公开(公告)号：US07160672B2

公开(公告)日：2007-01-09

申请号：US11150547

申请日：2005-06-10

申请人： Joseph H. Schulman ,  Joseph Y. Lucisano ,  Rajiv Shah ,  Charles L. Byers ,  Shaun M. Pendo

发明人： Joseph H. Schulman ,  Joseph Y. Lucisano ,  Rajiv Shah ,  Charles L. Byers ,  Shaun M. Pendo

IPC分类号： G03C5/00 ,  C23C14/00

CPC分类号： G03F7/70641 ,  A61N1/02 ,  A61N1/375 ,  C23C14/042 ,  H01L21/308 ,  H01L23/291 ,  H01L2924/0002 ,  H05K3/284 ,  Y10T29/49144 ,  Y10T428/24802 ,  Y10T428/24917 ,  Y10T428/24926 ,  Y10T428/265 ,  H01L2924/00

摘要： A protective, biocompatible coating or encapsulation material protects and insulates a component or device intended to be implanted in living tissue. The coating or encapsulation material comprises a thin layer or layers of alumina, zerconia, or other ceramic, less than 25 microns thick, e.g., 5–10 microns thick. The alumina layer(s) may be applied at relatively low temperature. Once applied, the layer provides excellent hermeticity, and prevents electrical leakage. Even though very thin, the alumina layer retains excellent insulating characteristics. In one embodiment, an alumina layer less than about 6 microns thick provides an insulative coating that exhibits less than 10 pA of leakage current over an area 75 mils by 25 mils area while soaking in a saline solution at temperatures up to 80° C. over a three month period.

摘要翻译： 保护性的，生物相容的涂层或包封材料保护和绝缘想要植入生物体组织的组件或装置。 涂层或包封材料包括薄层或多层氧化铝，稀土或其它小于25微米厚，例如5-10微米厚的陶瓷。 氧化铝层可以在相对较低的温度下施加。 一旦施加，该层提供优异的气密性，并防止漏电。 即使非常薄，氧化铝层保持优异的绝缘特性。 在一个实施方案中，小于约6微米厚的氧化铝层提供了一种绝缘涂层，其在75密耳25密耳面积的面积上表现出低于10pA的漏电流，同时在高达80℃的温度下浸入盐水溶液中 一个三个月的时间。

公开(公告)号：US07079881B2

公开(公告)日：2006-07-18

申请号：US10288038

申请日：2002-11-04

申请人： Joseph H. Schulman ,  Charles L. Byers ,  John C. Gord ,  Rajiv Shah ,  Lyle Dean Canfield

发明人： Joseph H. Schulman ,  Charles L. Byers ,  John C. Gord ,  Rajiv Shah ,  Lyle Dean Canfield

IPC分类号： A61N5/00

CPC分类号： A61N1/36585 ,  A61B5/0031 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/14865 ,  A61B5/4839 ,  A61B2560/0219 ,  A61M5/1723 ,  A61N1/05 ,  A61N1/372 ,  A61N1/3754 ,  H01L23/3107 ,  H01L29/0657 ,  H01L2924/0002 ,  H01L2924/19041 ,  H01L2924/00

摘要： An implantable substrate sensor has electronic circuitry and electrodes formed on opposite sides of a substrate. A protective coating covers the substrate, effectively hermetically sealing the electronic circuitry under the coating. Exposed areas of the electrodes are selectively left uncovered by the protective coating, thereby allowing such electrodes to be exposed to body tissue and fluids when the sensor is implanted in living tissue. The substrate on which the electronic circuitry and electrodes are formed is the same substrate or “chip” on which an integrated circuit (IC) is formed, which integrated circuit contains the desired electronic circuitry. Such approach eliminates the need for an hermetically sealed lid or cover to cover hybrid electronic circuitry, and allows the sensor to be made much thinner than would otherwise be possible. In one embodiment, two such substrate sensors may be placed back-to-back, with the electrodes facing outward. As required, capacitors that form part of the sensor's electronic circuits are formed on the substrate by placing metalization layers and a dielectric in vacant areas of the substrate surface.

