中科微点-全球专利检索

  1. Login
  2. Sign Up

Search Results

44 records (took 0.017 seconds)

    FABRICATION OF TUNNELING JUNCTION FOR NANOPORE DNA SEQUENCING
    11.
    发明申请
    FABRICATION OF TUNNELING JUNCTION FOR NANOPORE DNA SEQUENCING 有权
    NANOPORE DNA测序中隧道结的制备

    公开(公告)号：US20140312003A1

    公开(公告)日：2014-10-23

    申请号：US13971532

    申请日：2013-08-20

    Applicant: International Business Machines Corporation

    Inventor： Hongbo Peng ,  Stephen M. Rossnagel ,  Ajay K. Royyuru ,  Gustavo A. Stolovitzky ,  Deqiang Wang

    IPC: C12Q1/68 ,  C25D7/12

    CPC classification number: G01N33/48721 ,  C12Q1/6869 ,  C23C18/161 ,  C23C18/1644 ,  C23C18/1675 ,  C23C18/42 ,  C25D3/50 ,  C25D5/02 ,  C25D7/00 ,  C25D7/12 ,  C25D21/12

    Abstract: A mechanism is provided for forming a nanodevice. A reservoir is filled with a conductive fluid, and a membrane is formed to separate the reservoir in the nanodevice. The membrane includes an electrode layer having a tunneling junction formed therein. The membrane is formed to have a nanopore formed through one or more other layers of the membrane such that the nanopore is aligned with the tunneling junction of the electrode layer. The tunneling junction of the electrode layer is narrowed to a narrowed size by electroplating or electroless deposition. When a voltage is applied to the electrode layer, a tunneling current is generated by a base in the tunneling junction to be measured as a current signature for distinguishing the base. When an organic coating is formed on an inside surface of the tunneling junction, transient bonds are formed between the electrode layer and the base.

    Abstract translation: 提供了用于形成纳米器件的机构。 储存器填充有导电流体，并且形成膜以分离纳米装置中的储存器。 膜包括其中形成有隧道结的电极层。 膜形成为具有通过膜的一个或多个其它层形成的纳米孔，使得纳米孔与电极层的隧道结对准。 电极层的隧道结通过电镀或无电沉积而变窄到窄的尺寸。 当向电极层施加电压时，通过在要测量的隧道结中的基底产生隧道电流作为区分基底的当前签名。 当在隧道结的内表面上形成有机涂层时，在电极层和基底之间形成瞬态结合。

    Integrated carbon nanotube field effect transistor and nanochannel for sequencing
    15.
    发明授权
    Integrated carbon nanotube field effect transistor and nanochannel for sequencing 有权
    集成碳纳米管场效应晶体管和纳米通道进行测序

    公开(公告)号：US08963215B2

    公开(公告)日：2015-02-24

    申请号：US13690963

    申请日：2012-11-30

    Applicant: International Business Machines Corporation

    Inventor： Ali Afzali-Ardakani ,  Gustavo A. Stolovitzky ,  Deqiang Wang

    IPC: G01N27/403 ,  G01N27/414 ,  B82Y15/00 ,  B82Y30/00 ,  G01N27/02 ,  G01N33/487

    CPC classification number: G01N27/4146 ,  B82Y15/00 ,  B82Y30/00 ,  G01N27/02 ,  G01N33/48721 ,  Y10S977/958

    Abstract: A mechanism is provided for base recognition of an integrated transistor and nanochannel. A target molecule is forced down to a carbon nanotube a single base at a time in the nanochannel by applying a gate voltage to a top electrode, and/or a narrow thickness of the nanochannel. The nanochannel exposes an exposed portion of the carbon nanotube at a bottom wall, and the top electrode is positioned over the exposed portion. The exposed portion of the carbon nanotube is smaller than the distance between bases to only accommodate the single base at a time. The target molecule is stretched by the narrow thickness and by applying a traverse voltage across a length direction of the nanochannel. The target molecule is frictionally restricted by the narrow thickness of the nanochannel to stretch is restrictedly translocates in the length direction. Current is measured to determine an identity of the single base.

    Abstract translation: 提供了用于集成晶体管和纳米通道的基础识别的机制。 通过向顶部电极施加栅极电压和/或纳米通道的窄厚度，靶分子在纳米通道中一次被强制下降到单个碱基。 纳米通道暴露在底壁处的碳纳米管的暴露部分，并且顶部电极位于暴露部分上方。 碳纳米管的暴露部分小于基底之间的距离，以便一次仅容纳单个基底。 靶分子通过窄的厚度被拉伸并且通过在纳米通道的长度方向施加横动电压。 目标分子被纳米通道的窄厚度摩擦地限制，以在长度方向上被限制性地转位。 测量电流以确定单个碱基的身份。

