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    HIGH SHEAR APPLICATION IN DRUG DELIVERY
    12.
    发明申请
    HIGH SHEAR APPLICATION IN DRUG DELIVERY 审中-公开
    药物递送中的高剪切应用

    公开(公告)号：US20140066852A1

    公开(公告)日：2014-03-06

    申请号：US14075105

    申请日：2013-11-08

    Applicant: H R D Corporation

    Inventor： Abbas HASSAN ,  Aziz HASSAN ,  Rayford G. ANTHONY

    IPC: B01F7/00 ,  A61M5/142

    CPC classification number: A61J3/00 ,  A61K9/0019 ,  A61M5/142 ,  B01F7/00766 ,  B01F7/008 ,  B01F13/1016

    Abstract: In this disclosure, methods and systems for drug delivery utilizing high shear are disclosed. In an embodiment, a method comprises (1) subjecting a therapeutic fluid containing a drug to high shear; and (2) obtaining a processed therapeutic fluid, wherein the processed therapeutic fluid contains the drug in nano-size. In an embodiment, a method comprises (1) subjecting a drug carrier and a therapeutic fluid containing a drug to high shear; and (2) obtaining a processed therapeutic fluid, wherein the processed therapeutic fluid contains the drug carrier loaded with the drug. In an embodiment, a method comprises (1) applying high shear to a drug carrier and a therapeutic fluid containing a drug; (2) obtaining a processed therapeutic fluid, wherein the processed therapeutic fluid contains the drug-loaded carrier; and (3) modifying the drug-loaded carrier with a targeting moiety to obtain a modified drug-loaded carrier.

    Abstract translation: 在本公开中，公开了利用高剪切的药物递送的方法和系统。 在一个实施方案中，一种方法包括（1）使含有药物的治疗流体经受高剪切; 和（2）获得加工的治疗液，其中所述经处理的治疗液含有纳米尺寸的药物。 在一个实施方案中，一种方法包括（1）使药物载体和含有药物的治疗液体经受高剪切; 和（2）获得加工的治疗流体，其中所述经处理的治疗液含有载有药物的药物载体。 在一个实施方案中，一种方法包括（1）对药物载体和含有药物的治疗液施加高剪切力; （2）获得经处理的治疗液，其中所述经处理的治疗液含有载药载体; 和（3）用靶向部分修饰载有药物的载体以获得修饰的药物载体。

    PROCESS FOR UPGRADING LOW VALUE RENEWABLE OILS
    15.
    发明申请
    PROCESS FOR UPGRADING LOW VALUE RENEWABLE OILS 审中-公开
    升级低价值可再生油的工艺

    公开(公告)号：US20140154392A1

    公开(公告)日：2014-06-05

    申请号：US14174589

    申请日：2014-02-06

    Applicant: H R D Corporation

    Inventor： Abbas HASSAN ,  Aziz Hassan ,  Gregory G. Borsinger

    IPC: C11C3/12 ,  C09K8/26 ,  A23B7/153 ,  C09D11/06 ,  C09D7/12 ,  C08L95/00 ,  C10L11/04 ,  C09J131/04

    CPC classification number: C11C3/12 ,  A23B7/153 ,  C08L95/00 ,  C09D7/63 ,  C09D11/06 ,  C09J131/04 ,  C09K8/265 ,  C10L11/04 ,  C11B13/00 ,  Y02A30/333 ,  Y02W30/74

    Abstract: Steps in the processing of oils derived from plants or vegetables include the degumming, deodorizing and bleaching of the oil before it can be used for further applications. By eliminating one or more of these steps from the processing of the oil, followed by hydrogenating the oil to a specified degree of hydrogenation, the resulting upgraded oils can be incorporated into products having commercial applications. The process uses a high shear mixing device and a hydrogenation catalyst. The process can utilize a single or multiple high shear devices, and utilize renewable oils instead of increasingly scarce petroleum based products. The resulting hydrogenated products may then be utilized in a variety of other commercial applications, such as to render cellulosic products water resistant, provide a coating for numerous cellulosic products, adhesive compositions, ink compositions, firelog compositions, drilling muds or asphalt modifiers.