公开(公告)号：US06472122B1

公开(公告)日：2002-10-29

申请号：US09393438

申请日：1999-09-09

申请人： Joseph H. Schulman ,  Joseph Y. Lucisano ,  Rajiv Shah ,  Charles L. Byers ,  Shaun M. Pendo

发明人： Joseph H. Schulman ,  Joseph Y. Lucisano ,  Rajiv Shah ,  Charles L. Byers ,  Shaun M. Pendo

IPC分类号： G03F716

CPC分类号： G03F7/70641 ,  A61N1/02 ,  A61N1/375 ,  C23C14/042 ,  H01L21/308 ,  H01L23/291 ,  H01L2924/0002 ,  H05K3/284 ,  Y10T29/49144 ,  Y10T428/24802 ,  Y10T428/24917 ,  Y10T428/24926 ,  Y10T428/265 ,  H01L2924/00

摘要： A protective, biocompatible coating or encapsulation material protects and insulates a component or device intended to be implanted in living tissue. The coating or encapsulation material comprises a thin layer or layers of alumina, zerconia, or other ceramic, less than 25 microns thick, e.g., 5-10 microns thick. The alumina layer(s) may be applied at relatively low temperature. Once applied, the layer provides excellent hermeticity, and prevents electrical leakage. Even though very thin, the alumina layer retains excellent insulating characteristics. In one embodiment, an alumina layer less than about 6 microns thick provides an insulative coating that exhibits less than 10 pA of leakage current over an area 75 mils by 25 mils area while soaking in a saline solution at temperatures up to 80° C. over a three month period.

摘要翻译： 保护性的，生物相容的涂层或包封材料保护和绝缘想要植入生物体组织的组件或装置。 涂层或包封材料包括薄层或多层氧化铝，稀土或其它小于25微米厚，例如5-10微米厚的陶瓷。 氧化铝层可以在相对较低的温度下施加。 一旦施加，该层提供优异的气密性，并防止漏电。 即使非常薄，氧化铝层保持优异的绝缘特性。 在一个实施方案中，小于约6微米厚的氧化铝层提供了一种绝缘涂层，其在75密耳25密耳面积的面积上表现出低于10pA的泄漏电流，同时在高达80℃的温度下浸入盐水溶液中 一个三个月的时间。

公开(公告)号：US06387048B1

公开(公告)日：2002-05-14

申请号：US09360343

申请日：1999-07-22

申请人： Joseph H. Schulman ,  Rajiv Shah

发明人： Joseph H. Schulman ,  Rajiv Shah

IPC分类号： A61B500

CPC分类号： A61B5/14532

摘要： An implantable sensor includes electronic circuitry for automatically performing on a periodic basis, e.g., every 1 to 24 hours, specified integrity tests which verify proper operation of the sensor.

公开(公告)号：US08948836B2

公开(公告)日：2015-02-03

申请号：US10746129

申请日：2003-12-26

申请人： Bahar Reghabi ,  Rebecca K. Gottlieb ,  Rajiv Shah ,  Bradley J. Enegren ,  William P. Van Antwerp

发明人： Bahar Reghabi ,  Rebecca K. Gottlieb ,  Rajiv Shah ,  Bradley J. Enegren ,  William P. Van Antwerp

IPC分类号： A61B5/145 ,  A61B5/1473 ,  A61B5/1468 ,  A61B5/1486 ,  A61B5/02 ,  A61B5/024 ,  A61B5/021 ,  A61B5/0215 ,  A61B5/01 ,  A61B5/1459 ,  A61B5/00 ,  A61B5/1455

CPC分类号： A61B5/14865 ,  A61B5/01 ,  A61B5/0215 ,  A61B5/14532 ,  A61B5/14539 ,  A61B5/14542 ,  A61B5/14546 ,  A61B5/14551 ,  A61B5/1459 ,  A61B5/412 ,  A61B5/4839 ,  A61B5/6852 ,  A61B2562/063

摘要： An apparatus for sensing multiple parameters includes an implantable housing and a plurality of implantable sensors disposed within the implantable housing. The plurality of implantable sensors sense parameters in a patient, such as biological or physiological parameters, for example, and each responds to an analyte in the patient. The plurality of implantable sensors may include, but is not limited to, electrochemical, potentiometric, current and optical sensors.

