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    Process and culture medium for the production of cells infected by a multiple sclerosis-associated virus
    12.
    发明授权
    Process and culture medium for the production of cells infected by a multiple sclerosis-associated virus 失效
    用于产生由多发性硬化症相关病毒感染的细胞的过程和培养基

    公开(公告)号：US06291225B1

    公开(公告)日：2001-09-18

    申请号：US08485145

    申请日：1995-06-07

    Applicant: Herve Perron ,  Jean-Marie Seigneurin

    Inventor： Herve Perron ,  Jean-Marie Seigneurin

    IPC: A61K3912

    CPC classification number: G01N33/56983 ,  C07K14/005 ,  C07K16/10 ,  C12N7/00 ,  C12N15/85 ,  C12N2710/16622 ,  C12N2740/10022 ,  C12N2740/10051 ,  G01N2469/20

    Abstract: Process for in vitro production of a culture or cell line infected by a viral strain associated with multiple sclerosis (MS), according to which a body sample is taken from an individual suffering from MS, the sample is cultivated in a culture medium which promotes the growth of infected cells to obtain a culture of primary infected cells, and a sample of the culture of primary cells or of a subculture of the latter is cultivated in series, that is to say by successive passages, in the culture medium to obtain the culture or cell line infected by a virus associated with MS. The process includes a procedure in which the culture medium also contains a beta anti-interferon antibody or an antibody which is directed against an antigenically close molecule, the antibody playing an inhibiting role in viral expression and allowing long-lasting expression and propagation of the viral strain in the culture or cell line.

    Abstract translation: 用于体外产生由与多发性硬化症（MS）相关的病毒株感染的培养物或细胞系的方法，根据该方法，从患有MS的个体取出身体样品，将样品在培养基中培养， 感染细胞的生长以获得原代感染细胞的培养物，将原始细胞培养物或后代培养物的培养物样品串联培养，即通过连续传代培养在培养基中以获得培养物 或由与MS相关的病毒感染的细胞系。 该方法包括其中培养基还含有针对抗原性紧密分子的β抗干扰素抗体或抗体的方法，所述抗体在病毒表达中起抑制作用，并允许病毒的长期表达和繁殖 在培养或细胞系中的菌株。

    Viral isolates associated with multiple sclerosis
    13.
    发明授权
    Viral isolates associated with multiple sclerosis 有权
    与多发性硬化相关的病毒分离物

    公开(公告)号：US06184025B2

    公开(公告)日：2001-02-06

    申请号：US09200990

    申请日：1998-11-30

    Applicant: Herve Perron ,  Francois Mallet ,  Bernard Mandrand ,  Frederic Bedin ,  Frederic Beseme

    Inventor： Herve Perron ,  Francois Mallet ,  Bernard Mandrand ,  Frederic Bedin ,  Frederic Beseme

    IPC: C12N112

    CPC classification number: C07K14/005 ,  A61K38/00 ,  C12N7/00 ,  C12N2740/10021 ,  C12N2740/10022 ,  Y10S435/912

    Abstract: Composition comprising two pathogenic and/or infective agents associated with multiple sclerosis, namely a first agent which consists of a human virus possessing reverse transcriptase activity and related to a family of endogenous retroviral elements, or a variant of said virus, and a second agent, or a variant of said second agent, these two pathogenic and/or infective agents originating from the same viral strain chosen from the strains designated, respectively, POL-2 deposited with the ECACC on Jul. 22, 1992 under Accession Number V92072202 and MS7PG deposited with the ECACC on Jan. 8, 1993 under Accession Number V93010816, and from their variant strains.

    Abstract translation: 包含与多发性硬化相关的两种致病和/或感染因子的组合物，即由具有逆转录酶活性并与内源性逆转录病毒元件家族相关的人病毒或所述病毒的变体组成的第一药剂和第二药剂， 或所述第二药剂的变体，这两种源自相同病毒株的两种致病和/或感染剂分别选自1992年7月22日以ECACC保藏的保藏号为V92072202的POL-2和存储的MS7PG的菌株 1993年1月8日，ECACC以保藏号V93010816和其变体菌株。

    Process for the production of a viable cell culture infected by a multiple sclerosis-associated virus
    15.
    发明授权
    Process for the production of a viable cell culture infected by a multiple sclerosis-associated virus 失效
    用于产生由多发性硬化相关病毒感染的活细胞培养物的方法

