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    Process for producing optically active olefin
    11.
    发明授权
    Process for producing optically active olefin 失效
    光学活性烯烃的制造方法

    公开(公告)号：US5600047A

    公开(公告)日：1997-02-04

    申请号：US459637

    申请日：1995-06-02

    申请人： Tadakatsu Mandai ,  Jiro Tsuji ,  Manzo Shiono

    发明人： Tadakatsu Mandai ,  Jiro Tsuji ,  Manzo Shiono

    IPC分类号： B01J31/24 ,  C07B31/00 ,  C07B53/00 ,  C07B61/00 ,  C07C1/213 ,  C07C13/47 ,  C07C68/06 ,  C07C69/96 ,  C07C401/00 ,  C07F7/18 ,  C07J3/00 ,  C07J9/00 ,  C07J51/00 ,  C07J75/00 ,  C07C1/20 ,  C07C1/32

    CPC分类号： C07J9/00 ,  C07C401/00 ,  C07C69/96 ,  C07J51/00

    摘要： A process for producing an optically active olefin represented by a formula ##STR1## wherein R.sup.1 represents an organic group and X represents a polycyclic carbon ring group, by reacting a corresponding optically active ester derivative represented by a formula ##STR2## wherein R.sup.1 and X are as defined above and R represents a hydrogen atom, an alkoxy group, an alkenyloxy group or a substituted or unsubstituted aralkyloxy group, with formic acid or a salt thereof in the presence of a catalyst comprising a palladium salt and a tertiary phosphine.Said process makes it possible to produce, at a high yield at a high selectivity, an optically active olefin which has a physiological activity and is useful as a medicine or is useful as an intermediate for the synthesis of physiologically active steroids. Further, said process uses no harmful reagent such as mercury or the like. Thus, it is advantageous as an industrial process.

    摘要翻译： 其中R 1表示有机基团，X表示多环碳环基团，其中R 1和X是相应的由下式表示的光学活性酯衍生物：其中R1和X为 如上所述，R表示氢原子，烷氧基，烯氧基或取代或未取代的芳烷氧基，与甲酸或其盐在钯盐和叔膦的催化剂存在下反应。 所述方法使得可以高选择性地产生具有生理活性的光学活性烯烃并且可用作药物或可用作合成生理活性类固醇的中间体。 此外，所述方法不使用诸如汞等的有害试剂。 因此，作为工业过程是有利的。