摘要翻译： 用于感测多个参数的装置包括可植入的壳体和设置在可植入壳体内的多个可植入传感器。 多个可植入传感器感测患者中的参数，例如生物或生理参数，并且各自对患者中的分析物进行响应。 多个可植入传感器可以包括但不限于电化学，电位，电流和光学传感器。

公开(公告)号：US08850688B2

公开(公告)日：2014-10-07

申请号：US12980255

申请日：2010-12-28

申请人： Rajiv Shah ,  Rebecca K. Gottlieb

发明人： Rajiv Shah ,  Rebecca K. Gottlieb

IPC分类号： H01S4/00 ,  A61B5/1486 ,  A61B5/145 ,  A61B5/00 ,  C12Q1/00

CPC分类号： A61B5/14865 ,  A61B5/0004 ,  A61B5/0017 ,  A61B5/14532 ,  A61B5/6848 ,  A61B5/6849 ,  C12Q1/006 ,  C23C14/20 ,  C23C14/3414 ,  G01N27/307 ,  G01N27/3273 ,  G01N27/4166 ,  Y10T29/49002 ,  Y10T29/49005 ,  Y10T29/49007 ,  Y10T29/49117 ,  Y10T29/49155

摘要： A thin film sensor, such as a glucose sensor, is provided for transcutaneous placement at a selected site within the body of a patient. The sensor includes several sensor layers that include conductive layers and includes a proximal segment defining conductive contacts adapted for electrical connection to a suitable monitor, and a distal segment with sensor electrodes for transcutaneous placement. The sensor electrode layers are disposed generally above each other, for example with the reference electrode above the working electrode and the working electrode above the counter electrode. The electrode layers are separated by dielectric layer.

摘要翻译： 提供薄膜传感器，例如葡萄糖传感器，用于经皮放置在患者体内的选定部位。 传感器包括几个传感器层，其包括导电层，并且包括限定适于与合适的监视器电连接的导电触点的近端段，以及具有用于经皮放置的传感器电极的远端段。 传感器电极层大致彼此上下设置，例如，在工作电极上方的参考电极和对置电极上方的工作电极。 电极层由电介质层分离。

公开(公告)号：US08700114B2

公开(公告)日：2014-04-15

申请号：US12184117

申请日：2008-07-31

申请人： Rebecca K. Gottlieb ,  Rajiv Shah ,  Eric Allan Larson ,  Chia Chiu

发明人： Rebecca K. Gottlieb ,  Rajiv Shah ,  Eric Allan Larson ,  Chia Chiu

IPC分类号： A61B5/00 ,  A61B5/05 ,  A61M31/00 ,  C12Q1/54

CPC分类号： A61B5/14532 ,  A61B5/1473 ,  A61B5/14865 ,  A61B5/6848 ,  A61B5/6849 ,  C12Q1/006

摘要： Embodiments of the invention provide analyte sensors having optimized elements and/or configurations of elements as well as methods for making and using such sensors. Typical embodiments of the invention include glucose sensors used in the management of diabetes.

摘要翻译： 本发明的实施例提供了具有优化的元件和/或元件构造的分析物传感器以及用于制造和使用这种传感器的方法。 本发明的典型实施方案包括用于治疗糖尿病的葡萄糖传感器。

公开(公告)号：US08591416B2

公开(公告)日：2013-11-26

申请号：US12887451

申请日：2010-09-21

申请人： Rajiv Shah ,  Wayne A. Morgan ,  David Y. Choy ,  James L. Henke ,  Bahar Reghabi ,  Gopikrishnan Soundararajan ,  Peter Schultz ,  Udo Hoss