    Abstract translation: 来自植物或蔬菜的油的加工步骤包括在将其用于进一步应用之前，油的脱胶，除臭和漂白。 通过从油的处理中除去一个或多个这些步骤，然后将油氢化至指定的氢化程度，所得到的升级油可以掺入具有商业应用的产品中。 该方法使用高剪切混合装置和氢化催化剂。 该方法可以利用单个或多个高剪切装置，并利用可再生油代替日益稀缺的石油基产品。 所得到的氢化产物可用于各种其他商业应用中，例如使纤维素产品具有防水性，为许多纤维素产品，粘合剂组合物，油墨组合物，防火组合物，钻井泥浆或沥青改性剂提供涂层。

    HIGH SHEAR APPLICATION IN MEDICAL THERAPY
    17.
    发明申请
    HIGH SHEAR APPLICATION IN MEDICAL THERAPY 有权
    医疗治疗中的高剪切应用

    公开(公告)号：US20140081198A1

    公开(公告)日：2014-03-20

    申请号：US14085420

    申请日：2013-11-20

    Applicant: H R D Corporation

    Inventor： Abbas HASSAN ,  Aziz HASSAN ,  Rayford G. ANTHONY

    IPC: A61J3/00

    CPC classification number: A61J3/00 ,  A61K9/0019 ,  A61M5/142 ,  B01F7/00766 ,  B01F7/008 ,  B01F13/1016

    Abstract: In this disclosure, a method is described wherein the method comprises mixing a therapeutic gas or a therapeutic liquid or a combination thereof and a liquid carrier in a high shear device to produce a dispersion; and administering the produced dispersion intravenously to a patient; wherein the produced dispersion contains nanobubbles of the therapeutic gas or droplets of the therapeutic liquid with a mean diameter of less than about 1.5 μm. In this disclosure, a system is also described wherein the system comprises a therapeutic gas source or a therapeutic liquid source or a combination thereof; a liquid carrier source; a high shear device (HSD) having an inlet, an outlet, at least one rotor, and at least one stator separated by a shear gap; and a pump configured to control the flow rate and residence time of a fluid passing through the high shear device.

    Abstract translation: 在本公开中，描述了一种方法，其中所述方法包括在高剪切装置中混合治疗气体或治疗液体或其组合和液体载体以产生分散体; 并将产生的分散体静脉内施用于患者; 其中所制备的分散体含有平均直径小于约1.5μm的治疗液体的治疗气体或液滴的纳米气泡。 在本公开中，还描述了一种系统，其中所述系统包括治疗气体源或治疗液体源或其组合; 液体载体源; 具有入口，出口，至少一个转子和由剪切间隔分开的至少一个定子的高剪切装置（HSD）; 以及构造成控制通过高剪切装置的流体的流速和停留时间的泵。

    HIGH SHEAR APPLICATION IN PROCESSING OILS
    18.
    发明申请
    HIGH SHEAR APPLICATION IN PROCESSING OILS 有权
    加工油中的高剪切应用

    公开(公告)号：US20140010725A1

    公开(公告)日：2014-01-09

    申请号：US14029504

    申请日：2013-09-17

    Applicant: H R D Corporation

    Inventor： Abbas HASSAN ,  Aziz Hassan ,  Rayford G. Anthony

    IPC: C11B3/00

    CPC classification number: C11B3/001 ,  A23D9/007 ,  A23D9/04 ,  B01F3/00 ,  B01F3/04 ,  B01F3/04099 ,  B01F7/00766 ,  B01F13/1016 ,  C07C51/00 ,  C10G3/00 ,  C10G2300/1011 ,  C10G2300/1014 ,  C10G2300/1018 ,  Y02P30/20

    Abstract: Herein disclosed is a method of processing oil, comprising providing a high shear device comprising at least one rotor and at least one complementarily-shaped stator configured to mix a gas with a liquid; contacting a gas with an oil in the high shear device, wherein the gas is an inert gas or a reactive gas; and forming a product, wherein the product is a solution, a dispersion, or combination thereof. Herein also disclosed is a high shear system for processing oil, comprising; at least one high shear device, having an inlet and at least one rotor and at least one complementarily-shaped stator configured to mix a gas with a liquid; a gas source fluidly connected to the inlet; an oil source fluidly connected to the inlet; and a pump positioned upstream of a high shear device, the pump in fluid connection with the inlet and the oil source.

