公开(公告)号：US20140053910A1

公开(公告)日：2014-02-27

申请号：US14114330

申请日：2012-04-24

Applicant: Bernard Bunner ,  Joseph Michienzi ,  Keith Fadgen

Inventor： Bernard Bunner ,  Joseph Michienzi ,  Keith Fadgen

IPC: F16K3/10 ,  F16K3/18 ,  G01N35/10 ,  F16K31/04

CPC classification number: F16K3/10 ,  F16K3/18 ,  F16K31/041 ,  G01N35/1097 ,  G01N2030/202 ,  Y10T137/0318

Abstract: Described are a rotary shear seal valve and a method for switching a high pressure fluid. The method includes applying a fixed force between a planar surface of a rotor and a planar surface of a stator. The planar surface of the rotor includes a fluidic channel and the planar surface of the stator has a pair of ports to receive and provide the fluid. A control signal is applied to a linear actuator coupled to the rotor to generate a controllable force between the planar surfaces of the rotor and stator. The control signal is responsive to a rotational state of the rotor. The total force between the planar surfaces of the rotor and the stator is substantially equal to a sum of the fixed force and the controllable force. The method reduces the wear and extends the lifetime of components in a rotary shear seal valve.

Abstract translation: 描述了一种旋转剪切密封阀和一种用于切换高压流体的方法。 该方法包括在转子的平坦表面和定子的平坦表面之间施加固定的力。 转子的平面表面包括流体通道，并且定子的平坦表面具有一对接口并提供流体的端口。 控制信号被施加到耦合到转子的线性致动器，以在转子和定子的平面之间产生可控的力。 控制信号响应转子的旋转状态。 转子和定子的平面之间的总的力基本上等于固定力和可控力之和。 该方法减少了磨损并延长了旋转剪切密封阀中部件的使用寿命。

公开(公告)号：US20130206240A1

公开(公告)日：2013-08-15

申请号：US13808263

申请日：2011-08-26

Applicant: Geoff C. Gerhardt ,  Keith Fadgen

Inventor： Geoff C. Gerhardt ,  Keith Fadgen

IPC: F16K11/00

CPC classification number: F16K11/00 ,  F16K11/0743 ,  Y10T137/0318 ,  Y10T137/86863

Abstract: Variable-volume injection valves include a stator and a rotor. The stator has a first port, a second port, and a contact surface with a groove therein. The first port opens into the stator groove. The rotor has a contact surface with a groove therein. The contact surface of the rotor is urged against the contact surface of the stator such that the rotor groove opposes the stator groove with one end of the rotor groove overlapping the stator groove and the opposite end of the rotor groove overlapping the second port of the stator. The overlapping grooves of the rotor and stator provide a fluidic channel between the first and second ports of the stator. The rotor is movable with respect to the stator in order to vary a length of overlap between their overlapping grooves.

Abstract translation: 可变容积喷射阀包括定子和转子。 定子具有第一端口，第二端口和与其中的凹槽的接触表面。 第一端口通向定子槽。 转子具有与其中的凹槽的接触表面。 转子的接触表面被推靠在定子的接触表面上，使得转子槽与定子槽相对，转子槽的一端与定子槽重叠，转子槽的相对端与定子的第二端重叠 。 转子和定子的重叠槽在定子的第一和第二端口之间提供流体通道。 转子可相对于定子移动，以便改变其重叠槽之间的重叠长度。

公开(公告)号：US08394275B2

公开(公告)日：2013-03-12

申请号：US12811158

申请日：2008-12-16

Applicant: Christopher C. Benevides ,  Keith Fadgen ,  Michael Lavallee ,  Anthony Jeannotte

Inventor： Christopher C. Benevides ,  Keith Fadgen ,  Michael Lavallee ,  Anthony Jeannotte

IPC: B01D15/08

CPC classification number: B01D15/14 ,  B01D15/22 ,  G01N30/6004 ,  G01N30/6026 ,  G01N30/603 ,  G01N30/6039 ,  Y10T29/49826

Abstract: A method for making a liquid-chromatography apparatus includes inserting two inner conduits into an intermediate tube, inserting the intermediate tube into an outer tube, forming a proximal seal between the intermediate tube and at least one of the inner conduits, and forming a distal seal between the intermediate tube and at least one of the inner conduits. A liquid-chromatography apparatus includes an outer tube, an intermediate tube disposed in the outer tube, two inner conduits disposed in the intermediate tube, a proximal seal between the intermediate tube and at least one of the inner conduits, and a distal seal between the intermediate tube and at least one of the inner conduits.