发明人： Rajiv Shah ,  Wayne A. Morgan ,  David Y. Choy ,  James L. Henke ,  Bahar Reghabi ,  Gopikrishnan Soundararajan ,  Peter Schultz ,  Udo Hoss

IPC分类号： A61B5/05 ,  A61B5/00

CPC分类号： G01N27/403 ,  A61B5/14532 ,  A61B5/1473 ,  A61B2560/0223 ,  A61B2562/02 ,  C12Q1/006 ,  G01N27/327 ,  G01N27/416

摘要： A sensor system includes a sensor and a sensor electronics device. The sensor includes a plurality of electrodes. The sensor electronics device includes a connection detection device, a power source, and a delay circuit. The connection detection device determines if the sensor electronics device is connected to the sensor and transmits a connection signal. The delay circuit receives the connection signal, waits a preset hydration time, and couples the regulated voltage from the power source to an electrode in the sensor after the preset hydration time has elapsed. Alternatively, the sensor electronics device may include an electrical detection circuit and a microcontroller. The electrical detection circuit determines if the plurality of electrodes are hydrated and generates an interrupt if the electrodes are hydrated. A microcontroller receives the interrupt and transmits a signal representative of a voltage to an electrode of the plurality of electrodes.

公开(公告)号：US08414489B2

公开(公告)日：2013-04-09

申请号：US11034371

申请日：2005-01-12

申请人： Rajiv Shah ,  Shaun M. Pendo ,  Rebecca K. Gottlieb ,  Gil Bruso ,  Gopikrishnan Soundararajan ,  Katherine T. Wolfe

发明人： Rajiv Shah ,  Shaun M. Pendo ,  Rebecca K. Gottlieb ,  Gil Bruso ,  Gopikrishnan Soundararajan ,  Katherine T. Wolfe

IPC分类号： A61B5/00 ,  A61B5/05

CPC分类号： A61B5/14532 ,  A61B5/0031 ,  A61B5/14865 ,  A61B5/412 ,  C12Q1/006

摘要： The disclosure provides methods for fabricating a long-term analyte sensor for measuring at least one analyte in the body of a user. The analyte sensors made by these methods include a plurality of analyte contacting sensor elements and at least one structure for relaying information to and from the sensor. The analyte sensor so fabricated further includes at least one sensor protection membrane that is controllable in a manner such that sensor elements may be activated (e.g. exposed to the external environment) at different times so as to extend the useful life of the sensor. In illustrative analyte sensors, the analyte is glucose.

摘要翻译： 本公开提供了制造用于测量使用者身体中的至少一种分析物的长期分析物传感器的方法。 通过这些方法制造的分析物传感器包括多个分析物接触传感器元件和用于将信息传递到传感器和从传感器传递信息的至少一个结构。 如此制造的分析物传感器还包括至少一个传感器保护膜，该传感器保护膜可以以不同时间使得传感器元件被激活（例如暴露于外部环境）的方式被控制，以延长传感器的使用寿命。 在说明性的分析物传感器中，分析物是葡萄糖。

公开(公告)号：US08394463B1

公开(公告)日：2013-03-12

申请号：US12692001

申请日：2010-01-22

申请人： Chia-Hung Chiu ,  Marco Sillus ,  Barry Pham ,  Ly Phou ,  Gil Bruso ,  Christopher R. Enegren ,  Heath Jensen ,  Michael Paul Minor ,  Rajiv Shah

发明人： Chia-Hung Chiu ,  Marco Sillus ,  Barry Pham ,  Ly Phou ,  Gil Bruso ,  Christopher R. Enegren ,  Heath Jensen ,  Michael Paul Minor ,  Rajiv Shah

IPC分类号： C08J7/16

CPC分类号： G01N27/3272 ,  C08J3/246

摘要： Embodiments of the invention provide methods of crosslinking various compounds and materials made by these methods. Materials made by embodiments of the invention include glucose sensors used in the management of diabetes.

摘要翻译： 本发明的实施方案提供了交联通过这些方法制备的各种化合物和材料的方法。 由本发明的实施方案制备的材料包括用于治疗糖尿病的葡萄糖传感器。