    公开(公告)号：US5925555A

    公开(公告)日：1999-07-20

    申请号：US651573

    申请日：1996-05-22

    Applicant: Herve Perron ,  Jean-Marie Seigneurin

    Inventor： Herve Perron ,  Jean-Marie Seigneurin

    IPC: A61K39/21 ,  C07K14/035 ,  C07K16/10 ,  C12N5/08 ,  C12N7/00 ,  C12N15/85 ,  G01N33/569 ,  C12N5/00

    CPC classification number: G01N33/56983 ,  C07K14/005 ,  C07K16/10 ,  C12N15/85 ,  C12N7/00 ,  C12N2710/16622 ,  C12N2740/10021 ,  C12N2740/10022 ,  C12N2740/10051 ,  G01N2469/20

    Abstract: The present invention relates to a process for in vitro culture of cells infected by a virus associated with multiple sclerosis and to the infected cell lines thus produced. According to the invention, the process includes: a) cultivation of human cells infected by a viral strain to obtain at least one culture of primary cells infected by the viral strain, b) cultivation of non-infected human cells permissive to the viral strain to obtain at least one permissive culture, c) cocultivation of at least one sample of a culture of infected primary cells and one sample of the permissive culture to obtain a first infected derived culture, d) cultivation in series of the first infected derived culture. The invention is used in particular in the pharmaceutical diagnostics industry sector.

    Abstract translation: 本发明涉及由与多发性硬化相关的病毒感染的细胞和由此产生的感染细胞系的体外培养方法。 根据本发明，该方法包括：a）培养受病毒株感染的人类细胞，以获得至少一种感染病毒株的原代细胞培养物，b）将允许病毒株的未感染人细胞培养至 获得至少一种允许培养物，c）共培养感染的原代细胞的培养物的至少一个样品和允许培养物的一个样品，以获得第一感染的衍生培养物，d）串联第一感染的衍生培养物的培养。 本发明特别用于制药诊断行业。

    Process and culture medium for the production of cells infected by a multiple sclerosis-associated virus
    17.
    发明授权
    Process and culture medium for the production of cells infected by a multiple sclerosis-associated virus 失效
    用于产生由多发性硬化症相关病毒感染的细胞的过程和培养基

    公开(公告)号：US5650318A

    公开(公告)日：1997-07-22

    申请号：US157061

    申请日：1994-02-02

    Applicant: Herve Perron ,  Jean-Marie Seigneurin

    Inventor： Herve Perron ,  Jean-Marie Seigneurin

    IPC: A61K39/21 ,  C07K14/035 ,  C07K16/10 ,  C12N5/08 ,  C12N7/00 ,  C12N15/38 ,  C12N15/85 ,  C12P21/08 ,  G01N33/569 ,  A01N63/00 ,  A61K38/17 ,  C12N5/00

    CPC classification number: G01N33/56983 ,  C07K14/005 ,  C07K16/10 ,  C12N15/85 ,  C12N7/00 ,  C12N2710/16622 ,  C12N2740/10022 ,  C12N2740/10051 ,  G01N2469/20

    Abstract: Process for in vitro production of a culture or cell line infected by a viral strain associated with multiple sclerosis (MS), according to which a body sample is taken from an individual suffering from MS, said sample is cultivated in a culture medium which promotes the growth of infected cells to obtain a culture of primary infected cells, and a sample of the culture of primary cells or of a subculture of the latter is cultivated in series, that is to say by successive passages, in said culture medium to obtain the culture or cell line infected by a virus associated with MS, which comprises a procedure in which the culture medium also contains a beta anti-interferon antibody or an antibody which is directed against an antigenically close molecule, the antibody playing an inhibiting role in viral expression and allowing long-lasting expression and propagation of the viral strain in the culture or cell line.

    Abstract translation: PCT No.PCT / FR93 / 00336 Sec。 371日期：1994年2月2日 102（e）日期1994年2月2日PCT提交1993年4月2日PCT公布。 公开号WO93 / 20188 PCT 日期1993年10月14日由与多发性硬化症（MS）相关的病毒株感染的培养物或细胞系的体外生产过程，根据该过程，从患有MS的个体取出身体样品，所述样品在 促进受感染细胞生长以获得原代感染细胞培养物的培养基，原代细胞培养物或后代培养物的培养物样品在所述培养物中串联培养，即连续传代培养 培养基以获得由与MS相关的病毒感染的培养物或细胞系，其包括其中培养基还含有针对抗原性紧密分子的β抗干扰素抗体或抗体的方法，所述抗体发挥抑制作用 在病毒表达中的作用，并允许病毒株在培养物或细胞系中的长期表达和繁殖。

    Process for the production of a viable cell culture infected by a multiple sclerosis-associated virus
    18.
    发明授权
    Process for the production of a viable cell culture infected by a multiple sclerosis-associated virus 失效
    用于产生由多发性硬化相关病毒感染的活细胞培养物的方法