Abstract translation: 制备液相色谱装置的方法包括将两个内部导管插入中间管中，将中间管插入外管中，在中间管与至少一个内管之间形成近端密封，并形成远端密封 在中间管与至少一个内部管道之间。 液相色谱装置包括外管，设置在外管中的中间管，设置在中间管中的两个内导管，中间管与至少一个内导管之间的近侧密封，以及位于中间管之间的远端密封 中间管和至少一个内部管道。

公开(公告)号：US06962077B2

公开(公告)日：2005-11-08

申请号：US10328986

申请日：2002-12-23

Applicant: Geoff C. Gerhardt ,  Keith Fadgen

Inventor： Geoff C. Gerhardt ,  Keith Fadgen

IPC: G01F1/684 ,  G01N30/32 ,  G01N30/64 ,  G01F1/68

CPC classification number: G01F1/6847 ,  G01N30/64 ,  G01N2030/324

Abstract: A method and system for measuring the flow rate of a liquid or gas within a flow channel utilizing a centrally located excitation source and a plurality of sensor means. Said excitation means is comprised of a heating element coupled with an alternating current generator. Of the plurality of sensor means, at least one of said sensors is located in a position upstream of the excitation source location, and additionally a second of said plurality of sensors is located in a position downstream of the excitation source. Instantaneous fluid flow rate is calculated utilizing a high gain differential amplifier electrically coupled to said sensors, wherein the convectively induced inductive gradient of the flowing fluid is compared to the symmetrical zero flow induction gradient. Following such a comparison, a voltage signal proportional to the flow of fluid within the channel is derived.

Abstract translation: 一种用于利用位于中心的激励源和多个传感器装置来测量流动通道内的液体或气体的流量的方法和系统。 所述激励装置包括与交流发电机耦合的加热元件。 在多个传感器装置中，至少一个所述传感器位于激励源位置的上游位置，并且所述多个传感器中的另一个位于激发源的下游位置。 利用电耦合到所述传感器的高增益差分放大器来计算瞬时流体流速，其中流动流体的对流感应感应梯度与对称零流感应梯度进行比较。 在进行这样的比较之后，导出与通道内的流体流量成比例的电压信号。

公开(公告)号：US20050160833A1

公开(公告)日：2005-07-28

申请号：US11088120

申请日：2005-03-22

Applicant: Geoff Gerhardt ,  Keith Fadgen

Inventor： Geoff Gerhardt ,  Keith Fadgen

IPC: G01F1/684 ,  G01N30/32 ,  G01N30/64 ,  G01F1/708

CPC classification number: G01F1/6847 ,  G01N30/64 ,  G01N2030/324

Abstract: A method and system for measuring the flow rate of a liquid or gas within a flow channel utilizing a centrally located excitation source and a plurality of sensor means. Said excitation means is comprised of a heating element coupled with an alternating current generator. Of the plurality of sensor means, at least one of said sensors is located in a position upstream of the excitation source location, and additionally a second of said plurality of sensors is located in a position downstream of the excitation source. Instantaneous fluid flow rate is calculated utilizing a high gain differential amplifier electrically coupled to said sensors, wherein the convectively induced inductive gradient of the flowing fluid is compared to the symmetrical zero flow induction gradient. Following such a comparison, a voltage signal proportional to the flow of fluid within the channel is derived.

公开(公告)号：US20140151541A1

公开(公告)日：2014-06-05

申请号：US14004236

申请日：2012-03-08

Applicant: Geoff C. Gerhardt ,  Keith Fadgen

Inventor： Geoff C. Gerhardt ,  Keith Fadgen

IPC: H01J49/00

CPC classification number: H01J49/0009 ,  H01J49/00 ,  H01J49/04

Abstract: An electrokinetic pump can be used to deliver calibrant (“lock mass”) ions to a mass spectrometer for calibration of a mass spectrometry system. Electrokinetically controlled calibrant delivery can help to eliminate the need for the more cumbersome mechanisms that are often used for ion delivery. In addition, electrokinetically controlled calibrant delivery can provide for a more user-friendly system in which a calibrant solution can be packaged into a disposable cartridge. Furthermore, when implemented in a microfluidic format, electrokinetically controlled calibrant delivery can be coupled with an electrokinetically controlled separation system, such as capillary electrophoresis (CE), to allow efficient solid-state switching between analytical and calibrant sprays.

Abstract translation: 可以使用电动泵将校准物（“锁定质量”）离子输送到质谱仪用于校准质谱系统。 电动控制的校准物输送可以帮助消除对经常用于离子传递的更繁琐的机制的需要。 此外，电动控制的校准物输送可以提供更加用户友好的系统，其中校准液可以被包装到一次性盒中。 此外，当以微流体形式实施时，电动控制的校准物输送可与电动控制的分离系统（例如毛细管电泳（CE））结合，以允许分析和校准喷雾之间的有效的固态切换。

公开(公告)号：US08312762B2

公开(公告)日：2012-11-20

申请号：US12282895

申请日：2007-03-16

Applicant: Keith Fadgen ,  James E. Usowicz ,  Miguel Soares

Inventor： Keith Fadgen ,  James E. Usowicz ,  Miguel Soares

IPC: G01M30/02

CPC classification number: G01N30/20 ,  G01N30/22 ,  G01N2030/201 ,  G01N2030/202 ,  G05D7/0688 ,  G05D16/208

Abstract: Embodiments of the present invention are directed to methods and apparatus for placing a sample in a chromatographic system. The device and method feature placing samples held in a sample loop to pressurization prior to placing such sample loop in communication with high pressure conduits.