    INTEGRATED CARBON NANOTUBE FIELD EFFECT TRANSISTOR AND NANOCHANNEL FOR SEQUENCING
    16.
    发明申请
    INTEGRATED CARBON NANOTUBE FIELD EFFECT TRANSISTOR AND NANOCHANNEL FOR SEQUENCING 有权
    集成碳纳米管场效应晶体管和用于测序的纳米通道

    公开(公告)号：US20140152291A1

    公开(公告)日：2014-06-05

    申请号：US13690963

    申请日：2012-11-30

    Applicant: INTERNATIONAL BUSINESS MACHINES CORPORATION

    Inventor： Ali Afzali-Ardakani ,  Gustavo A. Stolovitzky ,  Deqiang Wang

    IPC: G01N27/414

    CPC classification number: G01N27/4146 ,  B82Y15/00 ,  B82Y30/00 ,  G01N27/02 ,  G01N33/48721 ,  Y10S977/958

    Abstract: A mechanism is provided for base recognition of an integrated transistor and nanochannel. A target molecule is forced down to a carbon nanotube a single base at a time in the nanochannel by applying a gate voltage to a top electrode, and/or a narrow thickness of the nanochannel. The nanochannel exposes an exposed portion of the carbon nanotube at a bottom wall, and the top electrode is positioned over the exposed portion. The exposed portion of the carbon nanotube is smaller than the distance between bases to only accommodate the single base at a time. The target molecule is stretched by the narrow thickness and by applying a traverse voltage across a length direction of the nanochannel. The target molecule is frictionally restricted by the narrow thickness of the nanochannel to stretch is restrictedly translocates in the length direction. Current is measured to determine an identity of the single base.

    Abstract translation: 提供了用于集成晶体管和纳米通道的基础识别的机制。 通过向顶部电极施加栅极电压和/或纳米通道的窄厚度，靶分子在纳米通道中一次被强制下降到单个碱基。 纳米通道暴露在底壁处的碳纳米管的暴露部分，并且顶部电极位于暴露部分上方。 碳纳米管的暴露部分小于基底之间的距离，以便一次仅容纳单个基底。 靶分子通过窄的厚度被拉伸并且通过在纳米通道的长度方向施加横动电压。 目标分子被纳米通道的窄厚度摩擦地限制，以在长度方向上被限制性地转位。 测量电流以确定单个碱基的身份。

    Increasing the capture zone by nanostructure patterns
    17.
    发明授权
    Increasing the capture zone by nanostructure patterns 有权

    公开(公告)号：US10094805B2

    公开(公告)日：2018-10-09

    申请号：US15583501

    申请日：2017-05-01

    Applicant: International Business Machines Corporation

    Inventor： Binquan Luan ,  Gustavo A. Stolovitzky ,  Chao Wang ,  Deqiang Wang

    IPC: G01N1/10 ,  G01N27/447 ,  G01N33/487 ,  C12Q1/6869

    Abstract: Techniques for increasing the capture zone in nano and microchannel-based polymer testing structures using concentric arrangements of nanostructures, such as nanopillars are provided. In one aspect, a testing structure for testing polymers is provided that includes a first fluid reservoir and a second fluid reservoir formed in an electrically insulating substrate; at least one channel formed in the insulating substrate that interconnects the first fluid reservoir and the second fluid reservoir; and an arrangement of nanostructures within either the first fluid reservoir or the second fluid reservoir wherein the nanostructures are arranged so as to form multiple concentric circles inside either the first fluid reservoir or the second fluid reservoir with each of the concentric circles being centered at an entry point of the channel. A method of analyzing a polymer using the testing structure is also provided.

    Increasing the capture zone by nanostructure patterns
    19.
    发明授权
    Increasing the capture zone by nanostructure patterns 有权

    公开(公告)号：US09658184B2

    公开(公告)日：2017-05-23

    申请号：US14271926

    申请日：2014-05-07

    Applicant: International Business Machines Corporation

    Inventor： Binquan Luan ,  Gustavo A. Stolovitzky ,  Chao Wang ,  Deqiang Wang

    IPC: G01N1/10 ,  G01N27/403 ,  B82Y30/00 ,  G01N33/487

    CPC classification number: G01N27/44791 ,  B82Y30/00 ,  C12Q1/6869 ,  G01N27/403 ,  G01N33/48721

    Abstract: Techniques for increasing the capture zone in nano and microchannel-based polymer testing structures using concentric arrangements of nanostructures, such as nanopillars are provided. In one aspect, a testing structure for testing polymers is provided that includes a first fluid reservoir and a second fluid reservoir formed in an electrically insulating substrate; at least one channel formed in the insulating substrate that interconnects the first fluid reservoir and the second fluid reservoir; and an arrangement of nanostructures within either the first fluid reservoir or the second fluid reservoir wherein the nanostructures are arranged so as to form multiple concentric circles inside either the first fluid reservoir or the second fluid reservoir with each of the concentric circles being centered at an entry point of the channel. A method of analyzing a polymer using the testing structure is also provided.

Patent Agency Ranking