    公开(公告)号：US5585262A

    公开(公告)日：1996-12-17

    申请号：US157060

    申请日：1994-02-02

    Applicant: Herve Perron ,  Jean-Marie Seigneurin

    Inventor： Herve Perron ,  Jean-Marie Seigneurin

    IPC: A61K39/21 ,  C07K14/035 ,  C07K16/10 ,  C12N5/08 ,  C12N7/00 ,  C12N15/85 ,  G01N33/569 ,  C12N5/02 ,  C12N7/01

    CPC classification number: G01N33/56983 ,  C07K14/005 ,  C07K16/10 ,  C12N15/85 ,  C12N7/00 ,  C12N2710/16622 ,  C12N2740/10021 ,  C12N2740/10022 ,  C12N2740/10051 ,  G01N2469/20

    Abstract: The present invention relates to a process for in vitro culture of cells infected by a virus associated with multiple sclerosis and to the infected cell lines thus produced. The process is the cultivation of human cells infected by a viral strain to obtain at least one culture of primary cells infected by the said viral strain, along with the cultivation of non-infected human cells permissive to the viral strain to obtain at least one permissive culture, followed by cocultivation of at least one sample of a culture of infected primary cells and one sample of the permissive culture to obtain a first infected derived culture, then cultivating in series of the first infected derived culture. The invention is used in particular in the pharmaceutical diagnostics industry sector. In the preferred process, the infected cells are leptomeningeal cells and the permissive cells are leptomeningeal cells or plexuschoroideus cells.

    Abstract translation: PCT No.PCT / FR93 / 00337 Sec。 371日期：1994年2月2日 102（e）日期1994年2月2日PCT提交1993年4月2日PCT公布。 公开号WO93 / 20189 日期：1993年10月14日本发明涉及由与多发性硬化相关的病毒感染的细胞和由此产生的感染细胞系进行体外培养的方法。 该过程是培养由病毒株感染的人类细胞，以获得至少一种由所述病毒株感染的原代细胞培养物，以及允许病毒株获得至少一种允许的非感染人细胞的培养 培养，然后共培养感染的原代细胞的培养物的至少一个样品和允许培养物的一个样品，以获得第一感染的衍生培养物，然后一系列培养第一感染的衍生培养物。 本发明特别用于制药诊断行业。 在优选的方法中，感染的细胞是脑膜炎细胞，允许的细胞是脑膜上皮细胞或丛神经细胞。

    Therapeutic use of specific ligand in MSRV associated diseases
    19.
    发明授权
    Therapeutic use of specific ligand in MSRV associated diseases 有权
    特异性配体在MSRV相关疾病中的治疗用途

    公开(公告)号：US08715656B2

    公开(公告)日：2014-05-06

    申请号：US12997486

    申请日：2009-07-08

    Applicant: Corinne Bernard ,  Alois Bernhardt Lang ,  Herve Perron ,  Jean-Baptiste Bertrand

    Inventor： Corinne Bernard ,  Alois Bernhardt Lang ,  Herve Perron ,  Jean-Baptiste Bertrand

    IPC: A61K39/395

    CPC classification number: C07K16/1036 ,  A61K2039/505 ,  C07K2317/24 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/92

    Abstract: The present invention deals with a ligand comprising each of the complementary-determining regions (CDRs) set forth in SEQ ID No. 1, SEQ ID No. 2, SEQ ID No. 3 SEQ ID No. 4, SEQ ID No. 5 and SEQ ID No. 6 or sequence having either number of substituted aminoacids within said sequences as indicated in the following, from 0 to 3 in CDR1(SEQ ID No. 1), from 0 to 2 in CDR2(SEQ ID No. 2), from 0 to 2 in CDR3(SEQ ID No. 3), from 0 to 1 in CDR4(SEQ ID No. 4), from 0 to 4 in CDR5(SEQ ID No. 5), from 0 to 2 in CDR6(SEQ ID No. 6), or aminoacids substituted with other aminoacids having equivalent chemical functions and properties, within said sequences SEQ ID No. 1 to SEQ ID No. 6.

    Abstract translation: 本发明涉及包含SEQ ID No.1，SEQ ID No.2，SEQ ID No.3，SEQ ID No.4，SEQ ID No.5所示的每个互补决定区（CDR）和 SEQ ID No.6或在所述序列中具有任意数目的取代氨基酸的序列，如下所示，CDR1（SEQ ID No.1）中为0至3，CDR2（SEQ ID No.2）为0至2， 在CDR3（SEQ ID No.3）中为0至2，CDR4（SEQ ID No.4）为0至1，CDR5（SEQ ID No.5）为0至4，CDR6（SEQ ID NO：0）为0至2 SEQ ID NO：6），或在所述序列SEQ ID No.1至SEQ ID No.6内具有等同化学功能和性质的其它氨基酸取代的氨基酸。

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