Abstract translation: 本发明的实施方案涉及将样品置于色谱系统中的方法和装置。 该装置和方法的特征是将放置样品回路中的样品置于加压之前，使样品环与高压导管连通。

公开(公告)号：US07059185B2

公开(公告)日：2006-06-13

申请号：US11088120

申请日：2005-03-22

Applicant: Geoff C. Gerhardt ,  Keith Fadgen

Inventor： Geoff C. Gerhardt ,  Keith Fadgen

IPC: G01F1/68

CPC classification number: G01F1/6847 ,  G01N30/64 ,  G01N2030/324

Abstract: A method and system for measuring the flow rate of a liquid or gas within a flow channel utilizing a centrally located excitation source and a plurality of sensors. The excitation source is comprised of a heating element coupled with an alternating current generator. Of the plurality of sensors, at least one of the sensors is located in a position upstream of the excitation source location, and additionally a second of the plurality of sensors is located in a position downstream of the excitation source. Instantaneous fluid flow rate is calculated utilizing a high gain differential amplifier electrically coupled to the sensors, wherein the convectively induced inductive gradient of the flowing fluid is compared to the symmetrical zero flow induction gradient. Following such a comparison, a voltage signal proportional to the flow of fluid within the channel is derived.

Abstract translation: 一种用于利用位于中心的激发源和多个传感器来测量流动通道内的液体或气体的流量的方法和系统。 激发源由与交流发电机耦合的加热元件组成。 在多个传感器中，传感器中的至少一个位于激励源位置的上游位置，另外多个传感器中的第二传感器位于激励源的下游位置。 利用电耦合到传感器的高增益差分放大器计算瞬时流体流速，其中将流动流体的对流感应感应梯度与对称零流感应梯度进行比较。 在进行这样的比较之后，导出与通道内的流体流量成比例的电压信号。

公开(公告)号：US20050109699A1

公开(公告)日：2005-05-26

申请号：US10723973

申请日：2003-11-26

Applicant: Geoff Gerhardt ,  Keith Fadgen

Inventor： Geoff Gerhardt ,  Keith Fadgen

IPC: G01F1/36 ,  G01F1/68 ,  G01N30/10 ,  G01N30/30 ,  G01N30/32 ,  B01D21/24 ,  B01D29/88

CPC classification number: G01F1/363 ,  G01F1/68 ,  G01N30/10 ,  G01N30/30 ,  G01N30/32 ,  G01N2030/324 ,  G01N2030/326

Abstract: A method and apparatus for monitoring and controlling the nano-scale flow rate of fluid in the operating flow path of a HPLC system without relying on a nano-scale sensor in the operating flow path. A main flow sensor is disposed in the main flow path between the pump and a flow-divider. A waste flow sensor is disposed in the waste flow path downstream of the splitter. The output signal of the waste flow sensor is subtracted from the output signal of the main flow sensor in a difference circuit. The difference signal is divided by the output signal from the main flow sensor in a divider circuit. The output of the divider circuit represents an empirical split ratio of the flow-divider and is independent of media composition.

Abstract translation: 一种用于在不依赖于操作流程中的纳米级传感器的情况下监视和控制HPLC系统的操作流路中的流体的纳米流量的方法和装置。 主流量传感器设置在泵和分流器之间的主流路中。 废液流量传感器设置在分流器下游的废流路中。 在差分电路中，从主流量传感器的输出信号中减去废液流量传感器的输出信号。 差分信号除以分流器电路中的主流量传感器的输出信号。 分压电路的输出表示分流器的经验分流比，并且与介质组成无关。

公开(公告)号：US09396916B2

公开(公告)日：2016-07-19

申请号：US14004236

申请日：2012-03-08

Applicant: Geoff C. Gerhardt ,  Keith Fadgen

Inventor： Geoff C. Gerhardt ,  Keith Fadgen

IPC: G01D18/00 ,  G12B13/00 ,  H01J49/00 ,  H01J49/04

CPC classification number: H01J49/0009 ,  H01J49/00 ,  H01J49/04

Abstract: An electrokinetic pump can be used to deliver calibrant (“lock mass”) ions to a mass spectrometer for calibration of a mass spectrometry system. Electrokinetically controlled calibrant delivery can help to eliminate the need for the more cumbersome mechanisms that are often used for ion delivery. In addition, electrokinetically controlled calibrant delivery can provide for a more user-friendly system in which a calibrant solution can be packaged into a disposable cartridge. Furthermore, when implemented in a microfluidic format, electrokinetically controlled calibrant delivery can be coupled with an electrokinetically controlled separation system, such as capillary electrophoresis (CE), to allow efficient solid-state switching between analytical and calibrant sprays.

Abstract translation: 可以使用电动泵将校准物（“锁定质量”）离子输送到质谱仪用于校准质谱系统。 电动控制的校准物输送可以帮助消除对经常用于离子传递的更繁琐的机制的需要。 此外，电动控制的校准物输送可以提供更加用户友好的系统，其中校准液可以被包装到一次性盒中。 此外，当以微流体形式实施时，电动控制的校准物输送可与电动控制的分离系统（例如毛细管电泳（CE））结合，以允许分析和校准喷雾之间的有效固态切换。