    Abstract translation: 本文公开了一种处理油的方法，包括提供高剪切装置，其包括至少一个转子和构造成将气体与液体混合的至少一个互补形定子; 在高剪切装置中使气体与油接触，其中气体是惰性气体或反应气体; 并形成产品，其中产物是溶液，分散体或其组合。 本文还公开了一种用于加工油的高剪切系统，其包括： 至少一个高剪切装置，具有入口和至少一个转子以及构造成将气体与液体混合的至少一个互补形状的定子; 与入口流体连接的气体源; 与入口流体连接的油源; 以及位于高剪切装置上游的泵，该泵与入口和油源流体连接。

    HIGH SHEAR APPLICATION IN PROCESSING OILS
    19.
    发明申请
    HIGH SHEAR APPLICATION IN PROCESSING OILS 审中-公开
    加工油中的高剪切应用

    公开(公告)号：US20130266703A1

    公开(公告)日：2013-10-10

    申请号：US13787569

    申请日：2013-03-06

    Applicant: H R D CORPORATION

    Inventor： Abbas HASSAN ,  Aziz Hassan ,  Rayford G. Anthony

    IPC: B01F3/04 ,  A23D9/02

    CPC classification number: B01F3/04 ,  A23D9/02 ,  B01F3/04531 ,  B01F7/00766 ,  B01F13/1016 ,  C11B1/00 ,  C11B1/02 ,  C11B1/10 ,  C11B3/00 ,  C11B3/14

    Abstract: Herein disclosed is a method of processing oil, comprising providing a high shear device comprising at least one rotor and at least one complementarily-shaped stator configured to mix a gas with a liquid; contacting a gas with an oil in the high shear device, wherein the gas is an inert gas or a reactive gas; and forming a product, wherein the product is a solution, a dispersion, or combination thereof. Herein also disclosed is a high shear system for processing oil, comprising; at least one high shear device, having an inlet and at least one rotor and at least one complementarily-shaped stator configured to mix a gas with a liquid; a gas source fluidly connected to the inlet; an oil source fluidly connected to the inlet; and a pump positioned upstream of a high shear device, the pump in fluid connection with the inlet and the oil source.

    Abstract translation: 本文公开了一种处理油的方法，包括提供高剪切装置，其包括至少一个转子和构造成将气体与液体混合的至少一个互补形定子; 在高剪切装置中使气体与油接触，其中气体是惰性气体或反应气体; 并形成产品，其中产物是溶液，分散体或其组合。 本文还公开了一种用于加工油的高剪切系统，其包括： 至少一个高剪切装置，具有入口和至少一个转子以及构造成将气体与液体混合的至少一个互补形状的定子; 与入口流体连接的气体源; 与入口流体连接的油源; 以及位于高剪切装置上游的泵，该泵与入口和油源流体连接。

    APPARATUS, SYSTEM, AND METHOD FOR CONVERTING A FIRST SUBSTANCE INTO A SECOND SUBSTANCE
    20.
    发明申请
    APPARATUS, SYSTEM, AND METHOD FOR CONVERTING A FIRST SUBSTANCE INTO A SECOND SUBSTANCE 审中-公开

    公开(公告)号：US20130251613A1

    公开(公告)日：2013-09-26

    申请号：US13847355

    申请日：2013-03-19

    Applicant: H R D CORPORATION

    Inventor： Abbas HASSAN ,  Aziz HASSAN ,  Rayford G. ANTHONY ,  Alishah HASSAN

    IPC: C01B23/00 ,  G21G5/00

    CPC classification number: C01B23/00 ,  B01F7/00766 ,  B01F13/1016 ,  B01J19/1806 ,  G21G5/00

    Abstract: A system for converting a first substance into a second substance, the system including a mixing reactor configured to provide a reactant mixture comprising a first reactant, a second reactant, and a solvent; and a high shear device fluidly connected to the mixing reactor, wherein the high shear device comprises at least one rotor/stator set comprising a rotor and a complementarily-shaped stator symmetrically positioned about an axis of rotation and separated by a shear gap, wherein the shear gap is in the range of from about 10 microns to about 250 microns; and a motor configured for rotating the rotor about the axis of rotation, whereby energy can be transferred from the rotor to the reactants thereby inducing reactions between the first reactant and the second reactant to form a product.

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