5/6821 ,  A61B2562/0214

Abstract: A body-mountable retinal sensing device includes an electrochemical sensor embedded in a polymeric material configured for mounting to a body surface, such as a cornea. The electrochemical sensor includes a working electrode, a reference electrode, and a reagent localized near the working electrode that selectively reacts with retinal. Application of a voltage between the working electrode and the reference electrode causes a current related to a concentration of retinal in a fluid to which the electrochemical sensor is exposed. The current is measured by the body-mountable device and wirelessly communicated.

Abstract translation: 身体安装的视网膜感测装置包括嵌入聚合物材料中的电化学传感器，该聚合物材料构造成用于安装到身体表面，例如角膜。 电化学传感器包括工作电极，参比电极和位于工作电极附近选择性地与视网膜反应的试剂。 在工作电极和参比电极之间施加电压导致与电化学传感器暴露于的流体中的视网膜的浓度相关的电流。 电流由身体安装的设备测量并进行无线通信。

公开(公告)号：US20150188197A1

公开(公告)日：2015-07-02

申请号：US14143697

申请日：2013-12-30

Applicant: Google Inc.

Inventor： Zenghe Liu ,  Brian Otis ,  William Biederman

IPC: H01M10/38

CPC classification number: H01M4/46 ,  G02C7/04 ,  H01M4/92 ,  H01M12/06 ,  H01M12/08 ,  H01M2220/30 ,  H01M2300/0085 ,  Y02E60/128

Abstract: A method may involve forming a first electrode on a structure, where the first electrode defines an anode of a battery, and where the battery is configured to provide electrical power to a circuit located on the structure. The method may further involve forming a second electrode on the structure, where the second electrode defines a cathode of the battery, and where the second electrode is configured to reduce oxygen. And the method may involve embedding the structure in a polymer.

Abstract translation: 方法可以包括在结构上形成第一电极，其中第一电极限定电池的阳极，并且其中电池被配置为向位于结构上的电路提供电力。 该方法还可以包括在结构上形成第二电极，其中第二电极限定电池的阴极，并且其中第二电极被配置为减少氧气。 并且该方法可以包括将结构嵌入聚合物中。